A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs.
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K. Duffin | S. Chandrasekhar | K. Thirunavukkarasu | M. Chambers | C. Swearingen | M. R. Wiley | T. Durham | C. J. Rito | J. Marimuthu | C. Lin | J. Dotzlaf | P. Mitchell | Q. Carter | C. Liu | M. Wiley