Shared pathogenesis of human and canine tumors - an inextricable link between cancer and evolution

Jaime F. Modiano*, Matthew Breen* Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Masonic Cancer Center, University of Minnesota, Minneapolis/St. Paul, MN Department of Molecular Biomedical Sciences, College of Veterinary Medicine, and Center for Comparative Medicine and Translational Research, North Carolina State University, Raleigh, NC __________________________________________________________________________________ *Correspondence: Dr. Jaime F. Modiano, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, 1365 Gortner Ave., St Paul, MN 55108, USA; Tel: 612-625-7436; fax: 612-624-0751; e-mail: modiano@umn.edu Dr. Matthew Breen, Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA; Tel: 919-513-1467; Fax: 919-513-7301; e-mail: Matthew_Breen@ncsu.edu

[1]  M. Paoloni,et al.  Translation of new cancer treatments from pet dogs to humans , 2008, Nature Reviews Cancer.

[2]  J. Modiano,et al.  Evolutionarily conserved cytogenetic changes in hematological malignancies of dogs and humans – man and his best friend share more than companionship , 2008, Chromosome Research.

[3]  G. Cutter,et al.  Inactivation of the p16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin's T-Cell Lymphoma , 2007, Veterinary pathology.

[4]  P. Tsai,et al.  A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog. , 2007, The Journal of heredity.

[5]  Pablo Landgraf,et al.  Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB mice. , 2007, Blood.

[6]  G. Cutter,et al.  Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma , 2007, Leukemia.

[7]  Freeman,et al.  Inactivation of the p 16 Cyclin-Dependent Kinase Inhibitor in High-Grade Canine Non-Hodgkin ’ s T-Cell Lymphoma , 2007 .

[8]  K. Lindblad-Toh,et al.  The dog as a cancer model , 2006, Nature Biotechnology.

[9]  C. Croce,et al.  Genomics of chronic lymphocytic leukemia microRNAs as new players with clinical significance. , 2006, Seminars in oncology.

[10]  J. Modiano,et al.  22 Breed-specific Canine Lymphoproliferative Diseases , 2006 .

[11]  K. Lindblad-Toh,et al.  The dog and its genome , 2006 .

[12]  James A. Cuff,et al.  Genome sequence, comparative analysis and haplotype structure of the domestic dog , 2005, Nature.

[13]  Francis Galibert,et al.  Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors. , 2005, Genome research.

[14]  C. Croce,et al.  miR-15 and miR-16 induce apoptosis by targeting BCL2. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[15]  P. Pevzner,et al.  Dynamics of Mammalian Chromosome Evolution Inferred from Multispecies Comparative Maps , 2005, Science.

[16]  Paul R. Avery,et al.  Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk. , 2005, Cancer research.

[17]  Fengtang Yang,et al.  Karyotype of canine soft tissue sarcomas: a multi-colour, multi-species approach to canine chromosome painting , 2005, Chromosome Research.

[18]  K. Offit,et al.  The genetics of familial lymphomas , 2004, Current oncology reports.

[19]  E. Kirkness,et al.  A high-resolution comparative map of canine Chromosome 5q14.3–q33 constructed utilizing the 1.5× canine genomesequence , 2004, Mammalian Genome.

[20]  C. Khanna,et al.  Spontaneous and genetically engineered animal models; use in preclinical cancer drug development. , 2004, European journal of cancer.

[21]  L. Schmidt,et al.  A germ-line insertion in the Birt–Hogg–Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[22]  E. Macewen,et al.  Spontaneous tumors in dogs and cats: Models for the study of cancer biology and treatment , 1990, Cancer and Metastasis Reviews.

[23]  Marshall A Lichtman,et al.  Familial (inherited) leukemia, lymphoma, and myeloma: an overview. , 2004, Blood cells, molecules & diseases.

[24]  M. Breen,et al.  Molecular cytogenetic analysis of a novel high-grade canine T-lymphoblastic lymphoma demonstrating co-expression of CD3 and CD79a cell markers , 2004, Chromosome Research.

[25]  Natalie,et al.  Genetic Structure of the Purebred Domestic Dog , 2004 .

[26]  M. Breen,et al.  Isolation and chromosomal assignment of canine genomic BAC clones representing 25 cancer-related genes , 2004, Cytogenetic and Genome Research.

[27]  N. Carter,et al.  A canine cancer-gene microarray for CGH analysis of tumors , 2004, Cytogenetic and Genome Research.

[28]  O. Hino Hereditary renal carcinogenesis fitting Knudson's two‐hit model: Genotype, environment, and phenotype , 2003, Genes, chromosomes & cancer.

[29]  E. Kirkness,et al.  A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd dog. , 2003, Human molecular genetics.

[30]  F. Galibert,et al.  Chromosome aberrations in canine multicentric lymphomas detected with comparative genomic hybridisation and a panel of single locus probes , 2003, British Journal of Cancer.

[31]  E. Kirkness,et al.  The Dog Genome: Survey Sequencing and Comparative Analysis , 2003, Science.

[32]  Razelle Kurzrock,et al.  Philadelphia ChromosomePositive Leukemias: From Basic Mechanisms to Molecular Therapeutics , 2003, Annals of Internal Medicine.

[33]  M. Segal,et al.  Genomic anatomy of the specific reciprocal translocation t(15;17) in acute promyelocytic leukemia , 2003, Genes, chromosomes & cancer.

[34]  J. Modiano,et al.  Diagnosis of Canine Lymphoid Neoplasia Using Clonal Rearrangements of Antigen Receptor Genes , 2003, Veterinary pathology.

[35]  W. Pear,et al.  The biology of chronic myelogenous leukemia:mouse models and cell adhesion , 2002, Oncogene.

[36]  D. Thamm,et al.  Evaluation of a 6-month chemotherapy protocol with no maintenance therapy for dogs with lymphoma. , 2002, Journal of veterinary internal medicine.

[37]  Meland,et al.  The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. , 2002, The New England journal of medicine.

[38]  J. V. Moran,et al.  Initial sequencing and analysis of the human genome. , 2001, Nature.

[39]  International Human Genome Sequencing Consortium Initial sequencing and analysis of the human genome , 2001, Nature.

[40]  A Benner,et al.  Genomic aberrations and survival in chronic lymphocytic leukemia. , 2000, The New England journal of medicine.

[41]  J. Aster,et al.  Molecular biology of Burkitt's lymphoma. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[42]  M. Breen,et al.  Comparative genomic hybridization (CGH) in dogs--application to the study of a canine glial tumour cell line. , 2000, Veterinary journal.

[43]  Fengtang Yang,et al.  A complete comparative chromosome map for the dog, red fox, and human and its integration with canine genetic maps. , 1999, Genomics.

[44]  J. Postlethwait,et al.  Genome maps 10. Comparative genomics. Mammalian radiations. Wall chart. , 1999, Science.

[45]  N. Carter,et al.  Reciprocal chromosome painting reveals detailed regions of conserved synteny between the karyotypes of the domestic dog (Canis familiaris) and human. , 1999, Genomics.

[46]  D. Head,et al.  Acute lymphoblastic leukemia with the (8;14)(q24;q32) translocation and FAB L3 morphology associated with a B-precursor immunophenotype: the Pediatric Oncology Group experience , 1999, Leukemia.

[47]  E. Fearon Human cancer syndromes: clues to the origin and nature of cancer. , 1997, Science.

[48]  A. Sette,et al.  Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo , 1995, The Journal of experimental medicine.

[49]  K. Hahn,et al.  Diagnostic and Prognostic Importance of Chromosomal Aberrations Identified in 61 Dogs with Lymphosarcoma , 1994, Veterinary pathology.

[50]  H. Egberink,et al.  Clustering in canine malignant lymphoma. , 1994, The Veterinary quarterly.

[51]  K. Lennert,et al.  Cytogenetic findings in peripheral T-cell lymphomas as a basis for distinguishing low-grade and high-grade lymphomas. , 1994, Blood.

[52]  K. Lennert,et al.  Cytogenetic Findings in Peripheral T-cell Lymphomas as a Basis for Distinguishing Low-Grade and High-Grade Lymphomas , 2002 .

[53]  C. Croce,et al.  A common mechanism of chromosomal translocation in T- and B-cell neoplasia. , 1986, Science.

[54]  J. Rowley,et al.  Molecular cloning of the breakpoint junction of a human chromosomal 8;14 translocation involving the T-cell receptor alpha-chain gene and sequences on the 3' side of MYC. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[55]  J. Rowley,et al.  Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[56]  P. Nowell,et al.  Chromosome translocations and B cell neoplasia. , 1984, Laboratory investigation; a journal of technical methods and pathology.

[57]  D. Onions A prospective survey of familial canine lymphosarcoma. , 1984, Journal of the National Cancer Institute.

[58]  Priester Wa,et al.  The occurrence of tumors in domestic animals. , 1980 .

[59]  W. Priester,et al.  The occurrence of tumors in domestic animals. , 1980, National Cancer Institute monograph.

[60]  M. Klauber,et al.  Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. , 1968, Journal of the National Cancer Institute.