Drug Resistance in Leukemia and Lymphoma III

[1]  K. Schulze-Osthoff,et al.  Molecular mechanisms of glucocorticoid resistance. , 2000, Gastroenterology.

[2]  T. Yano,et al.  Ph-positive acute lymphocytic leukemia in a man with Klinefelter syndrome. , 2000, Cancer genetics and cytogenetics.

[3]  John Calvin Reed,et al.  Expression of Bcl-2-related genes in normal and AML progenitors: changes induced by chemotherapy and retinoic acid , 1999, Leukemia.

[4]  M. Noteborn,et al.  The effect of Bcl-2 on Apoptin in ‘normal' vs transformed human cells , 1999, Leukemia.

[5]  F Lampert,et al.  Philadelphia chromosome-positive (Ph+) childhood acute lymphoblastic leukemia: good initial steroid response allows early prediction of a favorable treatment outcome. , 1998, Blood.

[6]  M. Minden,et al.  Phosphorylation of BCL-2 after exposure of human leukemic cells to retinoic acid. , 1998, Blood.

[7]  M. D. Boer,et al.  Relation between age, immunophenotype and in vitro drug resistance in 395 children with acute lymphoblastic leukemia–implications for treatment of infants , 1998, Leukemia.

[8]  P. Hamilton,et al.  Bcl-2/Bax ratios in chronic lymphocytic leukaemia and their correlation with in vitro apoptosis and clinical resistance. , 1998, British Journal of Cancer.

[9]  K. Debatin,et al.  CD95 (APO-1/FAS)-mediated apoptosis in cytokine-activated hematopoietic cells. , 1998, Experimental hematology.

[10]  R. Pieters,et al.  Prednisolone resistance in childhood acute lymphoblastic leukemia: vitro-vivo correlations and cross-resistance to other drugs. , 1998, Blood.

[11]  V. Dixit,et al.  ERICE, a Novel FLICE-activatable Caspase* , 1998, The Journal of Biological Chemistry.

[12]  S. Korsmeyer,et al.  Involvement of Microtubules in the Regulation of Bcl2 Phosphorylation and Apoptosis through Cyclic AMP-Dependent Protein Kinase , 1998, Molecular and Cellular Biology.

[13]  P. Maslak,et al.  A phase I trial of a single high dose of idarubicin combined with high-dose cytarabine as induction therapy in relapsed or refractory adult patients with acute lymphoblastic leukemia , 1998, Leukemia.

[14]  A. van der Eb,et al.  Apoptin specifically causes apoptosis in tumor cells and after UV-treatment in untransformed cells from cancer-prone individuals: a review. , 1998, Mutation research.

[15]  John Calvin Reed,et al.  Modulation of Bcl-2 protein levels by an intracellular anti-Bcl-2 single-chain antibody increases drug-induced cytotoxicity in the breast cancer cell line MCF-7. , 1998, Cancer research.

[16]  S. Demo,et al.  A Novel Splice Variant of the Cell Death-promoting Protein BAX* , 1998, The Journal of Biological Chemistry.

[17]  G. Kroemer,et al.  Caspases disrupt mitochondrial membrane barrier function , 1998, FEBS letters.

[18]  C. Croce,et al.  Expression of apoptosis-regulating proteins in chronic lymphocytic leukemia: correlations with In vitro and In vivo chemoresponses. , 1998, Blood.

[19]  S. Korsmeyer,et al.  Hematopoietic malignancies demonstrate loss-of-function mutations of BAX. , 1998, Blood.

[20]  J C Reed,et al.  A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases* , 1998, The Journal of Biological Chemistry.

[21]  R. Pieters,et al.  Relationship between major vault protein/lung resistance protein, multidrug resistance-associated protein, P-glycoprotein expression, and drug resistance in childhood leukemia. , 1998, Blood.

[22]  C. Borner,et al.  The Binding Properties and Biological Activities of Bcl-2 and Bax in Cells Exposed to Apoptotic Stimuli* , 1998, The Journal of Biological Chemistry.

[23]  M. Andreeff,et al.  Differential induction of apoptosis by fludarabine monophosphate in leukemic B and normal T cells in chronic lymphocytic leukemia. , 1998, Blood.

[24]  M. Relling,et al.  Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. , 1998, The New England journal of medicine.

[25]  John Calvin Reed,et al.  Elevated expression of the apoptotic regulator Mcl-1 at the time of leukemic relapse. , 1998, Blood.

[26]  F. Sigaux,et al.  Genomic alterations of the p19ARF encoding exons in T-cell acute lymphoblastic leukemia. , 1998, Blood.

[27]  D G Kirsch,et al.  Modulation of cell death by Bcl-XL through caspase interaction. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[28]  E. Sausville,et al.  Early induction of apoptosis in hematopoietic cell lines after exposure to flavopiridol. , 1998, Blood.

[29]  G. Borasio,et al.  Survival-Promoting Activity of Inhibitors of Cyclin-Dependent Kinases on Primary Neurons Correlates with Inhibition of c-Jun Kinase-1 , 1997, Neurobiology of Disease.

[30]  E. Cheng,et al.  Conversion of Bcl-2 to a Bax-like death effector by caspases. , 1997, Science.

[31]  M. Andreeff,et al.  Activity of TNF‐related apoptosis‐inducing ligand (TRAIL) in haematological malignancies , 1997, British journal of haematology.

[32]  F. Durrieu,et al.  Bcr-abl translocation can occur during the induction of multidrug resistance and confers apoptosis resistance on myeloid leukemic cell lines , 1997, Cell Death and Differentiation.

[33]  P. Golstein.  Cell death: TRAIL and its receptors. , 1997, Current biology : CB.

[34]  Richard A. Ashmun,et al.  Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19 ARF , 1997, Cell.

[35]  S. Gollapudi,et al.  Altered expression of the genes regulating apoptosis in multidrug resistant human myeloid leukemia cell lines overexpressing MDR1 or MRP gene. , 1997, International Journal of Oncology.

[36]  L. Peso,et al.  Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. , 1997, Science.

[37]  S. R. Datta,et al.  Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.

[38]  I. Herr,et al.  Activation of CD95 (APO‐1/Fas) signaling by ceramide mediates cancer therapy‐induced apoptosis , 1997, The EMBO journal.

[39]  L. Meijer,et al.  The effect of the cyclin-dependent kinase inhibitor olomoucine on cell cycle kinetics. , 1997, Experimental cell research.

[40]  G. Kroemer,et al.  The Mitochondrion as a Sensor/Effector of Oxidative Stress During Apoptosis , 1997 .

[41]  A. Watson,et al.  v-Abl protein tyrosine kinase (PTK) mediated suppression of apoptosis is associated with the up-regulation of Bcl-XL , 1997, Oncogene.

[42]  K. Kinzler,et al.  A model for p53-induced apoptosis , 1997, Nature.

[43]  S. Raimondi,et al.  Philadelphia chromosome-positive acute lymphoblastic leukemia in children: durable responses to chemotherapy associated with low initial white blood cell counts , 1997, Leukemia.

[44]  K. Sullivan,et al.  Marrow transplants from unrelated donors for treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia. , 1997, Blood.

[45]  Xiaodong Wang,et al.  Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3 , 1997, Cell.

[46]  D. Vaux,et al.  CED-4—The Third Horseman of Apoptosis , 1997, Cell.

[47]  A. Strasser,et al.  The anti‐apoptosis function of Bcl‐2 can be genetically separated from its inhibitory effect on cell cycle entry , 1997, The EMBO journal.

[48]  N. Thornberry,et al.  Caspases: killer proteases. , 1997, Trends in biochemical sciences.

[49]  D. Altieri,et al.  A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma , 1997, Nature Medicine.

[50]  J. Bertino,et al.  Disparate affinities of antifolates for folylpolyglutamate synthetase from human leukemia cells , 1997 .

[51]  G. Kroemer.  The proto-oncogene Bcl-2 and its role in regulating apoptosis , 1997, Nature Medicine.

[52]  K. Debatin,et al.  Modulation of resistance to anti‐APO‐1‐induced apoptosis in osteosarcoma cells by cytokines , 1997, International journal of cancer.

[53]  N. Thornberry,et al.  A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B , 1997, The Journal of Biological Chemistry.

[54]  Margot Thome,et al.  Inhibition of death receptor signals by cellular FLIP , 1997, Nature.

[55]  P. Chambon,et al.  Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[56]  M. Tomonaga,et al.  Soluble and membrane isoforms of Fas/CD95 in fresh adult T‐cell leukemia (ATL) cells and ATL‐cell lines , 1997, International journal of cancer.

[57]  Guy S. Salvesen,et al.  X-linked IAP is a direct inhibitor of cell-death proteases , 1997, Nature.

[58]  John Calvin Reed.  Double identity for proteins of the Bcl-2 family , 1997, Nature.

[59]  P. W. Mesner,et al.  Affinity labeling displays the stepwise activation of ICE-related proteases by Fas, staurosporine, and CrmA-sensitive caspase-8 , 1997, Oncogene.

[60]  A. Hart,et al.  The Baxα:Bcl‐2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia , 1997, International journal of cancer.

[61]  H. Sather,et al.  Augmented Berlin-Frankfurt-Munster therapy abrogates the adverse prognostic significance of slow early response to induction chemotherapy for children and adolescents with acute lymphoblastic leukemia and unfavorable presenting features: a report from the Children's Cancer Group. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[62]  J. Román,et al.  MYELOPEROXIDASE GENE EXPRESSION IN ACUTE LYMPHOBLASTIC LEUKAEMIA , 1997, British journal of haematology.

[63]  B. Groner,et al.  Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain , 1997, Nature Medicine.

[64]  P. Burton,et al.  Homozygous deletion of the p16/MTS1 gene in pediatric acute lymphoblastic leukemia is associated with unfavorable clinical outcome. , 1997, Blood.

[65]  J. Falkenburg,et al.  Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[66]  H. Sather,et al.  Cellular Expression of Antiapoptotic BCL-2 Oncoprotein in Newly Diagnosed Childhood Acute Lymphoblastic Leukemia: A Children's Cancer Group Study , 1997 .

[67]  J C Reed,et al.  Channel formation by antiapoptotic protein Bcl-2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[68]  J. Moul,et al.  Inhibition of the growth of pre‐established subcutaneous tumor nodules of human prostate cancer cells by single injection of the recombinant adenovirus p53 expression vector , 1997, International journal of cancer.

[69]  R. Greil,et al.  Expression of Apo‐1/Fas (CD95), Bcl‐2, Bax and Bcl‐x in myeloma cell lines: relationship between responsiveness to anti‐Fas mab and p53 functional status , 1997, British journal of haematology.

[70]  P. Bucher,et al.  The CARD domain: a new apoptotic signalling motif. , 1997, Trends in biochemical sciences.

[71]  C. Simbulan-Rosenthal,et al.  Intact cell evidence for the early synthesis, and subsequent late apopain-mediated suppression, of poly(ADP-ribose) during apoptosis. , 1997, Experimental cell research.

[72]  E. Estey,et al.  Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[73]  G. Freeman,et al.  Role of the CD40 and CD95 (APO‐1/Fas) antigens in the apoptosis of human B‐cell malignancies , 1997, British journal of haematology.

[74]  Yuri Lazebnik,et al.  Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells , 1997, The EMBO journal.

[75]  D. Grobbee,et al.  Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance , 1997, Human Genetics.

[76]  A. Collins,et al.  The comet assay: what can it really tell us? , 1997, Mutation research.

[77]  E. Alnemri,et al.  Processing/Activation of At Least Four Interleukin-1β Converting Enzyme–like Proteases Occurs during the Execution Phase of Apoptosis in Human Monocytic Tumor Cells , 1997, The Journal of cell biology.

[78]  G. Laurent,et al.  Influence of Bcl-2 overexpression on the ceramide pathway in daunorubicin-induced apoptosis of leukemic cells , 1997, Oncogene.

[79]  P. Nicotera,et al.  Apoptosis in the absence of poly-(ADP-ribose) polymerase. , 1997, Biochemical and biophysical research communications.

[80]  H. Findley,et al.  Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia. , 1997, Blood.

[81]  T. Hongo,et al.  In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia. , 1997, Blood.

[82]  J. Mankovich,et al.  Substrate Specificities of Caspase Family Proteases* , 1997, The Journal of Biological Chemistry.

[83]  J. Tschopp,et al.  Direct physical interaction between the Caenorhabditis elegans ‘death proteins’ CED‐3 and CED‐4 , 1997, FEBS letters.

[84]  E. Sausville,et al.  Promising new agents under development by the Division of Cancer Treatment, Diagnosis, and Centers of the National Cancer Institute. , 1997, Seminars in oncology.

[85]  S. Jiang,et al.  Expression of CD95(FAS) by gene transfer does not sensitize K562 to Fas-killing. , 1997, Hematology and cell therapy.

[86]  E. Bossy‐Wetzel,et al.  Induction of apoptosis by the transcription factor c‐Jun , 1997, The EMBO journal.

[87]  Y. Hannun,et al.  Apoptosis and the dilemma of cancer chemotherapy. , 1997, Blood.

[88]  W. Earnshaw,et al.  Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis* , 1997, The Journal of Biological Chemistry.

[89]  Hall,et al.  Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA , 1997, British journal of haematology.

[90]  H. Drexler,et al.  Expression and function of CD95 (FAS/APO‐1) in leukaemia‐lymphoma tumour lines , 1997, British journal of haematology.

[91]  J. Bartek,et al.  Adenovirally transferred p16INK4/CDKN2 and p53 genes cooperate to induce apoptotic tumor cell death , 1997, Nature Medicine.

[92]  S. McKenna,et al.  MULTIDRUG RESISTANCE IN LEUKAEMIA , 1997, Bailliere's clinical haematology.

[93]  D. Green,et al.  The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis , 1997, Science.

[94]  Dean P. Jones,et al.  Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked , 1997, Science.

[95]  G. Núñez,et al.  Interaction and Regulation of Subcellular Localization of CED-4 by CED-9 , 1997, Science.

[96]  A. Chinnaiyan,et al.  Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death , 1997, Science.

[97]  Daniel J. Hoeppner,et al.  Interaction between the C. elegans cell-death regulators CED-9 and CED-4 , 1997, Nature.

[98]  A. Levine.  p53, the Cellular Gatekeeper for Growth and Division , 1997, Cell.

[99]  S. Nagata,et al.  Apoptosis by Death Factor , 1997, Cell.

[100]  A. Delmer,et al.  Multidrug resistance gene expression in acute myeloid leukemia: Major prognosis significance for in vivo drug resistance to induction treatment , 1997, Annals of Hematology.

[101]  E. White,et al.  Bcl-2 and the ICE family of apoptotic regulators: making a connection. , 1997, Current opinion in genetics & development.

[102]  Seamus J. Martin,et al.  Downregulation of Bcr-Abl in K562 cells restores susceptibility to apoptosis: Characterization of the apoptotic death , 1997, Cell Death and Differentiation.

[103]  C. Preudhomme,et al.  Good correlation between RT-PCR analysis and relapse in Philadelphia (Ph1)-positive acute lymphoblastic leukemia (ALL) , 1997, Leukemia.

[104]  N. Young,et al.  Involvement of Fas-mediated apoptosis in the inhibitory effects of interferon-alpha in chronic myelogenous leukemia. , 1997, Blood.

[105]  E. Wang,et al.  Acute lymphoblastic leukaemia in childhood: cell proliferation without rest , 1997, British journal of haematology.

[106]  Andy J. Minn,et al.  Bcl-xL forms an ion channel in synthetic lipid membranes , 1997, Nature.

[107]  C. Croce,et al.  Bcl2 is the guardian of microtubule integrity. , 1997, Cancer research.

[108]  S H Kim,et al.  Inhibition of cyclin-dependent kinases by purine analogues: crystal structure of human cdk2 complexed with roscovitine. , 1997, European journal of biochemistry.

[109]  R. Craig,et al.  Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions. , 1997, Blood.

[110]  Vishva M. Dixit,et al.  RAIDD is a new 'death' adaptor molecule , 1997, Nature.

[111]  T. Lister,et al.  Intensive chemotherapy for adult acute lymphoblastic leukaemia given with or without granulocyte-macrophage colony stimulating factor , 1996, Annals of Hematology.

[112]  G. Gil-Gómez,et al.  Bax alpha perturbs T cell development and affects cell cycle entry of T cells. , 1996, The EMBO journal.

[113]  P. Olive,et al.  Development of apoptosis and polyploidy in human lymphoblast cells as a function of position in the cell cycle at the time of irradiation. , 1996, Radiation research.

[114]  C. Pepper,et al.  REGULATION OF CLINICAL CHEMORESISTANCE BY bcl‐2 AND BAX ONCOPROTEINS IN B‐CELL CHRONIC LYMPHOCYTIC LEUKAEMIA , 1996, British journal of haematology.

[115]  K. Sullivan,et al.  Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity. , 1996, The New England journal of medicine.

[116]  D. Goeddel,et al.  A death-domain-containing receptor that mediates apoptosis , 1996, Nature.

[117]  M. J. Ehrke,et al.  Evidence for the involvement of ecto‐5′‐nucleotidase (CD73) in drug resistance , 1996, International journal of cancer.

[118]  Z. Estrov,et al.  Flt3 ligand stimulates proliferation and inhibits apoptosis of acute myeloid leukemia cells: regulation of Bcl-2 and Bax. , 1996, Blood.

[119]  S. Chouaib,et al.  Impairment of Fas‐antigen expression in adriamycin‐resistant but not TNF‐resistant MCF7 tumor cells , 1996, International journal of cancer.

[120]  A. Chinnaiyan,et al.  Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95 , 1996, Science.

[121]  A. Gartel,et al.  p21—Negative Regulator of the Cell Cycle , 1996, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[122]  N. Saijo,et al.  Antitumor effects of butyrolactone I, a selective cdc2 kinase inhibitor, on human lung cancer cell lines. , 1996, Anticancer research.

[123]  R. Pirker,et al.  Multidrug resistance in leukemias and its reversal. , 1996, Leukemia & lymphoma.

[124]  S. Srinivasula,et al.  The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32* , 1996, The Journal of Biological Chemistry.

[125]  Junying Yuan,et al.  Human ICE/CED-3 Protease Nomenclature , 1996, Cell.

[126]  C. Harris,et al.  Structure and function of the p53 tumor suppressor gene: clues for rational cancer therapeutic strategies. , 1996, Journal of the National Cancer Institute.

[127]  M. Waltham,et al.  Intrinsic and acquired resistance to methotrexate in acute leukemia. , 1996, The New England journal of medicine.

[128]  J. M. Adams,et al.  Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival. , 1996, Oncogene.

[129]  G. Kroemer,et al.  Bcl-2 inhibits the mitochondrial release of an apoptogenic protease , 1996, The Journal of experimental medicine.

[130]  E. Mechetner,et al.  Expression of Fas/CD95 and Bcl-2 by primitive hematopoietic progenitors freshly isolated from human fetal liver. , 1996, Blood.

[131]  B. Ogretmen,et al.  Down‐regulation of apoptosis‐related bcl‐2 but not bcl‐xL or bax proteins in multidrug‐resistant MCF‐7/Adr human breast cancer cells , 1996, International journal of cancer.

[132]  G. Linette,et al.  Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[133]  G. Tsangaris,et al.  Study of apoptosis in peripheral blood of patients with acute lymphoblastic leukemia during induction therapy. , 1996, Anticancer research.

[134]  Joseph A. DiGiuseppe,et al.  Multiparameter flow-cytometric analysis of bcl-2 and Fas expression in normal and neoplastic hematopoiesis. , 1996, American journal of clinical pathology.

[135]  F. Shanahan,et al.  The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand , 1996, The Journal of experimental medicine.

[136]  N. Copeland,et al.  bcl-w, a novel member of the bcl-2 family, promotes cell survival. , 1996, Oncogene.

[137]  E. Koonin,et al.  Genome Sequence of a Human Tumorigenic Poxvirus: Prediction of Specific Host Response-Evasion Genes , 1996, Science.

[138]  R. Pieters,et al.  Comparison of the antileukemic activity in vitro of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia. , 1996, Medical and pediatric oncology.

[139]  A. Munck,et al.  Glucocorticoid receptors: ATP and cell cycle dependence, phosphorylation, and hormone resistance. , 1996, American journal of respiratory and critical care medicine.

[140]  F. Mostofi,et al.  Protein expression of p53, bcl-2, and KI-67 (MIB-1) as prognostic biomarkers in patients with surgically treated, clinically localized prostate cancer. , 1996, Surgery.

[141]  D. Campana,et al.  Comparative cytotoxicity of dexamethasone and prednisolone in childhood acute lymphoblastic leukemia. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[142]  H. Jürgens,et al.  Monitoring of asparaginase activity and asparagine levels in children on different asparaginase preparations. , 1996, European journal of cancer.

[143]  A. Hall,et al.  The relationship between tumour glutathione concentration, glutathione S-transferase isoenzyme expression and response to single agent carboplatin in epithelial ovarian cancer patients. , 1996, British Journal of Cancer.

[144]  H. Horvitz,et al.  An Alternatively Spliced C. elegans ced-4 RNA Encodes a Novel Cell Death Inhibitor , 1996, Cell.

[145]  S. Srinivasula,et al.  In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[146]  S. Korsmeyer,et al.  Molecular thanatopsis: a discourse on the BCL2 family and cell death. , 1996, Blood.

[147]  G. Tsangaris,et al.  Development of a quantitative method for the study of apoptosis in peripheral blood. , 1996, In vivo.

[148]  T. Barbui,et al.  Age-adapted moderate-dose induction and flexible outpatient postremission therapy for elderly patients with acute lymphoblastic leukemia. , 1996, Leukemia & lymphoma.

[149]  R. Kolodner,et al.  Biochemistry and genetics of eukaryotic mismatch repair. , 1996, Genes & development.

[150]  P. Olive,et al.  Reduction of tumor hypoxia and inhibition of DNA repair by nicotinamide after irradiation of SCCVII murine tumors and normal tissues. , 1996, Cancer research.

[151]  David Wallach,et al.  Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death , 1996, Cell.

[152]  T. Palshof,et al.  RELATION OF BLAST CELL SURVIVAL AND PROLIFERATION TO CHEMOTHERAPY RESISTANCE IN AML , 1996, British journal of haematology.

[153]  Seok Lee,et al.  Expression of Fas antigen in acute myeloid leukaemia is associated with therapeutic response to chemotherapy , 1996, British Journal of Haematology.

[154]  C. Thompson,et al.  A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. , 1996, The EMBO journal.

[155]  M. Lehnert.  Clinical multidrug resistance in cancer: a multifactorial problem. , 1996, European journal of cancer.

[156]  R. Zarbo,et al.  Lack of correlation between flow cytometric and immunohistologic proliferation measurements of tumors. , 1996, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

[157]  J. Korenberg,et al.  Purification and Properties of Human Cytosolic Folylpoly-γ-glutamate Synthetase and Organization, Localization, and Differential Splicing of Its Gene* , 1996, The Journal of Biological Chemistry.

[158]  D. Vaux,et al.  Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[159]  I. Herr,et al.  Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells , 1996, Nature Medicine.

[160]  T. Barbui,et al.  Molecular diagnosis and clinical relevance of t(9;22), t(4;11) and t(1 ;19) chromosome abnormalities in a consecutive group of 141 adult patients with acute lymphoblastic leukemia. , 1996, Leukemia & lymphoma.

[161]  N. Thornberry,et al.  Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death , 1996, The Journal of experimental medicine.

[162]  S H Kim,et al.  Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[163]  A. List,et al.  Role of multidrug resistance and its pharmacological modulation in acute myeloid leukemia. , 1996, Leukemia.

[164]  G. Kroemer,et al.  Mitochondrial control of nuclear apoptosis , 1996, The Journal of experimental medicine.

[165]  J. Downing,et al.  Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age. , 1996, Blood.

[166]  Nalini Singh,et al.  POSITIVE CORRELATION BETWEEN APOPTOTIC AND PROLIFERATIVE INDICES IN GASTROINTESTINAL LYMPHOMAS OF MUCOSA‐ASSOCIATED LYMPHOID TISSUE (MALT) , 1996, The Journal of pathology.

[167]  S. Werner,et al.  Molecular basis of glucocorticoid-resistant syndromes , 1996, Steroids.

[168]  John Calvin Reed,et al.  Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2 (*) , 1996, The Journal of Biological Chemistry.

[169]  L. Devy,et al.  Evidence for distinct regulation processes in the aclacinomycin- and doxorubicin-mediated differentiation of human erythroleukemic cells. , 1996, Biochemical pharmacology.

[170]  P. Brousset,et al.  Frequent expression of the cell death-inducing gene Bax in Reed-Sternberg cells of Hodgkin's disease. , 1996, Blood.

[171]  H. Horvitz,et al.  Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activities. , 1996, Genes & development.

[172]  J. Bartek,et al.  A common path to tumor growth. , 1996, Oncology Report.

[173]  A. Berns,et al.  T cells from baxalpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage‐induced cell death in the absence of p53. , 1996, The EMBO journal.

[174]  J. Lotem,et al.  Protection of human myeloid leukemic cells against doxorubicin-induced apoptosis by granulocyte-macrophage colony-stimulating factor and interleukin 3. , 1996, Leukemia.

[175]  S. Singhal,et al.  Bone marrow transplantation for Philadelphia chromosome-positive acute lymphoblastic leukemia. , 1996, Bone marrow transplantation.

[176]  E. Cheng,et al.  Bax-independent inhibition of apoptosis by Bcl-XL , 1996, Nature.

[177]  J. Shuster,et al.  High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis. , 1996, Blood.

[178]  J. Larrick,et al.  Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide- deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation , 1996, The Journal of experimental medicine.

[179]  L. Smets,et al.  Agonist-free transformation of the glucocorticoid receptor in human B-lymphoma cells , 1996, The Journal of Steroid Biochemistry and Molecular Biology.

[180]  A. Iolascon,et al.  Homozygous deletions of cyclin-dependent kinase inhibitor genes, p16(INK4A) and p18, in childhood T cell lineage acute lymphoblastic leukemias. , 1996, Leukemia.

[181]  A. Fojo,et al.  bcl-2 protein downregulation is not required for differentiation of multidrug resistant HL60 leukemia cells. , 1996, Leukemia research.

[182]  F. Behm,et al.  Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia. , 1996, Leukemia.

[183]  F. Behm,et al.  Clinical relevance of BCL-2 overexpression in childhood acute lymphoblastic leukemia. , 1996, Blood.

[184]  S. Orrenius,et al.  CPP32/Apopain Is a Key Interleukin 1 Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis (*) , 1996, The Journal of Biological Chemistry.

[185]  R. Gottlieb,et al.  Apoptosis induced in Jurkat cells by several agents is preceded by intracellular acidification. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[186]  B. Asselain,et al.  Sequential assessment of multidrug resistance phenotype and measurement of S‐phase fraction as predictive markers of breast cancer response to neoadjuvant chemotherapy , 1996, Cancer.

[187]  Mike Rothe,et al.  The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins , 1995, Cell.

[188]  Gerald M. Rubin,et al.  Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death , 1995, Cell.

[189]  E. Alnemri,et al.  Mch3, a novel human apoptotic cysteine protease highly related to CPP32. , 1995, Cancer research.

[190]  J. Bartek,et al.  Unrestricted cell cycling and cancer , 1995, Nature Medicine.

[191]  P. de Coppet,et al.  Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription. , 1995, Cancer research.

[192]  John Calvin Reed.  Bcl-2 family proteins: regulators of chemoresistance in cancer. , 1995, Toxicology letters.

[193]  R. Pieters,et al.  In vitro cellular drug resistance in children with relapsed/refractory acute lymphoblastic leukemia. , 1995, Blood.

[194]  R. Pieters,et al.  In vitro chemosensitivity assessed with the MTT assay in childhood acute non-lymphoblastic leukemia. , 1995, Leukemia.

[195]  A. Rustgi,et al.  DNA mismatch repair and cancer. , 1995, Gastroenterology.

[196]  R. Pieters,et al.  Clinical and cell biological features related to cellular drug resistance of childhood acute lymphoblastic leukemia cells. , 1995, Leukemia & lymphoma.

[197]  T. Chittenden,et al.  A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions. , 1995, The EMBO journal.

[198]  D. Faller,et al.  Direction of p21ras-generated signals towards cell growth or apoptosis is determined by protein kinase C and Bcl-2. , 1995, Oncogene.

[199]  D. Green,et al.  The killer and the executioner: how apoptosis controls malignancy. , 1995, Current opinion in immunology.

[200]  J. Falkenburg,et al.  Apoptin, a protein encoded by chicken anemia virus, induces cell death in various human hematologic malignant cells in vitro. , 1995, Leukemia.

[201]  E. Thompson,et al.  Successful in vitro purging of leukemic blasts from marrow by cortivazol, a pyrazolosteroid: a preclinical study for autologous transplantation in acute lymphoblastic leukemia and non-Hodgkin's lymphoma. , 1995, Leukemia.

[202]  N. Curtin,et al.  Potentiation of temozolomide-induced cytotoxicity: a comparative study of the biological effects of poly(ADP-ribose) polymerase inhibitors. , 1995, British Journal of Cancer.

[203]  T. Lindahl,et al.  Post-translational modification of poly(ADP-ribose) polymerase induced by DNA strand breaks. , 1995, Trends in biochemical sciences.

[204]  K. Franssila,et al.  Reduced expression of proapoptotic gene BAX is associated with poor response rates to combination chemotherapy and shorter survival in women with metastatic breast adenocarcinoma. , 1995, Cancer research.

[205]  M. Spinella,et al.  Characterization of a Mutation in the Reduced Folate Carrier in a Transport Defective L1210 Murine Leukemia Cell Line (*) , 1995, The Journal of Biological Chemistry.

[206]  Seamus J. Martin,et al.  Regulation of the Fas Apoptotic Cell Death Pathway by Abl (*) , 1995, The Journal of Biological Chemistry.

[207]  S. Proctor,et al.  Corticosteroid resistance is increased in lymphoblasts from adults compared with children: preliminary results of in vitro drug sensitivity study in adults with acute lymphoblastic leukaemia , 1995, British journal of haematology.

[208]  J. Milner.  DNA damage, p53 and anticancer therapies , 1995, Nature Medicine.

[209]  C. Whitacre,et al.  Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences. , 1995, Cancer research.

[210]  H. Jürgens,et al.  Loss of activity of Erwinia asparaginase on repeat applications. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[211]  V. Kosma,et al.  Apoptosis suppressing protein bcl‐2 is expressed in well‐differentiated breast carcinomas with favourable prognosis , 1995, The Journal of pathology.

[212]  K. Takatsuki,et al.  Expression of Fas/Apo-1 (CD95) and apoptosis in tumor cells from patients with plasma cell disorders. , 1995, Blood.

[213]  Y. Tohno,et al.  Inhibition and down-regulation of poly(ADP-ribose) polymerase results in a marked resistance of HL-60 cells to various apoptosis-inducers. , 1995, Cellular and molecular biology.

[214]  C. Rudin,et al.  Expression of bcl-xL can confer a multidrug resistance phenotype. , 1995, Blood.

[215]  Z. Oltvai,et al.  Multiple Bcl-2 family members demonstrate selective dimerizations with Bax. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[216]  G. Losa,et al.  Apoptosis in human lymphoblastoid cells induced by acivicin, a specific γ glutamyltransferase inhibitor , 1995, International journal of cancer.

[217]  C. Chresta,et al.  Characterization of drug resistance mediated via the suppression of apoptosis by Abelson protein tyrosine kinase. , 1995, Molecular pharmacology.

[218]  A. Harris,et al.  Inactivation of Cdc2 increases the level of apoptosis induced by DNA damage. , 1995, Journal of cell science.

[219]  G. Kroemer,et al.  Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death , 1995, The Journal of experimental medicine.

[220]  L Meijer,et al.  Multiple modes of ligand recognition: Crystal structures of cyclin‐dependent protein kinase 2 in complex with ATP and two inhibitors, olomoucine and isopentenyladenine , 1995, Proteins.

[221]  D. Donner,et al.  Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor. , 1995, The Biochemical journal.

[222]  J. Smith,et al.  The effect of haemopoietic growth factors on the cell cycle of AML progenitors and their sensitivity to cytosine arabinoside in vitro , 1995, British journal of haematology.

[223]  C. Peterson,et al.  High-performance liquid chromatography with fluorometric detection for monitoring of etoposide and its cis-isomer in plasma and leukaemic cells. , 1995, Journal of chromatography. B, Biomedical applications.

[224]  X. Graña,et al.  Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). , 1995, Oncogene.

[225]  Patrick R. Griffin,et al.  Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis , 1995, Nature.

[226]  G. Janossy,et al.  Bcl-2 protein expression in normal human bone marrow precursors and in acute myelogenous leukemia. , 1995, Leukemia.

[227]  J. Carlstedt-Duke,et al.  The genetic basis of glucocorticoid resistance , 1995, Trends in Endocrinology & Metabolism.

[228]  L. Foroni,et al.  Expression and function of the FAS antigen in B chronic lymphocytic leukemia and hairy cell leukemia. , 1995, Leukemia.

[229]  R. Bouabdallah,et al.  A controlled study of recombinant human granulocyte colony-stimulating factor in elderly patients after treatment for acute myelogenous leukemia. AML Cooperative Study Group. , 1995, The New England journal of medicine.

[230]  Warren Strober,et al.  Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome , 1995, Cell.

[231]  C. Thompson,et al.  Bcl-xL is expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis. , 1995, Cancer research.

[232]  F. Rieux-Laucat,et al.  Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. , 1995, Science.

[233]  M. Poot,et al.  De novo synthesis of glutathione is required for both entry into and progression through the cell cycle , 1995, Journal of cellular physiology.

[234]  P. Sonneveld,et al.  Multidrug resistant cells with high proliferative capacity determine response to therapy in acute myeloid leukemia. , 1995, Leukemia.

[235]  N. Young,et al.  Fas antigen expression on CD34+ human marrow cells is induced by interferon gamma and tumor necrosis factor alpha and potentiates cytokine-mediated hematopoietic suppression in vitro. , 1995, Blood.

[236]  J. Roth,et al.  Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression , 1995, Molecular and cellular biology.

[237]  R. Pieters,et al.  In vitro anthracycline cross-resistance pattern in childhood acute lymphoblastic leukaemia. , 1995, British Journal of Cancer.

[238]  J. Bertino,et al.  Selective treatment of SCID mice bearing methotrexate-transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection. , 1995, Blood.

[239]  J. Massagué,et al.  Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1 , 1995, Nature.

[240]  K. Yamamoto,et al.  LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[241]  J. Jaffrezou,et al.  Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. , 1995, Leukemia.

[242]  R. Hanada,et al.  Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia. , 1995, Blood.

[243]  Y. Tsujimoto,et al.  Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL , 1995, Nature.

[244]  B. Sikic,et al.  Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance. , 1995, Biochimica et biophysica acta.

[245]  P. Freemont,et al.  The solution structure of the RING finger domain from the acute promyelocytic leukaemia proto‐oncoprotein PML. , 1995, The EMBO journal.

[246]  D. Weltin,et al.  Immunosuppressive activities of 6(5H)-phenanthridinone, a new poly(ADP-ribose)polymerase inhibitor. , 1995, International journal of immunopharmacology.

[247]  F. Mandelli,et al.  Good steroid response in vivo predicts a favorable outcome in children with T‐cell acute lymphoblastic leukemia , 1995 .

[248]  John Calvin Reed.  Bcl-2: prevention of apoptosis as a mechanism of drug resistance. , 1995, Hematology/oncology clinics of North America.

[249]  B. Dörken,et al.  Expression of the bcl‐2 gene family in normal and malignant breast tissue: Low bax‐α expression in tumor cells correlates with resistance towards apoptosis , 1995, International journal of cancer.

[250]  P. Krammer,et al.  Identification of soluble APO-1 in supernatants of human B- and T-cell lines and increased serum levels in B- and T-cell leukemias. , 1995, Blood.

[251]  S. Nagata,et al.  The Fas death factor , 1995, Science.

[252]  al. et,et al.  Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficient mice , 1995, Science.

[253]  D. Baltimore,et al.  Involvement of CRAF1, a relative of TRAF, in CD40 signaling , 1995, Science.

[254]  R. Craig,et al.  The intracellular distribution and pattern of expression of Mcl-1 overlap with, but are not identical to, those of Bcl-2 , 1995, The Journal of cell biology.

[255]  H. Minderman,et al.  Detection of incorporated iododeoxyuridine in colonies by immunoperoxidase staining: a novel method to measure the proportion of cycling colony-forming cells. , 1995, Experimental hematology.

[256]  E. Wagner,et al.  Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. , 1995, Genes & development.

[257]  F. Benvenuto,et al.  Philadelphia‐chromosome‐negative peripheral blood stem cells can be mobilized in the early phase of recovery after a myelosuppressive chemotherapy in Philadelphia‐chromosome‐positive acute lymphoblastic leukaemia , 1995, British journal of haematology.

[258]  G. Losa,et al.  Changes in the activities of signal transduction and transport membrane enzymes in CEM lymphoblastoid cells by glucocorticoid-induced apoptosis. , 1995, Analytical cellular pathology : the journal of the European Society for Analytical Cellular Pathology.

[259]  L. Benítez-Bribiesca.  [Apoptosis in the pathogenesis and treatment of disease]. , 1995, Gaceta medica de Mexico.

[260]  E. Kun,et al.  Identification of Domains of Poly(ADP-ribose) Polymerase for Protein Binding and Self-association (*) , 1995, The Journal of Biological Chemistry.

[261]  Seamus J. Martin,et al.  Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomas , 1995, Nature.

[262]  Y. Shima,et al.  Myeloma cells express Fas antigen/APO-1 (CD95) but only some are sensitive to anti-Fas antibody resulting in apoptosis. , 1995, Blood.

[263]  A. Jochemsen,et al.  Apoptin, a protein derived from chicken anemia virus, induces p53-independent apoptosis in human osteosarcoma cells. , 1995, Cancer research.

[264]  R. Ragusa,et al.  Levels of L-asparagine in CSF after intramuscular administration of asparaginase from Erwinia in children with acute lymphoblastic leukemia. , 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[265]  P. Olive,et al.  The comet assay: a comprehensive review. , 1995, Mutation research.

[266]  T. McDonnell,et al.  Implications of apoptotic cell death regulation in cancer therapy. , 1995, Seminars in cancer biology.

[267]  P. Gaynon,et al.  The Use of Glucocorticoids in Acute Lymphoblastic Leukemia of Childhood Molecular, Cellular, and Clinical Considerations , 1995, Journal of pediatric hematology/oncology.

[268]  M. Karin,et al.  Glucocorticoid‐induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. , 1995, The EMBO journal.

[269]  R. Pieters,et al.  Favorable prognosis of hyperdiploid common acute lymphoblastic leukemia may be explained by sensitivity to antimetabolites and other drugs: results of an in vitro study. , 1995, Blood.

[270]  S. Korsmeyer,et al.  Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death , 1995, Cell.

[271]  John Calvin Reed,et al.  A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40 , 1995, FEBS letters.

[272]  B. Hellman,et al.  Demonstration of chlorobenzene-induced DNA damage in mouse lymphocytes using the single cell gel electrophoresis assay. , 1995, Toxicology.

[273]  R. Kofler,et al.  Splice site mutation in the glucocorticoid receptor gene causes resistance to glucocorticoid-induced apoptosis in a human acute leukemic cell line. , 1995, Cancer research.

[274]  T. Crawford,et al.  The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy , 1995, Cell.

[275]  John Calvin Reed,et al.  Tumor suppressor p53 is a direct transcriptional activator of the human bax gene , 1995, Cell.

[276]  J. Hoshino,et al.  3-Aminobenzamide enhances dexamethasone-mediated mouse thymocyte depletion in vivo: implication for a role of poly ADP-ribosylation in the negative selection of immature thymocytes. , 1994, Biochimica et biophysica acta.

[277]  M. Boguski,et al.  A novel RING finger protein interacts with the cytoplasmic domain of CD40. , 1994, The Journal of biological chemistry.

[278]  R. Nowak,et al.  Detection of aneuploid cells in acute lymphoblastic leukemia with flow cytometry before and after therapy. , 1994, Leukemia research.

[279]  R. Pieters,et al.  Mononuclear cells contaminating acute lymphoblastic leukaemic samples tested for cellular drug resistance using the methyl-thiazol-tetrazolium assay. , 1994, British Journal of Cancer.

[280]  M. Peter,et al.  The Role of APO‐1‐Mediated Apoptosis in the Immune System , 1994, Immunological reviews.

[281]  S. Rosen,et al.  Glucocorticoid receptors and resistance to glucocorticoids in hematologic malignancies. , 1994, Leukemia & lymphoma.

[282]  S. Bourgeois,et al.  Expression of the mdr1 P-glycoprotein gene: a mechanism of escape from glucocorticoid-induced apoptosis. , 1994, Biochemistry and cell biology = Biochimie et biologie cellulaire.

[283]  M. Hsiao,et al.  Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia. , 1994, Blood.

[284]  P. G. Tyler,et al.  Interleukin-3 and bryostatin-1 mediate hyperphosphorylation of BCL2 alpha in association with suppression of apoptosis. , 1994, The Journal of biological chemistry.

[285]  M. Haber,et al.  Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma. , 1994, Cancer research.

[286]  C. Thompson,et al.  bcl-XL is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria. , 1994, Development.

[287]  Y. Lazebnik,et al.  Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE , 1994, Nature.

[288]  C. V. Howard,et al.  PCNA Ki‐67 dissociation in childhood acute lymphoblastic leukaemia. An Immunofluorescent Laser Confocal Scanning Microscopical study. , 1994, Cell biology international.

[289]  M. Kitagawa,et al.  A cyclin-dependent kinase inhibitor, butyrolactone I, inhibits phosphorylation of RB protein and cell cycle progression. , 1994, Oncogene.

[290]  C. Meijer,et al.  Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies. , 1994, Cancer research.

[291]  S. Proctor,et al.  The relationship between bcl‐2 expression and response to chemotherapy in acute leukaemia , 1994, British journal of haematology.

[292]  K. Crabtree.  Genetics, Natural History, Tumor Spectrum, and Pathology of Hereditary Nonpolyposis Colorectal Cancer: An Updated Review , 1994 .

[293]  D. Fisher.  Apoptosis in cancer therapy: Crossing the threshold , 1994, Cell.

[294]  A. Hara,et al.  A single cell gel electrophoresis technique for the detection of DNA damage induced by ACNU, an alkylating agent or irradiation in murine glioma cell lines. , 1994, Neurological research.

[295]  T. Yoshino,et al.  Expression of Bcl-2 protein and Fas antigen in non-Hodgkin's lymphomas. , 1994, The American journal of pathology.

[296]  H. Horvitz,et al.  Programmed cell death in Caenorhabditis elegans. , 1994, Current opinion in genetics & development.

[297]  R. J. Clem,et al.  Control of programmed cell death by the baculovirus genes p35 and iap , 1994, Molecular and cellular biology.

[298]  C. Thompson,et al.  Identification of immunosuppressant-induced apoptosis in a murine B-cell line and its prevention by bcl-x but not bcl-2. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[299]  K. Kinzler,et al.  Paradoxical inhibition of solid tumor cell growth by bcl2. , 1994, Cancer research.

[300]  A. Tsukamoto,et al.  Human fetal bone marrow early progenitors for T, B, and myeloid cells are found exclusively in the population expressing high levels of CD34. , 1994, Blood.

[301]  M. Negrini,et al.  Minor myeloid component in Ph chromosome‐positive acute lymphoblastic leukaemia: correlation with cytogenetic pattern and implication for poor response to therapy , 1994, British journal of haematology.

[302]  J. Harbott,et al.  Konzeption und Zwischenergebnis der Therapiestudie ALL-BFM 90 zur Behandlung der akuten lymphoblastischen Leukämie bei Kindern und Jugendlichen: Die Bedeutung des initialen Therapieansprechens in Blut und Knochenmark , 1994 .

[303]  E. Sausville,et al.  Potent inhibition of CDC2 kinase activity by the flavonoid L86-8275. , 1994, Biochemical and biophysical research communications.

[304]  M. Satoh,et al.  Dual function for poly(ADP-ribose) synthesis in response to DNA strand breakage. , 1994, Biochemistry.

[305]  R. Pirker,et al.  P-glycoprotein expression as unfavorable prognostic factor in acute myeloid leukemia. , 1994, Leukemia.

[306]  E. Thompson,et al.  Apoptosis and steroid hormones. , 1994, Molecular endocrinology.

[307]  Z. Oltvai,et al.  BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax , 1994, Nature.

[308]  M. Hsiao,et al.  Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase. , 1994, Blood.

[309]  J. Lilleyman,et al.  Mercaptopurine metabolism and risk of relapse in childhood lymphoblastic leukaemia , 1994, The Lancet.

[310]  J. Downing,et al.  11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. , 1994, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[311]  M. Jacobson,et al.  Increased sensitivity to DNA-alkylating agents in CHO mutants with decreased poly(ADP-ribose) polymerase activity. , 1994, Mutation research.

[312]  B. Zehnbauer,et al.  Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia. , 1994, Blood.

[313]  R. Pieters,et al.  Glucocorticoid resistance in childhood leukemia. , 1994, Leukemia & lymphoma.

[314]  F. Mandelli,et al.  Adult Philadelphia-chromosome-positive acute lymphoblastic leukemia: experience of treatments during a ten-year period. , 1994, Leukemia.

[315]  J. M. Murcia,et al.  Poly(ADP-ribose) polymerase: a molecular nick-sensor. , 1994, Trends in biochemical sciences.

[316]  John Calvin Reed,et al.  Cloning and sequencing of a cDNA encoding the rat Bcl-2 protein. , 1994, Gene.

[317]  R. Fleischmann,et al.  Mutation of a mutL homolog in hereditary colon cancer. , 1994, Science.

[318]  D. Ward,et al.  Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer , 1994, Nature.

[319]  D. Shibata,et al.  Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation , 1994, Nature Genetics.

[320]  J. Lotem,et al.  Control of sensitivity to induction of apoptosis in myeloid leukemic cells by differentiation and bcl-2 dependent and independent pathways. , 1994, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[321]  D. Ross,et al.  Synergistic reversal of multidrug-resistance phenotype in acute myeloid leukemia cells by cyclosporin A and cremophor EL. , 1994, Blood.

[322]  P. Krammer,et al.  Differential expression of APO‐1 on human thymocytes: Implications for negative selection? , 1994, European journal of immunology.

[323]  L. Smets.  Programmed cell death (apoptosis) and response to anti-cancer drugs. , 1994, Anti-cancer drugs.

[324]  M. Meuth,et al.  Resistance to cytosine arabinoside in acute leukemia: the significance of mutations in CTP synthetase. , 1994, Leukemia.

[325]  A. Okuyama,et al.  Inhibition of cell cycle oscillation of DNA replication by a selective inhibitor of the cdc2 kinase family, butyrolactone I, in Xenopus egg extracts. , 1994, Biochemical and biophysical research communications.

[326]  L. Nutter,et al.  Status of glutathione and glutathione-metabolizing enzymes in menadione-resistant human cancer cells. , 1994, Biochemical pharmacology.

[327]  A. van der Eb,et al.  A single chicken anemia virus protein induces apoptosis , 1994, Journal of virology.

[328]  John Calvin Reed.  Bcl-2 and the regulation of programmed cell death , 1994, The Journal of cell biology.

[329]  Robin J. Leach,et al.  Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer , 1993, Cell.

[330]  David Beach,et al.  p21 is a universal inhibitor of cyclin kinases , 1993, Nature.

[331]  L. Aaltonen,et al.  Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. , 1993, Cancer research.

[332]  D. Siemann,et al.  In vivo therapeutic potential of combination thiol depletion and alkylating chemotherapy. , 1993, British Journal of Cancer.

[333]  A. Rambaldi,et al.  Intensive therapy for adult acute lymphoblastic leukemia: preliminary results of the idarubicin/vincristine/L-asparaginase/prednisolone regimen. , 1993, Seminars in oncology.

[334]  H. Frischer,et al.  Glutathione, cell proliferation, and 1,3-bis-(2-chloroethyl)-1-nitrosourea in K562 leukemia. , 1993, The Journal of clinical investigation.

[335]  G. Núñez,et al.  Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification. , 1993, The American journal of pathology.

[336]  Shai Shaham,et al.  The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme , 1993, Cell.

[337]  G. Poirier,et al.  Poly(ADP-ribose) polymerase can bind melphalan damaged DNA. , 1993, Cancer research.

[338]  E. Sausville,et al.  Alteration of the phosphorylation state of p34cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. , 1993, Biochemical pharmacology.

[339]  John Calvin Reed,et al.  Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. , 1993, Cancer research.

[340]  P. Olive,et al.  Radiation-induced apoptosis measured in TK6 human B lymphoblast cells using the comet assay. , 1993, Radiation research.

[341]  K. O’Neill,et al.  Analysis of single-cell gel electrophoresis using laser-scanning microscopy. , 1993, Mutation research.

[342]  D. Housman,et al.  p53-dependent apoptosis modulates the cytotoxicity of anticancer agents , 1993, Cell.

[343]  V. Stewart,et al.  Disappearance of the lymphoid system in Bcl-2 homozygous mutant chimeric mice. , 1993, Science.

[344]  I. Judson,et al.  Poly(ADP-ribosylation) as target for cancer chemotherapy , 1993, The Lancet.

[345]  M. Kitagawa,et al.  Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. , 1993, Oncogene.

[346]  N. Davidson,et al.  Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. , 1993, Cancer research.

[347]  J. Harmon,et al.  Cloning and expression of mutant glucocorticoid receptors from glucocorticoid-sensitive and -resistant human leukemic cells. , 1993, Cancer research.

[348]  R. Fanin,et al.  The expression of the multidrug resistance related glycoprotein in adult acute lymphoblastic leukemia. , 1993, Haematologica.

[349]  W. Dalton,et al.  Phase I/II trial of cyclosporine as a chemotherapy-resistance modifier in acute leukemia. , 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[350]  S. Korsmeyer,et al.  Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death , 1993, Cell.

[351]  C. Thompson,et al.  bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death , 1993, Cell.

[352]  E. Thompson,et al.  Suppression of c-myc is a critical step in glucocorticoid-induced human leukemic cell lysis. , 1993, The Journal of biological chemistry.

[353]  M. Berger,et al.  Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2. , 1993, Journal of immunology.

[354]  M. Ikeguchi,et al.  Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells. , 1993, Endocrinology.

[355]  Darryl Shibata,et al.  Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis , 1993, Nature.

[356]  P. Krammer,et al.  Activation interferes with the APO-1 pathway in mature human T cells. , 1993, International immunology.

[357]  J. Viña,et al.  Depletion of tumour glutathione in vivo by buthionine sulphoximine: modulation by the rate of cellular proliferation and inhibition of cancer growth. , 1993, The Biochemical journal.

[358]  J. Magaud,et al.  High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy. , 1993, Blood.

[359]  K. Kinzler,et al.  Clues to the pathogenesis of familial colorectal cancer. , 1993, Science.

[360]  J. Weber,et al.  Genetic mapping of a locus predisposing to human colorectal cancer. , 1993, Science.

[361]  R. Larsson,et al.  In vitro testing of chemotherapeutic drug combinations in acute myelocytic leukaemia using the fluorometric microculture cytotoxicity assay (FMCA). , 1993, British Journal of Cancer.

[362]  O. Fardel,et al.  Expression of the multidrug resistance-associated P-glycoprotein (P-170) in 59 cases of de novo acute lymphoblastic leukemia: prognostic implications. , 1993, Blood.

[363]  S. Korsmeyer,et al.  Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. , 1993, Blood.

[364]  P. Janmey,et al.  Modulation of gelsolin function. Activation at low pH overrides Ca2+ requirement. , 1993, The Journal of biological chemistry.

[365]  G. Murcia,et al.  Identification of potential active-site residues in the human poly(ADP-ribose) polymerase. , 1993, The Journal of biological chemistry.

[366]  R. Craig,et al.  MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[367]  S. Orrenius,et al.  Cyclic AMP potentiates glucocorticoid‐induced endogenous endonuclease activation in thymocytes 1 , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[368]  R. Lovering,et al.  Identification and preliminary characterization of a protein motif related to the zinc finger. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[369]  R. Pieters,et al.  Cellular drug resistance profiles that might explain the prognostic value of immunophenotype and age in childhood acute lymphoblastic leukemia. , 1993, Leukemia.

[370]  H. Sather,et al.  Improved outcome with delayed intensification for children with acute lymphoblastic leukemia and intermediate presenting features: a Childrens Cancer Group phase III trial. , 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[371]  H. Tilly,et al.  Granulocyte-macrophage colony-stimulating factor in association to timed-sequential chemotherapy with mitoxantrone, etoposide, and cytarabine for refractory acute myelogenous leukemia. , 1993, Leukemia.

[372]  I. Olivotto,et al.  Gel electrophoresis of individual cells to quantify hypoxic fraction in human breast cancers. , 1993, Cancer research.

[373]  A. Bowcock,et al.  Microsatellite polymorphism linkage map of human chromosome 13q. , 1993, Genomics.

[374]  J. Craig,et al.  Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review. , 1993, Leukemia.

[375]  I. Touw,et al.  Hematopoietic growth factors and their receptors in acute leukemia. , 1993, Blood.

[376]  J. Trepel,et al.  Myeloperoxidase: an enzyme involved in intrinsic vincristine resistance in human myeloblastic leukemia. , 1993, Blood.

[377]  G. Elia,et al.  Bcl‐2 proto‐oncogene expression in epstein‐barr‐virus‐associated nasopharyngeal carcinoma , 1993, International journal of cancer.

[378]  I. Weissman,et al.  Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. , 1992, Science.

[379]  M. Campbell,et al.  Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. , 1992, Cancer research.

[380]  J. Harmon,et al.  Human glucocorticoid receptor gene deletion following exposure to cancer chemotherapeutic drugs and chemical mutagens. , 1992, Cancer research.

[381]  J. Gustafsson,et al.  Dexamethasone reverses glucocorticoid receptor rna depression in multi-drug resistant (MDR) myeloma cell lines , 1992, Medical oncology and tumor pharmacotherapy.

[382]  I. Roninson,et al.  Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. , 1992, Blood.

[383]  E. Sausville,et al.  Growth inhibition with reversible cell cycle arrest of carcinoma cells by flavone L86-8275. , 1992, Journal of the National Cancer Institute.

[384]  B. Chauffert,et al.  Feasibility of using quinine, a potential multidrug resistance-reversing agent, in combination with mitoxantrone and cytarabine for the treatment of acute leukemia. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[385]  B. Jonsson,et al.  Feasibility of the fluorometric microculture cytotoxicity assay (FMCA) for cytotoxic drug sensitivity testing of tumor cells from patients with acute lymphoblastic leukemia. , 1992, Leukemia.

[386]  D. Green,et al.  Apoptotic cell death induced by c-myc is inhibited by bcl-2 , 1992, Nature.

[387]  R. Pieters,et al.  Relation of 5'-nucleotidase and phosphatase activities with immunophenotype, drug resistance and clinical prognosis in childhood leukemia. , 1992, Leukemia research.

[388]  J. Hartley,et al.  Chlorambucil-monoglutathionyl conjugate is sequestered by human alpha class glutathione S-transferases. , 1992, British Journal of Cancer.

[389]  J. Todd,et al.  Microsatellites for linkage analysis of genetic traits. , 1992, Trends in genetics : TIG.

[390]  A. Bartolucci,et al.  A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: a Southeastern Cancer Study Group Study. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[391]  Y. Takasaki,et al.  Cell-cycle-associated expressions of proliferating cell nuclear antigen and Ki-67 reactive antigen of bone marrow blast cells in childhood acute leukemia. , 1992, Leukemia.

[392]  Y. Pommier,et al.  Depletion of poly(ADP-ribose) polymerase by antisense RNA expression results in a delay in DNA strand break rejoining. , 1992, The Journal of biological chemistry.

[393]  E. Berman,et al.  Comparative cellular pharmacology of daunorubicin and idarubicin in human multidrug-resistant leukemia cells. , 1992, Blood.

[394]  A. Antony,et al.  The biological chemistry of folate receptors. , 1992, Blood.

[395]  M Schena,et al.  Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. , 1992, Blood.

[396]  M. Pawlita,et al.  Purification and molecular cloning of the APO-1 cell surface antigen, a member of the tumor necrosis factor/nerve growth factor receptor superfamily. Sequence identity with the Fas antigen. , 1992, The Journal of biological chemistry.

[397]  R. Pieters,et al.  Hypoxanthine‐guanine phosphoribosyl‐transferase in childhood leukemia: Relation with immunophenotype, in vitro drug resistance and clinical prognosis , 1992, International journal of cancer.

[398]  P. Thall,et al.  Treatment of newly diagnosed acute myelogenous leukemia with granulocyte-macrophage colony-stimulating factor (GM-CSF) before and during continuous-infusion high-dose ara-C + daunorubicin: comparison to patients treated without GM-CSF. , 1992, Blood.

[399]  Y. Takasaki,et al.  Cell proliferation in childhood acute leukemia. Comparison of Ki‐67 and proliferating cell nuclear antigen immunocytochemical and DNA flow cytometric analysis , 1992, Cancer.

[400]  Gerard I. Evan,et al.  Induction of apoptosis in fibroblasts by c-myc protein , 1992, Cell.

[401]  M. Raff,et al.  Social controls on cell survival and cell death , 1992, Nature.

[402]  Masahiko S. Satoh,et al.  Role of poly(ADP-ribose) formation in DNA repair , 1992, Nature.

[403]  L. Nazareth,et al.  Glucocorticoids in malignant lymphoid cells: Gene regulation and the minimum receptor fragment for lysis , 1992, The Journal of Steroid Biochemistry and Molecular Biology.

[404]  R. Ozols,et al.  Depletion of glutathione in normal and malignant human cells in vivo by buthionine sulfoximine: clinical and biochemical results. , 1992, Journal of the National Cancer Institute.

[405]  K. Ueda,et al.  Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. , 1992, The Journal of biological chemistry.

[406]  Peter Nygren,et al.  Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA) , 1992, International journal of cancer.

[407]  E. Alnemri,et al.  Involvement of BCL-2 in glucocorticoid-induced apoptosis of human pre-B-leukemias. , 1992, Cancer research.

[408]  M. Karin,et al.  The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. , 1991, Biochimica et biophysica acta.

[409]  S. Korsmeyer,et al.  bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes , 1991, Cell.

[410]  C. Yu,et al.  Camptothecin overcomes MDR1-mediated resistance in human KB carcinoma cells. , 1991, Cancer research.

[411]  R. Ozols,et al.  Phase I study of thiotepa in combination with the glutathione transferase inhibitor ethacrynic acid. , 1991, Cancer Research.

[412]  H. Poulsen,et al.  Glucocorticoid receptors in human malignancies: a review. , 1991, Annals of oncology : official journal of the European Society for Medical Oncology.

[413]  E. McCulloch,et al.  Granulocyte-macrophage colony-stimulating factor and interleukin-3 protect leukemic blast cells from ara-C toxicity. , 1991, Leukemia.

[414]  Christine Chomienne,et al.  The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR , 1991, Cell.

[415]  R. Pieters,et al.  Relation of cellular drug resistance to long-term clinical outcome in childhood acute lymphoblastic leukaemia , 1991, The Lancet.

[416]  S. Korsmeyer,et al.  BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[417]  M. Minden,et al.  OCI/AML-4 an acute myeloblastic leukemia cell line: regulation and response to cytosine arabinoside. , 1991, Leukemia.

[418]  Y. Awasthi,et al.  Reversal of melphalan resistance in vivo and in vitro by modulation of glutathione metabolism. , 1991, Biochemical pharmacology.

[419]  B. Vogelstein,et al.  p53 mutations in human cancers. , 1991, Science.

[420]  J. Hickman,et al.  Drug-target interactions: only the first step in the commitment to a programmed cell death? , 1991, British Journal of Cancer.

[421]  N. Ifrah,et al.  Double intensive consolidation chemotherapy in adult acute myeloid leukemia. , 1991, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[422]  A. Levine,et al.  The p53 tumour suppressor gene , 1991, Nature.

[423]  C. Haanen,et al.  Prolonged exposure to cytosine arabinoside in the presence of hematopoietic growth factors preferentially kills leukemic versus normal clonogenic cells. , 1991, Experimental hematology.

[424]  E. Thompson,et al.  Cortivazol mediated induction of glucocorticoid receptor messenger ribonucleic acid in wild-type and dexamethasone-resistant human leukemic (CEM) cells , 1991, The Journal of Steroid Biochemistry and Molecular Biology.

[425]  Janice Gabrilove,et al.  Results of a randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia , 1991 .

[426]  D. Reece,et al.  High-dose cytarabine and daunorubicin induction and postremission chemotherapy for the treatment of acute myelogenous leukemia in adults. , 1991, Blood.

[427]  W. Prusoff,et al.  Inhibition of poly(adenosine diphosphate-ribose) polymerase by thymidine and thymidine analogues in L1210 cells and its relationship to the potentiation of the antitumor activity of 1,3-bis(2-chloroethyl)-1-nitrosourea but not of 3'-[3-(2-chloroethyl)-3-nitrosoureido]-3'-deoxythymidine. , 1991, Cancer research.

[428]  M. Andreeff,et al.  Recombinant human granulocyte-macrophage colony-stimulating factor in combination with standard induction chemotherapy in de novo acute myeloid leukemia. , 1991, Blood.

[429]  K. Constantine,et al.  Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. , 1991, The Journal of clinical investigation.

[430]  R. Weichselbaum,et al.  Increased glutathione peroxidase activity in a human sarcoma cell line with inherent doxorubicin resistance. , 1991, Cancer research.

[431]  T Ogura,et al.  The zinc fingers of human poly(ADP-ribose) polymerase are differentially required for the recognition of DNA breaks and nicks and the consequent enzyme activation. Other structures recognize intact DNA. , 1990, The Journal of biological chemistry.

[432]  D. Lane,et al.  Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: An index of cell proliferation with evidence of deregulated expression in some, neoplasms , 1990, The Journal of pathology.

[433]  R. Ozols,et al.  The role of glutathione in drug resistance. , 1990, Cancer treatment reviews.

[434]  J. Reid,et al.  Plasma pharmacokinetics and cerebrospinal fluid concentrations of idarubicin and idarubicinol in pediatric leukemia patients: a Childrens Cancer Study Group report. , 1990, Cancer research.

[435]  E. Thompson,et al.  Two glucocorticoid binding sites on the human glucocorticoid receptor. , 1990, Endocrinology.

[436]  J. Goldman,et al.  The role of the MDR-1/P-170 mechanism in the development of multidrug resistance in chronic myeloid leukemia. , 1990, Leukemia.

[437]  M. Karin,et al.  Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction , 1990, Cell.

[438]  S. Hanash,et al.  Proliferating cell nuclear antigen expression in childhood acute leukemia. , 1990, Blood.

[439]  T. Lister,et al.  High dose cytosine arabinoside in the initial treatment of adults with acute lymphoblastic leukaemia. , 1990, British Journal of Cancer.

[440]  T. Cotter,et al.  Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cells. , 1990, Anticancer research.

[441]  R. Larsson,et al.  Chemotherapeutic drug sensitivity testing of human leukemia cells in vitro using a semiautomated fluorometric assay. , 1990, Leukemia.

[442]  M. Cleary,et al.  The bcl-2 gene, follicular lymphoma, and Hodgkin's disease. , 1990, Journal of the National Cancer Institute.

[443]  P. Olive,et al.  Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells. , 1990, Journal of the National Cancer Institute.

[444]  S. Korsmeyer,et al.  Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. , 1990, Journal of immunology.

[445]  R R Tice,et al.  DNA damage and repair with age in individual human lymphocytes. , 1990, Mutation research.

[446]  B. Schweitzer,et al.  Dihydrofolate reductase as a therapeutic target , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[447]  Mark L. Greenberg,et al.  Osteonecrosis in pediatric patients with acute lymphoblastic leukemia , 1990, Cancer.

[448]  R. Pieters,et al.  DRUG SENSITIVITY ASSAYS IN LEUKAEMIA AND LYMPHOMA , 1990, British journal of haematology.

[449]  T. Waldmann,et al.  Monoclonal-antibody-mediated apoptosis in adult T-cell leukaemia , 1990, The Lancet.

[450]  P. Olive,et al.  Heterogeneity in radiation induced dna damage and repair measured using the comet assay , 1990 .

[451]  C. Haanen,et al.  Continuous intravenous administration of daunorubicin and cytarabine for remission induction of poor risk acute myelogenous leukaemias and myelodysplastic syndromes. , 1990, Netherlands Journal of Medicine.

[452]  A. Harris,et al.  Possible role of inhibition of glutathione S-transferase in the partial reversal of chlorambucil resistance by indomethacin in a Chinese hamster ovary cell line. , 1989, Cancer research.

[453]  C. Paul,et al.  In vitro drug testing in patients with acute leukemia with incubations mimicking in vivo intracellular drug concentrations , 1989, European journal of haematology.

[454]  T. Shimizu,et al.  VP-16-induced nucleotide pool changes and poly(ADP-ribose) synthesis: the role of VP-16 in interphase death. , 1989, Experimental cell research.

[455]  M. Manfait,et al.  Role of the aclacinomycin A--doxorubicin association in reversal of doxorubicin resistance in K562 tumour cells. , 1989, British Journal of Cancer.

[456]  C. Taylor,et al.  Appraisal of the MTT assay as a rapid test of chemosensitivity in acute myeloid leukaemia. , 1989, British Journal of Cancer.

[457]  I. Viano,et al.  In vitro chemosensitivity testing of leukemic cells: Prediction of response to chemotherapy in patients with acute non‐lymphocytic leukemia , 1989, Hematological oncology.

[458]  M. Lavin,et al.  Cell death by apoptosis in acute leukaemia , 1989, The Journal of pathology.

[459]  S. Cannistra,et al.  Granulocyte-macrophage colony-stimulating factor enhances the cytotoxic effects of cytosine arabinoside in acute myeloblastic leukemia and in the myeloid blast crisis phase of chronic myeloid leukemia. , 1989, Leukemia.

[460]  I. Viano,et al.  In vitro chemosensitivity testing of leukemic cells: Development of a semiautomated colorimetric assay , 1989, Hematological oncology.

[461]  J. Moss,et al.  Quantitative studies of inhibitors of ADP-ribosylation in vitro and in vivo. , 1989, The Journal of biological chemistry.

[462]  Y. Tsujimoto.  Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[463]  Y. Assaraf,et al.  Cross-resistance to the lipid-soluble antifolate trimetrexate in human carcinoma cells with the multidrug-resistant phenotype. , 1989, Journal of the National Cancer Institute.

[464]  M. Manfait,et al.  Correlation between growth inhibition and intranuclear doxorubicin and 4'-deoxy-4'-iododoxorubicin quantitated in living K562 cells by microspectrofluorometry. , 1989, Cancer research.

[465]  C. Haanen,et al.  Idarubicin v daunorubicin: preclinical and clinical pharmacokinetic studies. , 1989, Seminars in oncology.

[466]  M. Cleary,et al.  The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation , 1989, Molecular and cellular biology.

[467]  T. Waldmann,et al.  CD7+, CD4-, CD8- acute leukemia: a syndrome of malignant pluripotent lymphohematopoietic cells. , 1989, Blood.

[468]  D. Arthur,et al.  Establishment of a leukemic cell model for studying human pre-B to B cell differentiation. , 1989, Journal of immunology.

[469]  M. Grever,et al.  Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the national cancer institute‐sponsored working group , 1988, American journal of hematology.

[470]  A. Hagenbeek,et al.  In vivo uptake of daunorubicin by acute myeloid leukemia (AML) cells measured by flow cytometry. , 1988, Leukemia.

[471]  K. Asada,et al.  [Metabolism and function of glutathione in plants]. , 1988, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme.

[472]  D. Campana,et al.  Proliferation of normal and malignant human immature lymphoid cells , 1988 .

[473]  J. Wright,et al.  Molecular mechanisms of drug resistance involving ribonucleotide reductase: hydroxyurea resistance in a series of clonally related mouse cell lines selected in the presence of increasing drug concentrations. , 1988, Cancer research.

[474]  R. Tice,et al.  A simple technique for quantitation of low levels of DNA damage in individual cells. , 1988, Experimental cell research.

[475]  C. Sarraf,et al.  Proportions of Mitotic and Apoptotic Cells In A Range of Untreated Experimental Tumours , 1988, Cell and tissue kinetics.

[476]  J. Shelhamer,et al.  Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome. , 1987, The New England journal of medicine.

[477]  H. Preisler,et al.  Differences in cell cycle characteristics among patients with acute nonlymphocytic leukemia. , 1987, Blood.

[478]  B. De Bernardi,et al.  A short-term in vitro drug sensitivity assay in pediatric malignancies. , 1987, Anticancer research.

[479]  T. Barbui,et al.  Treatment of the lymphoid blast crisis of chronic myeloid leukemia. , 1987, European journal of cancer & clinical oncology.

[480]  J. Ritter,et al.  Die Corticosteroid-abhängige Dezimierung der Leukämiezellzahl im Blut als Prognosefaktor bei der akuten lymphoblastischen Leukämie im Kindesalter (Therapiestudie ALL-BFM 83) , 1987 .

[481]  H. Mikawa,et al.  Prevention of adriamycin-induced interphase death by 3-aminobenzamide and nicotinamide in a human promyelocytic leukemia cell line. , 1987, Biochemical and biophysical research communications.

[482]  F. Farzaneh,et al.  DNA repair in human promyelocytic cell line, HL-60. , 1987, Nucleic acids research.

[483]  J. Schlechte,et al.  Use of [3H]cortivazol to characterize glucocorticoid receptors in a dexamethasone-resistant human leukemic cell line. , 1987, The Journal of clinical endocrinology and metabolism.

[484]  J. Riordan,et al.  The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. , 1986, Biochemical and biophysical research communications.

[485]  T. Lister,et al.  Treatment of acute lymphoblastic leukaemia in adults , 1986, British journal of haematology.

[486]  E. Rozengurt.  Early signals in the mitogenic response. , 1986, Science.

[487]  J. Sklar,et al.  Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation , 1986, Cell.

[488]  R. Gelber,et al.  Four-agent induction and intensive asparaginase therapy for treatment of childhood acute lymphoblastic leukemia. , 1986, The New England journal of medicine.

[489]  P. Roberson,et al.  Correlation of drug sensitivity in vitro with clinical responses in childhood acute myeloid leukemia. , 1986, Blood.

[490]  P. Smith,et al.  Prediction of remission induction in childhood acute myeloid leukemia. , 1986, Australian and New Zealand journal of medicine.

[491]  T. Révész,et al.  The adverse effect of prolonged prednisolone pretreatment in children with acute lymphoblastic leukemia , 1985, Cancer.

[492]  L. Yang,et al.  Cytotoxic efficacy of reconstituted and stored antitumor agents. , 1985, Cancer research.

[493]  V. Rotter,et al.  Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[494]  H Stein,et al.  Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67. , 1984, Journal of immunology.

[495]  D. M. Brown,et al.  Enhancement of melphalan cytotoxicity in vivo and in vitro by inhibitors of poly (ADP-ribose) polymerase. , 1984, International journal of radiation oncology, biology, physics.

[496]  K J Johanson,et al.  Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. , 1984, Biochemical and biophysical research communications.

[497]  J. Bertino,et al.  Uptake and efficacy of trimetrexate (TMQ, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl] quinazoline), a non-classical antifolate in methotrexate-resistant leukemia cells in vitro. , 1984, Biochemical pharmacology.

[498]  K. Milam,et al.  Inhibitors of poly(adenosine diphosphate-ribose) synthesis: effect on other metabolic processes. , 1984, Science.

[499]  S. Jhanwar,et al.  Philadelphia chromosome and terminal transferase-positive acute leukemia: similarity of terminal phase of chronic myelogenous leukemia and de novo acute presentation. , 1983, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[500]  R. Gelber,et al.  Influence of intensive asparaginase in the treatment of childhood non-T-cell acute lymphoblastic leukemia. , 1983, Cancer research.

[501]  J. Riordan,et al.  Cell surface P-glycoprotein associated with multidrug resistance in mammalian cell lines. , 1983, Science.

[502]  I. Tannock,et al.  A critical appraisal of the "human tumor stem-cell assay". , 1983, The New England journal of medicine.

[503]  R. R. Howe,et al.  Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma. , 1982, The New England journal of medicine.

[504]  S. Sallan,et al.  Cytogenetics of acute lymphoblastic leukaemia in children as a factor in the prediction of long‐term survival , 1982, British journal of haematology.

[505]  C. Pui,et al.  Glucocorticoid receptors in childhood acute lymphocytic leukemia. , 1982, Cancer research.

[506]  J. Harmon,et al.  Non-glucocorticoid receptor-mediated effects of the potent glucocorticoid deacylcortivazol. , 1982, Cancer research.

[507]  S. Shall,et al.  Regulation of DNA ligase activity by poly(ADP-ribose) , 1982, Nature.

[508]  S. Sallan,et al.  The childhood leukemias. , 1981, The Journal of pediatrics.

[509]  H. Gadner,et al.  Ergebnisse der Studie BFM 76/79 zur Behandlung der akuten lymphoblastischen Leukämie bei Kindern und Jugendlichen* , 1981 .

[510]  H. Gralnick,et al.  The Morphological Classification of Acute Lymphoblastic Leukaemia: Concordance among Observers and Clinical Correlations , 1981, British journal of haematology.

[511]  J. Harmon,et al.  Deacylcortivazol acts through glucocorticoid receptors. , 1981, Journal of steroid biochemistry.

[512]  D. Crowther,et al.  Relationship between the pretreatment proliferative activity of marrow blast cells and prognosis of acute lymphoblastic leukaemia of childhood , 1980, British Journal of Cancer.

[513]  C. Skidmore,et al.  The enhancement of cytotoxicity of N-methyl-N-nitrosourea and of gamma-radiation by inhibitors of poly(ADP-ribose) polymerase. , 1980, European journal of biochemistry.

[514]  M. R. Purnell,et al.  Novel inhibitors of poly(ADP-ribose) synthetase. , 1980, The Biochemical journal.

[515]  B. Durkacz,et al.  (ADP-ribose)n participates in DNA excision repair , 1980, Nature.

[516]  H. Sather,et al.  Effective dose of L-asparaginase for induction of remission in previously treated children with acute lymphocytic leukemia: a report from Childrens Cancer Study Group. , 1979, Cancer research.

[517]  W. T. Beck,et al.  Altered surface membrane glycoproteins in Vinca alkaloid-resistant human leukemic lymphoblasts. , 1979, Cancer research.

[518]  J. E. Freeman,et al.  Combination chemotherapy for acute lymphoblastic leukaemia in adults. , 1978, British medical journal.

[519]  D. W. Mullins,et al.  A putative role for nicotinamide adenine dinucleotide-promoted nuclear protein modification in the antitumor activity of N-methyl-N-nitrosourea. , 1977, Cancer research.

[520]  A. Mittelman,et al.  CYTOKININS AS CHEMOTHERAPEUTIC AGENTS * , 1975, Annals of the New York Academy of Sciences.

[521]  J. Bertino,et al.  L-asparaginase: clinical, biochemical, pharmacological, and immunological studies. , 1971, Annals of internal medicine.

[522]  N. Bachur,et al.  Daunorubicin metabolism by rat tissue preparations. , 1971, The Journal of pharmacology and experimental therapeutics.

[523]  J. Holland,et al.  Biochemical and pharmacological studies with asparaginase in man. , 1970, Cancer research.

[524]  E. Mihich,et al.  Toxicological and antiproliferative effects of N6-(delta2-isopentenyl) adenosine, a natural component of mammalian transfer RNA. , 1970, Cancer research.

[525]  J. Whang‐Peng,et al.  Isopentenyladenosine Stimulates and Inhibits Mitosis of Human Lymphocytes Treated with Phytohemagglutinin , 1969, Science.

[526]  J. Wolff,et al.  Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. , 1948, The New England journal of medicine.

[527]  M. Noteborn,et al.  The Apoptin gene of chicken anemia virus in the induction of apoptosis in human tumorigenic cells and in gene therapy of cancer * , 2001 .

[528]  G. Kroemer.  [Mitochondrial control of apoptosis]. , 2001, Bulletin de l'Academie nationale de medecine.

[529]  B. Pollock,et al.  Weekly polyethylene glycol conjugated L-asparaginase compared with biweekly dosing produces superior induction remission rates in childhood relapsed acute lymphoblastic leukemia: a Pediatric Oncology Group Study. , 2000, Blood.

[530]  G.,et al.  Annexin V for Flow Cytometric Detection of Phosphatidylserine Expression on B Cells Undergoing Apoptosis , 2000 .

[531]  D. van Velzen,et al.  Microsatellite instability assessment in prediction of drug resistance in childhood Burkitt's and large cell diffuse malignant non-Hodgkin lymphoma (MNHL). , 1999, Advances in experimental medicine and biology.

[532]  M. Flens,et al.  Multidrug resistance related proteins in primary cutaneous lymphomas. , 1999, Advances in experimental medicine and biology.

[533]  D. van Velzen,et al.  Demonstration of differences in drug resistance by direct testing of DNA excision repair activity following standard and liposomal daunorubicin exposure in normal paediatric marrow using high resolution CLSM. , 1999, Advances in experimental medicine and biology.

[534]  E. Wattel,et al.  Assessment of P-glycoprotein expression by immunocytochemistry and flow cytometry using two different monoclonal antibodies coupled with functional efflux analysis in 34 patients with acute myeloid leukemia. , 1999, Advances in experimental medicine and biology.

[535]  F. Behm,et al.  Cyclosporin A induces apoptosis in childhood acute lymphoblastic leukemia cells. , 1998, Blood.

[536]  P. Thall,et al.  Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia. , 1998, Blood.

[537]  C. Distelhorst,et al.  Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: resurrection of old theories by new findings. , 1998, Blood.

[538]  J. Diebold,et al.  Developmentally regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse differentiation. , 1998, The American journal of pathology.

[539]  W. Lehmann,et al.  Multidrug resistance protein-mediated transport of chlorambucil and melphalan conjugated to glutathione. , 1998, British Journal of Cancer.

[540]  T. Barbui,et al.  Idarubicin Activity Against Multidrug-Resistant (mdr-1+) Cells is Increased by Cyclosporin A , 1998 .

[541]  W. Ludwig,et al.  Treatment of Ph+ and t(4;11)+ Acute Lymphoblastic Leukemia in Adults , 1998 .

[542]  J. Boos,et al.  Asparagine Synthetase in Pediatric Acute Leukemias: AML-M5 Subtype Shows Lowest Activity , 1998 .

[543]  V. Diehl,et al.  Predictive Value of Pretherapeutic In-Vitro Chemosensitivity Testing in Adult AML , 1998 .

[544]  Richard J. Jones,et al.  Biology and treatment of chronic myeloid leukemia. , 1997, Current opinion in oncology.

[545]  H. Findley,et al.  Expression and Regulation of Bcl-2 , Bcl-xl , and Bax Correlate With p 53 Status and Sensitivity to Apoptosis in Childhood Acute Lymphoblastic Leukemia , 1997 .

[546]  C. Edling,et al.  Alkaline single cell gel electrophoresis of DNA fragments in biomonitoring for genotoxicity: an introductory study on healthy human volunteers , 1997, International archives of occupational and environmental health.

[547]  M. Urashima,et al.  Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. , 1997, Blood.

[548]  J. Tschopp,et al.  TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). , 1997, Immunity.

[549]  G. Schwartz,et al.  Chemotherapeutically induced DNA damage, ATP depletion, and the apoptotic biochemical cascade. , 1997, Oncology research.

[550]  L Meijer,et al.  Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. , 1997, European journal of biochemistry.

[551]  M. Ohki,et al.  Glucocorticoids induce apoptosis in acute myeloid leukemia cell lines with A t(8;21) chromosome translocation. , 1997, Leukemia research.

[552]  S. Yao,et al.  Cloning of a human nucleoside transporter implicated in the Cellular uptake of adenosine and chemotherapeutic drugs , 1997, Nature Medicine.

[553]  M. Zhou,et al.  Incidence and clinical significance of CDKN2/MTS1/P16ink4A and MTS2/P15ink4B gene deletions in childhood acute lymphoblastic leukemia. , 1997, Pediatric hematology and oncology.

[554]  G. Kroemer,et al.  Bcl-2 and Bcl-XL antagonize the mitochondrial dysfunction preceding nuclear apoptosis induced by chemotherapeutic agents. , 1997, Cancer research.

[555]  R. Pieters,et al.  In vitro cellular drug resistance and prognosis in newly diagnosed childhood acute lymphoblastic leukemia. , 1997, Blood.

[556]  L. Owen-Schaub,et al.  Soluble FAS (CD95) is not elevated in the serum of patients with myeloid leukemias, myeloproliferative and myelodysplastic syndromes. , 1996, Leukemia.

[557]  J Diebold,et al.  Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma. Groupe d'Etude des Lymphomes de l'Adulte (GELA). , 1996, Blood.

[558]  E. White,et al.  Life, death, and the pursuit of apoptosis. , 1996, Genes & development.

[559]  T. Barbui,et al.  Therapeutic impact of adult-type acute lymphoblastic leukemia regimens in B-cell/L3 acute leukemia and advanced-stage Burkitt's lymphoma. , 1996, Haematologica.

[560]  H. Jürgens,et al.  Asparagine Levels in Children on E. Coli- and Erwinia-Asparaginase Therapy , 1996 .

[561]  A. Chinnaiyan,et al.  CD95 (APO-1/Fas)-associating signalling proteins. , 1996, Cell death and differentiation.

[562]  C. Pui,et al.  Uniform approach to risk classification and treatment assignment for children with acute lymphoblastic leukemia. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[563]  K O'Rourke,et al.  Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. , 1995, Cell.

[564]  E. Schierenberg,et al.  Cellular effects of olomoucine, an inhibitor of cyclin‐dependent kinases , 1995, Biology of the cell.

[565]  P. Krammer,et al.  Resistance to APO-1 (CD95) induced apoptosis in T-ALL is determined by a BCL-2 independent anti-apoptotic program. , 1995, Leukemia.

[566]  J. Ritz,et al.  Functional consequences of APO-1/Fas (CD95) antigen expression by normal and neoplastic hematopoietic cells. , 1995, Leukemia & lymphoma.

[567]  T. Barbui,et al.  Remission induction therapy for adults with acute myelogenous leukemia: towards the ICE age? , 1995, Haematologica.

[568]  N. Curtin,et al.  The role of inhibitors of poly(ADP-ribose) polymerase as resistance-modifying agents in cancer therapy. , 1995, Biochimie.

[569]  T. Sugimura,et al.  Role of poly(ADP-ribose) polymerase in cell-cycle checkpoint mechanisms following γ-irradiation , 1995 .

[570]  小鹿 学.  Mechanisms of glucocorticoid resistance in human leukemic cells : implication of abnormal 90 and 70 kDa heat shock proteins , 1995 .

[571]  R. Pieters,et al.  Clinical relevance of in vitro drug resistance testing in childhood acute lymphoblastic leukemia: the state of the art. , 1994, Medical and pediatric oncology.

[572]  T G Cotter,et al.  BCR-ABL maintains resistance of chronic myelogenous leukemia cells to apoptotic cell death. , 1994, Blood.

[573]  W Böcker,et al.  Comet assay studies of radiation-induced DNA damage and repair in various tumour cell lines. , 1994, International journal of radiation biology.

[574]  D. Bishop,et al.  The genetics of colorectal cancer. , 1994, European Journal of Cancer.

[575]  John Calvin Reed,et al.  Regulation of chemoresistance by the bcl-2 oncoprotein in non-Hodgkin's lymphoma and lymphocytic leukemia cell lines. , 1994, Annals of oncology : official journal of the European Society for Medical Oncology.

[576]  R. Fanin,et al.  Overexpression of MDR-related p170 glycoprotein in chronic myeloid leukemia. , 1994, Haematologica.

[577]  M. Stratton,et al.  Instability of short tandem repeats (microsatellites) in human cancers , 1994, Nature Genetics.

[578]  D. Weltin,et al.  Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. , 1994, Oncology research.

[579]  K. Debatin,et al.  APO-1 (CD95) and Bcl-2: determinants of cell death in the human thymus. , 1994, Research in immunology.

[580]  M. Relling,et al.  Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. , 1994, Blood.

[581]  J. Bertino,et al.  Karnofsky memorial lecture. Ode to methotrexate. , 1993, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[582]  T. Barbui,et al.  Reinforced HEAV'D therapy for adult acute lymphoblastic leukemia: Improved results and revised prognostic criteria , 1993, Hematological Oncology.

[583]  J. Bertino,et al.  Drug resistance in acute leukemia. , 1993, Leukemia & lymphoma.

[584]  E. Thompson,et al.  Glucocorticoid receptors in leukemias, lymphomas and myelomas of young and old. , 1993, Advances in experimental medicine and biology.

[585]  J. Lotem,et al.  Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells. , 1993, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[586]  W. Plunkett,et al.  Cellular pharmacodynamics of anticancer drugs. , 1993, Seminars in oncology.

[587]  N. Copeland,et al.  The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. , 1993, Cell.

[588]  R. Tice,et al.  High-dose combination alkylating agents with autologous bone-marrow support in patients with breast cancer: preliminary assessment of DNA damage in individual peripheral blood lymphocytes using the single cell gel electrophoresis assay. , 1992, Mutation research.

[589]  J. Sebolt-Leopold,et al.  Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly(ADP-ribose) synthetase inhibitor. , 1992, International journal of radiation oncology, biology, physics.

[590]  A. Rohatiner,et al.  Treatment of adult acute lymphoblastic leukaemia (ALL) over a 16 year period. , 1992, Leukemia.

[591]  M. Ames,et al.  Selected pharmacologic characteristics of idarubicin and idarubicinol. , 1992, Leukemia.

[592]  P. Ritch,et al.  Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia. , 1992, Blood.

[593]  P. Nurse,et al.  Animal cell cycles and their control. , 1992, Annual review of biochemistry.

[594]  Z. Darżynkiewicz,et al.  Features of apoptotic cells measured by flow cytometry. , 1992, Cytometry.

[595]  J. Bennett,et al.  Long term survival in acute myeloid leukemia: the Eastern Cooperative Oncology Group (ECOG) experience. , 1991, Leukemia research.

[596]  R. Larson,et al.  Some reasons for the lack of progress in the treatment of acute myelogenous leukemia: a review of three consecutive trials of the treatment of poor prognosis patients. , 1991, Leukemia research.

[597]  E. Baulieu.  The connection between steroid receptors and stress protein (hsp90). , 1991, Methods and achievements in experimental pathology.

[598]  W. Morgan,et al.  Poly(ADP-ribose)polymerase: a perplexing participant in cellular responses to DNA breakage. , 1991, Mutation research.

[599]  G. Peters,et al.  Expression of 5'-nucleotidase (CD73) related to other differentiation antigens in leukemias of B-cell lineage. , 1991, Blood.

[600]  J. Shuster,et al.  Lower incidence of meningeal leukemia when prednisone is replaced by dexamethasone in the treatment of acute lymphocytic leukemia. , 1991, Medical and pediatric oncology.

[601]  G. Daley,et al.  Implicating the bcr/abl gene in the pathogenesis of Philadelphia chromosome-positive human leukemia. , 1991, Advances in cancer research.

[602]  W. Kamps,et al.  Dutch Childhood Leukemia Study Group: early results of study ALL VI (1984-1988). , 1990, Haematology and blood transfusion.

[603]  T. Shimizu,et al.  Cell type dependent activation of poly (ADP-ribose) synthesis following treatment with etoposide. , 1990, Leukemia research.

[604]  V. Diehl,et al.  Pretherapeutic drug testing in acute leukemias for prediction of individual prognosis. , 1990, Haematology and blood transfusion.

[605]  M. Andreeff,et al.  Kinetic rationale for cytokine-induced recruitment of myeloblastic leukemia followed by cycle-specific chemotherapy in vitro. , 1990, Leukemia.

[606]  G. Henze,et al.  Results and significance of six randomized trials in four consecutive ALL-BFM studies. , 1990, Haematology and blood transfusion.

[607]  F. Balis,et al.  Central nervous system pharmacology of antileukemic drugs. , 1989, The American journal of pediatric hematology/oncology.

[608]  P. Chomez,et al.  Genes coding for T-cell-defined tum transplantation antigens: point mutations, antigenic peptides, and subgenic expression. , 1989, Cold Spring Harbor symposia on quantitative biology.

[609]  G. Chalepakis,et al.  Gene regulation by steroid hormones. , 1989, Cell.

[610]  S. Proctor,et al.  Mechanisms of drug resistance in acute leukaemia. , 1989, Leukemia research.

[611]  H. Sather,et al.  Modified BFM therapy for children with previously untreated acute lymphoblastic leukemia and unfavorable prognostic features. Report of Children's Cancer Study Group Study CCG-193P. , 1988, The American journal of pediatric hematology/oncology.

[612]  R. Ozols,et al.  Enhanced melphalan cytotoxicity in human ovarian cancer in vitro and in tumor-bearing nude mice by buthionine sulfoximine depletion of glutathione. , 1987, Biochemical pharmacology.

[613]  M. Schrappe,et al.  Therapy results in five ALL-BFM studies since 1970: implications of risk factors for prognosis. , 1987, Haematology and blood transfusion.

[614]  R Mastrangelo,et al.  Report and recommendations of the Rome workshop concerning poor-prognosis acute lymphoblastic leukemia in children: biologic bases for staging, stratification, and treatment. , 1986, Medical and pediatric oncology.

[615]  C. Pui,et al.  Sequential studies of lymphoblast glucocorticoid receptor levels at diagnosis and relapse in childhood leukemia: an update. , 1986, Leukemia research.

[616]  G. Woollard.  An unusual column effect during the analysis of 5-fluorocytosine by high-performance liquid chromatography. , 1986, Journal of chromatography.

[617]  J. Harmon,et al.  Glucocorticoid receptors and glucocorticoid resistance in human leukemia in vivo and in vitro. , 1986, Advances in experimental medicine and biology.

[618]  N. Cheung,et al.  Antibody response to Escherichia coli L-asparaginase. Prognostic significance and clinical utility of antibody measurement. , 1986, The American journal of pediatric hematology/oncology.

[619]  L. Weisenthal,et al.  Clonogenic and nonclonogenic in vitro chemosensitivity assays. , 1985, Cancer treatment reports.

[620]  N. Berger.  Poly(ADP-ribose) in the cellular response to DNA damage. , 1985, Radiation research.

[621]  D. W. Fry,et al.  Biochemical pharmacology of the lipophilic antifolate, trimetrexate. , 1984, Advances in enzyme regulation.

[622]  C. Pui,et al.  Impact of treatment efficacy on the prognostic value of glucocorticoid receptor levels in childhood acute lymphoblastic leukemia. , 1984, Leukemia research.

[623]  C. Distelhorst,et al.  Effect of cell cycle position on dexamethasone binding by mouse and human lymphoid cell lines: correlation between an increase in dexamethasone binding during S phase and dexamethasone sensitivity. , 1984, Blood.

[624]  S. Salmon.  Applications of the human tumor stem cell assay to new drug evaluation and screening. , 1980, Progress in clinical and biological research.

[625]  D C Case,et al.  Clinical staging of chronic lymphocytic leukemia. , 1977, The Journal of the Maine Medical Association.

[626]  M. Weil,et al.  Optimal use of L-asparaginase (NSC-109229) in acute lymphocytic leukemia. , 1977, Medical and pediatric oncology.

[627]  P. Prandoni,et al.  A Case-Control Study , 2022 .

[628]  C. Teerlink,et al.  Clinical Significance , 2022 .