Asymmetric Excitatory Synaptic Dynamics Underlie Interaural Time Difference Processing in the Auditory System

In order to localize sounds in the environment, the auditory system detects and encodes differences in signals between each ear. The exquisite sensitivity of auditory brain stem neurons to the differences in rise time of the excitation signals from the two ears allows for neuronal encoding of microsecond interaural time differences.

[1]  B. Grothe,et al.  Interaural Time Difference Processing in the Mammalian Medial Superior Olive: The Role of Glycinergic Inhibition , 2008, The Journal of Neuroscience.

[2]  Nace L. Golding,et al.  Posthearing Developmental Refinement of Temporal Processing in Principal Neurons of the Medial Superior Olive , 2005, The Journal of Neuroscience.

[3]  David McAlpine,et al.  Optimal neural population coding of an auditory spatial cue , 2004, Nature.

[4]  G. Spirou,et al.  Development of gerbil medial superior olive: integration of temporally delayed excitation and inhibition at physiological temperature , 2007, The Journal of physiology.

[5]  J. Rinzel,et al.  Enhancement of Signal-to-Noise Ratio and Phase Locking for Small Inputs by a Low-Threshold Outward Current in Auditory Neurons , 2002, The Journal of Neuroscience.

[6]  W Rall,et al.  Matching dendritic neuron models to experimental data. , 1992, Physiological reviews.

[7]  Hysell V. Oviedo,et al.  Boosting of neuronal firing evoked with asynchronous and synchronous inputs to the dendrite , 2002, Nature Neuroscience.

[8]  E. Overholt,et al.  A circuit for coding interaural time differences in the chick brainstem , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[9]  R. H. Arnott,et al.  Interaural Time Difference Discrimination Thresholds for Single Neurons in the Inferior Colliculus of Guinea Pigs , 2003, The Journal of Neuroscience.

[10]  A. Magnusson,et al.  Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset , 2005, The Journal of physiology.

[11]  N. Spruston,et al.  Voltage- and space-clamp errors associated with the measurement of electrotonically remote synaptic events. , 1993, Journal of neurophysiology.

[12]  D. Contreras,et al.  Dynamics of excitation and inhibition underlying stimulus selectivity in rat somatosensory cortex , 2005, Nature Neuroscience.

[13]  H. Heffner,et al.  Sound localization and use of binaural cues by the gerbil (Meriones unguiculatus). , 1988, Behavioral neuroscience.

[14]  Ethan M. Goldberg,et al.  K+ Channels at the Axon Initial Segment Dampen Near-Threshold Excitability of Neocortical Fast-Spiking GABAergic Interneurons , 2008, Neuron.

[15]  D. Oertel,et al.  Rate thresholds determine the precision of temporal integration in principal cells of the ventral cochlear nucleus , 2006, Hearing Research.

[16]  T. Yin,et al.  Envelope coding in the lateral superior olive. III. Comparison with afferent pathways. , 1998, Journal of neurophysiology.

[17]  M. Ferragamo,et al.  Octopus cells of the mammalian ventral cochlear nucleus sense the rate of depolarization. , 2002, Journal of neurophysiology.

[18]  T. Yin,et al.  Interaural time sensitivity in medial superior olive of cat. , 1990, Journal of neurophysiology.

[19]  Edwin W Rubel,et al.  Mechanisms for Adjusting Interaural Time Differences to Achieve Binaural Coincidence Detection , 2010, The Journal of Neuroscience.

[20]  T. Yin,et al.  A matter of time: internal delays in binaural processing , 2007, Trends in Neurosciences.

[21]  Philip H Smith,et al.  Projections of physiologically characterized spherical bushy cell axons from the cochlear nucleus of the cat: Evidence for delay lines to the medial superior olive , 1993, The Journal of comparative neurology.

[22]  Pablo E. Jercog,et al.  Control of submillisecond synaptic timing in binaural coincidence detectors by Kv1 channels , 2010, Nature Neuroscience.

[23]  J. Rinzel,et al.  The role of dendrites in auditory coincidence detection , 1998, Nature.

[24]  J. Rothman,et al.  Kinetic analyses of three distinct potassium conductances in ventral cochlear nucleus neurons. , 2003, Journal of neurophysiology.

[25]  R. Batra,et al.  Axons from Anteroventral Cochlear Nucleus that Terminate in Medial Superior Olive of Cat: Observations Related to Delay Lines , 1999, The Journal of Neuroscience.

[26]  J. Agapiou,et al.  The Synaptic Representation of Sound Source Location in Auditory Cortex , 2009, The Journal of Neuroscience.

[27]  L. Carney,et al.  A model for the responses of low-frequency auditory-nerve fibers in cat. , 1993, The Journal of the Acoustical Society of America.

[28]  L A JEFFRESS,et al.  A place theory of sound localization. , 1948, Journal of comparative and physiological psychology.

[29]  B. Grothe,et al.  Precise inhibition is essential for microsecond interaural time difference coding , 2002, Nature.

[30]  Nace L. Golding,et al.  Weak action potential backpropagation is associated with high‐frequency axonal firing capability in principal neurons of the gerbil medial superior olive , 2007, The Journal of physiology.

[31]  Idan Segev,et al.  Sound grounds for computing dendrites , 1998, Nature.

[32]  B. Grothe,et al.  New roles for synaptic inhibition in sound localization , 2003, Nature Reviews Neuroscience.

[33]  E. Rubel,et al.  Frequency-specific projections of individual neurons in chick brainstem auditory nuclei , 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[34]  M. Konishi,et al.  Axonal delay lines for time measurement in the owl's brainstem. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[35]  M. W. Spitzer,et al.  Neurons sensitive to interaural phase disparity in gerbil superior olive: diverse monaural and temporal response properties. , 1995, Journal of neurophysiology.

[36]  J. Rinzel,et al.  Sodium along with low-threshold potassium currents enhance coincidence detection of subthreshold noisy signals in MSO neurons. , 2004, Journal of neurophysiology.