Cryo-EM structure of 5-HT3A receptor in its resting conformation
暂无分享,去创建一个
Wei Huang | S. Chakrapani | Derek J. Taylor | S. Basak | V. Moiseenkova-Bell | T. Hughes | A. Samanta | M. Nieman | Yvonne Gicheru | S. Molugu | M. Fuente | M. D. L. Fuente
[1] E. Pardon,et al. Structural basis for GABAA receptor potentiation by neurosteroids , 2017, Nature Structural & Molecular Biology.
[2] S. Chakrapani,et al. Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel , 2017, eLife.
[3] D. Agard,et al. MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy , 2017, Nature Methods.
[4] Jue Chen,et al. Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator , 2016, Cell.
[5] C. L. Morales-Pérez,et al. X-ray structure of the human alpha 4 beta 2 nicotinic receptor. , 2016 .
[6] C. L. Morales-Pérez,et al. X-ray structure of the human α4β2 nicotinic receptor , 2016, Nature.
[7] E. Gouaux,et al. Glycine receptor mechanism elucidated by electron cryo-microscopy , 2015, Nature.
[8] C. Ulens,et al. Varenicline Interactions at the 5-HT3 Receptor Ligand Binding Site are Revealed by 5-HTBP , 2015, ACS chemical neuroscience.
[9] P. Biggin,et al. Agonist and antagonist binding in human glycine receptors. , 2014, Biochemistry.
[10] Surajit Banerjee,et al. X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors , 2014, Nature.
[11] T. Tomizaki,et al. X-ray structure of the mouse serotonin 5-HT3 receptor , 2014, Nature.
[12] A. R. Aricescu,et al. Crystal structure of a human GABAA receptor , 2014, Nature.
[13] J. Changeux,et al. Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation , 2013, Proceedings of the National Academy of Sciences.
[14] H. Tagare,et al. The Local Resolution of Cryo-EM Density Maps , 2013, Nature Methods.
[15] J. Baenziger,et al. A distinct mechanism for activating uncoupled nicotinic acetylcholine receptors. , 2013, Nature chemical biology.
[16] J. A. Peters,et al. Mutagenic Analysis of the Intracellular Portals of the Human 5-HT3A Receptor , 2013, The Journal of Biological Chemistry.
[17] S. Kato. Role of serotonin 5-HT₃ receptors in intestinal inflammation. , 2013, Biological & pharmaceutical bulletin.
[18] J. A. Peters,et al. The Minimum M3-M4 Loop Length of Neurotransmitter-activated Pentameric Receptors Is Critical for the Structural Integrity of Cytoplasmic Portals* , 2013, The Journal of Biological Chemistry.
[19] J. A. van Hooft,et al. The serotonin 5-HT3 receptor: a novel neurodevelopmental target , 2013, Front. Cell. Neurosci..
[20] P. Koehl,et al. Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels , 2013, The EMBO journal.
[21] A. J. Thompson,et al. 5-HT3 Receptors , 2012, The Journal of Biological Chemistry.
[22] Eric Gouaux,et al. Principles of activation and permeation in an anion-selective Cys-loop receptor , 2011, Nature.
[23] J. A. Peters,et al. Rings of Charge within the Extracellular Vestibule Influence Ion Permeation of the 5-HT3A Receptor* , 2011, The Journal of Biological Chemistry.
[24] A. Smit,et al. A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors , 2011, PLoS biology.
[25] R. Spiller. Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome. , 2011, Current opinion in pharmacology.
[26] J. Nortier,et al. Anti-emetic drugs in oncology: pharmacology and individualization by pharmacogenetics , 2011, International Journal of Clinical Pharmacy.
[27] Sung-Hou Kim,et al. Water polygons in high‐resolution protein crystal structures , 2009, Protein science : a publication of the Protein Society.
[28] J. Lynch,et al. Ligand-specific Conformational Changes in the α1 Glycine Receptor Ligand-binding Domain* , 2009, The Journal of Biological Chemistry.
[29] S. Sine,et al. Nicotinic Receptor Interloop Proline Anchors β1-β2 and Cys loops in Coupling Agonist Binding to Channel Gating , 2008, The Journal of general physiology.
[30] W. Wadman,et al. On the voltage‐dependent Ca2+ block of serotonin 5‐HT3 receptors: a critical role of intracellular phosphates , 2008, The Journal of physiology.
[31] R. Dutzler,et al. X-ray structure of a prokaryotic pentameric ligand-gated ion channel , 2008, Nature.
[32] C. Connolly. Trafficking of 5-HT3 and GABAA receptors (Review) , 2008, Molecular membrane biology.
[33] P. Taylor,et al. Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations , 2005, The EMBO journal.
[34] N. Unwin,et al. Refined structure of the nicotinic acetylcholine receptor at 4A resolution. , 2005, Journal of molecular biology.
[35] N. Barnes,et al. Identification and importance of N-glycosylation of the human 5-hydroxytryptamine3A receptor subunit. , 2004, Biochemical pharmacology.
[36] M. Gershon. Review article: serotonin receptors and transporters — roles in normal and abnormal gastrointestinal motility , 2004, Alimentary pharmacology & therapeutics.
[37] E. Kirkness,et al. The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance. , 2004, Biochemical Society transactions.
[38] B. Costall,et al. 5-HT3 receptors. , 2004, Current drug targets. CNS and neurological disorders.
[39] A. J. Thompson,et al. A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5‐HT3 receptor , 2003, British journal of pharmacology.
[40] N. Grigorieff,et al. Accurate determination of local defocus and specimen tilt in electron microscopy. , 2003, Journal of structural biology.
[41] J. Kapeller,et al. Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. , 2003, Gene.
[42] D. S. Weiss,et al. Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism , 2002, Nature Neuroscience.
[43] S. Panicker,et al. Evidence for a Centrally Located Gate in the Pore of a Serotonin-Gated Ion Channel , 2002, The Journal of Neuroscience.
[44] Nathan A. Baker,et al. Electrostatics of nanosystems: Application to microtubules and the ribosome , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[45] T. Sixma,et al. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors , 2001, Nature.
[46] A. Auerbach,et al. The Extracellular Linker of Muscle Acetylcholine Receptor Channels Is a Gating Control Element , 2000, The Journal of general physiology.
[47] J Pulokas,et al. Leginon: a system for fully automated acquisition of 1000 electron micrographs a day. , 1999, Ultramicroscopy.
[48] John A. Peters,et al. The 5-HT3B subunit is a major determinant of serotonin-receptor function , 1999, Nature.
[49] D. A. Dougherty,et al. From ab initio quantum mechanics to molecular neurobiology: a cation-pi binding site in the nicotinic receptor. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[50] B. Wallace,et al. HOLE: a program for the analysis of the pore dimensions of ion channel structural models. , 1996, Journal of molecular graphics.
[51] Collaborative Computational,et al. The CCP4 suite: programs for protein crystallography. , 1994, Acta crystallographica. Section D, Biological crystallography.
[52] R. Myers,et al. Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. , 1991, Science.
[53] D. Wong,et al. Localization of 5-HT3 receptors in the rat brain using [3H]LY278584 , 1991, Brain Research.
[54] P. Hargrave,et al. Localization of binding sites for carboxyl terminal specific anti-rhodopsin monoclonal antibodies using synthetic peptides. , 1984, Biochemistry.
[55] Yizhak Marcus,et al. Ionic radii in aqueous solutions , 1983 .
[56] S H W Scheres,et al. Processing of Structurally Heterogeneous Cryo-EM Data in RELION. , 2016, Methods in enzymology.
[57] P. Taylor,et al. On the Origin of Ion Selectivity in the Cys-Loop Receptor Family , 2009, Journal of Molecular Neuroscience.
[58] Wen Jiang,et al. EMAN2: an extensible image processing suite for electron microscopy. , 2007, Journal of structural biology.
[59] Bernhard Rupp,et al. Correspondence e-mail: , 2000 .
[60] Randy J Read,et al. Electronic Reprint Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination Biological Crystallography Phenix: Building New Software for Automated Crystallographic Structure Determination , 2022 .