Adiposity-Related Predictors of Vascular Aging From a Life Course Perspective–Findings From the Helsinki Birth Cohort Study

The main objective of this study was to study predictors of vascular health with focus on adiposity-related factors. Glucose metabolism, blood lipids, inflammatory markers and body composition were assessed 15 years before assessment of vascular health which was assessed with pulse wave velocity (PWV) in 660 subjects born 1934–44. In a univariate analysis in women the strongest association with PWV was seen for age, systolic blood pressure, dysglycemia, dyslipidemia, inflammatory markers and body fat percentage measured in late midlife and PWV measured 15 years later. In men age, body mass index (BMI), systolic blood pressure, dysglycemia, and body fat percentage in late midlife were associated with PWV. One novel finding was that adiposity-related factors were strong predictors of vascular health, something not fully encapsulated in BMI, lean body mass or body fat percentage alone. A higher fat mass index was associated with worse vascular health, which was not ameliorated by a higher lean mass index. Our findings stress the importance to study body composition and fat and lean body mass simultaneously because of their close interaction with each other also in relation to vascular health.

[1]  J. Eriksson,et al.  Body composition and changes in health-related quality of life in older age: a 10-year follow-up of the Helsinki Birth Cohort Study , 2020, Quality of Life Research.

[2]  A. Chait,et al.  Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease , 2020, Frontiers in Cardiovascular Medicine.

[3]  P. Nilsson,et al.  Concept of Extremes in Vascular Aging. , 2019, Hypertension.

[4]  J. Eriksson,et al.  Maternal obesity and gestational diabetes: Impact on arterial wall layer thickness and stiffness in early childhood - RADIEL study six-year follow-up. , 2019, Atherosclerosis.

[5]  M. Knoflach,et al.  The Impact of Being Born Preterm or Small for Gestational Age on Early Vascular Aging in Adolescents , 2018, The Journal of pediatrics.

[6]  C. Cooper,et al.  Childhood Fat and Lean Mass: Differing Relations to Vascular Structure and Function at Age 8 to 9 Years , 2018, Arteriosclerosis, thrombosis, and vascular biology.

[7]  F. Huang,et al.  Carotid–Femoral Pulse Wave Velocity in the Prediction of Cardiovascular Events and Mortality: An Updated Systematic Review and Meta-Analysis , 2018, Angiology.

[8]  M. Safar.  Arterial stiffness as a risk factor for clinical hypertension , 2018, Nature Reviews Cardiology.

[9]  O. Melander,et al.  A genetic risk score for fasting plasma glucose is independently associated with arterial stiffness: a Mendelian randomization study , 2017, Journal of hypertension.

[10]  A. Saltiel,et al.  Adapting to obesity with adipose tissue inflammation , 2017, Nature Reviews Endocrinology.

[11]  R. Touyz,et al.  Oxidative Stress, Inflammation, and Vascular Aging in Hypertension , 2017, Hypertension.

[12]  P. López-Jaramillo,et al.  A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension , 2016, The Lancet.

[13]  F. Paneni,et al.  Ageing, metabolism and cardiovascular disease , 2016, The Journal of physiology.

[14]  V. Aboyans,et al.  The role of vascular biomarkers for primary and secondary prevention. A position paper from the European Society of Cardiology Working Group on peripheral circulation: Endorsed by the Association for Research into Arterial Structure and Physiology (ARTERY) Society. , 2015, Atherosclerosis.

[15]  O. Melander,et al.  Non-hemodynamic predictors of arterial stiffness after 17 years of follow-up: the Malmö Diet and Cancer study , 2015, Journal of hypertension.

[16]  Enrico Grisan,et al.  Early origins of adult disease: low birth weight and vascular remodeling. , 2014, Atherosclerosis.

[17]  N. Mayo,et al.  Interrelated factors favoring physical performance and activity in older adults from the NuAge cohort study , 2014, Experimental Gerontology.

[18]  Jianping Ye.  Mechanisms of insulin resistance in obesity , 2013, Frontiers of Medicine.

[19]  Alan D. Lopez,et al.  A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010 , 2012, The Lancet.

[20]  J. Filipovský,et al.  Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. , 2012, Journal of hypertension.

[21]  A. Benetos,et al.  Blood pressure regulation during the aging process: the end of the 'hypertension era'? , 2011, Journal of hypertension.

[22]  Stéphane Laurent,et al.  Vascular aging: A tale of EVA and ADAM in cardiovascular risk assessment and prevention. , 2009, Hypertension.

[23]  J. Eriksson,et al.  Body mass index during childhood and adult body composition in men and women aged 56-70 y. , 2008, The American journal of clinical nutrition.

[24]  P. Nilsson.  Early vascular aging (EVA): consequences and prevention , 2008, Vascular health and risk management.

[25]  M. Brochu,et al.  Fat mass but not fat-free mass is related to physical capacity in well-functioning older individuals: nutrition as a determinant of successful aging (NuAge)--the Quebec Longitudinal Study. , 2007, The journals of gerontology. Series A, Biological sciences and medical sciences.

[26]  J. Eriksson,et al.  Trajectories of growth among children who have coronary events as adults. , 2005, The New England journal of medicine.

[27]  R. Ross,et al.  Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. , 2004, American journal of epidemiology.

[28]  H. Struijker‐Boudier,et al.  Current Perspectives on Arterial Stiffness and Pulse Pressure in Hypertension and Cardiovascular Diseases , 2003, Circulation.

[29]  M. Malavolti,et al.  Cross-calibration of eight-polar bioelectrical impedance analysis versus dual-energy X-ray absorptiometry for the assessment of total and appendicular body composition in healthy subjects aged 21-82 years , 2003, Annals of human biology.

[30]  R. Collins,et al.  Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies , 2002, The Lancet.

[31]  T. Lakka,et al.  Intra-person variability of various physical activity assessments in the Kuopio Ischaemic Heart Disease Risk Factor Study. , 1992, International journal of epidemiology.

[32]  D. Owens,et al.  Sensitive and specific two-site immunoradiometric assays for human insulin, proinsulin, 65-66 split and 32-33 split proinsulins. , 1989, The Biochemical journal.

[33]  L. Prencipe,et al.  Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. , 1982, Clinical chemistry.

[34]  N. Gochman,et al.  Cholesterol oxidase-based determination, by continuous-flow analysis, of total and free cholesterol in serum. , 1976, Clinical chemistry.