HRCT Findings ofBleomycin-Related Lung Toxicity : A Report of 2 Cases 1

Many drugs can result in a variety of pathologic reactions in the lung , especially the cytotoxic drugs. Among cytotoxic drugs bleomycin is a prototype. Bleomycin-related pulmonary toxicity is usually known as dose-dependent and can be enhanced with concurrent oxygen therapy , irradiation , or other chemotherapeutic agents. The inci dence of bleomycin-induced pulmonary toxicity has been reported as varying from 2 to 46 %, and 1 % offatallung disease. We describe the radiographic and HRCT findings of bleomycin-related pulmonary toxicity developed in two patients: one in ovarian teratocarcinoma , the other malignant lymphoma patient. Chest radiographs and HRCT of these patients showed ground-glass opacities , consolidation , linear and reticular opacities , and interlobular septal thicken ing. These abnormalities were bilateraL and symmetrical and were found predominantly in the area ofmid- and lower-lung zone.