The reduction of environmental burdens is required in recent years to mitigate global warming, ozone layer depletion and etc. in manufacturing fields. Hence, prediction system of environmental burden for machining operation has been developed so far. Hence, the evaluation indicator for eco-efficiency of process and operation planning is also proposed with considering the environmental burden, manufacturing time and total number of work piece setup times in this research. Global warming is selected as impact category and the feasibility of the developed system and evaluation indicator for eco-efficiency is demonstrated in this paper.