Phosphoinositide 3‐kinase/protein kinase B signaling pathway is involved in estradiol 17β‐d‐glucuronide–induced cholestasis: Complementarity with classical protein kinase c
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A. Zucchetti | M. Vore | A. Mottino | M. Roma | F. Crocenzi | J. Pellegrino | Andrea C. Boaglio | J. E. Ochoa | E. J. Sánchez Pozzi
[1] A. Zucchetti,et al. Ca2+‐dependent protein kinase C isoforms are critical to estradiol 17β‐D‐glucuronide–induced cholestasis in the rat , 2008, Hepatology.
[2] U. Beuers,et al. Role of mitogen‐activated protein kinases in tauroursodeoxycholic acid‐induced bile formation in cholestatic rat liver , 2008, Hepatology research : the official journal of the Japan Society of Hepatology.
[3] M. Roma,et al. Hepatocellular transport in acquired cholestasis: new insights into functional, regulatory and therapeutic aspects. , 2008, Clinical science.
[4] M. Vore,et al. Disruption of function and localization of tight junctional structures and Mrp2 in sustained estradiol-17beta-D-glucuronide-induced cholestasis. , 2007, American journal of physiology. Gastrointestinal and liver physiology.
[5] P. Milkiewicz,et al. Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.
[6] M. Vore,et al. Role of microtubules in estradiol-17beta-D-glucuronide-induced alteration of canalicular Mrp2 localization and activity. , 2005, American journal of physiology. Gastrointestinal and liver physiology.
[7] D. Häussinger,et al. Ca2+-dependent Protein Kinase C Isoforms Induce Cholestasis in Rat Liver* , 2004, Journal of Biological Chemistry.
[8] Jingsong Cao,et al. Estradiol-17beta-D-glucuronide induces endocytic internalization of Bsep in rats. , 2003, American journal of physiology. Gastrointestinal and liver physiology.
[9] L. Varticovski,et al. Mechanisms by which cAMP increases bile acid secretion in rat liver and canalicular membrane vesicles. , 2003, American journal of physiology. Gastrointestinal and liver physiology.
[10] P. Milkiewicz,et al. Impaired localisation and transport function of canalicular Bsep in taurolithocholate induced cholestasis in the rat , 2003, Gut.
[11] J. Boyer,et al. Taurolithocholic Acid Exerts Cholestatic Effects via Phosphatidylinositol 3-Kinase-dependent Mechanisms in Perfused Rat Livers and Rat Hepatocyte Couplets* , 2003, The Journal of Biological Chemistry.
[12] Jingsong Cao,et al. Altered localization and activity of canalicular Mrp2 in estradiol‐17β‐D‐glucuronide–induced cholestasis , 2002, Hepatology.
[13] D. Häussinger,et al. Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats. , 2001, Gastroenterology.
[14] D. Keppler,et al. Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C–dependent mechanisms in cholestatic rat liver , 2001, Hepatology.
[15] N. LaRusso,et al. The Water Channel Aquaporin-8 Is Mainly Intracellular in Rat Hepatocytes, and Its Plasma Membrane Insertion Is Stimulated by Cyclic AMP* , 2001, The Journal of Biological Chemistry.
[16] P. Milkiewicz,et al. Effect of tauroursodeoxycholate and S-adenosyl-L-methionine on 17beta-estradiol glucuronide-induced cholestasis. , 2001, Journal of hepatology.
[17] A. Toker. Protein kinases as mediators of phosphoinositide 3-kinase signaling. , 2000, Molecular pharmacology.
[18] P. Meier,et al. Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver. , 2000, Gastroenterology.
[19] D. Keppler,et al. Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance. , 1999, Biochimica et biophysica acta.
[20] C. Webster,et al. Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp. , 1999, American journal of physiology. Gastrointestinal and liver physiology.
[21] M. Waterfield,et al. Signaling by distinct classes of phosphoinositide 3-kinases. , 1999, Experimental cell research.
[22] J. Boyer,et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes , 1999, Hepatology.
[23] L. Varticovski,et al. The Role of Phosphoinositide 3-Kinase in Taurocholate-induced Trafficking of ATP-dependent Canalicular Transporters in Rat Liver* , 1998, The Journal of Biological Chemistry.
[24] R. Coleman,et al. Vasopressin‐induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: Possible involvement of protein kinase C , 1998, Hepatology.
[25] P. Meier,et al. The Sister of P-glycoprotein Represents the Canalicular Bile Salt Export Pump of Mammalian Liver* , 1998, The Journal of Biological Chemistry.
[26] D. Keppler,et al. Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMoat) to the apical domain in hepatocyte couplets. , 1998, Journal of cell science.
[27] L. Huang,et al. Cholestatic properties and hepatic transport of steroid glucuronides. , 1997, Drug metabolism reviews.
[28] J. Chipman,et al. Purification of hepatocyte couplets by centrifugal elutriation , 1991, Hepatology.
[29] H. Zimmerman,et al. Estradiol‐17β‐D‐glucuronide (E‐17G) cholestasis in perfused rat liver: Fate of E‐17G and choleretic responses to bile salts , 1990 .
[30] M. Monte,et al. Oestradiol 17β-glucuronide increases tight-junctional permeability in rat liver , 1989 .
[31] M. Vore,et al. Characterization of cholestasis induced by estradiol-17 beta-D-glucuronide in the rat. , 1980, The Journal of pharmacology and experimental therapeutics.
[32] F. Tietze. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. , 1969, Analytical biochemistry.
[33] O. H. Lowry,et al. Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.