Gene-environment correlations in parental emotional warmth and intolerance: genome-wide analysis over two generations of the Young Finns Study.

BACKGROUND Genomic analysis of the child might offer new potential to illuminate human parenting. We examined whether offspring (G2) genome-wide genotype variation (SNPs) is associated with their mother's (G1) emotional warmth and intolerance, indicating a gene-environment correlation. If this association is stronger than between G2's genes and their emotional warmth and intolerance toward their own children, then this would indicate the presence of an evocative gene-environment correlation. To further understand how G1 mother's parenting has been evoked by genetically influenced characteristics of the child (G2), we examined whether child (G2) temperament partially accounted for the association between offspring genes and parental responses. METHODS Participants were from the Young Finns Study. G1 mothers (N = 2,349; mean age 39 years) self-reported the emotional warmth and intolerance toward G2 in 1980 when the participants were from 3 to 18 years old. G2 participants answered the same parenting scales in 2007/2012 (N = 1,378; mean age = 38 years in 2007; 59% female) when their children were on average 11 years old. Offspring temperament traits were self-reported in 1992 (G2 age range 15-30 years). Estimation of the phenotypic variance explained by the SNPs of G2 was done by genome-wide complex trait analysis with restricted maximum likelihood (GCTA-GREML). RESULTS Results showed that the SNPs of a child (G2) explained 22.6% of the phenotypic variance of maternal intolerance (G1; p-value = .039). G2 temperament trait negative emotionality explained only 2.4% points of this association. G2 genes did not explain G1 emotional warmth or G2's own emotional warmth and intolerance. However, further analyses of a combined measure of both G1 parenting scales found genetic effects. Parent or child gender did not moderate the observed associations. CONCLUSIONS Presented genome-wide evidence is pointing to the important role a child plays in affecting and shaping his/her family environment, though the underlying mechanisms remain unclear.

[1]  D. Klein,et al.  Gene-environment correlations in the cross-generational transmission of parenting: Grandparenting moderates the effect of child 5-HTTLPR genotype on mothers' parenting. , 2017, Social development.

[2]  J. Viikari,et al.  Intergenerational transmission of qualities of the parent–child relationship in the population-based Young Finns Study , 2017 .

[3]  J. Viikari,et al.  Intergenerational Continuity in Qualities of the Parent–Child Relationship: Mediating and Moderating Mechanisms , 2017 .

[4]  A. Knafo-Noam,et al.  Parental brain‐derived neurotrophic factor genotype, child prosociality, and their interaction as predictors of parents’ warmth , 2017, Brain and behavior.

[5]  T. Esko,et al.  SNP-Based Heritability Estimates of Common and Specific Variance in Self- and Informant-Reported Neuroticism Scales. , 2017, Journal of personality.

[6]  J. Viikari,et al.  Hostile parenting, parental psychopathology, and depressive symptoms in the offspring: a 32-year follow-up in the Young Finns study. , 2017, Journal of affective disorders.

[7]  Stuart J. Ritchie,et al.  Genetic variants linked to education predict longevity , 2016, Proceedings of the National Academy of Sciences.

[8]  P. Visscher,et al.  GCTA-GREML accounts for linkage disequilibrium when estimating genetic variance from genome-wide SNPs , 2016, Proceedings of the National Academy of Sciences.

[9]  T. Esko,et al.  Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan , 2016, Nature Communications.

[10]  Patrick O. McGowan,et al.  Parent–offspring transaction: Mechanisms and the value of within family designs , 2016, Hormones and Behavior.

[11]  Shripad Tuljapurkar,et al.  Limitations of GCTA as a solution to the missing heritability problem , 2015, Proceedings of the National Academy of Sciences.

[12]  Liat Hasenfratz,et al.  Temperament and peer problems from early to middle childhood: Gene–environment correlations with negative emotionality and sociability , 2015, Development and Psychopathology.

[13]  Heather J. Smith,et al.  Evidence for evocative gene–environment correlation between child oxytocin receptor (OXTR) genotype and caregiver behavior , 2014 .

[14]  Naomi R. Wray,et al.  Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples , 2014, PLoS genetics.

[15]  S. A. Burt,et al.  Elucidating the etiology of individual differences in parenting: A meta-analysis of behavioral genetic research. , 2014, Psychological bulletin.

[16]  A. Knafo,et al.  Parenting as a Reaction Evoked by Children’s Genotype , 2014, Personality and social psychology review : an official journal of the Society for Personality and Social Psychology, Inc.

[17]  R. Ebstein,et al.  Boys' serotonin transporter genotype affects maternal behavior through self-control: A case of evocative gene–environment correlation , 2013, Development and Psychopathology.

[18]  D. Klein,et al.  Child dopamine active transporter 1 genotype and parenting: Evidence for evocative gene–environment correlations , 2013, Development and Psychopathology.

[19]  M. Zentner,et al.  What Is Temperament Now? Assessing Progress in Temperament Research on the Twenty‐Fifth Anniversary of Goldsmith et al. () , 2012 .

[20]  Shashaank Vattikuti,et al.  Heritability and Genetic Correlations Explained by Common SNPs for Metabolic Syndrome Traits , 2012, PLoS genetics.

[21]  P. Visscher,et al.  GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.

[22]  D. Klein,et al.  The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene–environment correlation and gene–environment interaction , 2010, Psychiatric genetics.

[23]  Wei Chen,et al.  Longitudinal Genome-Wide Association of Cardiovascular Disease Risk Factors in the Bogalusa Heart Study , 2010, PLoS genetics.

[24]  J. Viikari,et al.  A prospective cohort study of deficient maternal nurturing attitudes predicting adulthood work stress independent of adulthood hostility and depressive symptoms , 2010, Stress.

[25]  P. Donnelly,et al.  A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.

[26]  Risto Telama,et al.  Cohort profile: the cardiovascular risk in Young Finns Study. , 2008, International journal of epidemiology.

[27]  Cathi B. Propper,et al.  Bidirectional genetic and environmental influences on mother and child behavior: The family system as the unit of analyses , 2007, Development and Psychopathology.

[28]  D. Reich,et al.  Principal components analysis corrects for stratification in genome-wide association studies , 2006, Nature Genetics.

[29]  U. John,et al.  Negative perceived paternal parenting is associated with dopamine D2 receptor exon 8 and GABA(A) alpha 6 receptor variants: An explorative study , 2006, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[30]  R. Plomin,et al.  PERSONALITY PROCESSES AND INDIVIDUAL DIFFERENCES Parental Discipline and Affection and Children ’ s Prosocial Behavior : Genetic and Environmental Links , 2006 .

[31]  K. Saudino.  Behavioral Genetics and Child Temperament , 2005, Journal of developmental and behavioral pediatrics : JDBP.

[32]  D. Reiss,et al.  Genetic and environmental influences on mothering of adolescents: a comparison of two samples. , 2004, Developmental psychology.

[33]  Sheryl A. Hemphill,et al.  Connections between Temperament and Social Development: A Review , 2004 .

[34]  Femmie Juffer,et al.  Maternal sensitivity, infant attachment, and temperament in early childhood predict adjustment in middle childhood: the case of adopted children and their biologically unrelated parents. , 2002, Developmental psychology.

[35]  B. Roberts,et al.  The rank-order consistency of personality traits from childhood to old age: a quantitative review of longitudinal studies. , 2000, Psychological bulletin.

[36]  R. Cadoret,et al.  The developmental interface between nature and nurture: A mutual influence model of child antisocial behavior and parent behaviors. , 1996 .

[37]  K. Kendler.  Parenting: a genetic-epidemiologic perspective. , 1996, The American journal of psychiatry.

[38]  Kevin MacDonald,et al.  Warmth as a Developmental Construct: An Evolutionary Analysis , 1992 .

[39]  A. Buss.  The EAS Theory of Temperament , 1991 .

[40]  J. Viikari,et al.  Cardiovascular risk in young Finns. , 1991, Annals of medicine.

[41]  T. Dix,et al.  The affective organization of parenting: adaptive and maladaptive processes. , 1991, Psychological bulletin.

[42]  D. A. Kenny,et al.  The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and statistical considerations. , 1986, Journal of personality and social psychology.

[43]  J. Belsky,et al.  The determinants of parenting: a process model. , 1984, Child development.

[44]  R Plomin,et al.  Genotype-environment interaction and correlation in the analysis of human behavior. , 1977, Psychological bulletin.