Combinatorial and high-throughput approaches in polymer science

Combinatorial and high-throughput approaches have become topics of great interest in the last decade due to their potential ability to significantly increase research productivity. Recent years have witnessed a rapid extension of these approaches in many areas of the discovery of new materials including pharmaceuticals, inorganic materials, catalysts and polymers. This paper mainly highlights our progress in polymer research by using an automated parallel synthesizer, microwave synthesizer and ink-jet printer. The equipment and methodologies in our experiments, the high-throughput experimentation of different polymerizations (such as atom transfer radical polymerization, cationic ring-opening polymerization and emulsion polymerization) and the automated matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy (MALDI-TOF MS) sample preparation are described.

[1]  C. McCormick,et al.  Aqueous RAFT polymerization: recent developments in synthesis of functional water-soluble (co)polymers with controlled structures. , 2004, Accounts of chemical research.

[2]  Mar Michael Meier,et al.  Combinatorial Methods, Automated Synthesis and High-Throughput Screening in Polymer Research: Past and Present , 2003 .

[3]  H. Pasch,et al.  MALDI-TOF Mass Spectrometry of Synthetic Polymers , 2003 .

[4]  Ulrich S. Schubert,et al.  High-throughput experimentation in atom transfer radical polymerization : a general approach toward a directed design and understanding of optimal catalytic systems , 2004 .

[5]  Ulrich S. Schubert,et al.  Automated Parallel Temperature Optimization and Determination of Activation Energy for the Living Cationic Polymerization of 2‐Ethyl‐2‐oxazoline , 2003 .

[6]  Mohamed S. El-Aasser,et al.  Emulsion polymerization and emulsion polymers , 1997 .

[7]  U. Schubert,et al.  Monomode microwave-assisted atom transfer radical polymerization , 2004 .

[8]  Mar Michael Meier,et al.  Living cationic polymerizations utilizing an automated synthesizer : high-throughput synthesis of polyoxazolines , 2003 .

[9]  Ulrich S Schubert,et al.  Evaluation of a new multiple-layer spotting technique for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of synthetic polymers. , 2003, Rapid communications in mass spectrometry : RCM.

[10]  T. Saegusa,et al.  Isomerization Polymerization of 2-Oxazoline. VI. Kinetic Study on the Polymerization of 2-Methyl-2-oxazoline Initiated by Methyl Iodide , 1973 .

[11]  Eric J. Amis,et al.  Combinatorial Methods for Investigations in Polymer Materials Science , 2002 .

[12]  M. Okada,et al.  Polymerization of oxazolines , 1996 .

[13]  Ulrich S. Schubert,et al.  Application of a Parallel Synthetic Approach in Atom‐Transfer Radical Polymerization: Set‐Up and Feasibility Demonstration , 2003 .

[14]  Mar Michael Meier,et al.  Combinatorial Methods, Automated Synthesis and High‐Throughput Screening in Polymer Research: The Evolution Continues , 2004 .

[15]  W. H. Weinberg,et al.  A combinatorial approach to the discovery and optimization of luminescent materials , 1997, Nature.

[16]  E. Harth,et al.  New polymer synthesis by nitroxide mediated living radical polymerizations. , 2001, Chemical reviews.

[17]  W. Seeliger,et al.  Neuere Synthesen und Reaktionen cyclischer Imidsäureester , 1966 .

[18]  Ulrich S. Schubert,et al.  Parallel kinetic investigation of 2‐oxazoline polymerizations with different initiators as basis for designed copolymer synthesis , 2004 .

[19]  Richard Hoogenboom,et al.  Automated MALDI-TOF-MS sample preparation in combinatorial polymer research. , 2003, Journal of combinatorial chemistry.

[20]  Ulrich S. Schubert,et al.  Software Solutions for Combinatorial and High-Throughput Materials and Polymer Research , 2004 .

[21]  W. Seeliger,et al.  Recent syntheses and reactions of cyclic imidic esters. , 1966, Angewandte Chemie.

[22]  Ulrich S. Schubert,et al.  Potentials and Limitations of Automated Parallel Emulsion Polymerization , 2003 .

[23]  D. P. Sheetz,et al.  Homopolymerization of 2‐alkyl‐ and 2‐aryl‐2‐oxazolines , 1966 .

[24]  Selim M. Senkan,et al.  High-throughput screening of solid-state catalyst libraries , 1998, Nature.

[25]  S Stefan Schmatloch,et al.  Instrumentation for combinatorial and high-throughput polymer research: a short overview , 2003 .

[26]  M. Sawamoto,et al.  Metal-catalyzed living radical polymerization. , 2001, Chemical reviews.

[27]  S Stefan Schmatloch,et al.  High‐Throughput Experimentation in Organic Coating and Thin Film Research: State‐of‐the‐Art and Future Perspectives , 2004 .

[28]  Ulrich S Schubert,et al.  Automated multiple-layer spotting for matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of synthetic polymers utilizing ink-jet printing technology. , 2003, Rapid communications in mass spectrometry : RCM.

[29]  Barry A. Bunin,et al.  The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[30]  K. Matyjaszewski,et al.  Atom transfer radical polymerization. , 2001, Chemical reviews.

[31]  Combinatorial Materials Research in the Polymer Industry: Speed versus Flexibility , 2003 .