What have we learned from worldwide experiences on the management and treatment of hospital effluent? — An overview and a discussion on perspectives

Abstract This study overviews lessons learned from experimental investigations on dedicated treatment systems of hospital effluent carried out worldwide in the last twenty years. It includes 48 peer reviewed papers from 1995 to 2015 assessing the efficacy of different treatment levels (preliminary, primary, secondary and polishing) of hospital wastewater in removing a wide spectrum of pharmaceutical compounds as well as conventional contaminants. Moreover, it highlights the rationale and the reasons for each study: reducing the discharge of micropollutants in surface water, improving existing wastewater treatment technologies and reducing the risk of spread of pathogens causing endemic diseases and finally, it offers a critical analysis of the conclusions and suggestions of each study. The most investigated technologies are membrane bioreactors equipped with ultrafiltration membranes in the secondary step, ozonation followed by activated carbon filtration (in powder and in granules) in the polishing step. Interesting research projects deal with photo-Fenton processes acting as primary treatments to enhance biodegradation before biological treatment, and as a polishing step, thus further reducing micro-contaminant occurrence. Investment and operational costs are also presented and discussed for the different treatment technologies tested worldwide, in particular membrane bioreactors and various advanced oxidation processes. This study also discusses the need for further research to evaluate toxicity resulting from advanced oxidation processes as well as the need to develop an accurate feasibility study that encompasses technical, ecotoxicological and economic aspects to identify the best available treatment in the different situations from a global view point.

[1]  Y. Lévi,et al.  Modeling of hospital wastewater pollution by pharmaceuticals: first results of Mediflux study carried out in three French hospitals. , 2010, Water science and technology : a journal of the International Association on Water Pollution Research.

[2]  K Kümmerer,et al.  AOX-emissions from hospitals into municipal waste water. , 1998, Chemosphere.

[3]  X. Zhu,et al.  Concentration and detection of SARS coronavirus in sewage from Xiao Tang Shan Hospital and the 309th Hospital of the Chinese People's Liberation Army. , 2005, Water science and technology : a journal of the International Association on Water Pollution Research.

[4]  D. Barceló,et al.  Micro-pollutants in Hospital Effluent: Their Fate, Risk and Treatment Options , 2012 .

[5]  J. Comas,et al.  Ragging phenomenon characterisation and impact in a full-scale MBR. , 2013, Water science and technology : a journal of the International Association on Water Pollution Research.

[6]  Judit Lienert,et al.  Multiple-criteria decision analysis reveals high stakeholder preference to remove pharmaceuticals from hospital wastewater. , 2011, Environmental science & technology.

[7]  A. Martins,et al.  Determination of anti-anxiety and anti-epileptic drugs in hospital effluent and a preliminary risk assessment. , 2013, Chemosphere.

[8]  Ê. L. Machado,et al.  Secondary Hospital Wastewater Detoxification and Disinfection by Advanced Oxidation Processes , 2007, Environmental technology.

[9]  Ê. L. Machado,et al.  Hospital Laundry Wastewater Disinfection with Catalytic Photoozonation , 2008 .

[10]  P. Verlicchi,et al.  Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment--a review. , 2012, The Science of the total environment.

[11]  George Tchobanoglous,et al.  Small and decentralized wastewater management systems , 1998 .

[12]  C. Manaia,et al.  Urban wastewater treatment plants as hotspots for antibiotic resistant bacteria and genes spread into the environment: a review. , 2013, The Science of the total environment.

[13]  K Kümmerer,et al.  Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources--a review. , 2001, Chemosphere.

[14]  K. Kimura,et al.  Rejection of neutral endocrine disrupting compounds (EDCs) and pharmaceutical active compounds (PhACs) by RO membranes , 2004 .

[15]  H Kroiss,et al.  Removal of selected pharmaceuticals, fragrances and endocrine disrupting compounds in a membrane bioreactor and conventional wastewater treatment plants. , 2005, Water research.

[16]  H. Suty,et al.  Applications of advanced oxidation processes: present and future. , 2004, Water science and technology : a journal of the International Association on Water Pollution Research.

[17]  P. Pasalar,et al.  Wastewater Characteristics and Appropriate Method for Wastewater Management in the Hospitals , 2009 .

[18]  M. Fuerhacker,et al.  Fate of cancerostatic platinum compounds in biological wastewater treatment of hospital effluents. , 2007, Chemosphere.

[19]  A. Boxall,et al.  Occurrence and fate of human pharmaceuticals in the environment. , 2010, Reviews of environmental contamination and toxicology.

[20]  U. Gunten,et al.  Ozonation of drinking water: part II. Disinfection and by-product formation in presence of bromide, iodide or chlorine. , 2003, Water research.

[21]  Y. Perrodin,et al.  A posteriori assessment of ecotoxicological risks linked to building a hospital. , 2016, Chemosphere.

[22]  J. Anthony Byrne,et al.  Immobilisation of TiO2 powder for the treatment of polluted water , 1998 .

[23]  J. Pinnekamp,et al.  Treatment of hospital wastewater effluent by nanofiltration and reverse osmosis. , 2010, Water science and technology : a journal of the International Association on Water Pollution Research.

[24]  W. Bursch,et al.  Monitoring, removal and risk assessment of cytostatic drugs in hospital wastewater. , 2007, Water science and technology : a journal of the International Association on Water Pollution Research.

[25]  Dagot Christophe,et al.  Upgrading the performances of ultrafiltration membrane system coupled with activated sludge reactor by addition of biofilm supports for the treatment of hospital effluents , 2015 .

[26]  C. M. Radetski,et al.  Physico-chemical, microbiological and ecotoxicological evaluation of a septic tank/Fenton reaction combination for the treatment of hospital wastewaters. , 2009, Ecotoxicology and environmental safety.

[27]  T. Albanis,et al.  Occurrence and removal of PPCPs in municipal and hospital wastewaters in Greece. , 2010, Journal of hazardous materials.

[28]  Y. Perrodin,et al.  Daily physicochemical, microbiological and ecotoxicological fluctuations of a hospital effluent according to technical and care activities. , 2008, The Science of the total environment.

[29]  A. Martins,et al.  Degradation of β-blockers in hospital wastewater by means of ozonation and Fe2+/ozonation. , 2014, Water research.

[30]  Ali Khavanin,et al.  Hospital Wastewater Treatment Using an Integrated Anaerobic Aerobic Fixed Film Bioreactor , 2005 .

[31]  R. Shrestha,et al.  Constructed wetland technology transfer to Nepal. , 2001, Water science and technology : a journal of the International Association on Water Pollution Research.

[32]  J Pinnekamp,et al.  Full scale membrane bioreactor treatment of hospital wastewater as forerunner for hot-spot wastewater treatment solutions in high density urban areas. , 2011, Water science and technology : a journal of the International Association on Water Pollution Research.

[33]  H R Rogers,et al.  Sources, behaviour and fate of organic contaminants during sewage treatment and in sewage sludges. , 1996, The Science of the total environment.

[34]  Y. Perrodin,et al.  A priori assessment of ecotoxicological risks linked to building a hospital. , 2013, Chemosphere.

[35]  E. Korzeniewska,et al.  Antibiotic resistant Escherichia coli in hospital and municipal sewage and their emission to the environment. , 2013, Ecotoxicology and environmental safety.

[36]  H. A. El-Gawad,et al.  Assessment of Aquatic Environmental for Wastewater Management Quality in the Hospitals : a Case Study , 2011 .

[37]  G. H. Kristensen,et al.  Removal of APIs and bacteria from hospital wastewater by MBR plus O(3), O(3) + H(2)O(2), PAC or ClO(2). , 2013, Water science and technology : a journal of the International Association on Water Pollution Research.

[38]  Tatiana Prado,et al.  Quantification and molecular characterization of enteric viruses detected in effluents from two hospital wastewater treatment plants. , 2011, Water research.

[39]  J. Byrne,et al.  Photocatalytic degradation of 17-β-oestradiol on immobilised TiO2 , 2000 .

[40]  J. Straub Environmental risk assessment for new human pharmaceuticals in the European Union according to the draft guideline/discussion paper of January 2001. , 2002, Toxicology letters.

[41]  A. Martins,et al.  Ciprofloxacin in hospital effluent: degradation by ozone and photoprocesses. , 2009, Journal of hazardous materials.

[42]  H Kroiss,et al.  Relevance of the sludge retention time (SRT) as design criteria for wastewater treatment plants for the removal of endocrine disruptors and pharmaceuticals from wastewater. , 2004, Water science and technology : a journal of the International Association on Water Pollution Research.

[43]  U. von Gunten,et al.  Oxidative transformation of micropollutants during municipal wastewater treatment: comparison of kinetic aspects of selective (chlorine, chlorine dioxide, ferrate VI, and ozone) and non-selective oxidants (hydroxyl radical). , 2010, Water research.

[44]  A. Martins,et al.  Concentration of Ciprofloxacin in Brazilian Hospital Effluent and Preliminary Risk Assessment: A Case Study , 2008 .

[45]  A Joss,et al.  Review on the fate of organic micropollutants in wastewater treatment and water reuse with membranes. , 2012, Water science and technology : a journal of the International Association on Water Pollution Research.

[46]  Kamyar Yaghmaeian,et al.  Quality and quantity survey of hospital wastewaters in Hormozgan Province , 2007 .

[47]  W Verstraete,et al.  The treatment of hospital wastewater: an appraisal. , 2006, Journal of water and health.

[48]  J Pinnekamp,et al.  MBR technology: a promising approach for the (pre-)treatment of hospital wastewater. , 2012, Water science and technology : a journal of the International Association on Water Pollution Research.

[49]  Jung-Hwan Kwon,et al.  Evaluation of pharmaceuticals and personal care products with emphasis on anthelmintics in human sanitary waste, sewage, hospital wastewater, livestock wastewater and receiving water. , 2013, Journal of hazardous materials.

[50]  J. Hollender,et al.  Einsatz von Pulveraktivkohle zur Elimination von Mikroverunreinigungen aus kommunalem Abwasser , 2010 .

[51]  H. Siegrist,et al.  Input and elimination of pharmaceuticals and disinfectants from hospital wastewater. Emission von Arzneimitteln und Desinfektionsmitteln aus Spitälern und Behandlung von Spitalabwasser , 2011 .

[52]  Puangrat Kajitvichyanukul,et al.  Evaluation of biodegradability and oxidation degree of hospital wastewater using photo-Fenton process as the pretreatment method. , 2006, Journal of hazardous materials.

[53]  Steve Carter,et al.  Determining the fraction of pharmaceutical residues in wastewater originating from a hospital. , 2010, Water research.

[54]  G. H. Kristensen,et al.  Removal of APIs and bacteria from hospital wastewater by MBR plus O3, O3þH2O2, PAC or ClO2 , 2013 .

[55]  Getachew Redaie,et al.  Assessment of Waste Stabilization Ponds for the Treatment of Hospital Wastewater: The Case of Hawassa University Referral Hospital , 2011 .

[56]  Adriano Joss,et al.  Biological degradation of pharmaceuticals in municipal wastewater treatment: proposing a classification scheme. , 2006, Water research.

[57]  P Verlicchi,et al.  Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. , 2012, The Science of the total environment.

[58]  Sunil Kumar,et al.  Preliminary study of physico-chemical treatment options for hospital wastewater. , 2007, Journal of environmental management.

[59]  K. Naddafi,et al.  Wastewater Characteristics and Appropriate Method for Wastewater Management in the Hospitals , 2009 .

[60]  D. Barceló,et al.  Emerging Organic Contaminants and Human Health , 2012 .

[61]  Y. Perrodin,et al.  Study of the combined effects of a peracetic acid-based disinfectant and surfactants contained in hospital effluents on Daphnia magna , 2007, Ecotoxicology.

[62]  Heinz Singer,et al.  Hospital wastewater treatment by membrane bioreactor: performance and efficiency for organic micropollutant elimination. , 2012, Environmental science & technology.

[63]  D. Barceló,et al.  Hospital wastewater treatment by fungal bioreactor: removal efficiency for pharmaceuticals and endocrine disruptor compounds. , 2014, The Science of the total environment.

[64]  Karin Treyer,et al.  Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater. , 2011, Water research.

[65]  Francisco Omil,et al.  Pre-treatment of hospital wastewater by coagulation-flocculation and flotation. , 2009, Bioresource technology.

[66]  Hansruedi Siegrist,et al.  Elimination of micropollutants during post-treatment of hospital wastewater with powdered activated carbon, ozone, and UV. , 2013, Environmental science & technology.

[67]  W. Verstraete,et al.  Effluent Quality of a Conventional Activated Sludge and a Membrane Bioreactor System Treating Hospital Wastewater , 2006, Environmental technology.

[68]  Damià Barceló,et al.  Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals. , 2013, The Science of the total environment.

[69]  G Keck,et al.  Ecotoxicological risk assessment of hospital wastewater: a proposed framework for raw effluents discharging into urban sewer network. , 2005, Journal of hazardous materials.

[70]  N. Voulvoulis,et al.  A framework for the assessment of the environmental risk posed by pharmaceuticals originating from hospital effluents. , 2014, The Science of the total environment.

[71]  W. Hijnen,et al.  Inactivation credit of UV radiation for viruses, bacteria and protozoan (oo)cysts in water: a review. , 2006, Water research.

[72]  Lingyun Chen,et al.  Application of MBR for hospital wastewater treatment in China , 2009, Desalination.

[73]  H. K. Cordell,et al.  Framework for the assessment , 1999 .

[74]  K. Klepiszewski,et al.  Elimination of pharmaceutical residues in biologically pre-treated hospital wastewater using advanced UV irradiation technology: a comparative assessment. , 2012, Journal of hazardous materials.

[75]  Ching-Tsan Tsai,et al.  Disinfection of Hospital Wastewater by Continuous Ozonization , 2003, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[76]  S. Chitnis,et al.  Bacterial population changes in hospital effluent treatment plant in central India. , 2004, Water research.

[77]  U. von Gunten,et al.  Characterization of Oxidation processes: ozonation and the AOP O3/H2O2 , 2001 .

[78]  V. Cunningham,et al.  Special Characteristics of Pharmaceuticals Related to Environmental Fate , 2008 .

[79]  T. Abbas,et al.  PERFORMANCE OF SEQUENCING ANOXIC/ANAEROBIC MEMBRANE BIOREACTOR (SAM) SYSTEM IN HOSPITAL WASTEWATER TREATMENT AND REUSE , 2013 .

[80]  Long D Nghiem,et al.  Removal of trace organics by MBR treatment: the role of molecular properties. , 2011, Water research.

[81]  P. Verlicchi,et al.  Removal of Pharmaceuticals by Conventional Wastewater Treatment Plants , 2013 .

[82]  D. Bingöl,et al.  Use of response surface methodology for pretreatment of hospital wastewater by O3/UV and O3/UV/H2O2 processes , 2014 .

[83]  Paola Verlicchi,et al.  Management of hospital wastewaters: the case of the effluent of a large hospital situated in a small town. , 2010, Water science and technology : a journal of the International Association on Water Pollution Research.

[84]  Shane Snyder,et al.  Fate of endocrine-disruptor, pharmaceutical, and personal care product chemicals during simulated drinking water treatment processes. , 2005, Environmental science & technology.

[85]  Yves Perrodin,et al.  Toxicological effects of disinfections using sodium hypochlorite on aquatic organisms and its contribution to AOX formation in hospital wastewater. , 2004, Environment international.

[86]  S. Abubaker,et al.  Investigation of optimal method for hospital wastewater treatment. , 2010 .

[87]  A. Rajabizadeh,et al.  Survey Wastewater Treatment Condition and Effluent Quality of Kerman Province Hospitals , 2009 .

[88]  R M Mader,et al.  Fate of 5-fluorouracil, doxorubicin, epirubicin, and daunorubicin in hospital wastewater and their elimination by activated sludge and treatment in a membrane-bio-reactor system. , 2007, Chemosphere.

[89]  Xia Huang,et al.  Treatment of hospital wastewater using a submerged membrane bioreactor , 2004 .