miRNAs role in bladder cancer pathogenesis and targeted therapy: Signaling pathways interplay - A review.

[1]  Sylvia F. Fawzi,et al.  The role of miRNAs in insulin resistance and diabetic macrovascular complications - A review. , 2023, International journal of biological macromolecules.

[2]  M. Elkady,et al.  miRNAs as cornerstones in adipogenesis and obesity. , 2023, Life sciences.

[3]  H. M. El-Husseiny,et al.  miRNAs insights into rheumatoid arthritis: Favorable and detrimental aspects of key performers. , 2022, Life sciences.

[4]  M. Eldeib,et al.  miRNAs as cornerstones in diabetic microvascular complications. , 2022, Molecular genetics and metabolism.

[5]  Yu Liu,et al.  Diagnostic performance of urine and blood microRNAs for bladder cancer: a meta-analysis , 2022, Expert review of anticancer therapy.

[6]  Ahmed S. Doghish,et al.  The role of miRNAs in ovarian cancer pathogenesis and therapeutic resistance - A focus on signaling pathways interplay. , 2022, Pathology, research and practice.

[7]  M. Sobhy,et al.  Hydroxycitric acid reverses tamoxifen resistance through inhibition of ATP citrate lyase. , 2022, Pathology, research and practice.

[8]  Y. Jeon,et al.  Ishophloroglucin A Ameliorates VEGF-Induced Epithelial-Mesenchymal Transition via VEGFR2 Pathway Inhibition in Microgravity-Stimulated Human Retinal Pigment Epithelial Cells , 2022, Antioxidants.

[9]  Ahmed S. Doghish,et al.  Beneficial and detrimental aspects of miRNAs as chief players in breast cancer: A comprehensive review. , 2022, International journal of biological macromolecules.

[10]  Qingling Jiang,et al.  Circ_0002099 is a novel molecular therapeutic target for bladder cancer , 2022, Drug development research.

[11]  Sajad Najafi,et al.  MiR-211 play dual regulatory role in cancer development: From tumor suppressor to tumor enhancer. , 2022, Cellular signalling.

[12]  T. Al-Warhi,et al.  Identification of Novel Cyanopyridones and Pyrido[2,3-d]pyrimidines as Anticancer Agents with Dual VEGFR-2/HER-2 Inhibitory Action: Synthesis, Biological Evaluation and Molecular Docking Studies , 2022, Pharmaceuticals.

[13]  S. Salem,et al.  Nanocomposite based on gold nanoparticles and carboxymethyl cellulose: Synthesis, characterization, antimicrobial, and anticancer activities , 2022, Journal of Drug Delivery Science and Technology.

[14]  T. Cenci,et al.  PTTG1/ZEB1 Axis Regulates E-Cadherin Expression in Human Seminoma , 2022, Cancers.

[15]  J. Witjes,et al.  Current best practice for bladder cancer: a narrative review of diagnostics and treatments , 2022, The Lancet.

[16]  Anbarasu Kannan,et al.  Potential nanocarrier-mediated miRNA-based therapy approaches for multiple sclerosis. , 2022, Drug discovery today.

[17]  S. Salem,et al.  Synthesis of Silver Nanocomposite Based on Carboxymethyl Cellulose: Antibacterial, Antifungal and Anticancer Activities , 2022, Polymers.

[18]  Ahmed S. Doghish,et al.  A study of miRNAs as cornerstone in lung cancer pathogenesis and therapeutic resistance: A focus on signaling pathways interplay. , 2022, Pathology, research and practice.

[19]  K. Satyamoorthy,et al.  Diagnostic and prognostic potential clustered miRNAs in bladder cancer , 2022, 3 Biotech.

[20]  Rekha R. Shenoy,et al.  Sirtuins as therapeutic targets for improving delayed wound healing in diabetes , 2022, Journal of drug targeting.

[21]  Walaa A. El-Dakroury,et al.  Design, Characterization and In Vivo Performance of Solid Lipid Nanoparticles (SLNs)-Loaded Mucoadhesive Buccal Tablets for Efficient Delivery of Lornoxicam in Experimental Inflammation. , 2022, International journal of pharmaceutics.

[22]  Gongxian Wang,et al.  miR-1307-5p suppresses proliferation and tumorigenesis of bladder cancer via targeting MDM4 and the Hippo signaling pathway , 2022, Discover Oncology.

[23]  A. A. Ahmed,et al.  miRNAs as cornerstones in colorectal cancer pathogenesis and resistance to therapy: A spotlight on signaling pathways interplay - A review. , 2022, International journal of biological macromolecules.

[24]  G. Ricevuti,et al.  The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence , 2022, Antioxidants.

[25]  Wei He,et al.  MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer , 2022, Oncology reports.

[26]  Al-aliaa M. Sallam,et al.  miRNAs inspirations in hepatocellular carcinoma: Detrimental and favorable aspects of key performers. , 2022, Pathology, research and practice.

[27]  A. Jemal,et al.  Cancer statistics, 2022 , 2022, CA: a cancer journal for clinicians.

[28]  M. M. Khalifa,et al.  New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies , 2021, Journal of enzyme inhibition and medicinal chemistry.

[29]  I. Eissa,et al.  1,3,4-Oxadiazole-naphthalene hybrids as potential VEGFR-2 inhibitors: design, synthesis, antiproliferative activity, apoptotic effect, and in silico studies , 2021, Journal of enzyme inhibition and medicinal chemistry.

[30]  Zhao-hui Chen,et al.  MiR-20a-5p Negatively Regulates NR4A3 to Promote Metastasis in Bladder Cancer , 2021, Journal of oncology.

[31]  A. Ismail,et al.  A review of the biological role of miRNAs in prostate cancer suppression and progression. , 2021, International journal of biological macromolecules.

[32]  C. Pichon,et al.  miRNA Delivery by Nanosystems: State of the Art and Perspectives , 2021, Pharmaceutics.

[33]  G. Calin,et al.  Classical and noncanonical functions of miRNAs in cancers. , 2021, Trends in genetics : TIG.

[34]  H. Romanowicz,et al.  The Role of microRNA in Pancreatic Cancer , 2021, Biomedicines.

[35]  M. Mojarrad,et al.  MicroRNAs as the critical regulators of protein kinases in prostate and bladder cancers , 2021, Egyptian Journal of Medical Human Genetics.

[36]  Baosheng Li,et al.  SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis , 2021, Journal of translational medicine.

[37]  W. E. El Rouby,et al.  Graphene oxide and its nanocomposites with EDTA or chitosan induce apoptosis in MCF-7 human breast cancer , 2021, RSC advances.

[38]  Zhiwei Zhang,et al.  MicroRNA and cyclooxygenase-2 in Breast Cancer. , 2021, Clinica chimica acta; international journal of clinical chemistry.

[39]  Jian-kun Yang,et al.  BMI1 activates P-glycoprotein via transcription repression of miR-3682-3p and enhances chemoresistance of bladder cancer cell , 2021, Aging.

[40]  J. Sandoval,et al.  Cancer Epigenetic Biomarkers in Liquid Biopsy for High Incidence Malignancies , 2021, Cancers.

[41]  M. Alivand,et al.  MicroRNA-22 in female malignancies: Focusing on breast, cervical, and ovarian cancers. , 2021, Pathology, research and practice.

[42]  Shouzhen Chen,et al.  Berberinesuppresses bladdercancercell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p. , 2021, Biochemical pharmacology.

[43]  H. Katabuchi,et al.  The Hallmarks of Ovarian Cancer Stem Cells and Niches: Exploring Their Harmonious Interplay in Therapy Resistance. , 2021, Seminars in cancer biology.

[44]  G. Ferbeyre,et al.  New Insights into CDK Regulators: Novel Opportunities for Cancer Therapy. , 2021, Trends in cell biology.

[45]  M. Elshafey,et al.  MicroRNA-567 inhibits cell proliferation and induces cell apoptosis in A549 NSCLC cells by regulating cyclin-dependent kinase 8 , 2021, Saudi journal of biological sciences.

[46]  Wei Cheng,et al.  Downregulated exosomal microRNA-148b-3p in cancer associated fibroblasts enhance chemosensitivity of bladder cancer cells by downregulating the Wnt/β-catenin pathway and upregulating PTEN , 2021, Cellular oncology.

[47]  Liang Cheng,et al.  Role of microRNA-381 in bladder cancer growth and metastasis with the involvement of BMI1 and the Rho/ROCK axis , 2021, BMC Urology.

[48]  A. Amin,et al.  Circulating miR-148a-5p and miR-21-5p as Novel Diagnostic Biomarkers in Adult Egyptian Male Patients With Metabolic Syndrome. , 2021, Canadian journal of diabetes.

[49]  E. M. Gedawy,et al.  Design, synthesis, anticancer evaluation, and molecular modelling studies of novel tolmetin derivatives as potential VEGFR-2 inhibitors and apoptosis inducers , 2021, Journal of enzyme inhibition and medicinal chemistry.

[50]  G. Gomatou,et al.  Mechanisms of resistance to cyclin-dependent kinase 4/6 inhibitors , 2021, Molecular Biology Reports.

[51]  Hui Li,et al.  Emerging roles of MiR-133a in human cancers , 2021, Journal of Cancer.

[52]  Xing Huang,et al.  MiRNA‐516a promotes bladder cancer metastasis by inhibiting MMP9 protein degradation via the AKT/FOXO3A/SMURF1 axis , 2020, Clinical and translational medicine.

[53]  Y. Kandil,et al.  Diltiazem potentiates the cytotoxicity of gemcitabine and 5-fluorouracil in PANC-1 human pancreatic cancer cells through inhibition of P-glycoprotein. , 2020, Life sciences.

[54]  Bing-qian Liu,et al.  RAC3 Promotes Proliferation, Migration and Invasion via PYCR1/JAK/STAT Signaling in Bladder Cancer , 2020, Frontiers in Molecular Biosciences.

[55]  F. McCormick,et al.  RAS-targeted therapies: is the undruggable drugged? , 2020, Nature Reviews Drug Discovery.

[56]  B. Elsadek,et al.  Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase , 2020, Steroids.

[57]  P. Astudillo.  Wnt5a Signaling in Gastric Cancer , 2020, Frontiers in Cell and Developmental Biology.

[58]  Y. Gong,et al.  The CUL4B-miR-372/373-PIK3CA-AKT axis regulates metastasis in bladder cancer , 2020, Oncogene.

[59]  S. Yeh,et al.  Androgen receptor‐regulated circFNTA activates KRAS signaling to promote bladder cancer invasion , 2020, EMBO reports.

[60]  H. Riechelmann,et al.  Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance , 2020, Cells.

[61]  Jing Wang,et al.  Loss of p53 drives neuron reprogramming in head and neck cancer , 2020, Nature.

[62]  Dexi Chen,et al.  The significance of exosomes in the development and treatment of hepatocellular carcinoma , 2020, Molecular Cancer.

[63]  L. Egevad,et al.  The natural history of untreated muscle‐invasive bladder cancer , 2020, BJU international.

[64]  X. Gou,et al.  Bladder cancer cell-secreted exosomal miR-21 activates the PI3K/AKT pathway in macrophages to promote cancer progression , 2019, International journal of oncology.

[65]  S. Poletajew,et al.  TGF-β and microRNA Interplay in Genitourinary Cancers , 2019, Cells.

[66]  Xiaokun Zhao,et al.  MicroRNA-200c affects bladder cancer angiogenesis by regulating the Akt2/mTOR/HIF-1 axis , 2019, Translational cancer research.

[67]  Jingxia Li,et al.  Overexpressed miR-200a promotes bladder cancer invasion through direct regulating Dicer/miR-16/JNK2/MMP-2 axis , 2019, Oncogene.

[68]  Jin-hai Tang,et al.  MiR-145: a potential biomarker of cancer migration and invasion. , 2019, American journal of translational research.

[69]  L. Kiemeney,et al.  The global burden of urinary bladder cancer: an update , 2019, World Journal of Urology.

[70]  I. Berindan‐Neagoe,et al.  Connecting the dots between different networks: miRNAs associated with bladder cancer risk and progression , 2019, Journal of experimental & clinical cancer research : CR.

[71]  Yue Wang,et al.  MiR-125b-5p suppresses the bladder cancer progression via targeting HK2 and suppressing PI3K/AKT pathway , 2019, Human Cell.

[72]  Weizhang Xu,et al.  Exosomal MicroRNA-9-3p Secreted from BMSCs Downregulates ESM1 to Suppress the Development of Bladder Cancer , 2019, Molecular therapy. Nucleic acids.

[73]  M. Fassan,et al.  Non-coding RNAs, a real Next-Gen Class of Biomarkers? , 2019, Non-coding RNA research.

[74]  H. Weng,et al.  Development of a 21-miRNA Signature Associated With the Prognosis of Patients With Bladder Cancer , 2019, Front. Oncol..

[75]  Xiaoqiang Wang,et al.  MicroRNA-621 inhibits cell proliferation and metastasis in bladder cancer by suppressing Wnt/β-catenin signaling. , 2019, Chemico-biological interactions.

[76]  Ting Huyan,et al.  MicroRNAs: Key Players in Bladder Cancer , 2019, Molecular Diagnosis & Therapy.

[77]  Hai-feng Wang,et al.  miR-3622a promotes proliferation and invasion of bladder cancer cells by downregulating LASS2. , 2019, Gene.

[78]  Yi Fang,et al.  Increased miR‐323a induces bladder cancer cell apoptosis by suppressing c‐Met , 2019, The Kaohsiung journal of medical sciences.

[79]  Hongcheng Lu,et al.  Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF1 expression through miR‐1270 inhibition , 2019, Molecular oncology.

[80]  T. Hwang,et al.  Benzyl isothiocyanate suppresses IGF1R, FGFR3 and mTOR expression by upregulation of miR-99a-5p in human bladder cancer cells. , 2019, International journal of oncology.

[81]  Y. Akao,et al.  MicroRNA‐143/Musashi‐2/KRAS cascade contributes positively to carcinogenesis in human bladder cancer , 2019, Cancer science.

[82]  O. Mansour,et al.  Potential role of circulating microRNAs (486-5p, 497, 509-5p and 605) in metabolic syndrome Egyptian male patients , 2019, Diabetes, metabolic syndrome and obesity : targets and therapy.

[83]  B. Henríquez,et al.  RUNX family: Oncogenes or tumor suppressors , 2019, Oncology reports.

[84]  Masahiro Shibata,et al.  Targeting Cancer Stem Cells: A Strategy for Effective Eradication of Cancer , 2019, Cancers.

[85]  Jie Fan,et al.  Circular RNA hsa_circ_0068871 regulates FGFR3 expression and activates STAT3 by targeting miR-181a-5p to promote bladder cancer progression , 2019, Journal of experimental & clinical cancer research : CR.

[86]  Hongbo Sun,et al.  NET1 enhances proliferation and chemoresistance in Acute Lymphoblastic Leukemia cells. , 2019, Oncology research.

[87]  Jianping Wu,et al.  MicroRNA-146b Overexpression Promotes Human Bladder Cancer Invasion via Enhancing ETS2-Mediated mmp2 mRNA Transcription , 2019, Molecular therapy. Nucleic acids.

[88]  D. Richardson,et al.  The Role of the Antioxidant Response in Mitochondrial Dysfunction in Degenerative Diseases: Cross-Talk between Antioxidant Defense, Autophagy, and Apoptosis , 2019, Oxidative medicine and cellular longevity.

[89]  Y. Zhao,et al.  MiR-203a functions as a tumor suppressor in bladder cancer by targeting SIX4. , 2019, Neoplasma.

[90]  Zhenhua Li,et al.  Long non-coding RNA ZEB1-AS1 regulates miR-200b/FSCN1 signaling and enhances migration and invasion induced by TGF-β1 in bladder cancer cells , 2019, Journal of experimental & clinical cancer research : CR.

[91]  Fenghua Zhang,et al.  Inhibition of NET-1 suppresses proliferation and promotes apoptosis of hepatocellular carcinoma cells by activating the PI3K/AKT signaling pathway. , 2019, Experimental and therapeutic medicine.

[92]  Wei Chen,et al.  Downregulation of microRNA-532-5p promotes the proliferation and invasion of bladder cancer cells through promotion of HMGB3/Wnt/β-catenin signaling. , 2019, Chemico-biological interactions.

[93]  A. Fawzy,et al.  Diagnostic Significance of miR-639 and miR-10b in Βreast Cancer Patients , 2019, Meta Gene.

[94]  G. Caracciolo,et al.  Very low intensity ultrasounds as a new strategy to improve selective delivery of nanoparticles-complexes in cancer cells , 2019, Journal of experimental & clinical cancer research : CR.

[95]  Tao Li,et al.  MicroRNA-101 inhibits cell migration and invasion in bladder cancer via targeting FZD4. , 2018, Experimental and therapeutic medicine.

[96]  Xia Wang,et al.  miRNA-373 promotes urinary bladder cancer cell proliferation, migration and invasion through upregulating epidermal growth factor receptor , 2018, Experimental and therapeutic medicine.

[97]  Xiaoyun Wu,et al.  The effect of miR-124-3p on cell proliferation and apoptosis in bladder cancer by targeting EDNRB , 2018, Archives of medical science : AMS.

[98]  Atef A Bassyouni,et al.  Plasma endoglin in Type2 diabetic patients with nephropathy. , 2019, Diabetes & metabolic syndrome.

[99]  P. Liu,et al.  MiR-103/107 induces tumorigenicity in bladder cancer cell by suppressing PTEN. , 2018, European review for medical and pharmacological sciences.

[100]  Yuelong Zhang,et al.  MiR-125a-5p suppresses bladder cancer progression through targeting FUT4. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[101]  Hua Xu,et al.  MicroRNA-3619-5p suppresses bladder carcinoma progression by directly targeting β-catenin and CDK2 and activating p21 , 2018, Cell Death & Disease.

[102]  W. Xu,et al.  Long Noncoding RNA ATB Promotes Proliferation, Migration, and Invasion in Bladder Cancer by Suppressing MicroRNA-126. , 2018, Oncology research.

[103]  Xinquan Gu,et al.  MicroRNA-374a Inhibits Aggressive Tumor Biological Behavior in Bladder Carcinoma by Suppressing Wnt/β-Catenin Signaling , 2018, Cellular Physiology and Biochemistry.

[104]  Jun Xiao,et al.  miR‑22‑3p enhances multi‑chemoresistance by targeting NET1 in bladder cancer cells. , 2018, Oncology reports.

[105]  C. Croce,et al.  Friend or Foe: MicroRNAs in the p53 network. , 2018, Cancer letters.

[106]  Xiaokun Zhao,et al.  LncRNA XIST/miR-200c regulates the stemness properties and tumourigenicity of human bladder cancer stem cell-like cells , 2018, Cancer Cell International.

[107]  Chuanshu Huang,et al.  MicroRNA-411 Downregulation Enhances Tumor Growth by Upregulating MLLT11 Expression in Human Bladder Cancer , 2018, Molecular therapy. Nucleic acids.

[108]  Linfu Xie,et al.  MiR-22 suppresses epithelial–mesenchymal transition in bladder cancer by inhibiting Snail and MAPK1/Slug/vimentin feedback loop , 2018, Cell Death & Disease.

[109]  Wei Zhang,et al.  Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression , 2018, Molecular Cancer.

[110]  Rong Wang,et al.  MicroRNA-940 Targets INPP4A or GSK3β and Activates the Wnt/β-Catenin Pathway to Regulate the Malignant Behavior of Bladder Cancer Cells. , 2018, Oncology research.

[111]  N. Zhang,et al.  Effects of microRNA-135a on the epithelial–mesenchymal transition, migration and invasion of bladder cancer cells by targeting GSK3β through the Wnt/β-catenin signaling pathway , 2018, Experimental & Molecular Medicine.

[112]  Xiangyi Zheng,et al.  MET/SMAD3/SNAIL circuit mediated by miR-323a-3p is involved in regulating epithelial–mesenchymal transition progression in bladder cancer , 2017, Cell Death & Disease.

[113]  Ruimin Huang,et al.  TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer , 2017, Theranostics.

[114]  Xiuheng Liu,et al.  MicroRNA-139-5p inhibits bladder cancer proliferation and self-renewal by targeting the Bmi1 oncogene , 2017, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

[115]  Y. Pu,et al.  MiR‐193b Mediates CEBPD‐Induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells , 2017, Journal of cellular biochemistry.

[116]  J. Schalken,et al.  miRNA-520f Reverses Epithelial-to-Mesenchymal Transition by Targeting ADAM9 and TGFBR2. , 2017, Cancer research.

[117]  K. Rieger-Christ,et al.  DISTINCT EXOSOMAL MIRNA PROFILES IN CHEMORESISTANT BLADDER CARCINOMA CELL LINES: MP88‐15 , 2017 .

[118]  Yongwei Li,et al.  MicroRNA-294 promotes cellular proliferation and motility through the PI3K/AKT and JAK/STAT pathways by upregulation of NRAS in bladder cancer , 2017, Biochemistry (Moscow).

[119]  Maximilian Burger,et al.  EAU Guidelines on Non-Muscle-invasive Urothelial Carcinoma of the Bladder: Update 2016. , 2017, European urology.

[120]  P. Li,et al.  MicroRNA-218 Increases the Sensitivity of Bladder Cancer to Cisplatin by Targeting Glut1 , 2017, Cellular Physiology and Biochemistry.

[121]  M. Boutros,et al.  Wnt signaling in cancer , 2016, Oncogene.

[122]  Qi Li,et al.  miR-143 inhibits bladder cancer cell proliferation and enhances their sensitivity to gemcitabine by repressing IGF-1R signaling. , 2017, Oncology letters.

[123]  R. Jiang,et al.  Genome-Wide Screen of miRNAs and Targeting mRNAs Reveals the Negatively Regulatory Effect of miR-130b-3p on PTEN by PI3K and Integrin β1 Signaling Pathways in Bladder Carcinoma , 2016, International journal of molecular sciences.

[124]  Wenjing Wu,et al.  Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells. , 2016, Cancer letters.

[125]  T. Lange,et al.  Intracellular and extracellular microRNA: An update on localization and biological role. , 2016, Progress in histochemistry and cytochemistry.

[126]  BoKyung Moon,et al.  MicroRNA-892b influences proliferation, migration and invasion of bladder cancer cells by mediating the p19ARF/cyclin D1/CDK6 and Sp-1/MMP-9 pathways. , 2016, Oncology reports.

[127]  P. Zhou,et al.  MicroRNA-542-3p suppresses cellular proliferation of bladder cancer cells through post-transcriptionally regulating survivin. , 2016, Gene.

[128]  M. Zeegers,et al.  Modifiable risk factors for the prevention of bladder cancer: a systematic review of meta-analyses , 2016, European Journal of Epidemiology.

[129]  Hiroshi Egawa,et al.  The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN , 2016, Scientific Reports.

[130]  Linfu Xie,et al.  c-Met and CREB1 are involved in miR-433-mediated inhibition of the epithelial–mesenchymal transition in bladder cancer by regulating Akt/GSK-3β/Snail signaling , 2016, Cell Death and Disease.

[131]  K. Xia,et al.  miR‐222 attenuates cisplatin‐induced cell death by targeting the PPP2R2A/Akt/mTOR Axis in bladder cancer cells , 2016, Journal of cellular and molecular medicine.

[132]  F. Akçay,et al.  The determination of serum and urinary endocan concentrations in patients with bladder cancer , 2016, Annals of clinical biochemistry.

[133]  Aiju Fang,et al.  Direct quantitative detection for cell-free miR-155 in urine: a potential role in diagnosis and prognosis for non-muscle invasive bladder cancer , 2015, Oncotarget.

[134]  Zhi-yu Wang 王智宇,et al.  Expression of miRNA-630 in bladder urothelial carcinoma and its clinical significance , 2016, Journal of Huazhong University of Science and Technology [Medical Sciences].

[135]  M. Kuang,et al.  MicroRNA-15a-5p suppresses cancer proliferation and division in human hepatocellular carcinoma by targeting BDNF , 2016, Tumor Biology.

[136]  Aiju Fang,et al.  MicroRNA-203 Is a Prognostic Indicator in Bladder Cancer and Enhances Chemosensitivity to Cisplatin via Apoptosis by Targeting Bcl-w and Survivin , 2015, PloS one.

[137]  Wei He,et al.  MiRNA-125b inhibits proliferation and migration by targeting SphK1 in bladder cancer. , 2015, American journal of translational research.

[138]  Shuo Gu,et al.  Upregulation of microRNA-96 and its oncogenic functions by targeting CDKN1A in bladder cancer , 2015, Cancer Cell International.

[139]  Bin Xu,et al.  miR‐124 exerts tumor suppressive functions on the cell proliferation, motility and angiogenesis of bladder cancer by fine‐tuning UHRF1 , 2015, The FEBS journal.

[140]  S. Beck,et al.  A Polycomb-mir200 loop regulates clinical outcome in bladder cancer , 2015, Oncotarget.

[141]  Na Li,et al.  microRNA-21 Regulates Cell Proliferation and Migration and Cross Talk with PTEN and p53 in Bladder Cancer. , 2015, DNA and cell biology.

[142]  S. Kotamraju,et al.  AMPK inhibits MTDH expression via GSK3β and SIRT1 activation: potential role in triple negative breast cancer cell proliferation , 2015, The FEBS journal.

[143]  Hui-hui Zhang,et al.  Expression and clinical significance of microRNA-21, maspin and vascular endothelial growth factor-C in bladder cancer. , 2015, Oncology letters.

[144]  Yu Zhang,et al.  siRNA Versus miRNA as Therapeutics for Gene Silencing , 2015, Molecular therapy. Nucleic acids.

[145]  A. Corvalán,et al.  Molecular classification of gastric cancer: Towards a pathway-driven targeted therapy , 2015, Oncotarget.

[146]  L. Du,et al.  Downregulation of urinary cell‐free microRNA‐214 as a diagnostic and prognostic biomarker in bladder cancer , 2015, Journal of surgical oncology.

[147]  M. Hegazy,et al.  Evaluation of urinary microRNA panel in bladder cancer diagnosis: relation to bilharziasis. , 2015, Translational research : the journal of laboratory and clinical medicine.

[148]  X. Yang,et al.  MicroRNA-218 inhibits bladder cancer cell proliferation, migration, and invasion by targeting BMI-1 , 2015, Tumor Biology.

[149]  Hui Wang,et al.  Correlation of Increased Expression of MicroRNA-155 in Bladder Cancer and Prognosis. , 2015, Laboratory medicine.

[150]  Xiaokun Zhao,et al.  miR-221 facilitates the TGFbeta1-induced epithelial-mesenchymal transition in human bladder cancer cells by targeting STMN1 , 2015, BMC Urology.

[151]  R. Spizzo,et al.  The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis , 2015, Gut.

[152]  Honglin Hu,et al.  rs11671784 G/A variation in miR-27a decreases chemo-sensitivity of bladder cancer by decreasing miR-27a and increasing the target RUNX-1 expression. , 2015, Biochemical and biophysical research communications.

[153]  Hong Chen,et al.  MicroRNA-576-3p inhibits proliferation in bladder cancer cells by targeting cyclin D1. , 2015, Molecules and cells.

[154]  L. Du,et al.  MicroRNA-214 Suppresses Oncogenesis and Exerts Impact on Prognosis by Targeting PDRG1 in Bladder Cancer , 2015, PloS one.

[155]  L. Du,et al.  Serum microRNA expression signatures identified from genome‐wide microRNA profiling serve as novel noninvasive biomarkers for diagnosis and recurrence of bladder cancer , 2015, International journal of cancer.

[156]  Jingde Zhu,et al.  MiR-193a-3p promotes the multi-chemoresistance of bladder cancer by targeting the HOXC9 gene. , 2015, Cancer letters.

[157]  N. Seki,et al.  Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer , 2014, International journal of oncology.

[158]  S. Ray,et al.  Hepatocellular carcinoma and microRNA: new perspectives on therapeutics and diagnostics. , 2015, Advanced drug delivery reviews.

[159]  K. Gupta,et al.  Cancer epigenetics: an introduction. , 2015, Methods in molecular biology.

[160]  Youcheng Xiu,et al.  MicroRNA-137 Upregulation Increases Bladder Cancer Cell Proliferation and Invasion by Targeting PAQR3 , 2014, PloS one.

[161]  Jingde Zhu,et al.  miR-193a-3p regulates the multi-drug resistance of bladder cancer by targeting the LOXL4 gene and the Oxidative Stress pathway , 2014, Molecular Cancer.

[162]  Yuan Cao,et al.  Enforced expression of miR-101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase-2 pathway. , 2014, Molecular medicine reports.

[163]  J. Gore,et al.  The burden of bladder cancer care: direct and indirect costs , 2014, Current opinion in urology.

[164]  L. Wang,et al.  The DNA methylation-regulated miR-193a-3p dictates the multi-chemoresistance of bladder cancer via repression of SRSF2/PLAU/HIC2 expression , 2014, Cell Death and Disease.

[165]  X. Zu,et al.  Transforming growth factor‑β1 induces epithelial‑mesenchymal transition and increased expression of matrix metalloproteinase‑16 via miR‑200b downregulation in bladder cancer cells. , 2014, Molecular medicine reports.

[166]  S. Butz,et al.  Esm1 Modulates Endothelial Tip Cell Behavior and Vascular Permeability by Enhancing VEGF Bioavailability , 2014, Circulation research.

[167]  Tianyuan Xu,et al.  MicroRNA‐145 directly targets the insulin‐like growth factor receptor I in human bladder cancer cells , 2014, FEBS letters.

[168]  Ping Yang,et al.  miR-19a acts as an oncogenic microRNA and is up-regulated in bladder cancer , 2014, Journal of Experimental & Clinical Cancer Research.

[169]  E. Fuchs,et al.  Wnt some lose some: transcriptional governance of stem cells by Wnt/β-catenin signaling , 2014, Genes & development.

[170]  Yu-Ching Fan,et al.  microRNA-99a inhibiting cell proliferation, migration and invasion by targeting fibroblast growth factor receptor 3 in bladder cancer , 2014, Oncology letters.

[171]  Lei Wang,et al.  Upregulated microRNA-301a in breast cancer promotes tumor metastasis by targeting PTEN and activating Wnt/β-catenin signaling. , 2014, Gene.

[172]  A. Hartmann,et al.  Reduced Expression of miRNA-27a Modulates Cisplatin Resistance in Bladder Cancer by Targeting the Cystine/Glutamate Exchanger SLC7A11 , 2014, Clinical Cancer Research.

[173]  O. Slabý,et al.  Urine microRNAs as potential noninvasive biomarkers in urologic cancers. , 2014, Urologic oncology.

[174]  C. Yin,et al.  A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis , 2014, Tumor Biology.

[175]  Donald J Buchsbaum,et al.  The Wnt/β-catenin pathway in ovarian cancer: a review. , 2013, Gynecologic oncology.

[176]  W. Kim,et al.  Cell-Free microRNA-214 From Urine as a Biomarker for Non-Muscle-Invasive Bladder Cancer , 2013, Korean journal of urology.

[177]  P. Lei,et al.  Mutation of TGF-β receptor II facilitates human bladder cancer progression through altered TGF-β1 signaling pathway , 2013, International journal of oncology.

[178]  S. Vacher,et al.  microRNA expression profile in a large series of bladder tumors: Identification of a 3‐miRNA signature associated with aggressiveness of muscle‐invasive bladder cancer , 2013, International journal of cancer.

[179]  Xiangyi Zheng,et al.  MicroRNA-409-3p inhibits migration and invasion of bladder cancer cells via targeting c-Met , 2013, Molecules and cells.

[180]  Wei Cai,et al.  miR-708 promotes the development of bladder carcinoma via direct repression of Caspase-2 , 2013, Journal of Cancer Research and Clinical Oncology.

[181]  M. Abbaszadegan,et al.  Association of PYGO2 and EGFR in esophageal squamous cell carcinoma , 2013, Medical Oncology.

[182]  R. Aharonov,et al.  Predicting progression of bladder urothelial carcinoma using microRNA expression , 2013, BJU international.

[183]  A. Hartmann,et al.  Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis. , 2013, Cancer research.

[184]  K. Rieger-Christ,et al.  MicroRNA Profile to Predict Gemcitabine Resistance in Bladder Carcinoma Cell Lines. , 2013, Genes & cancer.

[185]  R. Dahiya,et al.  Oncogenic miRNA-182-5p Targets Smad4 and RECK in Human Bladder Cancer , 2012, PloS one.

[186]  H. Döhner,et al.  Impact of serum storage conditions on microRNA stability , 2012, Leukemia.

[187]  Won-Tae Kim,et al.  Cell-free microRNAs in urine as diagnostic and prognostic biomarkers of bladder cancer. , 2012, International journal of oncology.

[188]  R. deVere White,et al.  MiR‐34a chemosensitizes bladder cancer cells to cisplatin treatment regardless of p53‐Rb pathway status , 2012, International journal of cancer.

[189]  M. Bushell,et al.  microRNAs in cancer management. , 2012, The Lancet. Oncology.

[190]  S. Yip,et al.  Expression of microRNAs in the urine of patients with bladder cancer. , 2012, Clinical genitourinary cancer.

[191]  N. Seki,et al.  Tumour suppressors miR-1 and miR-133a target the oncogenic function of purine nucleoside phosphorylase (PNP) in prostate cancer , 2011, British Journal of Cancer.

[192]  R. Dahiya,et al.  MicroRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancer. , 2012, Carcinogenesis.

[193]  Shinobu Ueda,et al.  miR‐92 is a key oncogenic component of the miR‐17–92 cluster in colon cancer , 2011, Cancer science.

[194]  R. Dahiya,et al.  Tumor Suppressor MicroRNA-493 Decreases Cell Motility and Migration Ability in Human Bladder Cancer Cells by Downregulating RhoC and FZD4 , 2011, Molecular Cancer Therapeutics.

[195]  Wei Zhang,et al.  microRNA-21 modulates cell proliferation and sensitivity to doxorubicin in bladder cancer cells. , 2011, Oncology reports.

[196]  N. Seki,et al.  The tumour-suppressive function of miR-1 and miR-133a targeting TAGLN2 in bladder cancer , 2011, British Journal of Cancer.

[197]  J. Chiang,et al.  Transcriptional activation of the Axl and PDGFR-α by c-Met through a ras- and Src-independent mechanism in human bladder cancer , 2011, BMC Cancer.

[198]  Leigh-Ann MacFarlane,et al.  MicroRNA: Biogenesis, Function and Role in Cancer , 2010, Current genomics.

[199]  Upender Manne,et al.  Prognostic value of mucin 4 expression in colorectal adenocarcinomas , 2010, Cancer.

[200]  C. Ching,et al.  Expanding therapeutic targets in bladder cancer: the PI3K/Akt/mTOR pathway , 2010, Laboratory Investigation.

[201]  Jie Xiang,et al.  Feud or Friend? The Role of the miR-17-92 Cluster in Tumorigenesis , 2010, Current genomics.

[202]  N. Seki,et al.  miR-145 and miR-133a function as tumour suppressors and directly regulate FSCN1 expression in bladder cancer , 2010, British Journal of Cancer.

[203]  Woonyoung Choi,et al.  miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy , 2009, Clinical Cancer Research.

[204]  W. Shipley,et al.  Bladder cancer , 2009, The Lancet.

[205]  H. Lodish,et al.  MicroRNA-125b is a novel negative regulator of p53. , 2009, Genes & development.

[206]  A. Ravaud,et al.  Molecular targeting in the treatment of either advanced or metastatic bladder cancer or both according to the signalling pathways , 2008, Current opinion in urology.

[207]  O. Hobert.  Gene Regulation by Transcription Factors and MicroRNAs , 2008, Science.

[208]  Jiayuh Lin,et al.  Signal transducer and activator of transcription 3 activation is associated with bladder cancer cell growth and survival , 2008, Molecular Cancer.

[209]  Margaret S. Ebert,et al.  MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells , 2007, Nature Methods.

[210]  M. Todesco,et al.  Target mimicry provides a new mechanism for regulation of microRNA activity , 2007, Nature Genetics.

[211]  L. Lim,et al.  A microRNA component of the p53 tumour suppressor network , 2007, Nature.

[212]  S. Janković,et al.  Risk Factors for Bladder Cancer , 2007, Tumori.

[213]  Sarka Pospisilova,et al.  MicroRNA biogenesis, functionality and cancer relevance. , 2006, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[214]  Liang Cheng,et al.  Bladder cancer: epidemiology, staging and grading, and diagnosis. , 2005, Urology.

[215]  Kathryn A. O’Donnell,et al.  c-Myc-regulated microRNAs modulate E2F1 expression , 2005, Nature.

[216]  A. Semjonow,et al.  Expression of the endothelin axis in bladder cancer: relationship to clinicopathologic parameters and long-term survival. , 2005, European urology.

[217]  H. Lane,et al.  ERBB receptors and cancer: the complexity of targeted inhibitors , 2005, Nature Reviews Cancer.

[218]  S. Shariat,et al.  p53, p21, pRB, and p16 expression predict clinical outcome in cystectomy with bladder cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[219]  C. Croce,et al.  Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[220]  V. Ambros.  microRNAs Tiny Regulators with Great Potential , 2001, Cell.

[221]  A. N. Meyer,et al.  Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 , 2000, Oncogene.

[222]  H. Hermeking,et al.  Mediation of c-Myc-induced apoptosis by p53. , 1994, Science.