Experimental system for measuring the full scattering profile of circular phantoms.

Optical methods for monitoring physiological tissue state are important and useful because they are non-invasive and sensitive. Experimental measurements of the full scattering profile of circular phantoms are presented. We report, for the first time, an experimental observation of a typical reflected light intensity behavior for a circular structure characterized by the isobaric point. We previously suggested a new theoretically method for measuring the full scattering profile, which is the angular distribution of light intensity, of cylindrical tissues. In this work we present that the experimental result match the simulation results. We show the isobaric point at 105° for a cylindrical phantom with a 7mm diameter, while for a 16mm diameter phantom the isobaric point is at 125°. Furthermore, the experimental work present a new crossover point of the full scattering profiles of subjects with different diameters of the cylindrical tissues.

[1]  Britton Chance,et al.  Influence of blood vessels on the measurement of hemoglobin oxygenation as determined by time-resolved reflectance spectroscopy. , 1995, Medical physics.

[2]  Dirk J. Faber,et al.  Localized measurement of optical attenuation coefficients of atherosclerotic plaque constituents by quantitative optical coherence tomography , 2005, IEEE Transactions on Medical Imaging.

[3]  Hamootal Duadi,et al.  The influence of the blood vessel diameter on the full scattering profile from cylindrical tissues: experimental evidence for the shielding effect , 2016, Journal of biophotonics.

[4]  Zeev Zalevsky,et al.  Determination of coherence length in biological tissues , 2011, Lasers in surgery and medicine.

[5]  P. A. Martin Multiple Scattering: an Invitation , 1995 .

[6]  Wanrong Gao,et al.  Performance of single-scattering model versus multiple-scattering model in the determination of optical properties of biological tissue with optical coherence tomography. , 2010, Applied optics.

[7]  R Cubeddu,et al.  A solid tissue phantom for photon migration studies. , 1997, Physics in medicine and biology.

[8]  Steven L Jacques,et al.  Optical assessment of cutaneous blood volume depends on the vessel size distribution: a computer simulation study , 2009, Journal of biophotonics.

[9]  Jennifer J. Gibson,et al.  In vivo hemoglobin and water concentrations, oxygen saturation, and scattering estimates from near-infrared breast tomography using spectral reconstruction. , 2006, Academic radiology.

[10]  H. Yura,et al.  Analysis of optical coherence tomography systems based on the extended Huygens-Fresnel principle. , 2000, Journal of the Optical Society of America. A, Optics, image science, and vision.

[11]  David Levitz,et al.  Determination of optical scattering properties of highly-scattering media in optical coherence tomography images. , 2004, Optics express.

[12]  S. Jacques Optical properties of biological tissues: a review , 2013, Physics in medicine and biology.

[13]  Joseph M. Schmitt,et al.  MODEL OF OPTICAL COHERENCE TOMOGRAPHY OF HETEROGENEOUS TISSUE , 1997 .

[14]  J B Gross,et al.  Principles of Pulse Oximetry: Theoretical and Practical Considerations , 1989, Anesthesia and analgesia.

[15]  Hamootal Duadi,et al.  Influence of multiple scattering and absorption on the full scattering profile and the isobaric point in tissue , 2015, Journal of biomedical optics.

[16]  Martina Meinke,et al.  Determination of optical properties of human blood in the spectral range 250 to 1100 nm using Monte Carlo simulations with hematocrit-dependent effective scattering phase functions. , 2006, Journal of biomedical optics.

[17]  Q. Milner,et al.  An assessment of the accuracy of pulse oximeters , 2012, Anaesthesia.

[18]  L Wang,et al.  MCML--Monte Carlo modeling of light transport in multi-layered tissues. , 1995, Computer methods and programs in biomedicine.

[19]  J. Schmitt,et al.  Measurement of optical properties of biological tissues by low-coherence reflectometry. , 1993, Applied optics.

[20]  Menachem Motiei,et al.  Gold nanorods as absorption contrast agents for the noninvasive detection of arterial vascular disorders based on diffusion reflection measurements. , 2014, Nano letters.

[21]  Shlomo Engelberg,et al.  Three-wavelength technique for the measurement of oxygen saturation in arterial blood and in venous blood. , 2009, Journal of biomedical optics.

[22]  S. A. Prahl,et al.  A Monte Carlo model of light propagation in tissue , 1989, Other Conferences.

[23]  D T Delpy,et al.  Investigation of the effect of discrete absorbers upon the measurement of blood volume with near-infrared spectroscopy. , 1997, Physics in medicine and biology.

[24]  Rachela Popovtzer,et al.  Dependence of light scattering profile in tissue on blood vessel diameter and distribution: a computer simulation study , 2013, Journal of biomedical optics.

[25]  M. Elgendi On the Analysis of Fingertip Photoplethysmogram Signals , 2012, Current cardiology reviews.

[26]  Dror Fixler,et al.  On Phantom Experiments of the Photon Migration Model in Tissues , 2011 .

[27]  Hamootal Duadi,et al.  Linear dependency of full scattering profile isobaric point on tissue diameter , 2014, Journal of biomedical optics.

[28]  Hamootal Duadi,et al.  In‐vivo Tumor detection using diffusion reflection measurements of targeted gold nanorods – a quantitative study , 2012, Journal of biophotonics.

[29]  V. V. Tuchin Light scattering study of tissues , 1997 .

[30]  A. Roggan,et al.  Optical Properties of Circulating Human Blood in the Wavelength Range 400-2500 nm. , 1999, Journal of biomedical optics.

[31]  Yukio Yamada,et al.  Influences of blood flow changes in cerebrospinal fluid and skin layers on optical mapping , 2013, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[32]  Guolan Lu,et al.  Medical hyperspectral imaging: a review , 2014, Journal of biomedical optics.

[33]  Hamootal Duadi,et al.  A new diagnostic tool based on diffusion reflection measurements of gold nanoparticles , 2012, Other Conferences.