Extracellular acidity and increased exosome release as key phenotypes of malignant tumors
暂无分享,去创建一个
Stefano Fais | M. Logozzi | S. Fais | Mariantonia Logozzi | E. Spugnini | Davide Mizzoni | R. Di Raimo | D. Mizzoni | Enrico Spugnini | Rossella Di Raimo | R. Raimo
[1] L. Battistini,et al. Acridine Orange/exosomes increase the delivery and the effectiveness of Acridine Orange in human melanoma cells: A new prototype for theranostics of tumors , 2017, Journal of enzyme inhibition and medicinal chemistry.
[2] Raghu Kalluri,et al. Exosomes in tumor microenvironment influence cancer progression and metastasis , 2013, Journal of Molecular Medicine.
[3] P. Vaupel,et al. Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine , 2017, Front. Immunol..
[4] P. Vaupel,et al. Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance , 2014, Cancers.
[5] J. Dear,et al. Quantification of human urinary exosomes by nanoparticle tracking analysis , 2013, The Journal of physiology.
[6] E. Iessi,et al. The key role of extracellular vesicles in the metastatic process. , 2018, Biochimica et biophysica acta. Reviews on cancer.
[7] L. O’Driscoll,et al. Extracellular vesicles and anti-cancer drug resistance. , 2018, Biochimica et biophysica acta. Reviews on cancer.
[8] R. Cerione,et al. Microvesicles as mediators of intercellular communication in cancer. , 2014, Methods in molecular biology.
[9] Peter J Ratcliffe,et al. Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways , 2014, Cancer & metabolism.
[10] Xin Luan,et al. Engineering exosomes as refined biological nanoplatforms for drug delivery , 2017, Acta Pharmacologica Sinica.
[11] S. Fais,et al. Proton pump inhibition and cancer therapeutics: A specific tumor targeting or it is a phenomenon secondary to a systemic buffering? , 2017, Seminars in cancer biology.
[12] M. Overholtzer,et al. Cell-in-cell phenomena in cancer , 2018, Nature Reviews Cancer.
[13] S. Fais. A nonmainstream approach against cancer , 2016, Journal of enzyme inhibition and medicinal chemistry.
[14] R A Jungmann,et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[15] Bo Li,et al. Brain microvascular endothelial cell exosome–mediated S100A16 up‐regulation confers small‐cell lung cancer cell survival in brain , 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[16] A. Molinari,et al. Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells* , 2009, The Journal of Biological Chemistry.
[17] M. Kester,et al. Formation and role of exosomes in cancer , 2014, Cellular and Molecular Life Sciences.
[18] A. Guo,et al. Leukemia cell-derived microvesicles induce T cell exhaustion via miRNA delivery , 2018, Oncoimmunology.
[19] Mario Falchi,et al. Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes , 2018, Cancers.
[20] M. Yashiro,et al. Clinico-pathological significance of exosome marker CD63 expression on cancer cells and stromal cells in gastric cancer , 2018, PloS one.
[21] H. Peinado,et al. The influence of tumour-derived extracellular vesicles on local and distal metastatic dissemination. , 2017, Molecular aspects of medicine.
[22] F. Lozupone,et al. Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs. , 2004, Journal of the National Cancer Institute.
[23] A. Carè,et al. Acidic microenvironment plays a key role in human melanoma progression through a sustained exosome mediated transfer of clinically relevant metastatic molecules , 2018, Journal of Experimental & Clinical Cancer Research.
[24] P. Chavrier,et al. Social networking in tumor cell communities is associated with increased aggressiveness , 2016, Intravital.
[25] M. Logozzi,et al. A Role of Tumor-Released Exosomes in Paracrine Dissemination and Metastasis , 2018, International journal of molecular sciences.
[26] I. Tannock,et al. Drug resistance and the solid tumor microenvironment. , 2007, Journal of the National Cancer Institute.
[27] P. Vaupel,et al. Hypoxia-/HIF-1α-Driven Factors of the Tumor Microenvironment Impeding Antitumor Immune Responses and Promoting Malignant Progression. , 2018, Advances in experimental medicine and biology.
[28] M. Signore,et al. Exosomes from human colorectal cancer induce a tumor-like behavior in colonic mesenchymal stromal cells , 2016, Oncotarget.
[29] W. Ding,et al. Intercellular Communication by Exosome-Derived microRNAs in Cancer , 2013, International journal of molecular sciences.
[30] G. Semenza,et al. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. , 2013, The Journal of clinical investigation.
[31] M. Logozzi,et al. Detection of exosomal prions in blood by immunochemistry techniques. , 2015, The Journal of general virology.
[32] C. Pilarsky,et al. Analysis of DNA Hypermethylation in Pancreatic Cancer Using Methylation-Specific PCR and Bisulfite Sequencing. , 2018, Methods in molecular biology.
[33] G. Parmiani,et al. Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape. , 2005, Gastroenterology.
[34] M. Kuroda,et al. Roles of exosomes and microvesicles in disease pathogenesis. , 2013, Advanced drug delivery reviews.
[35] E. Ruppin,et al. Targeting the Warburg effect via LDHA inhibition engages ATF4 signaling for cancer cell survival , 2018, The EMBO journal.
[36] S. Fais,et al. Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy , 2014, Cancer and Metastasis Reviews.
[37] J. Lötvall,et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells , 2007, Nature Cell Biology.
[38] Y. You,et al. Characterization of exosomes derived from ovarian cancer cells and normal ovarian epithelial cells by nanoparticle tracking analysis , 2016, Tumor Biology.
[39] L. O’Driscoll,et al. Biological properties of extracellular vesicles and their physiological functions , 2015, Journal of extracellular vesicles.
[40] Manho Kim,et al. Low pH increases the yield of exosome isolation. , 2015, Biochemical and biophysical research communications.
[41] F. Lozupone,et al. Cancer Cell Cannibalism: A Primeval Option to Survive. , 2015, Current molecular medicine.
[42] Zhen Wang,et al. Exosomes in tumor microenvironment: novel transporters and biomarkers , 2016, Journal of Translational Medicine.
[43] N. C. Rochael,et al. Tumor-Derived Exosomes Induce the Formation of Neutrophil Extracellular Traps: Implications For The Establishment of Cancer-Associated Thrombosis , 2017, Scientific Reports.
[44] Carla Oliveira,et al. Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine. , 2016, ACS nano.
[45] Matthew P. Jacobson,et al. Dysregulated pH: a perfect storm for cancer progression , 2011, Nature Reviews Cancer.
[46] Peter Vaupel,et al. Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy? , 2013, Advances in experimental medicine and biology.
[47] M. Overholtzer,et al. Cell-in-cell phenomena, cannibalism, and autophagy: is there a relationship? , 2018, Cell Death & Disease.
[48] S. Bauersachs,et al. Deciphering the oviductal extracellular vesicles content across the estrous cycle: implications for the gametes-oviduct interactions and the environment of the potential embryo , 2018, BMC Genomics.
[49] L. Fliegel,et al. Regulation of the Na+/H+ Exchanger (NHE1) in Breast Cancer Metastasis. , 2013, Cancer research.
[50] K. Sandhoff,et al. Biological Function of the Cellular Lipid BMP—BMP as a Key Activator for Cholesterol Sorting and Membrane Digestion , 2011, Neurochemical Research.
[51] D. Barber,et al. Cancer cell behaviors mediated by dysregulated pH dynamics at a glance , 2017, Journal of Cell Science.
[52] T. Whiteside. Tumor-Derived Exosomes and Their Role in Cancer Progression. , 2016, Advances in clinical chemistry.
[53] C. Supuran,et al. Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity , 2019, Journal of enzyme inhibition and medicinal chemistry.
[54] Gema Moreno-Bueno,et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET , 2012, Nature Medicine.
[55] H. Yamaue,et al. Clinical implications of carcinoembryonic antigen distribution in serum exosomal fraction—Measurement by ELISA , 2017, PloS one.
[56] F. Petrucci,et al. Exosome Release and Low pH Belong to a Framework of Resistance of Human Melanoma Cells to Cisplatin , 2014, PloS one.
[57] Na+-H+ exchanger, pH regulation and cancer. , 2012 .
[58] F. Lozupone,et al. pH‐dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity , 2010, International journal of cancer.
[59] L. Ding,et al. Carcinoma-associated fibroblasts promote the stemness and chemoresistance of colorectal cancer by transferring exosomal lncRNA H19 , 2018, Theranostics.
[60] Francesco Cappello,et al. Exosome levels in human body fluids: A tumor marker by themselves? , 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
[61] J. Dear,et al. Quantification of human urinary exosomes by nanoparticle tracking analysis , 2014 .
[62] S. Glynn,et al. Mesenchymal stem cells: key players in cancer progression , 2017, Molecular Cancer.
[63] Robert J Gillies,et al. Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow , 2018, Nature Reviews Cancer.
[64] W. Guo,et al. Exosomes: New players in cancer , 2017, Oncology reports.
[65] Thomas R. Cox,et al. Pre-metastatic niches: organ-specific homes for metastases , 2017, Nature Reviews Cancer.
[66] Massimo Spada,et al. High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients , 2009, PloS one.
[67] Veronica Huber,et al. Induction of Lymphocyte Apoptosis by Tumor Cell Secretion of FasL-bearing Microvesicles , 2002, The Journal of experimental medicine.
[68] Nunzio Iraci,et al. Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles , 2016, International journal of molecular sciences.
[69] N. Restifo,et al. Novel “Elements” of Immune Suppression within the Tumor Microenvironment , 2017, Cancer Immunology Research.
[70] F. Baltazar,et al. Value of pH regulators in the diagnosis, prognosis and treatment of cancer. , 2017, Seminars in cancer biology.
[71] M. Logozzi,et al. Exosomes: the ideal nanovectors for biodelivery , 2013, Biological chemistry.
[72] T. Fuchs,et al. Circulating Extracellular DNA: Cause or Consequence of Thrombosis? , 2017, Seminars in Thrombosis and Hemostasis.
[73] J. Pouysségur,et al. Targeting pH regulating proteins for cancer therapy-Progress and limitations. , 2017, Seminars in cancer biology.
[74] Ciro Tetta,et al. Exosome/microvesicle-mediated epigenetic reprogramming of cells. , 2011, American journal of cancer research.
[75] Hongmei Zheng,et al. The roles of tumor-derived exosomes in non-small cell lung cancer and their clinical implications , 2018, Journal of Experimental & Clinical Cancer Research.
[76] Juan Wang,et al. Five serum-based miRNAs were identified as potential diagnostic biomarkers in gastric cardia adenocarcinoma. , 2018, Cancer biomarkers : section A of Disease markers.
[77] Y. Matsuki,et al. Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells*♦ , 2010, The Journal of Biological Chemistry.
[78] J. Griffiths,et al. The altered metabolism of tumors: HIF-1 and its role in the Warburg effect. , 2010, Advances in enzyme regulation.
[79] Mian-hua Wu,et al. Exosome-related tumor microenvironment , 2018, Journal of Cancer.
[80] Daya Luo,et al. Exosomal microRNA remodels the tumor microenvironment , 2017, PeerJ.
[81] Lilian Cruz,et al. Extracellular Vesicles: Decoding a New Language for Cellular Communication in Early Embryonic Development , 2018, Front. Cell Dev. Biol..
[82] Stefano Fais,et al. Exosomes: the future of biomarkers in medicine. , 2013, Biomarkers in medicine.
[83] S. Fais,et al. Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma. , 2015, Cancer letters.
[84] C. Supuran,et al. Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells , 2016, Journal of enzyme inhibition and medicinal chemistry.
[85] K. Pantel,et al. Different signatures of miR-16, miR-30b and miR-93 in exosomes from breast cancer and DCIS patients , 2018, Scientific Reports.
[86] Qiao Li,et al. Tumor cell-derived exosomes: a message in a bottle. , 2012, Biochimica et biophysica acta.
[87] R. Gu,et al. Downregulation of exosome‐encapsulated miR‐548c‐5p is associated with poor prognosis in colorectal cancer , 2018, Journal of cellular biochemistry.
[88] C. Supuran,et al. Rethinking the Combination of Proton Exchanger Inhibitors in Cancer Therapy , 2017, Metabolites.
[89] A. Carè,et al. Exosome-mediated transfer of miR-222 is sufficient to increase tumor malignancy in melanoma , 2016, Journal of Translational Medicine.
[90] M. Michael,et al. Hypoxic enhancement of exosome release by breast cancer cells , 2012, BMC Cancer.
[91] High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors , 2014, Journal of Translational Medicine.
[92] Alessandro Sciarra,et al. Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients. , 2017, Cancer letters.
[93] T. Ochiya,et al. How cancer cells dictate their microenvironment: present roles of extracellular vesicles , 2016, Cellular and Molecular Life Sciences.
[94] S. Avnet,et al. Proton channels and exchangers in cancer. , 2015, Biochimica et biophysica acta.
[95] R. Ni,et al. Characterization and proteomic profiling of pancreatic cancer‐derived serum exosomes , 2018, Journal of cellular biochemistry.
[96] Lijun Wu,et al. Exosomes in cancer: small particle, big player , 2015, Journal of Hematology & Oncology.
[97] Robert J Gillies,et al. Metabolism and Its Sequelae in Cancer Evolution and Therapy , 2015, Cancer journal.
[98] Mengwen Zhang,et al. Colorectal cancer-derived small extracellular vesicles establish an inflammatory premetastatic niche in liver metastasis , 2018, Carcinogenesis.
[99] R. Canese,et al. Effect of Modified Alkaline Supplementation on Syngenic Melanoma Growth in CB57/BL Mice , 2016, PloS one.
[100] G. Parmiani,et al. Tumour-released exosomes and their implications in cancer immunity , 2008, Cell Death and Differentiation.
[101] Z. Duan,et al. Application of liquid biopsy in bone and soft tissue sarcomas: Present and future. , 2018, Cancer letters.
[102] Alessia Ricupito,et al. Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. , 2012, Cancer research.
[103] Colin L Hisey,et al. Microfluidic affinity separation chip for selective capture and release of label-free ovarian cancer exosomes. , 2018, Lab on a chip.
[104] Y. Assaraf,et al. Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach. , 2015, Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
[105] Joshua M. Weiss,et al. Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis. , 2016, Cancer cell.
[106] L. Jia,et al. The potential of exosomes derived from colorectal cancer as a biomarker. , 2019, Clinica chimica acta; international journal of clinical chemistry.
[107] J. Roa,et al. Circulating MicroRNAs as Biomarkers in Biliary Tract Cancers , 2016, International journal of molecular sciences.
[108] R. Cardone,et al. Na+-H+ exchanger, pH regulation and cancer. , 2012, Recent patents on anti-cancer drug discovery.
[109] A. Yoshimura,et al. Exosomal miR-1290 is a potential biomarker of high-grade serous ovarian carcinoma and can discriminate patients from those with malignancies of other histological types , 2018, Journal of Ovarian Research.
[110] E. Iessi,et al. Proton pump inhibitors induce a caspase-independent antitumor effect against human multiple myeloma. , 2016, Cancer letters.
[111] L. Huang,et al. Complex role of HIF in cancer: the known, the unknown, and the unexpected , 2014, Hypoxia.
[112] A. Magnano,et al. LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions , 2018, Molecular therapy. Nucleic acids.