N‐terminal engineering of amyloid‐β‐binding Affibody molecules yields improved chemical synthesis and higher binding affinity
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Anna Wahlström | Astrid Gräslund | Sebastian K T S Wärmländer | Natalia Markova | A. Karlström | L. Abrahmsén | C. Ekblad | J. Danielsson | A. Gräslund | N. Markova | Anna Wahlström | S. Wärmländer | Jens Danielsson | Caroline Ekblad | Lars Abrahmsén | Amelie Eriksson Karlström | Joel Lindgren | J. Lindgren | A. Wahlström
[1] I. Bertini,et al. Dynamic properties of the G93A mutant of copper-zinc superoxide dismutase as detected by NMR spectroscopy: implications for the pathology of familial amyotrophic lateral sclerosis. , 2003, Biochemistry.
[2] L. K. Baker,et al. Oligomeric and Fibrillar Species of Amyloid-β Peptides Differentially Affect Neuronal Viability* , 2002, The Journal of Biological Chemistry.
[3] T. Tokuda,et al. High-molecular weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients , 2010, Alzheimer's & Dementia.
[4] T. Tokuda,et al. High-molecular weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients , 2010, Alzheimer's & Dementia.
[5] M. Uhlén,et al. Binding proteins selected from combinatorial libraries of an alpha-helical bacterial receptor domain. , 1997, Nature biotechnology.
[6] C. Cotman,et al. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[7] A. Karlström,et al. Synthesis and chemoselective intramolecular crosslinking of a HER2‐binding affibody , 2009, Biopolymers.
[8] E. Check. Nerve inflammation halts trial for Alzheimer's drug , 2002, Nature.
[9] D. Selkoe,et al. Natural oligomers of the amyloid-β protein specifically disrupt cognitive function , 2005, Nature Neuroscience.
[10] A. Karlström,et al. Affibody protein capture microarrays: synthesis and evaluation of random and directed immobilization of affibody molecules. , 2005, Analytical biochemistry.
[11] J. Danielsson,et al. Positioning of the Alzheimer Aβ(1–40) peptide in SDS micelles using NMR and paramagnetic probes , 2007, Journal of biomolecular NMR.
[12] C. Cotman,et al. β-Amyloid peptides induce degeneration of cultured rat microglia , 1993, Brain Research.
[13] G. Glenner,et al. The amyloid deposits in Alzheimer's disease: their nature and pathogenesis. , 1984, Applied pathology.
[14] D. Holtzman,et al. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[15] R. Riek,et al. 3D structure of Alzheimer's amyloid-β(1–42) fibrils , 2005 .
[16] An improved method of preparing the amyloid β-protein for fibrillogenesis and neurotoxicity experiments , 2000 .
[17] P. Chiang,et al. The many faces of amyloid beta in Alzheimer's disease. , 2008, Current molecular medicine.
[18] R. Nitsch,et al. Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease , 2002, Nature Medicine.
[19] L Serrano,et al. Elucidating the folding problem of alpha-helices: local motifs, long-range electrostatics, ionic-strength dependence and prediction of NMR parameters. , 1998, Journal of molecular biology.
[20] M. Uhlén,et al. A combinatorial library of an α-helical bacterial receptor domain , 1995 .
[21] R. Riek,et al. 3D structure of Alzheimer's amyloid-beta(1-42) fibrils. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[22] David J. Cummins,et al. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[23] H. Brumer,et al. Chemical Synthesis of Triple‐Labelled Three‐Helix Bundle Binding Proteins for Specific Fluorescent Detection of Unlabelled Protein , 2005, Chembiochem : a European journal of chemical biology.
[24] M. Ramirez-Alvarado,et al. In vivo targeting of antibody fragments to the nervous system for Alzheimer’s disease immunotherapy and molecular imaging of amyloid plaques , 2007, Journal of neurochemistry.
[25] M. Goedert,et al. A Century of Alzheimer's Disease , 2006, Science.
[26] P. Chiang,et al. The Many Faces of Amyloid β in Alzheimers Disease , 2008 .
[27] T. Härd,et al. Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation , 2008, Proceedings of the National Academy of Sciences.
[28] R. Martins,et al. Neuronal origin of a cerebral amyloid: neurofibrillary tangles of Alzheimer's disease contain the same protein as the amyloid of plaque cores and blood vessels. , 1985, The EMBO journal.
[29] S. Grzesiek,et al. NMRPipe: A multidimensional spectral processing system based on UNIX pipes , 1995, Journal of biomolecular NMR.
[30] S. Lindström,et al. Selection and characterization of Affibody ligands binding to Alzheimer amyloid β peptides , 2007 .
[31] K. Henke,et al. Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease , 2003, Neuron.
[32] D. Walsh,et al. An improved method of preparing the amyloid β-protein for fibrillogenesis and neurotoxicity experiments , 2000, Neurobiology of Aging.
[33] Ad Bax,et al. Three-dimensional triple-resonance NMR Spectroscopy of isotopically enriched proteins. 1990. , 1990, Journal of magnetic resonance.
[34] M. Garwood,et al. Selective Contrast Enhancement of Individual Alzheimer’s Disease Amyloid Plaques Using a Polyamine and Gd-DOTA Conjugated Antibody Fragment Against Fibrillar Aβ42 for Magnetic Resonance Molecular Imaging , 2008, Pharmaceutical Research.
[35] C. Barbas. Faculty Opinions recommendation of Stabilization of a beta-hairpin in monomeric Alzheimer's amyloid-beta peptide inhibits amyloid formation. , 2008 .
[36] Carl W. Cotman,et al. Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[37] R. Motter,et al. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease , 2000, Nature Medicine.
[38] R. Leapman,et al. Supramolecular structural constraints on Alzheimer's beta-amyloid fibrils from electron microscopy and solid-state nuclear magnetic resonance. , 2002, Biochemistry.
[39] G. Glenner,et al. Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. , 1984, Biochemical and biophysical research communications.
[40] C. Dobson,et al. Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo , 2010, PLoS biology.
[41] K. Henke,et al. Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease. , 2003, Neuron.
[42] T. Härd,et al. Interaction of Alzheimer's A beta peptide with an engineered binding protein--thermodynamics and kinetics of coupled folding-binding. , 2008, Journal of molecular biology.
[43] M. Uhlén,et al. A combinatorial library of an alpha-helical bacterial receptor domain. , 1995, Protein engineering.
[44] S. Lindström,et al. Selection and characterization of Affibody ligands binding to Alzheimer amyloid beta peptides. , 2007, Journal of biotechnology.
[45] L. Abrahmsén,et al. Design, synthesis and biological evaluation of a multifunctional HER2-specific Affibody molecule for molecular imaging , 2009, European Journal of Nuclear Medicine and Molecular Imaging.
[46] J. Danielsson,et al. 15N relaxation study of the amyloid β‐peptide: structural propensities and persistence length , 2006, Magnetic resonance in chemistry : MRC.