Difficult Asthma: Unmet Needs and Future Directions

[1]  S. Szefler,et al.  Feasibility of medication monitoring sensors in high risk asthmatic children , 2019, The Journal of asthma : official journal of the Association for the Care of Asthma.

[2]  F. Holguin.  Biological Treatments for Eosinophilic Asthma Enter the Airways. , 2018, American journal of respiratory and critical care medicine.

[3]  A. Turner,et al.  Efficacy of an Inhaled IL‐13 Antibody Fragment in a Model of Chronic Asthma , 2018, American journal of respiratory and critical care medicine.

[4]  R. Deterding,et al.  Bringing Technology to Day-to-Day Asthma Management. , 2018, American journal of respiratory and critical care medicine.

[5]  Bronwyn U. Harris,et al.  Passive Nocturnal Physiologic Monitoring Enables Early Detection of Exacerbations in Children with Asthma. A Proof‐of‐Concept Study , 2018, American journal of respiratory and critical care medicine.

[6]  P. Galan,et al.  Associations between dietary scores with asthma symptoms and asthma control in adults , 2018, European Respiratory Journal.

[7]  K. Chung.  Tralokinumab unsuccessful for management of severe, uncontrolled asthma. , 2018, The Lancet. Respiratory medicine.

[8]  C. Galeone,et al.  Towards precision medicine: The application of omics technologies in asthma management , 2018, F1000Research.

[9]  T. Nurmagambetov,et al.  The Economic Burden of Asthma in the United States, 2008‐2013 , 2018, Annals of the American Thoracic Society.

[10]  T. Chatila,et al.  Anti-IL-6 treatment in two pediatric patients with severe persistent asthma with the IL4R 576 variant , 2018 .

[11]  E. Bleecker,et al.  Internet‐Based Monitoring in the Severe Asthma Research Program Identifies a Subgroup of Patients With Labile Asthma Control , 2017, Chest.

[12]  M. Kraft,et al.  Eosinophilic and Noneosinophilic Asthma , 2018, American journal of respiratory and critical care medicine.

[13]  L. Wood,et al.  Diet and Asthma: Is It Time to Adapt Our Message? , 2017, Nutrients.

[14]  Wei Wu,et al.  Gene Expression Correlated with Severe Asthma Characteristics Reveals Heterogeneous Mechanisms of Severe Disease , 2017, American journal of respiratory and critical care medicine.

[15]  Frédéric Baribaud,et al.  U‐BIOPRED clinical adult asthma clusters linked to a subset of sputum omics , 2017, The Journal of allergy and clinical immunology.

[16]  C. Auffray,et al.  A Severe Asthma Disease Signature from Gene Expression Profiling of Peripheral Blood from U‐BIOPRED Cohorts , 2017, American journal of respiratory and critical care medicine.

[17]  Jennifer E. Johnson,et al.  Enrolling in Clinical Research While Incarcerated: What Influences Participants' Decisions? , 2017, The Hastings Center report.

[18]  J. Smyth,et al.  Impact of online patient reminders to improve asthma care: A randomized controlled trial , 2017, PloS one.

[19]  K. Davis,et al.  Disease Burden of Patients with Asthma/COPD Overlap in a US Claims Database: Impact of ICD-9 Coding-based Definitions , 2017, COPD.

[20]  M. Morais‐Almeida,et al.  Asthma costs and social impact , 2017, Asthma Research and Practice.

[21]  田口修.  喘息とCOPDのオーバーラップ症候群(ACOS)―病態と治療―4 ACOS(Asthma‐COPD Overlap Syndrome)の診断 , 2017 .

[22]  L. Swedin,et al.  Patient stratification and the unmet need in asthma. , 2017, Pharmacology & therapeutics.

[23]  D. Rios,et al.  Conducting Accessible Research: Including People With Disabilities in Public Health, Epidemiological, and Outcomes Studies. , 2016, American journal of public health.

[24]  E. Bateman,et al.  Efficacy and safety of lebrikizumab in patients with uncontrolled asthma (LAVOLTA I and LAVOLTA II): replicate, phase 3, randomised, double-blind, placebo-controlled trials. , 2016, The Lancet. Respiratory medicine.

[25]  C. Lindskog,et al.  Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma , 2016, Allergy.

[26]  O. Niemelä,et al.  Comorbidities and elevated IL-6 associate with negative outcome in adult-onset asthma , 2016, European Respiratory Journal.

[27]  E. Bleecker,et al.  Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts. , 2016, The Lancet. Respiratory medicine.

[28]  L. Wood,et al.  Changes in Expression of Genes Regulating Airway Inflammation Following a High-Fat Mixed Meal in Asthmatics , 2016, Nutrients.

[29]  G. Canonica,et al.  Biomarkers and severe asthma: a critical appraisal , 2015, Clinical and Molecular Allergy.

[30]  Anuradha Ray,et al.  Evolving Concepts of Asthma. , 2015, American journal of respiratory and critical care medicine.

[31]  C. Camargo,et al.  Prevalence of eosinophilia in hospitalized patients with asthma exacerbation. , 2015, Respiratory medicine.

[32]  S. Wise,et al.  Epidemiology and economic burden of asthma , 2015, International forum of allergy & rhinology.

[33]  P. Barnes.  Therapeutic approaches to asthma-chronic obstructive pulmonary disease overlap syndromes. , 2015, The Journal of allergy and clinical immunology.

[34]  S. Amur,et al.  Biomarker Qualification: Toward a Multiple Stakeholder Framework for Biomarker Development, Regulatory Acceptance, and Utilization , 2015, Clinical pharmacology and therapeutics.

[35]  E. Bel,et al.  Management of the patient with eosinophilic asthma: a new era begins , 2015, ERJ Open Research.

[36]  Blanca E Himes,et al.  Mobile health applications for asthma. , 2015, The journal of allergy and clinical immunology. In practice.

[37]  R. Peng,et al.  Neighborhood poverty, urban residence, race/ethnicity, and asthma: Rethinking the inner-city asthma epidemic. , 2015, The Journal of allergy and clinical immunology.

[38]  D. Globe,et al.  The relationship between asthma, asthma control and economic outcomes in the United States , 2014, The Journal of asthma : official journal of the Association for the Care of Asthma.

[39]  Thomas Blicher,et al.  A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations , 2013, Nature Genetics.

[40]  E. Bleecker,et al.  International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma , 2013, European Respiratory Journal.

[41]  K. Riekert,et al.  Adherence monitoring and e-health: how clinicians and researchers can use technology to promote inhaler adherence for asthma. , 2013, The journal of allergy and clinical immunology. In practice.

[42]  Lorraine Brennan,et al.  Metabolomics in nutrition research: current status and perspectives. , 2013, Biochemical Society transactions.

[43]  E. R. Sutherland,et al.  A large subgroup of mild-to-moderate asthma is persistently noneosinophilic. , 2012, American journal of respiratory and critical care medicine.

[44]  David C. Nickle,et al.  Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma , 2012, PLoS genetics.

[45]  Yusuke Nakamura,et al.  Genome-Wide Association Analysis in Asthma Subjects Identifies SPATS2L as a Novel Bronchodilator Response Gene , 2012, PLoS genetics.

[46]  L. Akinbami,et al.  Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010. , 2012, NCHS data brief.

[47]  Yusuke Nakamura,et al.  Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. , 2011, The New England journal of medicine.

[48]  Parameswaran Nair,et al.  Mepolizumab for prednisone-dependent asthma with sputum eosinophilia. , 2009, The New England journal of medicine.

[49]  P. Libby,et al.  Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. , 2008, The New England journal of medicine.

[50]  C. Baena-Cagnani,et al.  Unmet needs in asthma: Global Asthma Physician and Patient (GAPP) Survey: global adult findings , 2007, Allergy.

[51]  B. Bender,et al.  Patient-identified barriers to asthma treatment adherence: responses to interviews, focus groups, and questionnaires. , 2005, Immunology and allergy clinics of North America.

[52]  L. Fabbri,et al.  Improving patient compliance with asthma therapy. , 2000, Respiratory medicine.

[53]  C. Rand,et al.  Measuring adherence to asthma medication regimens. , 1994, American journal of respiratory and critical care medicine.

[54]  Alfred O. Berg,et al.  Clinical Guidelines And Primary Care Guidelines For The Diagnosis And Management Of Asthma , 2012 .