论文信息 - Estimation of drug shape in drug delivery system by simulation

Estimation of drug shape in drug delivery system by simulation

In order to realize an effective Drug Delivery System (DDS) for solid tumor, we study the most suitable shape of a drug. For this purpose, we constructed a mathematical model of drug movement in blood vessel, and made a simulation of it [1, 2]. In the model, we take into consideration a particular reaction of tumor tissues called the Enhanced Permeability and Retention effect (EPR effect) and the recognition by the reticuloendothelial system. These have not been studied mathematically yet, thus the study is especially significant for DDS. We succeeded to estimate the drug shape which is most effective for remedy of tumor. In this paper, we show some of our results of calculation.

M. Ohya | S. Iriyama | Toshihide Hara

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