Levels of Serum Nerve Growth Factor in Autistic Children in Benha City

It has been hypothesized that abnormal levels of serum nerve growth factor (NGF) may represent a serological marker for autistic children. The objective of this study was to measure serum NGF concentrations of autistic children and compare these levels with those of healthy children. We incorporated 20 mentally unbalanced know youngsters in the patients group, same time 20 sound kids were incorporated Concerning illustration controls. Then afterward history bringing Furthermore physical examination, serum ngf levels were measured for patients and control aggregations. No critical Contrast might have been distinguished the middle of patients Furthermore controls (p > 0. 05). Serum ngf might have been essentially lifted in the patients assembly contrasted with controls (220. 0 vs. 140. 0, p < 0. 001), and it needed a affectability about 85% What's more An specificity for 76% The point when its level will be higher over 185. 5 pg/ml. Moreover, serum ngf might have been fundamentally higher done cases with sure historical backdrop from claiming issues Throughout pregnancy and conception difficulties (P <0. 001). Our outcomes indicated that serum ngf focuses might make utilized Likewise An possibility symptomatic device over autism, however, further investigations including an expansive number about patients would needed to affirm those discoveries.

[1]  M. Gil-Campos,et al.  Children With Autism Spectrum Disorder With Regression Exhibit a Different Profile in Plasma Cytokines and Adhesion Molecules Compared to Children Without Such Regression , 2018, Front. Pediatr..

[2]  S. Chirumbolo,et al.  Metabolism-Associated Markers and Childhood Autism Rating Scales (CARS) as a Measure of Autism Severity , 2018, Journal of Molecular Neuroscience.

[3]  Caroline E. Robertson,et al.  Sensory perception in autism , 2017, Nature Reviews Neuroscience.

[4]  Keun-Ah Cheon,et al.  Characteristics of Brains in Autism Spectrum Disorder: Structure, Function and Connectivity across the Lifespan , 2015, Experimental neurobiology.

[5]  L. Pacini,et al.  Autism Spectrum Disorders: Translating human deficits into mouse behavior , 2015, Neurobiology of Learning and Memory.

[6]  M. Georgieva,et al.  Autism spectrum disorders: neurotrophins enter the dance , 2014 .

[7]  M. Ceylan,et al.  Serum nerve growth factor (NGF) levels in children with attention deficit/hyperactivity disorder (ADHD) , 2014, Neuroscience Letters.

[8]  B. Hu,et al.  What We Have Learned about Autism Spectrum Disorder from Valproic Acid , 2013, Pathology research international.

[9]  A. Ünalp,et al.  Serum nerve growth factor levels in autistic children in Turkish population: A preliminary study , 2013, The Indian journal of medical research.

[10]  A. Russo Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism , 2013, Biomarker insights.

[11]  A. Tonchev,et al.  NGF and BDNF: from nerves to adipose tissue, from neurokines to metabokines. , 2009, Rivista di psichiatria.

[12]  C. Mellis,et al.  Perinatal and maternal risk factors for autism spectrum disorders in New South Wales, Australia. , 2008, Child: care, health and development.

[13]  J. Gilmore,et al.  Maternal infection regulates BDNF and NGF expression in fetal and neonatal brain and maternal–fetal unit of the rat , 2003, Journal of Neuroimmunology.

[14]  J. Dambrosia,et al.  Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation , 2001, Annals of neurology.

[15]  T. Klyushnik,et al.  Autoantibodies to Nerve Growth Factor in Disorders of Mental Development in Infants , 2001, Neuroscience and Behavioral Physiology.

[16]  R. Vanhala,et al.  Levels of cerebrospinal fluid nerve‐growth factor differ in infantile autism and Rett syndrome , 1999, Developmental medicine and child neurology.

[17]  P. Fusar-Poli,et al.  Linking autism, regression and Landau-Kleffner syndrome: integrative role of nerve growth factor. , 2007, Medical hypotheses.