Recent Advances in 1,2-Amino(hetero)arylation of Alkenes.

Alkene amino(hetero)arylation presents a highly efficient and straightforward strategy for direct installation of amino groups and heteroaryl rings across a double bond simultaneously. An extensive array of practical transformations has been developed via alkene difunctionalization approach to access a broad range of medicinally valuable (hetero)arylethylamine motifs. This review presents recent progress in 1,2-amino(hetero)arylation of alkenes organized in three different modes. First, intramolecular transformations employing C, N tethered alkenes will be introduced. Next, two-component reactions will be discussed with different combination of precursors, N -tethered alkenes and external aryl precursor, C -tethered alkenes and external amine precursor, or C, N -tethered reagents, and alkenes. Last, threecomponent intermolecular amino(hetero)arylation reactions will be covered.