FTY720-Mitoxy reduces synucleinopathy and neuroinflammation, restores behavior and mitochondria function, and increases GDNF expression in Multiple System Atrophy mouse models
暂无分享,去创建一个
Javier Vargas-Medrano | Guadalupe Vidal-Martínez | Barbara Yang | R. Perez | Ismael Segura-Ulate | Valeria Diaz-Pacheco | J. Barragán | Jocelyn De-Leon Esquivel | Stephanie A. Chaparro
[1] J. B. Arterburn,et al. FTY720-Mitoxy reduces toxicity associated with MSA-like α-synuclein and oxidative stress by increasing trophic factor expression and myelin protein in OLN-93 oligodendroglia cell cultures , 2019, Neuropharmacology.
[2] N. Lazar,et al. Moving to a World Beyond “p < 0.05” , 2019, The American Statistician.
[3] Alejandro F Frangi,et al. Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions , 2019, PloS one.
[4] Javier Vargas-Medrano,et al. Up-regulation of protective neuronal MicroRNAs by FTY720 and novel FTY720-derivatives , 2019, Neuroscience Letters.
[5] R. Gottlieb,et al. Oxidative muscles have better mitochondrial homeostasis than glycolytic muscles throughout life and maintain mitochondrial function during aging , 2018, Aging.
[6] S. Salani,et al. Mitochondrial Dysregulation and Impaired Autophagy in iPSC-Derived Dopaminergic Neurons of Multiple System Atrophy , 2018, Stem cell reports.
[7] L. Giono,et al. Target RNAs Strike Back on MicroRNAs , 2018, Front. Genet..
[8] S. Taheri,et al. The Effect of Diet on Improved Endurance in Male C57BL/6 Mice , 2018, Nutrients.
[9] C. Strand,et al. Immunohistochemical and Molecular Investigations Show Alteration in the Inflammatory Profile of Multiple System Atrophy Brain , 2018, Journal of neuropathology and experimental neurology.
[10] D. Gomez-Nicola,et al. Neuroinflammation: Microglia and T Cells Get Ready to Tango , 2018, Front. Immunol..
[11] W. Poewe,et al. Progressive striatonigral degeneration in a transgenic mouse model of multiple system atrophy: translational implications for interventional therapies , 2018, Acta Neuropathologica Communications.
[12] J. Joseph,et al. Mitochondria-Targeted Triphenylphosphonium-Based Compounds: Syntheses, Mechanisms of Action, and Therapeutic and Diagnostic Applications. , 2017, Chemical reviews.
[13] W. D. den Dunnen,et al. Increased White Matter Inflammation in Aging- and Alzheimer’s Disease Brain , 2017, Front. Mol. Neurosci..
[14] Javier Vargas-Medrano,et al. FTY720 (Fingolimod) reverses α-synuclein-induced downregulation of brain-derived neurotrophic factor mRNA in OLN-93 oligodendroglial cells , 2017, Neuropharmacology.
[15] E. Benarroch,et al. Anhidrosis in multiple system atrophy involves pre‐ and postganglionic sudomotor dysfunction , 2017, Movement disorders : official journal of the Movement Disorder Society.
[16] Javier Vargas-Medrano,et al. FTY720-derivatives do not induce FTY720-like lymphopenia , 2017, Journal of pharmacological sciences.
[17] Y. Yoshida,et al. The Effects of Aging and Treadmill Running on Soleus and Gastrocnemius Muscle Morphology in the Senescence-Accelerated Mouse ( SAMP 1 ) , 2017 .
[18] E. Masliah,et al. Multiple system atrophy: experimental models and reality , 2017, Acta Neuropathologica.
[19] Xinbing Wei,et al. FTY720 Attenuates 6-OHDA-Associated Dopaminergic Degeneration in Cellular and Mouse Parkinsonian Models , 2017, Neurochemical Research.
[20] C. Kleinschnitz,et al. Fingolimod (FTY720) Reduces Cortical Infarction and Neurological Deficits During Ischemic Stroke Through Potential Maintenance of Microvascular Patency. , 2016, Current neurovascular research.
[21] A. Watanyar,et al. Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy , 2016, PloS one.
[22] Javier Vargas-Medrano,et al. FTY720/Fingolimod Reduces Synucleinopathy and Improves Gut Motility in A53T Mice , 2016, The Journal of Biological Chemistry.
[23] P. Popoli,et al. Fingolimod: A Disease-Modifier Drug in a Mouse Model of Amyotrophic Lateral Sclerosis , 2016, Neurotherapeutics.
[24] K. Jellinger. Recent advances in multiple system atrophy , 2016 .
[25] I. Kleiter,et al. Fingolimod for multiple sclerosis and emerging indications: appropriate patient selection, safety precautions, and special considerations , 2016, Therapeutics and clinical risk management.
[26] G. Wenning,et al. Review: Multiple system atrophy: emerging targets for interventional therapies , 2016, Neuropathology and applied neurobiology.
[27] H. Al-Hindi,et al. Large‐scale mitochondrial DNA deletion underlying familial multiple system atrophy of the cerebellar subtype , 2015, Clinical case reports.
[28] I. Strömberg,et al. GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function , 2015, PLoS genetics.
[29] A. Margioris,et al. Fingolimod induces neurogenesis in adult mouse hippocampus and improves contextual fear memory , 2015, Translational Psychiatry.
[30] W. Poewe,et al. Involvement of Peripheral Nerves in the Transgenic PLP-α-Syn Model of Multiple System Atrophy: Extending the Phenotype , 2015, PloS one.
[31] C. Trebst,et al. Effect of FTY720-phosphate on the expression of inflammation-associated molecules in astrocytes in vitro. , 2015, Molecular medicine reports.
[32] H. Hartung,et al. Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype , 2015, Experimental Neurology.
[33] Stephanie L. Alberico,et al. The Vulnerable Ventral Tegmental Area in Parkinson's Disease. , 2015, Basal ganglia.
[34] A. Giralt,et al. Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation. , 2015, Human molecular genetics.
[35] Filamentous aggregations of phosphorylated α-synuclein in Schwann cells (Schwann cell cytoplasmic inclusions) in multiple system atrophy , 2015, Acta neuropathologica communications.
[36] G. Wenning,et al. Multiple-system atrophy. , 2015, The New England journal of medicine.
[37] K. Jellinger. Neuropathology of multiple system atrophy: New thoughts about pathogenesis , 2014, Movement disorders : official journal of the Movement Disorder Society.
[38] E. Masliah,et al. α-Synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy , 2014, Neurobiology of Aging.
[39] H. Mizoguchi,et al. Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment , 2014, Behavioural Brain Research.
[40] J. B. Arterburn,et al. Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells. , 2014, ACS medicinal chemistry letters.
[41] Cheng Luo,et al. Active, phosphorylated fingolimod inhibits histone deacetylases and facilitates fear extinction memory , 2014, Nature Neuroscience.
[42] E. Amico,et al. FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease. , 2014, Human molecular genetics.
[43] Wei Tang,et al. Potential Therapeutic Effects of Neurotrophins for Acute and Chronic Neurological Diseases , 2014, BioMed research international.
[44] D. Galasko,et al. Widespread microRNA dysregulation in multiple system atrophy – disease‐related alteration in miR‐96 , 2014, The European journal of neuroscience.
[45] G. Wenning,et al. Animal models of multiple system atrophy , 2005, Clinical Autonomic Research.
[46] Jun Chen,et al. Age-related decline of myelin proteins is highly correlated with activation of astrocytes and microglia in the rat CNS. , 2013, International journal of molecular medicine.
[47] T. Révész,et al. Identification and Quantification of Oligodendrocyte Precursor Cells in Multiple System Atrophy, Progressive Supranuclear Palsy and Parkinson's Disease , 2013, Brain pathology.
[48] Shijie Jin,et al. Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons , 2013, PloS one.
[49] A. Suzumura,et al. Fingolimod phosphate promotes the neuroprotective effects of microglia , 2013, Journal of Neuroimmunology.
[50] K. Vogt,et al. Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome , 2012, Proceedings of the National Academy of Sciences.
[51] A. Singleton,et al. Lewy-like aggregation of α-synuclein reduces protein phosphatase 2A activity in vitro and in vivo , 2012, Neuroscience.
[52] J. Winkler,et al. Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy , 2012, Experimental Neurology.
[53] E. Tolosa,et al. Premotor signs and symptoms of multiple system atrophy , 2012, The Lancet Neurology.
[54] Patrick S. Aranda,et al. Bleach gel: A simple agarose gel for analyzing RNA quality , 2012, Electrophoresis.
[55] E. Masliah,et al. Multiple system atrophy: a clinical and neuropathological perspective , 2011, Trends in Neurosciences.
[56] A. Toga,et al. Callosal tissue loss in multiple system atrophy—A one‐year follow‐up study , 2010, Movement disorders : official journal of the Movement Disorder Society.
[57] A. Sidhu,et al. Mice expressing the A53T mutant form of human alpha‐synuclein exhibit hyperactivity and reduced anxiety‐like behavior , 2010, Journal of neuroscience research.
[58] E. Masliah,et al. Neurodegeneration in a Transgenic Mouse Model of Multiple System Atrophy Is Associated with Altered Expression of Oligodendroglial-Derived Neurotrophic Factors , 2010, The Journal of Neuroscience.
[59] D. D. Di Monte,et al. Serine 129 Phosphorylation Reduces the Ability of α-Synuclein to Regulate Tyrosine Hydroxylase and Protein Phosphatase 2A in Vitro and in Vivo , 2010, The Journal of Biological Chemistry.
[60] T. Nayak,et al. Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. , 2010, Journal of medicinal chemistry.
[61] V. Brinkmann. FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system , 2009, British journal of pharmacology.
[62] E. Masliah,et al. Mitochondrial inhibitor 3‐nitroproprionic acid enhances oxidative modification of alpha‐synuclein in a transgenic mouse model of multiple system atrophy , 2009, Journal of neuroscience research.
[63] Sid Gilman,et al. Prospective differentiation of multiple system atrophy from Parkinson disease, with and without autonomic failure. , 2009, Archives of neurology.
[64] M. Graeber,et al. Microglia: biology and pathology , 2009, Acta Neuropathologica.
[65] E. Waxman,et al. Specificity and Regulation of Casein Kinase-Mediated Phosphorylation of &agr;-Synuclein , 2008, Journal of neuropathology and experimental neurology.
[66] W. Poewe,et al. Microglial activation mediates neurodegeneration related to oligodendroglial α‐synucleinopathy: Implications for multiple system atrophy , 2007, Movement disorders : official journal of the Movement Disorder Society.
[67] B. Bloem,et al. Too hot to handle: heat stroke in multiple system atrophy , 2007, Journal of Neurology.
[68] M. Straume,et al. Transient T cell accumulation in lymph nodes and sustained lymphopenia in mice treated with FTY720 , 2005, European journal of immunology.
[69] Makoto Hashimoto,et al. Neurological and Neurodegenerative Alterations in a Transgenic Mouse Model Expressing Human α-Synuclein under Oligodendrocyte Promoter: Implications for Multiple System Atrophy , 2005, The Journal of Neuroscience.
[70] Klaus Seppi,et al. Grading of neuropathology in multiple system atrophy: Proposal for a novel scale , 2005, Movement disorders : official journal of the Movement Disorder Society.
[71] L. Stefanis,et al. α-Synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells , 2005, Journal of Cell Science.
[72] J. Trojanowski,et al. Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration , 2005, Neuron.
[73] Werner Poewe,et al. Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy. , 2005, The American journal of pathology.
[74] A. Takahashi,et al. The assessment of sudomotor dysfunction in multiple system atrophy , 1991, Clinical Autonomic Research.
[75] Tomohiro Yoshida. Immunohistochemical localization of glial cell line-derived neurotrophic factor and its receptor Ret in the rat sweat gland. , 2004, The Kurume medical journal.
[76] Y. Yoshida,et al. The effects of aging and treadmill running on soleus and gastrocnemius muscle morphology in the senescence-accelerated mouse (SAMP1). , 2004, The journals of gerontology. Series A, Biological sciences and medical sciences.
[77] David W. Miller,et al. Glial cell inclusions and the pathogenesis of neurodegenerative diseases. , 2004, Neuron glia biology.
[78] M. Eccles,et al. Delivery of antisense peptide nucleic acids (PNAs) to the cytosol by disulphide conjugation to a lipophilic cation , 2004, FEBS letters.
[79] T. Mizutani,et al. Microglial Activation Parallels System Degeneration in Multiple System Atrophy , 2004, Journal of neuropathology and experimental neurology.
[80] S. Payne,et al. The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2 , 2003, FEBS letters.
[81] M. Zigmond,et al. Can the brain be protected through exercise? Lessons from an animal model of parkinsonism☆ , 2003, Experimental Neurology.
[82] K. Jellinger,et al. Neuropathological and behavioral changes induced by various treatment paradigms with MPTP and 3-nitropropionic acid in mice: towards a model of striatonigral degeneration (multiple system atrophy) , 2003, Acta Neuropathologica.
[83] J. Trojanowski,et al. Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein , 2003, Science.
[84] M. Zigmond,et al. Neuroprotective effects of prior limb use in 6‐hydroxydopamine‐treated rats: possible role of GDNF , 2003, Journal of neurochemistry.
[85] D. Wright,et al. Restorative effects of neurotrophin treatment on diabetes-induced cutaneous axon loss in mice , 2003, Experimental Neurology.
[86] Hideo Fujiwara,et al. Hyperphosphorylation and insolubility of α‐synuclein in transgenic mouse oligodendrocytes , 2002 .
[87] C. Cotman,et al. Exercise: a behavioral intervention to enhance brain health and plasticity , 2002, Trends in Neurosciences.
[88] J. Trojanowski,et al. Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein , 2002, Neuron.
[89] G. Horgan,et al. Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR , 2002 .
[90] J. Trojanowski,et al. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. , 2002, Neuron.
[91] A. Scallet,et al. Biomarkers of 3‐Nitropropionic Acid (3‐NPA)‐Induced Mitochondrial Dysfunction as Indicators of Neuroprotection , 2001, Annals of the New York Academy of Sciences.
[92] H U Rehman,et al. Multiple system atrophy , 2001, Postgraduate medical journal.
[93] I. Akiguchi,et al. Glial cell line-derived neurotrophic factor-like immunoreactivity in the cerebella of normal subjects and patients with multiple system atrophy , 2000, Acta Neuropathologica.
[94] D. Dickson,et al. Multiple System Atrophy: A Sporadic Synucleinopathy , 1999, Brain pathology.
[95] J. Kimura,et al. Increased brain-derived neurotrophic factor-containing axons in the basal ganglia of patients with multiple system atrophy. , 1999, Journal of neuropathology and experimental neurology.
[96] Y. Yanagawa,et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats, III. Increase in frequency of CD62L‐positive T cells in Peyer’s patches by FTY720‐induced lymphocyte homing , 1998, Immunology.
[97] Hitoshi Takahashi,et al. Accumulation of α-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy , 1998, Acta Neuropathologica.
[98] H. Kataoka,et al. FTY720, a novel immunosuppressant, induces sequestration of circulating mature lymphocytes by acceleration of lymphocyte homing in rats. I. FTY720 selectively decreases the number of circulating mature lymphocytes by acceleration of lymphocyte homing. , 1998, Journal of immunology.
[99] A. Kakita,et al. Accumulation of alpha-synuclein/NACP is a cytopathological feature common to Lewy body disease and multiple system atrophy. , 1998, Acta neuropathologica.
[100] S. Landis,et al. The Role of Acetylcholine in Regulating Secretory Responsiveness in Rat Sweat Glands , 1995, Molecular and Cellular Neuroscience.
[101] O. Blin,et al. Mitochondrial respiratory failure in skeletal muscle from patients with Parkinson's disease and multiple system atrophy , 1994, Journal of the Neurological Sciences.
[102] Peter L. Lantos,et al. Glial cytoplasmic inclusions in the CNS of patients with multiple system atrophy (striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome) , 1989, Journal of the Neurological Sciences.
[103] S. Landis,et al. Neonatal treatment with nerve growth factor antiserum eliminates cholinergic sympathetic innervation of rat sweat glands. , 1985, Developmental biology.
[104] P. K. Smith,et al. Measurement of protein using bicinchoninic acid. , 1985, Analytical biochemistry.
[105] 北村 聖. "The New England Journal of Medicine". , 1962, British medical journal.