Maximum Likelihood Estimation for Stochastic Differential Equations with Random Effects

We consider $N$ independent stochastic processes $(X_i(t), t\in [0,T_i])$, $i=1,\ldots, N$, defined by a stochastic differential equation with drift term depending on a random variable $\phi_i$. The distribution of the random effect $\phi_i$ depends on unknown parameters which are to be estimated from the continuous observation of the processes $X_i$. We give the expression of the exact likelihood. When the drift term depends linearly on the random effect $\phi_i$ and $\phi_i$ has Gaussian distribution, an explicit formula for the likelihood is obtained. We prove that the maximum likelihood estimator is consistent and asymptotically Gaussian, when $T_i=T$ for all $i$ and $N$ tends to infinity. We discuss the case of discrete observations. Estimators are computed on simulated data for several models and show good performances even when the length time interval of observations is not very large.

[1]  Russell D. Wolfinger,et al.  Laplace's approximation for nonlinear mixed models. , 1993 .

[2]  L. Skovgaard NONLINEAR MODELS FOR REPEATED MEASUREMENT DATA. , 1996 .

[3]  S. Bhattacharya,et al.  On Bayesian Asymptotics in Stochastic Differential Equations with Random Effects , 2014, 1407.3971.

[4]  Xiongzhi Chen Brownian Motion and Stochastic Calculus , 2008 .

[5]  Andrea De Gaetano,et al.  MIXED EFFECTS IN STOCHASTIC DIFFERENTIAL EQUATION MODELS , 2005 .

[6]  E. Kuhn,et al.  Coupling a stochastic approximation version of EM with an MCMC procedure , 2004 .

[7]  H. Madsen,et al.  Non-Linear Mixed-Effects Models with Stochastic Differential Equations: Implementation of an Estimation Algorithm , 2005, Journal of Pharmacokinetics and Pharmacodynamics.

[8]  Lei Nie,et al.  Strong Consistency of MLE in Nonlinear Mixed-effects Models with Large Cluster Size , 2005 .

[9]  Sophie Donnet,et al.  Parametric inference for mixed models defined by stochastic differential equations , 2008 .

[10]  Susanne Ditlevsen,et al.  Practical estimation of high dimensional stochastic differential mixed-effects models , 2010, Comput. Stat. Data Anal..

[11]  L B Sheiner,et al.  Estimating population kinetics. , 1982, Critical reviews in biomedical engineering.

[12]  A. Gaetano,et al.  Stochastic vs. deterministic uptake of dodecanedioic acid by isolated rat livers , 2005, Bulletin of mathematical biology.

[13]  A. Shiryayev,et al.  Statistics of Random Processes I: General Theory , 1984 .

[14]  Susanne Ditlevsen,et al.  Maximum likelihood estimation of a time-inhomogeneous stochastic differential model of glucose dynamics. , 2008, Mathematical medicine and biology : a journal of the IMA.

[15]  L. Nie,et al.  Strong Consistency of the Maximum Likelihood Estimator in Generalized Linear and Nonlinear Mixed-Effects Models , 2006 .

[16]  Umberto Picchini,et al.  Stochastic Differential Mixed‐Effects Models , 2010 .

[17]  Lei Nie,et al.  Convergence rate of MLE in generalized linear and nonlinear mixed-effects models: Theory and applications , 2007 .