Generation of the respiratoryrhy thm: state-dependencyand switching

Two alternative concepts have been o1ered to explain the neural mechanisms responsible for the generation of the respiratorymotor pattern in the brainstem: a network paradigm and a hybrid pacemaker-network paradigm. Our computational and experimental studies were aimed at “building a bridge” between these concepts and considering the conditions that mayde6ne switching from one mechanism of rhythmogenesis to the other. c � 2002 Elsevier Science B.V. All rights reserved.

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