Consensus statement on heart xenotransplantation in children: Toward clinical translation.

[1]  J. Jacobs,et al.  Sixth Annual Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) Report. , 2022, The Annals of thoracic surgery.

[2]  R. Baliga.  Genetically Modified Porcine-to-Human Cardiac Xenotransplantation. , 2022, The New England journal of medicine.

[3]  Luz A. Padilla,et al.  Will previous palliative surgery for congenital heart disease be detrimental to subsequent pig heart xenotransplantation? , 2022, Transplant immunology.

[4]  H. Hara,et al.  The respective relevance of sensitization to alloantigens and xenoantigens in pig organ xenotransplantation. , 2022, Human immunology.

[5]  B. Griffith,et al.  Genetically Modified Porcine-to-Human Cardiac Xenotransplantation. , 2022, The New England journal of medicine.

[6]  E. Phimister.  Genetic Modification in Pig-to-Human Transplantation. , 2022, The New England journal of medicine.

[7]  J. Denner.  Risk of pathogenic virus transmission by somatic cell nuclear transfer: implications for xenotransplantation , 2022, Biology of Reproduction.

[8]  J. Denner.  The porcine cytomegalovirus (PCMV) will not stop xenotransplantation , 2022, Xenotransplantation.

[9]  A. Kirk,et al.  Introducing thymus for promoting transplantation tolerance. , 2022, The Journal of allergy and clinical immunology.

[10]  P. Reese,et al.  Promoting Safety, Transparency, and Quality in Xenotransplantation , 2022, Annals of Internal Medicine.

[11]  D. Cooper,et al.  Pig heart and lung xenotransplantation: Present status. , 2022, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[12]  R. Pierson,et al.  Shooting for the moon: Genome editing for pig heart xenotransplantation. , 2022, The Journal of thoracic and cardiovascular surgery.

[13]  Luz A. Padilla,et al.  Informed Consent for Potential Recipients of Pig Kidney Xenotransplantation in the United States. , 2022, Transplantation.

[14]  M. Rothblatt.  Commentary on achievement of first life‐saving xenoheart transplant , 2022, Xenotransplantation.

[15]  B. Griffith,et al.  Progressive genetic modifications of porcine cardiac xenografts extend survival to 9 months , 2022, Xenotransplantation.

[16]  R. Pierson,et al.  The future of cardiac xenotransplantation , 2022, Nature Reviews Cardiology.

[17]  H. Hara,et al.  The potential of genetically engineered pig heart transplantation in infants with complex congenital heart disease , 2022, Pediatric transplantation.

[18]  L. West,et al.  Alterations in the immune phenotype of thymectomized children and the development of atopic disorders after heart transplantation , 2022, Pediatric transplantation.

[19]  D. Cooper.  Initial reflections on the world's first clinical genetically engineered pig heart transplant. , 2022, Xenotransplantation.

[20]  I. Konstantinov,et al.  Heart transplantation after Fontan operation , 2022, JTCVS techniques.

[21]  C. Villa,et al.  Mechanical support for the failing single ventricle after Fontan , 2022, JTCVS techniques.

[22]  I. Konstantinov,et al.  From genome editing to blastocyst complementation: A new horizon in heart transplantation? , 2022, JTCVS techniques.

[23]  J. Turek,et al.  Induction of donor-specific tolerance to heart transplantation: From concept to clinical translation. , 2022, The Journal of thoracic and cardiovascular surgery.

[24]  C. Hansen-Estruch,et al.  Initial evidence that blockade of the CD40/CD154 costimulation pathway alone is sufficient as maintenance therapy in xenotransplantation , 2021, Xenotransplantation.

[25]  J. Jacobs,et al.  Ventricular assist device support in neonates and infants with a failing functionally univentricular circulation , 2021, JTCVS techniques.

[26]  B. Griffith,et al.  The growth of xenotransplanted hearts can be reduced with growth hormone receptor knockout pig donors. , 2021, The Journal of thoracic and cardiovascular surgery.

[27]  B. Griffith,et al.  Blood Cardioplegia Induction, Perfusion Storage and Graft Dysfunction in Cardiac Xenotransplantation , 2021, Frontiers in Immunology.

[28]  Luz A. Padilla,et al.  The Genetically Engineered Heart as a Bridge to Allotransplantation in Infants Just Around the Corner? , 2021, The Annals of thoracic surgery.

[29]  D. Cooper,et al.  Evidence that sensitization to triple‐knockout pig cells will not be detrimental to subsequent allotransplantation , 2021, Xenotransplantation.

[30]  A. Dipchand,et al.  Clinical outcomes of children receiving ABO-incompatible versus ABO-compatible heart transplantation: a multicentre cohort study. , 2021, The Lancet. Child & adolescent health.

[31]  M. Burch,et al.  T cell phenotype in paediatric heart transplant recipients , 2020, Pediatric transplantation.

[32]  D. Cooper,et al.  Growth hormone receptor knockout: Relevance to xenotransplantation , 2020, Xenotransplantation.

[33]  Luz A. Padilla,et al.  Attitudes toward xenotransplantation: A survey of parents and pediatric cardiac providers , 2020, Pediatric transplantation.

[34]  D. Cooper,et al.  The immune system in infants: Relevance to xenotransplantation , 2020, Pediatric transplantation.

[35]  E. Wolf,et al.  Cold non‐ischemic heart preservation with continuous perfusion prevents early graft failure in orthotopic pig‐to‐baboon xenotransplantation , 2020, Xenotransplantation.

[36]  Luz A. Padilla,et al.  Attitudes to Cardiac Xenotransplantation by Pediatric Heart Surgeons and Physicians , 2020, World journal for pediatric & congenital heart surgery.

[37]  E. Wolf,et al.  Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation? , 2020, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[38]  A. Kirk,et al.  Cultured thymus tissue implementation promotes donor-specific tolerance to allogeneic heart transplants. , 2020, JCI insight.

[39]  R. Pierson,et al.  Pig‐to‐human heart transplantation: Who goes first? , 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[40]  E. Wolf,et al.  Impact of porcine cytomegalovirus on long-term orthotopic cardiac xenotransplant survival , 2020, Scientific Reports.

[41]  Luz A. Padilla,et al.  ANTI-PIG ANTIBODY IN INFANTS: CAN A GENETICALLY-ENGINEERED PIG HEART BRIDGE TO ALLOTRANSPLANTATION? , 2020, The Annals of thoracic surgery.

[42]  A. Dipchand,et al.  Pediatric cardiac waitlist mortality—Still too high , 2020, Pediatric transplantation.

[43]  L. Bailey,et al.  Primary Transplantation for Congenital Heart Disease in the Neonatal Period: Long-term Outcomes. , 2019, The Annals of thoracic surgery.

[44]  Luz A. Padilla,et al.  Paediatric xenotransplantation clinical trials and the right to withdraw , 2019, Journal of Medical Ethics.

[45]  Jordan T. Shin,et al.  The role of industry in advancing xenotransplantation. , 2019, Current opinion in organ transplantation.

[46]  E. Albers,et al.  Donor‐specific anti‐HLA antibody production following pediatric ABO‐incompatible heart transplantation , 2018, Pediatric transplantation.

[47]  E. Wolf,et al.  Consistent success in life-supporting porcine cardiac xenotransplantation , 2018, Nature.

[48]  D. Cooper,et al.  The Case for Cardiac Xenotransplantation in Neonates: Is Now the Time to Reconsider Xenotransplantation for Hypoplastic Left Heart Syndrome? , 2018, Pediatric Cardiology.

[49]  J. Tweddell,et al.  Listing Low-Weight or Ill Infants for Heart Transplantation: Is It Prudent? , 2018, The Annals of thoracic surgery.

[50]  D. Cooper,et al.  An approach to induction of tolerance to pig cardiac xenografts in neonates , 2018, Xenotransplantation.

[51]  J. Newburger,et al.  Transplant-Free Survival and Interventions at 6 Years in the SVR Trial , 2018, Circulation.

[52]  M. Rothblatt.  A personal perspective on the science, ethics, and commercialization of xenotransplantation , 2018, Xenotransplantation.

[53]  M. Breimer,et al.  Is sensitization to pig antigens detrimental to subsequent allotransplantation? , 2018, Xenotransplantation.

[54]  J. Denner.  Why was PERV not transmitted during preclinical and clinical xenotransplantation trials and after inoculation of animals? , 2018, Retrovirology.

[55]  A. Hoeflich,et al.  Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver , 2018, Molecular metabolism.

[56]  J. Newburger,et al.  Heart failure after the Norwood procedure: An analysis of the Single Ventricle Reconstruction Trial. , 2018, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[57]  L. Lund,et al.  The Registry of the International Society for Heart and Lung Transplantation: Twentieth Pediatric Heart Transplantation Report-2017; Focus Theme: Allograft ischemic time. , 2017, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[58]  G. Church,et al.  Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 , 2017, Science.

[59]  D. Sachs,et al.  Role of Intrinsic (Graft) Versus Extrinsic (Host) Factors in the Growth of Transplanted Organs Following Allogeneic and Xenogeneic Transplantation , 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[60]  J. Kirklin,et al.  Risk stratification to determine the impact of induction therapy on survival, rejection and adverse events after pediatric heart transplant: A multi-institutional study. , 2017, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[61]  E. Klein,et al.  Immunological and physiological observations in baboons with life‐supporting genetically engineered pig kidney grafts , 2017, Xenotransplantation.

[62]  U. Barkai,et al.  Extended microbiological characterization of Göttingen minipigs: porcine cytomegalovirus and other viruses , 2016, Xenotransplantation.

[63]  J. Denner,et al.  A new Western blot assay for the detection of porcine cytomegalovirus (PCMV). , 2016, Journal of immunological methods.

[64]  A. Belot,et al.  Transplant Tolerance Induction in Newborn Infants: Mechanisms, Advantages, and Potential Strategies , 2016, Front. Immunol..

[65]  R. F. Hoyt,et al.  Chimeric 2C10R4 anti-CD40 antibody therapy is critical for long-term survival of GTKO.hCD46.hTBM pig-to-primate cardiac xenograft , 2016, Nature Communications.

[66]  S. Urschel,et al.  Allergies and autoimmune disorders in children after heart transplantation , 2018, Clinical transplantation.

[67]  E. Klein,et al.  Pig kidney graft survival in a baboon for 136 days: longest life‐supporting organ graft survival to date , 2015, Xenotransplantation.

[68]  D. Ross,et al.  C3d plasma levels and CD21 expressing B-cells in children after ABO-incompatible heart transplantation: Alterations associated with blood group tolerance. , 2014, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[69]  Patricia Friedmann,et al.  The use of the Berlin Heart EXCOR in patients with functional single ventricle. , 2014, The Journal of thoracic and cardiovascular surgery.

[70]  M. Burch,et al.  ABO-incompatible heart transplantation in early childhood: an international multicenter study of clinical experiences and limits. , 2013, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

[71]  L. Bailey,et al.  Heart Transplantation for Congenital Heart Disease in the First Year of Life , 2011, Current cardiology reviews.

[72]  B. McCrindle,et al.  Equivalent Outcomes for Pediatric Heart Transplantation Recipients: ABO‐Blood Group Incompatible versus ABO‐Compatible , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[73]  V. Appay,et al.  The role of the thymus in immunosenescence: lessons from the study of thymectomized individuals , 2010, Aging.

[74]  S. Urschel,et al.  Absence of Donor‐Specific Anti‐HLA Antibodies After ABO‐Incompatible Heart Transplantation in Infancy: Altered Immunity or Age? , 2010, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[75]  M. Mendicino,et al.  Production of transgenic pigs that express porcine endogenous retrovirus small interfering RNAs , 2009, Xenotransplantation.

[76]  R. Thiagarajan,et al.  Waiting List Mortality Among Children Listed for Heart Transplantation in the United States , 2009, Circulation.

[77]  R. Hetzer,et al.  Diagnosis and treatment of post‐transplantation lymphoproliferative disorder in pediatric heart transplant patients , 2009, Pediatric transplantation.

[78]  R. Kurth,et al.  Knockdown of porcine endogenous retrovirus (PERV) expression by PERV‐specific shRNA in transgenic pigs , 2008, Xenotransplantation.

[79]  B. Reichart,et al.  ABO incompatible heart transplantation in infants , 2006 .

[80]  D. Driscoll,et al.  Effacing of the T Cell Compartment by Cardiac Transplantation in Infancy1 , 2006, The Journal of Immunology.

[81]  D. Cooper,et al.  The ethics debate in relation to xenotransplantation. , 2005, Revue scientifique et technique.

[82]  H. Ogmundsdottir,et al.  The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life , 2004, Clinical and experimental immunology.

[83]  D. Sachs,et al.  High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. , 2000, Transplantation.

[84]  B. Soin,et al.  Growth of porcine kidneys in their native and xenograft environment , 2000, Xenotransplantation.

[85]  J. Hamburger.  The future of transplantation. , 1981, Transplantation proceedings.

[86]  I. Adachi,et al.  Mechanical Support for The Failing Single Ventricle at Pre-Fontan Stage: Current State of The Field and Future Directions. , 2021, Seminars in thoracic and cardiovascular surgery. Pediatric cardiac surgery annual.

[87]  E. Gray,et al.  Addressing Regulatory Requirements for the Organ-Source Pig – A Pragmatic Approach to Facility Design and Pathogen Prevention , 2020 .

[88]  W. Williams,et al.  Is a hybrid strategy a lower‐risk alternative to stage 1 Norwood operation? , 2017, The Journal of thoracic and cardiovascular surgery.

[89]  J. Scalea,et al.  Thymic transplantation in pig-to-nonhuman primates for the induction of tolerance across xenogeneic barriers. , 2012, Methods in molecular biology.

[90]  L. Scobie,et al.  Porcine endogenous retroviruses in xenotransplantation , 2011 .

[91]  P. Krogstad,et al.  Thymic Function and Impaired Maintenance of Peripheral T Cell Populations in Children with Congenital Heart Disease and Surgical Thymectomy , 2005, Pediatric Research.

[92]  E. Roseau.  [ABO-incompatible heart transplantation in infants]. , 2001, Presse medicale.