The ProCESS trial--a new era of sepsis management.

The importance of early detection and treatment for reducing the mortality associated with sepsis has been a tenet of medical training since the middle ages, when it was noted that “. . . the physicians say it happens in hectic fever, that in the beginning of the malady it is easy to cure but difficult to detect, but in the course of time, not having been either detected or treated in the beginning, it becomes easy to detect but difficult to cure.”1,2 The critical role of the clinician in the early recognition of sepsis continues to this day to be fundamental . . .