The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

In this study, Ignatova et al. performed a systematic screen to uncover new RNA methyltransferases, and demonstrate that the methyltransferase-like 5 (METTL5) protein catalyzes m6A in 18S rRNA at position A1832. Their biochemical, molecular, and in vivo characterization of METTL5 highlights the importance of m6A in rRNA in stemness, differentiation, development, and diseases.

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