Respiratory Tract Tumors in Hamsters Induced by Benzo(a)pyrene and 210Po α-Radiation

Summary A high incidence of respiratory cancer has been induced in Syrian golden hamsters by repeated intratracheal instillations of either benzo( a )pyrene or 210 Po adsorbed onto hematite carrier particles. Both the tumor incidence and the mean induction time were related to the dose of carcinogen. Benzo( a )pyrene induced a spectrum of tumors, among which, the types occurring most frequently were epidermoid carcinomas of the trachea or major bronchi. 210 Po-induced tumors were almost exclusively combined epidermoid and adenocarcinomas that arose peripherally; these tumors occurred in 94% of animals in the highest exposure group. Hamsters appear particularly susceptible to the induction of lung cancer by α-radiation at doses that do not produce concomitant lung damage, and they may provide a good model for the study of interactions between radiation and chemical agents in respiratory carcinogenesis.

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