An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

[1]  J. Lehmann,et al.  Activation of the orphan receptor RIP14 by retinoids. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Christopher K. Glass,et al.  The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function , 1997, Nature.

[3]  David M. Heery,et al.  A signature motif in transcriptional co-activators mediates binding to nuclear receptors , 1997, Nature.

[4]  W. Wahli,et al.  Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. , 1997, Molecular endocrinology.

[5]  D. Mangelsdorf,et al.  Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[6]  Peter J. Brown,et al.  Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ , 1997 .

[7]  Barry M. Forman,et al.  Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ , 1997 .

[8]  Timothy M. Willson,et al.  Activation of the Nuclear Receptor LXR by Oxysterols Defines a New Hormone Response Pathway* , 1997, The Journal of Biological Chemistry.

[9]  E. Baulieu,et al.  RU486 (mifepristone): mechanisms of action and clinical uses. , 1997, Annual review of medicine.

[10]  J. Gustafsson,et al.  Orphan nuclear receptors--the first eight years. , 1996, Molecular endocrinology.

[11]  D. Mangelsdorf,et al.  An oxysterol signalling pathway mediated by the nuclear receptor LXRα , 1996, Nature.

[12]  K. Horwitz,et al.  Nuclear receptor coactivators and corepressors. , 1996, Molecular endocrinology.

[13]  A. Takeshita,et al.  Molecular cloning and properties of a full-length putative thyroid hormone receptor coactivator. , 1996, Endocrinology.

[14]  C. Kasper,et al.  Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[15]  Thorsten Heinzel,et al.  A CBP Integrator Complex Mediates Transcriptional Activation and AP-1 Inhibition by Nuclear Receptors , 1996, Cell.

[16]  William Bourguet,et al.  A canonical structure for the ligand-binding domain of nuclear receptors , 1996, Nature Structural Biology.

[17]  R. Edwards,et al.  Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. , 1995, Biochemical pharmacology.

[18]  R. Evans,et al.  The RXR heterodimers and orphan receptors , 1995, Cell.

[19]  K. Umesono,et al.  The nuclear receptor superfamily: The second decade , 1995, Cell.

[20]  Miguel Beato,et al.  Steroid hormone receptors: Many Actors in search of a plot , 1995, Cell.

[21]  P. Guzelian,et al.  A Novel cis-Acting Element in a Liver Cytochrome P450 3A Gene Confers Synergistic Induction by Glucocorticoids plus Antiglucocorticoids * , 1995, The Journal of Biological Chemistry.

[22]  B. O’Malley,et al.  Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily , 1995, Science.

[23]  J. Lehmann,et al.  An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ) (*) , 1995, The Journal of Biological Chemistry.

[24]  Jasmine Chen,et al.  Identification of a nuclear receptor that is activated by farnesol metabolites , 1995, Cell.

[25]  R. Kato,et al.  Transcriptional Elements Directing a Liver-Specific Expression of P450/6βA (CYP3A2) Gene-Encoding Testosterone 6β-Hydroxylase , 1995 .

[26]  R. Kato,et al.  Transcriptional elements directing a liver-specific expression of P450/6 beta A (CYP3A2) gene-encoding testosterone 6 beta-hydroxylase. , 1995, Archives of biochemistry and biophysics.

[27]  C. Glass.  Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. , 1994, Endocrine reviews.

[28]  K. Parker,et al.  A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation , 1994, Cell.

[29]  D P Smith,et al.  A novel nuclear receptor superfamily member in Xenopus that associates with RXR, and shares extensive sequence similarity to the mammalian vitamin D3 receptor , 1994, Nucleic Acids Res..

[30]  W. Pratt.  The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. , 1993, The Journal of biological chemistry.

[31]  Gregor Eichele,et al.  9-cis retinoic acid is a high affinity ligand for the retinoid X receptor , 1992, Cell.

[32]  J. Grippo,et al.  9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα , 1992, Nature.

[33]  K. Umesono,et al.  Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors , 1991, Cell.

[34]  R. Evans,et al.  Nuclear receptor that identifies a novel retinoic acid response pathway , 1990, Nature.

[35]  M. Juchau.  Substrate specificities and functions of the P450 cytochromes. , 1990, Life sciences.

[36]  R. Evans,et al.  The steroid and thyroid hormone receptor superfamily. , 1988, Science.

[37]  J. Shine,et al.  Cloning and expression of full-length cDNA encoding human vitamin D receptor. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[38]  H. Willard,et al.  Cloning of human androgen receptor complementary DNA and localization to the X chromosome. , 1988, Science.

[39]  Chawnshang Chang,et al.  Molecular cloning of human and rat complementary DNA encoding androgen receptors. , 1988, Science.

[40]  B. Luckow,et al.  CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements , 1987, Nucleic Acids Res..

[41]  D W Nebert,et al.  P450 genes: structure, evolution, and regulation. , 1987, Annual review of biochemistry.

[42]  P. Argos,et al.  Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A , 1986, Nature.

[43]  D. Nebert,et al.  Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. , 1985, The Journal of biological chemistry.

[44]  W. Krause,et al.  Serum levels of testosterone precursors, testosterone and estradiol in 10 animal species. , 2009, Experimental and clinical endocrinology.

[45]  J. Dietschy,et al.  Modulation of the stimulatory effect of pregnenolone-16α-carbonitrile on biliary cholesterol output in the rat by manipulation of the rate of hepatic cholesterol synthesis , 1984 .

[46]  E. Schuetz,et al.  Induction of cytochrome P-450 by glucocorticoids in rat liver. II. Evidence that glucocorticoids regulate induction of cytochrome P-450 by a nonclassical receptor mechanism. , 1984, The Journal of biological chemistry.

[47]  S. Wrighton,et al.  Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo. , 1984, The Journal of biological chemistry.

[48]  J. Deslypere,et al.  Androgen and precursor levels in serum and testes of adult rats under basal conditions and after hCG stimulation. , 1983, Journal of steroid biochemistry.

[49]  C. Kasper,et al.  Cloning of DNA complementary to cytochrome P-450 induced by pregnenolone-16 alpha-carbonitrile. Characterization of its mRNA, gene, and induction response. , 1983, The Journal of biological chemistry.

[50]  N. Tietz.  Clinical guide to laboratory tests , 1983 .

[51]  N. Elshourbagy,et al.  Immunochemical evidence for induction of a common form of hepatic cytochrome P-450 in rats treated with pregnenolone-16 alpha-carbonitrile or other steroidal or non-steroidal agents. , 1982, Molecular pharmacology.

[52]  N. Elshourbagy,et al.  Separation, purification, and characterization of a novel form of hepatic cytochrome P-450 from rats treated with pregnenolone-16 alpha-carbonitrile. , 1980, The Journal of biological chemistry.

[53]  G. S. Boyd,et al.  The suppressive effect of the catatoxic steroid, pregnenolone-16α-carbonitrile, on liver microsomal cholesterol-7α-hydroxylase , 1978, Steroids.

[54]  E. Baulieu,et al.  Steroid hormone receptors. , 1975, Vitamins and hormones.

[55]  H. Selye.  Hormones and resistance. , 1970, Journal of pharmaceutical sciences.

[56]  H. Selye.  Catatoxic steroids. , 1970, Canadian Medical Association journal.

[57]  Robert Altenloh.  From a Novel , 1953 .