Variable response to low‐dose naltrexone in patients with Darier disease: a case series

Darier disease is a rare autosomal‐dominant genodermatosis with a loss of function of a Ca2+‐ATPase pump (SERCA2‐pump). Clinically, the disease is characterized by red–brown keratotic papules mainly in seborrhoeic areas and has only limited and unsatisfactory treatment options. Previously, low‐dose naltrexone was described as a successful treatment option in Hailey–Hailey disease, a genodermatosis with a genetic mutation coding for a similar loss of function of a Ca2+‐ATPase pump (hSPCA1‐pump).

[1]  O. Sarig,et al.  Identification of a recurrent mutation in ATP2C1 demonstrates that papular acantholytic dyskeratosis and Hailey–Hailey disease are allelic disorders , 2018, The British journal of dermatology.

[2]  V. Campbell,et al.  Low‐dose naltrexone: a novel treatment for Hailey–Hailey disease , 2018, The British journal of dermatology.

[3]  E. Lilly,et al.  Variable Response to Naltrexone in Patients With Hailey-Hailey Disease , 2018, JAMA dermatology.

[4]  D. Berlau,et al.  The Safety and Efficacy of Low‐Dose Naltrexone in the Management of Chronic Pain and Inflammation in Multiple Sclerosis, Fibromyalgia, Crohn's Disease, and Other Chronic Pain Disorders , 2018, Pharmacotherapy.

[5]  Qing-chun Diao,et al.  Identification of 2 Novel Mutations in ATP2C1 Gene in Hailey-Hailey Disease and a Literature Review of Variations in a Chinese Han Population , 2017, Medical science monitor basic research.

[6]  A. Vij,et al.  Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease) , 2017, JAMA dermatology.

[7]  J. Arbiser,et al.  Treatment of Hailey-Hailey Disease With Low-Dose Naltrexone , 2017, JAMA dermatology.

[8]  Pramod Kumar,et al.  Darier disease: A rare genodermatosis , 2017, Journal of oral and maxillofacial pathology : JOMFP.

[9]  Anna Żuchowska,et al.  The coexistence of Darier’s disease and Hailey-Hailey disease symptoms , 2017, Postepy dermatologii i alergologii.

[10]  Y. Tüzün,et al.  Darier disease: A fold (intertriginous) dermatosis. , 2015, Clinics in dermatology.

[11]  P. Pinton,et al.  Efficacy of magnesium chloride in the treatment of Hailey–Hailey disease: from serendipity to evidence of its effect on intracellular Ca2+ homeostasis , 2015, International journal of dermatology.

[12]  A. Kimball,et al.  Using the Physician Global Assessment in a clinical setting to measure and track patient outcomes. , 2015, JAMA dermatology.

[13]  A. Chiaravalloti,et al.  Hailey-Hailey disease and review of management. , 2014, Journal of drugs in dermatology : JDD.

[14]  J. Younger,et al.  The use of low-dose naltrexone (LDN) as a novel anti-inflammatory treatment for chronic pain , 2014, Clinical Rheumatology.

[15]  C. Georgescu,et al.  Darier disease and Hailey-Hailey disease. , 2007, Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie.