ANTI-ULCER ACTIVITY OF DIFFERENT LEAF EXTRACTS OF TECOMARIA CAPENSIS Research Article

Tecomaria capensis is being used as a traditional medicine for the treatment of various diseases. Considering the above claims, the present work was undertaken to validate the anti-ulcer potential of the ethanolic and ethylacetate extracts leaves of Tecomaria capensis against in vivo Aspirin induced method. The extracts (100 and 200 mg/kg) significantly reduced the ulcer index. The extracts also significantly increased the pH of gastric acid while at the same time reduced the volume of gastric juice and total acidities. In conclusion, the present study provide preliminary data on the antiulcer potential of Tecomaria capensis leaves and support the traditional uses of the plant for the treatment of gastric ulcer.

[1]  C. O. Okoye,et al.  Investigation into the Anti-ulcer Activity of the Aqueous Leaf Extract of Aspilia africana C.D. Adams , 2010 .

[2]  G. Franklin,et al.  Anti-Ulcer (Ulcer-Preventive) Activity of Ficus arnottiana Miq. (Moraceae) Leaf Methanolic Extract , 2009 .

[3]  P. Muralidharan,et al.  Antiulcer Activity of Morinda Citrifolia Linn Fruit Extract , 2009 .

[4]  P. Malfertheiner,et al.  Peptic ulcer disease , 2002, The Lancet.

[5]  J. Madan,et al.  Antiulcer Activity of Black Pepper against Absolute Ethanol Induced Gastric Mucosal Damage in Mice , 2008 .

[6]  Albina Arjuman,et al.  Effect of extract of Benincasa hispida on oxidative stress in rats with indomethacin induced gastric ulcers. , 2008, Indian journal of physiology and pharmacology.

[7]  G. Palit,et al.  Exploring Indian medicinal plants for antiulcer activity , 2006 .

[8]  L. M. Sánchez,et al.  Protective and antioxidant effects of Rhizophora mangle L. against NSAID-induced gastric ulcers. , 2006, Journal of ethnopharmacology.

[9]  R. Maurya,et al.  Allophylus serratus: a plant with potential anti-ulcerogenic activity. , 2005, Journal of ethnopharmacology.

[10]  D. Cortez,et al.  Evaluation of gastric anti-ulcer activity in a hydro-ethanolic extract from Kielmeyera coriacea , 2005 .

[11]  L. Kohn,et al.  Antiulcerogenic activity of a crude hydroalcoholic extract and coumarin isolated from Mikania laevigata Schultz Bip. , 2005, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[12]  V. Motilva,et al.  Effects of Dipyrone on Inflammatory Infiltration and Oxidative Metabolism in Gastric Mucosa: Comparison with Acetaminophen and Diclofenac , 2002, Digestive Diseases and Sciences.

[13]  M. Jegadeesan,et al.  Biochemical studies on the anti-ulcerogenic potential of Hemidesmus indicus R.Br. var. indicus. , 2003, Journal of ethnopharmacology.

[14]  S. Suerbaum,et al.  Helicobacter pylori infection , 2013, Nature Reviews Disease Primers.

[15]  S. Kulkarni,et al.  Modulation of NSAID-induced antinociceptive and anti-inflammatory effects by alpha2-adrenoceptor agonists with gastroprotective effects. , 2002, Life sciences.

[16]  F. Borrelli,et al.  The plant kingdom as a source of anti‐ulcer remedies , 2000, Phytotherapy research : PTR.

[17]  C. Ukwe,et al.  Gastrointestinal activities of Sterculia tragacantha leaf extracts , 1997 .

[18]  A. Lapa,et al.  Inhibition of gastric acid secretion by the aqueous extract and purified extracts of Stachytarpheta cayennensis. , 1997, Planta medica.

[19]  Y. Naito,et al.  Role of active oxygen, lipid peroxidation, and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. , 1993, Gut.

[20]  M. Roberts.  Indigenous healing plants , 1990 .

[21]  J. Harborne.  Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis , 1973 .