The promise, pitfalls and progress of RNA-interference-based antiviral therapy for respiratory viruses.
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[1] E. Luo,et al. Comparison of inhibitory efficacy of short interfering RNAs targeting different genes on Measles virus replication , 2012, Journal of basic microbiology.
[2] Yaosheng Chen,et al. Inhibition of highly pathogenic PRRSV replication in MARC-145 cells by artificial microRNAs , 2011, Virology Journal.
[3] Jiang-feng Du,et al. Broad-Spectrum Antiviral Activity of RNA Interference against Four Genotypes of Japanese Encephalitis Virus Based on Single MicroRNA Polycistrons , 2011, PloS one.
[4] B. Cullen,et al. Viruses and microRNAs: RISCy interactions with serious consequences. , 2011, Genes & development.
[5] J. Burnett,et al. Current progress of siRNA/shRNA therapeutics in clinical trials , 2011, Biotechnology journal.
[6] J. Lowenthal,et al. Immunostimulatory Motifs Enhance Antiviral siRNAs Targeting Highly Pathogenic Avian Influenza H5N1 , 2011, PloS one.
[7] Renata A Rawlings,et al. Viral RNAi suppressor reversibly binds siRNA to outcompete Dicer and RISC via multiple turnover. , 2011, Journal of molecular biology.
[8] T. Astor. RNA interference, RSV, and lung transplantation: a promising future for siRNA therapeutics. , 2011, American journal of respiratory and critical care medicine.
[9] M. Zamora,et al. RNA interference therapy in lung transplant patients infected with respiratory syncytial virus. , 2011, American journal of respiratory and critical care medicine.
[10] D. Palliser,et al. Optimizing siRNA delivery to the genital mucosa. , 2011, Discovery medicine.
[11] S. Barik. Intranasal Delivery of Antiviral siRNA , 2010, Methods in molecular biology.
[12] J. Oxford,et al. Viral load drives disease in humans experimentally infected with respiratory syncytial virus. , 2010, American journal of respiratory and critical care medicine.
[13] Adam P. Arkin,et al. Computational Models of HIV-1 Resistance to Gene Therapy Elucidate Therapy Design Principles , 2010, PLoS Comput. Biol..
[14] S. Barik. siRNA for Influenza Therapy , 2010, Viruses.
[15] Rob Lambkin-Williams,et al. A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus , 2010, Proceedings of the National Academy of Sciences.
[16] Daniel Becker,et al. Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication , 2010, Nature.
[17] R. König,et al. Human Host Factors Required for Influenza Virus Replication , 2010, Nature.
[18] S. Kauppinen,et al. Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection , 2010, Science.
[19] David J. Adams,et al. The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus , 2009, Cell.
[20] N. Hacohen,et al. A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection , 2009, Cell.
[21] J. Devincenzo,et al. Harnessing RNA interference to develop neonatal therapies: from Nobel Prize winning discovery to proof of concept clinical trials. , 2009, Early human development.
[22] Michael S. Goldberg,et al. Drug Delivery–mediated Control of RNA Immunostimulation , 2009, Molecular Therapy.
[23] Svetlana Shulga Morskaya,et al. RNA Interference-Mediated Silencing of the Respiratory Syncytial Virus Nucleocapsid Defines a Potent Antiviral Strategy , 2009, Antimicrobial Agents and Chemotherapy.
[24] B. Berkhout,et al. Stringent testing identifies highly potent and escape‐proof anti‐HIV short hairpin RNAs , 2009, The journal of gene medicine.
[25] T. Welte,et al. Community-Acquired Respiratory Viral Infections in Lung Transplant Recipients: A Single Season Cohort Study , 2009, Transplantation.
[26] Jian-Dong Huang,et al. Small Interfering RNA Targeting M2 Gene Induces Effective and Long Term Inhibition of Influenza A Virus Replication , 2009, PloS one.
[27] J. Lieberman,et al. Durable protection from Herpes Simplex Virus-2 transmission following intravaginal application of siRNAs targeting both a viral and host gene. , 2009, Cell host & microbe.
[28] Q. Jin,et al. Quick identification of effective small interfering RNAs that inhibit the replication of coxsackievirus A16. , 2008, Antiviral research.
[29] Priya S. Shah,et al. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. , 2008, Cell host & microbe.
[30] A. Judge,et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. , 2008, Human gene therapy.
[31] P. Hopkins,et al. Human metapneumovirus in lung transplant recipients and comparison to respiratory syncytial virus. , 2008, American journal of respiratory and critical care medicine.
[32] S. Barik. Treating Respiratory Viral Diseases with Chemically Modified, Second Generation Intranasal siRNAs , 2008, Methods in molecular biology.
[33] L. Lambeth,et al. Inhibition of Henipavirus infection by RNA interference , 2008, Antiviral Research.
[34] G. Boivin,et al. Inhibition of Human Metapneumovirus Replication by Small Interfering RNA , 2008, Antiviral therapy.
[35] C. Poh,et al. Development of RNA interference (RNAi) as potential antiviral strategy against enterovirus 70 , 2008, Journal of medical virology.
[36] Hongxuan He,et al. RNA interference of avian influenza virus H5N1 by inhibiting viral mRNA with siRNA expression plasmids. , 2008, Journal of biotechnology.
[37] S. Cryan,et al. Inhalable siRNA: potential as a therapeutic agent in the lungs. , 2008, Molecular pharmaceutics.
[38] T. Novobrantseva,et al. siRNA and the lung: research tool or therapeutic drug? , 2008, Current Opinion in Pharmacology.
[39] S. Elbashir,et al. Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV). , 2008, Antiviral research.
[40] B. Berkhout,et al. Human Immunodeficiency Virus Type 1 Escape Is Restricted When Conserved Genome Sequences Are Targeted by RNA Interference , 2007, Journal of Virology.
[41] B. Berkhout,et al. RNA interference against viruses: strike and counterstrike , 2007, Nature Biotechnology.
[42] F. Mooi,et al. Comparative gene expression profiling in two congenic mouse strains following Bordetella pertussis infection , 2007, BMC Microbiology.
[43] Michael S. Goldberg,et al. Effective RNAi-mediated gene silencing without interruption of the endogenous microRNA pathway , 2007, Nature.
[44] David Baltimore,et al. Stable reduction of CCR5 by RNAi through hematopoietic stem cell transplant in non-human primates , 2007, Proceedings of the National Academy of Sciences.
[45] B. Berkhout,et al. A systematic analysis of the effect of target RNA structure on RNA interference , 2007, Nucleic acids research.
[46] Jennifer L. Reed,et al. Severe Human Lower Respiratory Tract Illness Caused by Respiratory Syncytial Virus and Influenza Virus Is Characterized by the Absence of Pulmonary Cytotoxic Lymphocyte Responses , 2007, The Journal of infectious diseases.
[47] J. Devincenzo,et al. A new direction in understanding the pathogenesis of respiratory syncytial virus bronchiolitis: how real infants suffer. , 2007, The Journal of infectious diseases.
[48] M. Boeckh,et al. Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
[49] V. Hornung,et al. siRNA and isRNA: two edges of one sword. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[50] Yingjie Zhang,et al. Engineering mucosal RNA interference in vivo. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[51] P. Marsden. RNA interference as potential therapy--not so fast. , 2006, The New England journal of medicine.
[52] M. Kohara,et al. Effective Suppression of Human Immunodeficiency Virus Type 1 through a Combination of Short- or Long-Hairpin RNAs Targeting Essential Sequences for Retroviral Integration , 2006, Journal of Virology.
[53] T. Kanda,et al. Silencing of Hepatitis A Virus Infection by Small Interfering RNAs , 2006, Journal of Virology.
[54] Theresa A. Storm,et al. Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways , 2006, Nature.
[55] B. Berkhout,et al. Inhibition of human immunodeficiency virus type 1 by RNA interference using long-hairpin RNA , 2006, Gene Therapy.
[56] A. Lee,et al. Design of noninflammatory synthetic siRNA mediating potent gene silencing in vivo. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.
[57] J. Lieberman,et al. An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection , 2006, Nature.
[58] N. Zhong,et al. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque , 2005, Nature Medicine.
[59] Ben Berkhout,et al. Suppression of RNA Interference by Adenovirus Virus-Associated RNA , 2005, Journal of Virology.
[60] Deepali Kumar,et al. Clinical Impact of Community‐Acquired Respiratory Viruses on Bronchiolitis Obliterans After Lung Transplant , 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
[61] Christopher D. Richardson,et al. Hepatitis C Virus Replicons Escape RNA Interference Induced by a Short Interfering RNA Directed against the NS5b Coding Region , 2005, Journal of Virology.
[62] M. Sioud. Induction of inflammatory cytokines and interferon responses by double-stranded and single-stranded siRNAs is sequence-dependent and requires endosomal localization. , 2005, Journal of molecular biology.
[63] Anami R Patel,et al. Comparison of a Real-Time Reverse Transcriptase PCR Assay and a Culture Technique for Quantitative Assessment of Viral Load in Children Naturally Infected with Respiratory Syncytial Virus , 2005, Journal of Clinical Microbiology.
[64] A. Judge,et al. Sequence-dependent stimulation of the mammalian innate immune response by synthetic siRNA , 2005, Nature Biotechnology.
[65] S. Akira,et al. Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7 , 2005, Nature Medicine.
[66] Ben Berkhout,et al. HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome , 2005, Nucleic acids research.
[67] J. Stone,et al. Poliovirus Escape from RNA Interference: Short Interfering RNA-Target Recognition and Implications for Therapeutic Approaches , 2005, Journal of Virology.
[68] B. Cullen,et al. Adenovirus VA1 Noncoding RNA Can Inhibit Small Interfering RNA and MicroRNA Biogenesis , 2004, Journal of Virology.
[69] Matthias John,et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs , 2004, Nature.
[70] K. Schechtman,et al. Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death. , 2004, American journal of respiratory and critical care medicine.
[71] Qing Ge,et al. Inhibition of influenza virus production in virus-infected mice by RNA interference. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[72] T. Tumpey,et al. Protection against lethal influenza virus challenge by RNA interference in vivo. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[73] Patty J. Lee,et al. Small Interfering RNA Targeting Heme Oxygenase-1 Enhances Ischemia-Reperfusion-induced Lung Apoptosis* , 2004, Journal of Biological Chemistry.
[74] S. Akira,et al. Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8 , 2004, Science.
[75] Ben Berkhout,et al. Human Immunodeficiency Virus Type 1 Escapes from RNA Interference-Mediated Inhibition , 2004, Journal of Virology.
[76] B. Ramratnam,et al. Human Immunodeficiency Virus Type 1 Escape from RNA Interference , 2003, Journal of Virology.
[77] Michael T. McManus,et al. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[78] P. Collins,et al. Respiratory Syncytial Virus Infection of Human Airway Epithelial Cells Is Polarized, Specific to Ciliated Cells, and without Obvious Cytopathology , 2002, Journal of Virology.
[79] R. Flavell,et al. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 , 2001, Nature.
[80] T. Tuschl,et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells , 2001, Nature.
[81] J. Devincenzo,et al. Respiratory Syncytial Virus Infections in Hematopoietic Stem Cell Transplant Recipients and other Severely Immunocompromised Patients , 2000 .
[82] A. Fire,et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans , 1998, Nature.
[83] W. Sullender,et al. Analysis of respiratory syncytial virus genetic variability with amplified cDNAs , 1993, Journal of clinical microbiology.
[84] B. Berkhout,et al. Toward a durable treatment of HIV-1 infection using RNA interference. , 2011, Progress in molecular biology and translational science.
[85] J. Rossi,et al. Progress in RNAi-based antiviral therapeutics. , 2011, Methods in molecular biology.
[86] Measho H. Abreha,et al. Viral RNA silencing suppressors (RSS): novel strategy of viruses to ablate the host RNA interference (RNAi) defense system. , 2011, Virus research.
[87] D. Bumcrot,et al. Progress in the delivery of siRNA therapeutics: Potential in uveal melanoma , 2011, Drugs of the Future.
[88] M. Templin,et al. A potential therapeutic for pandemic influenza using RNA interference. , 2010, Methods in molecular biology.
[89] M. Sioud. Deciphering the code of innate immunity recognition of siRNAs. , 2009, Methods in molecular biology.
[90] B. Berkhout,et al. RNAi suppressors encoded by pathogenic human viruses. , 2008, The international journal of biochemistry & cell biology.
[91] B. Graham,et al. The histopathology of fatal untreated human respiratory syncytial virus infection , 2007, Modern Pathology.
[92] E. Domingo,et al. Viruses as Quasispecies: Biological Implications , 2006, Current topics in microbiology and immunology.
[93] S. Barik,et al. Inhibition of respiratory viruses by nasally administered siRNA , 2005, Nature Medicine.
[94] Hong Yang,et al. Inhibition of respiratory syncytial virus infection with intranasal siRNA nanoparticles targeting the viral NS1 gene , 2005, Nature Medicine.
[95] W. Sullender. Respiratory syncytial virus genetic and antigenic diversity. , 2000, Clinical microbiology reviews.
[96] Palivizumab, a Humanized Respiratory Syncytial Virus Monoclonal Antibody, Reduces Hospitalization From Respiratory Syncytial Virus Infection in High-risk Infants. , 1998, Pediatrics.