Design of the Women's Health Initiative clinical trial and observational study. The Women's Health Initiative Study Group.

JoAnn E. Manson | Emily White | S. Heckbert | Annlouise R. Assaf | Andrea Z. LaCroix | Ruth E. Patterson | Nicole Urban | Alan R. Kristal | R. Hiatt | Ross L. Prentice | J. Manson | A. LaCroix | S. Cummings | J. Buring | R. Hiatt | E. Braunwald | J. Hsia | D. Bowen | R. Prentice | L. Kuller | B. Psaty | D. Siscovick | A. Kristal | V. Stevens | M. Nevitt | G. Anderson | L. Pottern | A. McTiernan | S. Sidney | C. Hennekens | B. Ettinger | R. Chlebowski | J. Gaziano | V. Kipnis | N. Urban | S. Heckbert | L. Freedman | T. Fuerst | G. Burke | R. Patterson | E. White | J. Rossouw | N. Woods | J. Probstfield | S. Shumaker | N. Karanja | W. Frishman | J. Himes | E. Paskett | S. Wassertheil-Smoller | J. Hunt | E. Stein | Ching-Yun Wang | M. Miller | S. Beresford | J. Kotchen | B. Caan | E. Whitlock | A. Assaf | L. Finnegan | R. Detrano | V. Taylor | V. Barnabei | B. Cochrane | R. Young | T. Kotchen | J. McGowan | D. Barad | A. Oberman | B. Valanis | S. Pushkin | Anne McTiernan | Garnet L. Anderson | L. Tinker | Lesley F. Tinker | Jeffrey L. Probstfield | Deborah J. Bowen | John H. Himes | Jennifer Hays | V. Kipnis | Ching Yun Wang | Jacques E. Rossouw | Shirley A A Beresford | C. Furberg | M. Henderson | S. Johnson | C. Clifford | G. Bailey | C. Chen | B. Lund | P. Rautaharju | F. Rautaharju | P. Laskarzewski | P. Steiner | K. Sagar | M. Dockrell | M. Stevens | F. Cammarata | S. Lindenfelser | W. Longstreth | J. Wylie-Rosett | R. Freeman | S. Miller | J. Hays | C. Crowley | M. A. DePoe | L. Wagenknecht | R. Crouse | L. Parsons | R. Carleton | C. Wheeler | A. Hume | M. Pedersen | O. Strickland | M. Huber | V. Porter | M. Bovun | A. Nelson | J. Heiner | A. Clark | T. Fuerst | Rowan T. Chlebowski | S. Sidney | M. Nevitt | B. Ettinger | Julie R. Hunt | S. Cummings | E. Braunwald | L. Kuller | Maureen M. Henderson | J. Buring | R. Detrano | L. S. Freedman | C. Furberg | S. R. Johnson | A. Oberman | L. Finnegan | L. Pottern | J. McGowan | C. Clifford | B. Caan | G. Bailey | C. Chen | Barbara B. Cochrane | Brian J. Lund | J. M. Kotchen | S. Shumaker | P. Rautaharju | F. Rautaharju | E. Stein | P. Laskarzewski | P. Steiner | K. Sagar | M. Dockrell | M. Stevens | F. Cammarata | S. Lindenfelser | B. Psaty | D. Siscovick | W. Longstreth | S. Wassertheil-Smoller | W. Frishman | J. Wylie-Rosett | D. Barad | R. Freeman | S. Miller | R. Young | C. Crowley | G. Burke | E. Paskett | L. Wagenknecht | R. Crouse | L. Parsons | T. Kotchen | C. Hennekens | J. M. Gaziano | R. C. Carleton | M. Miller | C. Wheeler | A. Hume | M. Pedersen | O. Strickland | M. Huber | V. Porter | V. Taylor | N. Woods | J. Hsia | V. Barnabei | M. Bovun | A. Nelson | J. Heiner | S. Pushkin | B. Valanis | V. Stevens | E. Whitlock | N. Karanja | A. Clark | M. Miller | B. Psaty

[1]  R. Prentice,et al.  Measurement error and results from analytic epidemiology: dietary fat and breast cancer. , 1996, Journal of the National Cancer Institute.

[2]  Victor Kipnis,et al.  Approaches to monitoring the results of long-term disease prevention trials: Examples from the Women's Health Initiative , 1996 .

[3]  C. Lewis,et al.  The Women's Health Trial Feasibility Study in Minority Populations: design and baseline descriptions. , 1996, Annals of epidemiology.

[4]  N. Boyd,et al.  Long-term effects of participation in a randomized trial of a low-fat, high-carbohydrate diet. , 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[5]  F. Speizer,et al.  Cohort studies of fat intake and the risk of breast cancer--a pooled analysis. , 1996, The New England journal of medicine.

[6]  Susan R. Johnson,et al.  Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. , 1996, JAMA.

[7]  P. Kris-Etherton,et al.  Nutrition in Women's Health , 1996 .

[8]  R. Prentice Design issues in cohort studies , 1995, Statistical methods in medical research.

[9]  C. Furberg,et al.  Estrogen Replacement Therapy and Progression of Intimal-Medial Thickness in the Carotid Arteries of Postmenopausal Women , 1995 .

[10]  L. Lissner,et al.  Dietary underreporting by obese individuals--is it specific or non-specific? , 1995, BMJ.

[11]  Susan R. Johnson,et al.  Informed Consent in the Women's Health Initiative Clinical Trial and Observational Study , 1995 .

[12]  K. Helzlsouer,et al.  Colon cancer and serum vitamin D metabolite levels 10-17 years prior to diagnosis. , 1995, American journal of epidemiology.

[13]  S. Cummings,et al.  Estrogen Replacement Therapy and Fractures in Older Women , 1995, Annals of Internal Medicine.

[14]  K. Smith,et al.  Breast cancer mortality among immigrants in Australia and Canada. , 1995, Journal of the National Cancer Institute.

[15]  J. Stanford,et al.  Combined estrogen and progestin hormone replacement therapy in relation to risk of breast cancer in middle-aged women. , 1995, JAMA.

[16]  G A Colditz,et al.  The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. , 1995, The New England journal of medicine.

[17]  V. Pinn,et al.  The evolution of the Women's Health Initiative: perspectives from the NIH. , 1995, Journal of the American Medical Women's Association.

[18]  Susan R. Johnson,et al.  Effects of Estrogen or Estrogen/ Progestin Regimens on Heart Disease Risk Factors in Postmenopausal Women: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial , 1995 .

[19]  D. Wysowski,et al.  Use of Menopausal Estrogens and Medroxyprogesterone in the United States, 1982–1992 , 1995, Obstetrics and gynecology.

[20]  P. Ganz,et al.  Estrogen Improves Endothelium-Dependent, Flow-Mediated Vasodilation in Postmenopausal Women , 1994, Annals of Internal Medicine.

[21]  B. Walsh,et al.  Metabolic impact of adding medroxyprogesterone acetate to conjugated estrogen therapy in postmenopausal women , 1994, Obstetrics and gynecology.

[22]  C. Loria,et al.  Dietary intake of vitamins, minerals, and fiber of persons ages 2 months and over in the United States: Third National Health and Nutrition Examination Survey, Phase 1, 1988-91. , 1994, Advance data.

[23]  L. Freedman,et al.  Meta-analysis of animal experiments: elucidating relationships between dietary fat and mammary tumor development in rodents. , 1994, Advances in experimental medicine and biology.

[24]  E. Rimm,et al.  Calcium, vitamin D, dairy foods, and the occurrence of colorectal adenomas among men and women in two prospective studies. , 1994, American journal of epidemiology.

[25]  E. Hemminki,et al.  A REVIEW OF POSTMENOPAUSAL HORMONE THERAPY RECOMMENDATIONS: POTENTIAL FOR SELECTION BIAS , 1993, Obstetrics and gynecology.

[26]  A M Nomura,et al.  Migration patterns and breast cancer risk in Asian-American women. , 1993, Journal of the National Cancer Institute.

[27]  D. Kiel,et al.  The effect of postmenopausal estrogen therapy on bone density in elderly women. , 1993, The New England journal of medicine.

[28]  David C. Atkins,et al.  A review of the association of estrogens and progestins with cardiovascular disease in postmenopausal women. , 1993, Archives of internal medicine.

[29]  T. Sellers,et al.  Relation of calcium, vitamin D, and dairy food intake to incidence of colon cancer among older women. The Iowa Women's Health Study. , 1993, American journal of epidemiology.

[30]  Harry K. Genant,et al.  Consensus development conference: diagnosis, prophylaxis, and treatment of osteoporosis. , 1993, The American journal of medicine.

[31]  E. Rimm,et al.  A prospective study of dietary calcium and other nutrients and the risk of symptomatic kidney stones. , 1993, The New England journal of medicine.

[32]  S. Cummings,et al.  Bone density at various sites for prediction of hip fractures , 1993, The Lancet.

[33]  S. Heymsfield,et al.  Discrepancy between self-reported and actual caloric intake and exercise in obese subjects. , 1992, The New England journal of medicine.

[34]  A. Whittemore,et al.  Dietary intake of fiber and decreased risk of cancers of the colon and rectum: evidence from the combined analysis of 13 case-control studies. , 1992, Journal of the National Cancer Institute.

[35]  Caroline S. Fox,et al.  Hormone Therapy To Prevent Disease and Prolong Life in Postmenopausal Women , 1992, Annals of Internal Medicine.

[36]  F Duboeuf,et al.  Vitamin D3 and calcium to prevent hip fractures in elderly women. , 1992, The New England journal of medicine.

[37]  S. Yusuf,et al.  Report of the Conference on Low Blood Cholesterol: Mortality Associations , 1992, Circulation.

[38]  R. Prentice,et al.  Maintenance of a low-fat diet: follow-up of the Women's Health Trial. , 1992, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[39]  R. Doll The lessons of life: keynote address to the nutrition and cancer conference. , 1992, Cancer research.

[40]  A. Bostom,et al.  Postmenopausal estrogen therapy and cardiovascular disease. , 1992, The New England journal of medicine.

[41]  S. Cummings,et al.  Which Fractures Are Associated with Low Appendicular Bone Mass in Elderly Women , 1991 .

[42]  B. Rosner,et al.  Effects of postmenopausal estrogen replacement on the concentrations and metabolism of plasma lipoproteins. , 1991, The New England journal of medicine.

[43]  L. Sokoll,et al.  Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women. , 1991, Annals of internal medicine.

[44]  J. Manson,et al.  Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study. , 1991, The New England journal of medicine.

[45]  A. Tosteson,et al.  Uncertainty about postmenopausal estrogen. Time for action, not debate. , 1991, The New England journal of medicine.

[46]  B. Dawson-Hughes Calcium supplementation and bone loss: a review of controlled clinical trials. , 1991, The American journal of clinical nutrition.

[47]  W. Dupont,et al.  Menopausal Estrogen Replacement Therapy and Breast Cancer , 1991, Archives of internal medicine.

[48]  B. Henderson,et al.  Decreased Mortality in Users of Estrogen Replacement Therapy , 1991, Archives of internal medicine.

[49]  S. Thacker,et al.  A Meta-analysis of the Effect of Estrogen Replacement Therapy on the Risk of Breast Cancer , 1991 .

[50]  E. Barrett-Connor,et al.  Estrogen and coronary heart disease in women , 1991, JAMA.

[51]  R. Coombes,et al.  Topical calcipotriol treatment in advanced breast cancer , 1991, The Lancet.

[52]  B. Henderson,et al.  Exercise and Other Factors in the Prevention of Hip Fracture: The Leisure World Study , 1991, Epidemiology.

[53]  G. Nelson Health effects of dietary fatty acids , 1991 .

[54]  G. Colditz,et al.  Estrogen replacement therapy and coronary heart disease: A quantitative assessment of the epidemiologic evidence☆☆☆ , 1991 .

[55]  R. Prentice,et al.  Quantitative review of studies of dietary fat and rat colon carcinoma. , 1991, Nutrition and Cancer.

[56]  G A Colditz,et al.  Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. , 1990, The New England journal of medicine.

[57]  C. Garland,et al.  Sunlight and breast cancer incidence in the USSR. , 1990, International journal of epidemiology.

[58]  J. Cauley,et al.  Prevalence and determinants of estrogen replacement therapy in elderly women , 1990, American journal of obstetrics and gynecology.

[59]  J. F. Young,et al.  Geographic variation in breast cancer mortality in the United States: a hypothesis involving exposure to solar radiation. , 1990, Preventive medicine.

[60]  L. Freedman,et al.  Analysis of dietary fat, calories, body weight, and the development of mammary tumors in rats and mice: a review. , 1990, Cancer research.

[61]  A. Ruijs,et al.  Effects of post-menopausal oestrogen-progestogen replacement therapy on serum lipids and lipoproteins: a review. , 1990, Maturitas.

[62]  M. Thornquist,et al.  Types of dietary fat and the incidence of cancer at five sites. , 1990, Preventive medicine.

[63]  B. Modan,et al.  Dietary factors and risk of breast cancer: combined analysis of 12 case-control studies. , 1990, Journal of the National Cancer Institute.

[64]  M. Whitehead,et al.  The Role and Use of Progestogens , 1990, Obstetrics and gynecology.

[65]  M. Moskowitz,et al.  Feasibility of a randomized trial of a low-fat diet for the prevention of breast cancer: dietary compliance in the Women's Health Trial Vanguard Study. , 1990, Preventive medicine.

[66]  R. Prentice,et al.  Results of a randomized feasibility study of a low-fat diet. , 1990, Archives of internal medicine.

[67]  J. B. Henderson,et al.  Serum 25-hydroxyvitamin D and colon cancer , 1990, The Lancet.

[68]  Clive Osmond,et al.  Statistical Methods in Cancer Research, Vol. 2, the Design and Analysis of Cohort Studies , 1990 .

[69]  B. Trock,et al.  High fiber diet and colon cancer: a critical review. , 1990, Progress in clinical and biological research.

[70]  C. Garland,et al.  SERUM 25-HYDROXYVITAMIN D AND COLON CANCER: EIGHT-YEAR PROSPECTIVE STUDY , 1989, The Lancet.

[71]  S. Cummings,et al.  Lifetime risks of hip, Colles', or vertebral fracture and coronary heart disease among white postmenopausal women. , 1989, Archives of internal medicine.

[72]  K. Matthews,et al.  Menopause and Risk Factors for Coronary Heart Disease , 1989 .

[73]  R. Hoover,et al.  The risk of breast cancer after estrogen and estrogen-progestin replacement. , 1989, The New England journal of medicine.

[74]  R. Recker,et al.  Calcium absorption in women: Relationships to Calcium intake, Estrogen status, and age , 1989, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[75]  R. Hoover,et al.  Risk of endometrial cancer after treatment with oestrogens alone or in conjunction with progestogens: results of a prospective study. , 1989, BMJ.

[76]  M. Micozzi,et al.  Nutrition and cancer prevention: investigating the role of micronutrients. , 1989 .

[77]  S. Johnson,et al.  Estrogen replacement therapy. A survey of women's knowledge and attitudes. , 1989, Archives of internal medicine.

[78]  E. Barrett-Connor,et al.  DIETARY CALCIUM AND RISK OF HIP FRACTURE: 14-YEAR PROSPECTIVE POPULATION STUDY , 1988, The Lancet.

[79]  P. Kris-Etherton,et al.  The effect of diet on plasma lipids, lipoproteins, and coronary heart disease. , 1988, Journal of the American Dietetic Association.

[80]  M. Slattery,et al.  Dietary calcium intake as a mitigating factor in colon cancer. , 1988, American journal of epidemiology.

[81]  R. Prentice,et al.  Aspects of the rationale for the Women's Health Trial. , 1988, Journal of the National Cancer Institute.

[82]  W Insull,et al.  Statistical design of the Women's Health Trial. , 1988, Controlled clinical trials.

[83]  G. Giles,et al.  Cancer in migrants to Australia: extending the descriptive epidemiological data. , 1988, Cancer research.

[84]  I. Godsland,et al.  Sex, plasma lipoproteins, and atherosclerosis: prevailing assumptions and outstanding questions. , 1987, American heart journal.

[85]  J. Huttunen,et al.  Helsinki Heart Study: primary-prevention trial with gemfibrozil in middle-aged men with dyslipidemia. Safety of treatment, changes in risk factors, and incidence of coronary heart disease. , 1987, The New England journal of medicine.

[86]  E. Lanza,et al.  Dietary fiber in the reduction of colon cancer risk. , 1987, Journal of the American Dietetic Association.

[87]  N. Boyd,et al.  Critical appraisal of the evidence that dietary fat intake is related to breast cancer risk in humans. , 1987, Journal of the National Cancer Institute.

[88]  E. Barrett-Connor,et al.  Cardiovascular mortality and noncontraceptive use of estrogen in women: results from the Lipid Research Clinics Program Follow-up Study. , 1987, Circulation.

[89]  N. Breslow,et al.  Statistical methods in cancer research. Volume II--The design and analysis of cohort studies. , 1987, IARC scientific publications.

[90]  E. Wynder,et al.  International comparisons of mortality rates for cancer of the breast, ovary, prostate, and colon, and per capita food consumption , 1986 .

[91]  J. Stamler,et al.  Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. , 1986, Journal of the American College of Cardiology.

[92]  R. Recker,et al.  Distribution of calcium absorption in middle-aged women. , 1986, The American journal of clinical nutrition.

[93]  M. Lipkin,et al.  Effect of added dietary calcium on colonic epithelial-cell proliferation in subjects at high risk for familial colonic cancer. , 1985, New England Journal of Medicine.

[94]  W. Willett,et al.  Reproducibility and validity of a semiquantitative food frequency questionnaire. , 1985, American journal of epidemiology.

[95]  C. Ip,et al.  Requirement of essential fatty acid for mammary tumorigenesis in the rat. , 1985, Cancer research.

[96]  J. Hankin,et al.  DIETARY VITAMIN D AND CALCIUM AND RISK OF COLORECTAL CANCER , 1985, The Lancet.

[97]  E. Barrett-Connor,et al.  DIETARY VITAMIN D AND CALCIUM AND RISK OF COLORECTAL CANCER: A 19-YEAR PROSPECTIVE STUDY IN MEN , 1985, The Lancet.

[98]  G. Stemmermann,et al.  Dietary fat and the risk of colorectal cancer. , 1984, Cancer research.

[99]  R. Lindsay,et al.  The Minimum Effective Dose of Estrogen for Prevention of Postmenopausal Bone Loss , 1984, Obstetrics and gynecology.

[100]  L. Braden,et al.  Dietary fat and mammary carcinogenesis. , 1984, Nutrition and cancer.

[101]  A. Paganini-Hill,et al.  Estrogen Replacement Therapy and Coronary Heart Disease , 1983 .

[102]  J. Hankin,et al.  Dietary fat intake and cancer incidence among five ethnic groups in Hawaii. , 1981, Cancer research.

[103]  N. Kase,et al.  Estrogen replacement therapy. , 1981 .

[104]  G R Howe,et al.  A case‐control study of diet and colo‐rectal cancer , 1980, International journal of cancer.

[105]  N. Ernst,et al.  CHANGES IN PLASMA LIPIDS AND LIPOPROTEINS AFTER A MODIFIED FAT DIET , 1980, The Lancet.

[106]  A. Keys,et al.  Seven countries. A multivariate analysis of death and coronary heart disease. , 1980 .

[107]  J. Eisman,et al.  1,25-DIHYDROXYVITAMIN-D RECEPTOR IN BREAST CANCER CELLS , 1979, The Lancet.

[108]  S Ramcharan,et al.  Risk of vascular disease in women. Smoking, oral contraceptives, noncontraceptive estrogens, and other factors. , 1979, JAMA.

[109]  P. O'Brien,et al.  A multiple testing procedure for clinical trials. , 1979, Biometrics.

[110]  E. Beckman,et al.  Estrogen replacement therapy II: a prospective study in the relationship to carcinoma and cardiovascular and metabolic problems. , 1979, Obstetrics and gynecology.

[111]  R. Worth,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Coronary heart disease risk factors in Japan and Hawaii. , 1977, The American journal of cardiology.

[112]  M Marmot,et al.  Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California. Incidence of myocardial infarction and death from coronary heart disease. , 1977, The American journal of cardiology.

[113]  K K Carroll,et al.  Experimental evidence of dietary factors and hormone-dependent cancers. , 1975, Cancer research.

[114]  E. Sotaniemi,et al.  Serum lipid levels and thromboembolic complications during estrogen therapy of prostatic cancer. , 1975 .

[115]  G. Addison Letter: Serum-ferritin. , 1974, Lancet.

[116]  A. Beckett,et al.  AKUFO AND IBARAPA. , 1965, Lancet.

[117]  A. Tannenbaum The Genesis and Growth of Tumors. III. Effects of a High-Fat Diet , 1942 .