Involvement of nitric oxide in arginine, but not glucose, induced insulin secretion in normal men

OBJECTIVE At present, there are no reports in the literature of studies in humans concerning a possible role of nitric oxide (NO) in the regulation of pancreatic endocrine secretions, whereas studies in the rat provided discrepant results. The aim of this study was to clarify whether NO is involved in the control of insulin and/or glucagon secretion in basal conditions and/or in response to arginine or glucose administration in normal male subjects.

[1]  M. Magotti,et al.  Mediation by nitric oxide of LH-RH-stimulated gonadotropin secretions in human subjects , 1995, Neuropeptides.

[2]  F. Lang,et al.  The effects of nitric oxide on the membrane potential and ionic currents of mouse pancreatic B cells. , 1995, Endocrinology.

[3]  G. Kaysen,et al.  Oral administration of the nitric oxide biosynthesis inhibitor, N-nitro-L-arginine methyl ester (L-NAME), causes hypertension, but not glucose intolerance or insulin resistance, in rats. , 1995, American journal of hypertension.

[4]  A. Sakinis,et al.  The insulin secretory response to intravenous glucose in the rat is independent of NO formation. , 1995, Acta physiologica Scandinavica.

[5]  P. Chiodera,et al.  Mediation by nitric oxide of TRH-, but not metoclopramide-stimulated TSH secretion in humans. , 1995 .

[6]  Å. Wennmalm,et al.  NO‐dependent and ‐independent elevation of plasma levels of insulin and glucose in rats by L‐arginine , 1994, British journal of pharmacology.

[7]  P. Chiodera,et al.  Inhibitory control of nitric oxide on the arginine-vasopressin and oxytocin response to hypoglycaemia in normal men. , 1994, Neuroreport.

[8]  A. Nussler,et al.  Inflammation, immunoregulation, and inducible nitric oxide synthase , 1993, Journal of leukocyte biology.

[9]  S. Vincent.  Nitric oxide and arginine-evoked insulin secretion. , 1992, Science.

[10]  F. Murad,et al.  Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. , 1992, Science.

[11]  S. G. Laychock,et al.  L-arginine stimulates cyclic guanosine 3',5'-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: evidence for L-arginine:nitric oxide synthase. , 1991, Endocrinology.

[12]  L. Jansson,et al.  The nitric oxide synthase II inhibitor NG-nitro-L-arginine stimulates pancreatic islet insulin release in vitro, but not in the perfused pancreas. , 1991, Endocrinology.

[13]  W. Malaisse,et al.  Stimulus-secretion coupling of arginine-induced insulin release: comparison with histidine-induced insulin release. , 1990, Endocrinology.