GWAS meta-analysis of 16 852 women identifies new susceptibility locus for endometrial cancer.

Endometrial cancer is the most common gynecological malignancy in the developed world. Although there is evidence of genetic predisposition to the disease, most of the genetic risk remains unexplained. We present the meta-analysis results of four genome-wide association studies (4907 cases and 11 945 controls total) in women of European ancestry. We describe one new locus reaching genome-wide significance (P < 5 × 10 -8) at 6p22.3 (rs1740828; P = 2.29 × 10 -8, OR = 1.20), providing evidence of an additional region of interest for genetic susceptibility to endometrial cancer.

Harvey Risch | Peter Kraft | Mark McEvoy | Rodney J Scott | Lucy Xia | Jennifer Prescott | John Attia | Brian E Henderson | Loic Le Marchand | Jirong Long | Jolanta Lissowska | Ian Tomlinson | Alison M Dunning | Wei Zheng | Paul D P Pharoah | Montserrat Garcia-Closas | David J Hunter | Douglas F Easton | Stephen Chanock | Herbert Yu | Noel S Weiss | Irene Orlow | Xin Sheng | Elizabeth G Holliday | Jennifer Doherty | Susan E Hankinson | Constance Turman | Maggie Gorman | Lingeng Lu | C. Friedenreich | S. Chanock | M. García-Closas | P. Hartge | D. Hunter | T. Rebbeck | B. Henderson | C. Haiman | A. Spurdle | D. Easton | P. Kraft | R. Scott | P. Pharoah | S. Hankinson | L. Le Marchand | Zhaoming Wang | J. Long | X. Shu | Y. Xiang | W. Zheng | A. Dunning | Deborah J. Thompson | L. Brinton | J. Lissowska | M. Crous-Bou | I. Tomlinson | J. Attia | E. Holliday | D. J. Van Den Berg | P. Horn-Ross | N. Weiss | M. McEvoy | S. Olson | H. Risch | Herbert Yu | C. Sacerdote | I. Orlow | J. Doherty | S. Hodgson | J. Painter | X. Liang | Lynn Martin | M. Gorman | I. De Vivo | Hannah P. Yang | A. Magliocco | Xin Sheng | Loreall Pooler | Lucy Y. Xia | Chu Chen | N. Wentzensen | L. Cook | M. Gaudet | T. O’Mara | Lingeng Lu | Constance Turman | A. Black | J. Prescott | Sara H Olson | Zhaoming Wang | Amanda B Spurdle | Xiao-Ou Shu | Patricia Hartge | David Van Den Berg | Immaculata De Vivo | Amanda Black | Timothy R Rebbeck | Shirley Hodgson | Carlotta Sacerdote | Chu Chen | Yong-Bing Xiang | Deborah J Thompson | Linda S Cook | Mia M Gaudet | Lynn Martin | Louise Brinton | Loreall Pooler | Christopher Haiman | Timothy H. T. Cheng | Maxine M. Chen | Christine M Friedenreich | Anthony M Magliocco | Veronica Wendy Setiawan | Hannah P Yang | Marta Crous-Bou | Jodie N Painter | Tracy A O'Mara | Pamela L Horn-Ross | Radhai Rastogi | Maxine M Chen | Timothy Ht Cheng | Xiaolin Liang | Frederick Schumacher | Nicholas Wentzensen | X. Sheng | R. Rastogi | F. Schumacher | V. Wendy Setiawan | P. Horn‐Ross | Radhai Rastogi | Lucy Y. Xia | R. Scott | D. Hunter | R. Scott | B. Henderson | R. Scott | Lucy Xia

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