Nitric oxide pumps up calcium signalling

Nitric oxide released by vascular endothelial cells in the liver potentiates calcium signalling in surrounding hepatocytes. This may represent a mechanism by which endothelial cells of the microvasculature can play an active part in coordinating the cellular function of an organ.

[1]  S. Moncada.  Nitric Oxide in the Vasculature: Physiology and Pathophysiology , 1997, Annals of the New York Academy of Sciences.

[2]  S. Joseph,et al.  Cyclic GMP Induces Oscillatory Calcium Signals in Rat Hepatocytes* , 1996, The Journal of Biological Chemistry.

[3]  L. D. Robb-Gaspers,et al.  Coordination of calcium signalling by endothelial-derived nitric oxide in the intact liver , 1999, Nature Cell Biology.

[4]  Y. Taketani,et al.  Endothelium‐dependent frequency modulation of Ca2+ signalling in individual vascular smooth muscle cells of the rat , 1997, The Journal of physiology.

[5]  R. Young,et al.  Paracrine and Intracellular Signaling Mechanisms of Calcium Waves in Cultured Human Uterine Myocytes , 1997, Obstetrics and gynecology.

[6]  L. Ignarro.  Endothelium‐derived nitric oxide: actions and properties , 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  M. Berridge.  The AM and FM of calcium signalling , 1997, Nature.

[8]  S. B. Kater,et al.  ATP Released from Astrocytes Mediates Glial Calcium Waves , 1999, The Journal of Neuroscience.

[9]  A. Charles,et al.  Intercellular calcium waves in glia , 1998, Glia.

[10]  T. Lincoln,et al.  Phosphorylation of the inositol 1,4,5-trisphosphate receptor by cyclic GMP-dependent protein kinase. , 1994, The Journal of biological chemistry.

[11]  A. Araque,et al.  Tripartite synapses: glia, the unacknowledged partner , 1999, Trends in Neurosciences.

[12]  M J Sanderson,et al.  Intercellular propagation of calcium waves mediated by inositol trisphosphate. , 1992, Science.