Children with major depression show reduced rapid eye movement latencies.

A substantial body of research in adults has established that certain sleep polysomnographic abnormalities are commonly found in depressed patients, including sleep continuity disturbances, reduced slow-wave sleep, shortened rapid eye movement (REM) latency, and increased REM density. To date, these abnormalities have not been documented in depressed children compared with age-matched controls. Three consecutive nights of polysomnographic recordings were obtained in 25 hospitalized depressed children and 20 age-matched healthy controls. The depressed patients had reduced REM latencies. The shortest single-night REM latency of each individual was the most sensitive discriminating value between depressed subjects and controls. The influence of different scoring criteria in distinguishing depressed children from healthy children is discussed. In addition, depressed children had an increased sleep latency and increased REM time but did not have stage 4 differences.

[1]  M. Kovács,et al.  Depressive disorders in childhood. II. A longitudinal study of the risk for a subsequent major depression. , 1984, Archives of general psychiatry.

[2]  R. Brumback,et al.  Depression in children referred to an educational diagnostic center: diagnosis and treatment and analysis of criteria and literature review. , 1973, Diseases of the nervous system.

[3]  T. Petti.  Depression in hospitalized child psychiatry patients. Approaches to measuring depression. , 1978, Journal of the American Academy of Child Psychiatry.

[4]  G. Emslie,et al.  Depression and Suicide in Adolescents , 2020, Berkowitz’s Pediatrics Instructor’s Guide.

[5]  D. Kupfer,et al.  Interval between onset of sleep and rapid-eye-movement sleep as an indicator of depression. , 1972, Lancet.

[6]  D. Kupfer,et al.  The use of the sleep laboratory in the diagnosis of affective disorders. , 1983, The Psychiatric clinics of North America.

[7]  H. Mokros,et al.  Diagnostic criteria in childhood depression. , 1985, The American journal of psychiatry.

[8]  A. Rush,et al.  Sleep EEG and dexamethasone suppression test findings in outpatients with unipolar major depressive disorders. , 1982, Biological psychiatry.

[9]  A. Rush,et al.  Sleep EEG findings in depressed children and adolescents. , 1987, The American journal of psychiatry.

[10]  M. Kovács,et al.  Depressive disorders in childhood. I. A longitudinal prospective study of characteristics and recovery. , 1984, Archives of general psychiatry.

[11]  B. Pfefferbaum,et al.  The Brief Psychiatric Rating Scale for Children. , 1982, Psychopharmacology bulletin.

[12]  A. Rush,et al.  Reduced REM latency predicts response to tricyclic medication in depressed outpatients , 1989, Biological Psychiatry.

[13]  W. Reich,et al.  Reliability, validity, and parent-child agreement studies of the Diagnostic Interview for Children and Adolescents (DICA). , 1987, Journal of the American Academy of Child and Adolescent Psychiatry.

[14]  A. Rush,et al.  Polysomnographic findings and dexamethasone nonsuppression in unipolar depression: A replication and extension , 1987, Biological Psychiatry.

[15]  D. Kupfer,et al.  Internight variability of REM latency in major depression: Implications for the use of REM latency as a biological correlate , 1985, Biological Psychiatry.

[16]  R. Goetz,et al.  Sleep architecture and REM sleep measures in prepubertal major depressives. Studies during recovery from the depressive episode in a drug-free state. , 1983, Archives of general psychiatry.

[17]  D. Kupfer,et al.  Electroencephalographic sleep findings in depressed outpatients , 1982, Psychiatry Research.

[18]  J. Mendels,et al.  Sleep of depressed patients in remission. , 1974, Archives of general psychiatry.

[19]  Lahmeyer Hw,et al.  EEG sleep in depressed adolescents. , 1983 .

[20]  A. Rush,et al.  Depression and Dexamethasone Suppression Testing in Children and Adolescents , 1987, Journal of child neurology.

[21]  J M Tanner,et al.  Variations in the Pattern of Pubertal Changes in Boys , 1970, Archives of disease in childhood.

[22]  D J Kupfer,et al.  The application of EEG sleep for the differential diagnosis of affective disorders. , 1978, The American journal of psychiatry.

[23]  D. Kupfer,et al.  Electroencephalographic sleep of younger depressives. Comparison with normals. , 1985, Archives of general psychiatry.

[24]  N C Andreasen,et al.  The family history method using diagnostic criteria. Reliability and validity. , 1977, Archives of general psychiatry.

[25]  D. Kupfer,et al.  EEG sleep of normal healthy children. Part I: Findings using standard measurement methods. , 1984, Sleep.

[26]  D. Cantwell,et al.  Diagnosis of childhood depression: a comparison of the Weinberg and DSM-III criteria. , 1982, Journal of the American Academy of Child Psychiatry.

[27]  D. Kupfer,et al.  “Paradoxical” shortening of REM latency on first recording night in major depressive disorder: Clinical and polysomnographic correlates , 1985, Biological Psychiatry.

[28]  John P. Rice,et al.  The family history approach to diagnosis. How useful is it? , 1986, Archives of general psychiatry.

[29]  R. Goetz,et al.  Sleep architecture and REM sleep measures in prepubertal children with major depression: a controlled study. , 1982, Archives of general psychiatry.

[30]  A. Rush,et al.  Reduced rapid eye movement latency. A predictor of recurrence in depression. , 1987, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[31]  James M. Tanner,et al.  Variations in pattern of pubertal changes in girls. , 1969 .

[32]  D J Kupfer,et al.  REM latency: a psychobiologic marker for primary depressive disease. , 1976, Biological psychiatry.

[33]  Nancy C. Andreasen,et al.  The family history method using diagnostic criteria , 1978 .

[34]  B. Carroll,et al.  EEG studies of sleep in the diagnosis of depression. , 1982, Biological psychiatry.

[35]  A. Rechtschaffen,et al.  A manual of standardized terminology, technique and scoring system for sleep stages of human subjects , 1968 .

[36]  D. Kupfer,et al.  EEG sleep in primary depression. A longitudinal placebo study. , 1979, Journal of affective disorders.

[37]  R. Goetz,et al.  Electroencephalographic sleep of adolescents with major depression and normal controls. , 1987, Archives of general psychiatry.

[38]  J. Knowles,et al.  The sleep of childhood depressives: comparison with age-matched controls. , 1982, Biological psychiatry.

[39]  A. Rush,et al.  Polysomnographic findings in recently drug-free and clinically remitted depressed patients. , 1986, Archives of general psychiatry.

[40]  P. Linkowski,et al.  Dexamethasone Suppression Test and REM Sleep in Patients with Major Depressive Disorder , 1984, British Journal of Psychiatry.

[41]  M. Kovács.  Rating scales to assess depression in school-aged children. , 1981, Acta paedopsychiatrica.