A low cost MEMS based NDIR system for the monitoring of carbon dioxide in breath analysis at ppm levels

The molecules in our breath can provide a wealth of information about the health and well-being of a person. The level of carbon dioxide (CO2) is not only a sign of life but also when combined with the level of exhaled oxygen provides valuable health information in the form of our metabolic rate. We report upon the development of a MEMS-based non-dispersive infrared CO2 sensor for inclusion in a hand held portable breath analyser. Our novel sensor system comprises a thermopile detector and low power MEMS silicon on insulator (SOI) wideband infrared (IR) emitter. A lock-in amplifier design permits a CO2 concentration of 50 ppm to be detected on gas bench rig. Different IR path lengths were studied with gases in dry and humid (25% and 50% RH) in order to design a sensor suitable for detecting CO2 in breath with concentrations in the range of 4 to 5%. A breath analyser was constructed from acetal and in part 3D printed with a side-stream sampling mechanism and tested on a range of subjects with two data-sets presented here. The performance of the novel MEMS based sensor was validated using a reference commercial breath-by-breath sensor and produced comparable results and gave a response time of 1.3 s. Further work involves the detection of other compounds on breath for further metabolic analysis and reducing the overall resolution of our MEMS sensor system from ca. 250 ppm to 10 ppm.

[1]  Daniel Green,et al.  Maximising performance in triathlon: applied physiological and nutritional aspects of elite and non-elite competitions. , 2008, Journal of science and medicine in sport.

[2]  J. Gardner,et al.  Enhanced spectroscopic gas sensors using in-situ grown carbon nanotubes , 2015 .

[3]  I. Horváth,et al.  Standardised exhaled breath collection for the measurement of exhaled volatile organic compounds by proton transfer reaction mass spectrometry , 2013, BMC Pulmonary Medicine.

[4]  J. Andrew Yeh,et al.  A Sub-ppm Acetone Gas Sensor for Diabetes Detection Using 10 nm Thick Ultrathin InN FETs , 2012, Sensors.

[5]  G. de Graaf,et al.  Lock-in amplifier techniques for low-frequency modulated sensor applications , 2012, 2012 IEEE International Instrumentation and Measurement Technology Conference Proceedings.

[6]  Sotiris E Pratsinis,et al.  Si:WO(3) Sensors for highly selective detection of acetone for easy diagnosis of diabetes by breath analysis. , 2010, Analytical chemistry.

[7]  H. Haugen,et al.  Indirect calorimetry: a practical guide for clinicians. , 2007, Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition.

[8]  L. Wallace,et al.  Breath measurements as volatile organic compound biomarkers. , 1996, Environmental health perspectives.

[9]  S. Z. Ali,et al.  A Low-Power, Low-Cost Infra-Red Emitter in CMOS Technology , 2015, IEEE Sensors Journal.

[10]  Francis Tsow,et al.  Personalized Indirect Calorimeter for Energy Expenditure (EE) Measurement , 2015 .

[11]  J. Mechanick,et al.  Metabolic and Nutrition Support in the Chronic Critical Illness Syndrome , 2012, Respiratory Care.

[12]  S. Maier,et al.  A highly efficient CMOS nanoplasmonic crystal enhanced slow-wave thermal emitter improves infrared gas-sensing devices , 2015, Scientific Reports.

[13]  Michael J. Chappell,et al.  Design and modelling of a portable breath analyser for metabolic rate measurement , 2014 .

[14]  Walter Lang,et al.  Detection limit improvement for NDIR ethylene gas detectors using passive approaches , 2012 .

[15]  W. Milne,et al.  Enhanced infra-red emission from sub-millimeter microelectromechanical systems micro hotplates via inkjet deposited carbon nanoparticles and fullerenes , 2013 .

[16]  K. Dubowski Breath analysis as a technique in clinical chemistry. , 1974, Clinical chemistry.

[17]  S. Haasl,et al.  Breath Analyzer for Alcolocks and Screening Devices , 2010, IEEE Sensors Journal.

[18]  S. Littleton Impact of obesity on respiratory function , 2012, Respirology.

[19]  G. Gerlach,et al.  Review of micromachined thermopiles for infrared detection , 2007 .

[20]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.

[21]  Jean-Louis Ouvrier-Buffet,et al.  Low power CO2 NDIR sensing using a micro-bolometer detector and a micro-hotplate IR-source , 2013 .

[22]  C. Martin 2015 , 2015, Les 25 ans de l’OMC: Une rétrospective en photos.

[23]  Ren-wang Li,et al.  Research on Infrared Breath Alcohol Test Based on Differential Absorption , 2009, 2009 First International Conference on Information Science and Engineering.

[24]  D. Baschant,et al.  Temperature resistant IR-gas sensor for CO/sub 2/ and H/sub 2/O , 2004, Proceedings of IEEE Sensors, 2004..

[26]  S. Capewell,et al.  Modelling the Health Impact of an English Sugary Drinks Duty at National and Local Levels , 2015, PloS one.

[27]  Ralph P. Tatam,et al.  Non-dispersive infra-red (NDIR) measurement of carbon dioxide at 4.2μm in a compact and optically efficient sensor , 2013 .

[28]  Armin Lambrecht,et al.  Hollow fibers for compact infrared gas sensors , 2008, SPIE OPTO.

[29]  Bogusław Buszewski,et al.  Analysis of exhaled breath for disease detection. , 2014, Annual review of analytical chemistry.

[30]  J. Spannhake,et al.  Design, development and operational concept of an advanced MEMS IR source for miniaturized gas sensor systems , 2005, IEEE Sensors, 2005..

[31]  R. L. Jensen,et al.  Measuring the exhaled breath of a manikin and human subjects. , 2015, Indoor air.

[32]  T. Tille,et al.  A High-Precision NDIR $\hbox{CO}_{2}$ Gas Sensor for Automotive Applications , 2006, IEEE Sensors Journal.

[33]  John B. Shoven,et al.  I , Edinburgh Medical and Surgical Journal.

[34]  R. Tatam,et al.  Optical gas sensing: a review , 2012 .

[35]  C. Pérez Rodrigo Current mapping of obesity. , 2013, Nutricion hospitalaria.

[36]  Chenyang Xue,et al.  Three-gas detection system with IR optical sensor based on NDIR technology , 2015 .

[37]  C. P. Rodrigo,et al.  Current mapping of obesity. , 2013, Nutricion hospitalaria.

[38]  Jim Euchner Design , 2014, Catalysis from A to Z.

[39]  Desmond Gibson,et al.  A Novel Solid State Non-Dispersive Infrared CO2 Gas Sensor Compatible with Wireless and Portable Deployment , 2013, Sensors.