An automated early diabetic retinopathy detection through improved blood vessel and optic disc segmentation

Abstract This paper presents an automated early diabetic retinopathy detection scheme from color fundus images through improved segmentation strategies for optic disc and blood vessels. The red lesions, microaneurysms and hemorrhages are the earliest signs of diabetic retinopathy. This paper essentially proposes improved techniques for microaneurysm as well as hemorrhages detection, which eventually contribute in the overall improvement in the early detection of diabetic retinopathy. The proposed method consists of five stages- pre-processing, detection of blood vessels, segmentation of optic disc, localization of fovea, feature extraction and classification. Mathematical morphology operation is used for pre-processing and blood vessel detection. Watershed transform is used for optic disc segmentation. The main contribution of this model is to propose an improved blood vessel and optic disc segmentation methods. Radial basis function neural network is used for classification of the diseases. The parameters of radial basis function neural network are trained by the features of microaneurysm and hemorrhages. The accuracy of the proposed algorithm is evaluated based on sensitivity and specificity, which are 87% and 93% respectively.

[1]  Edward R. Dougherty,et al.  Hands-on Morphological Image Processing , 2003 .

[2]  Jamshid Dehmeshki,et al.  Automated detection of proliferative diabetic retinopathy using a modified line operator and dual classification , 2014, Comput. Methods Programs Biomed..

[3]  José Manuel Bravo,et al.  Obtaining optic disc center and pixel region by automatic thresholding methods on morphologically processed fundus images , 2015, Comput. Methods Programs Biomed..

[4]  Elisa Ricci,et al.  Retinal Blood Vessel Segmentation Using Line Operators and Support Vector Classification , 2007, IEEE Transactions on Medical Imaging.

[5]  Hadi Seyedarabi,et al.  A Comparative Study on Preprocessing Techniques in Diabetic Retinopathy Retinal Images: Illumination Correction and Contrast Enhancement , 2015, Journal of medical signals and sensors.

[6]  V. Thirilogasundari,et al.  Fuzzy Based Salt and Pepper Noise Removal Using Adaptive Switching Median Filter , 2012 .

[7]  Bart M. ter Haar Romeny,et al.  Retinal Microaneurysms Detection Using Local Convergence Index Features , 2017, IEEE Transactions on Image Processing.

[8]  R. Radha,et al.  Identification of Retinal Image Features Using Bitplane Separation and Mathematical Morphology , 2014, 2014 World Congress on Computing and Communication Technologies.

[9]  Basant Kumar,et al.  Diabetic Retinopathy Detection by Extracting Area and Number of Microaneurysm from Colour Fundus Image , 2018, 2018 5th International Conference on Signal Processing and Integrated Networks (SPIN).

[10]  Peter F. Sharp,et al.  Automated microaneurysm detection using local contrast normalization and local vessel detection , 2006, IEEE Transactions on Medical Imaging.

[11]  Ayyaz Hussain,et al.  A new cluster based adaptive fuzzy switching median filter for impulse noise removal , 2017, Multimedia Tools and Applications.

[13]  Jacob Scharcanski,et al.  Segmentation of the optic disk in color eye fundus images using an adaptive morphological approach , 2010, Comput. Biol. Medicine.

[14]  K. Parvati,et al.  Image Segmentation Using Gray-Scale Morphology and Marker-Controlled Watershed Transformation , 2008 .

[15]  Lin Li,et al.  Microaneurysm Detection Using Principal Component Analysis and Machine Learning Methods , 2018, IEEE Transactions on NanoBioscience.

[16]  Vasile Palade,et al.  Automatic screening and classification of diabetic retinopathy and maculopathy using fuzzy image processing , 2016, Brain Informatics.

[17]  John R. Anderson,et al.  MACHINE LEARNING An Artificial Intelligence Approach , 2009 .

[18]  Vasile Palade,et al.  Automatic detection of microaneurysms in colour fundus images for diabetic retinopathy screening , 2015, Neural Computing and Applications.

[19]  Rajiv Gupta,et al.  Comparative analysis of fundus image enhancement in detection of diabetic retinopathy , 2016, 2016 IEEE Region 10 Humanitarian Technology Conference (R10-HTC).

[20]  Dennis P. Han,et al.  Proliferative Diabetic Retinopathy , 2004, International ophthalmology clinics.

[21]  Qin Li,et al.  Retinopathy Online Challenge: Automatic Detection of Microaneurysms in Digital Color Fundus Photographs , 2010, IEEE Transactions on Medical Imaging.

[22]  Vasile Palade,et al.  Automatic Screening and Classification of Diabetic Retinopathy Fundus Images , 2014, EANN.

[23]  Pierre Soille,et al.  Mathematical Morphology and Its Applications to Image Processing , 1994, Computational Imaging and Vision.

[24]  Daniel Welfer,et al.  AUTOMATIC DETECTION OF MICROANEURYSMS AND HEMORRHAGES IN COLOR EYE FUNDUS IMAGES , 2013 .

[25]  Farida Cheriet,et al.  Red Lesion Detection Using Dynamic Shape Features for Diabetic Retinopathy Screening , 2016, IEEE Transactions on Medical Imaging.

[26]  Ho Chul Kang,et al.  A Study on Hemorrhage Detection Using Hybrid Method in Fundus Images , 2011, Journal of Digital Imaging.

[27]  Sharib Ali,et al.  Automated detection of microaneurysms using scale-adapted blob analysis and semi-supervised learning , 2014, Comput. Methods Programs Biomed..

[28]  Pascale Massin,et al.  A contribution of image processing to the diagnosis of diabetic retinopathy-detection of exudates in color fundus images of the human retina , 2002, IEEE Transactions on Medical Imaging.

[29]  Jacques Wainer,et al.  Beyond Lesion-Based Diabetic Retinopathy: A Direct Approach for Referral , 2017, IEEE Journal of Biomedical and Health Informatics.

[30]  O. Nelles Nonlinear System Identification: From Classical Approaches to Neural Networks and Fuzzy Models , 2000 .

[31]  Christopher M. Bishop,et al.  Neural networks for pattern recognition , 1995 .