Possible role of increased brain methylation in methionine sulfoximine epileptogenesis: Effects of administration of adenosine and homocysteine thiolactone

An intraventricular pulse of [14COOH]L‐methionine to mice pretreated with the convulsant L‐methionine‐dl‐sulfoximine (MSO) resulted in significantly higher than control specific radioactivity values of cerebral [14COOH]L‐methionine (Met), [14COOH]S‐adenosyl‐L‐methionine (AdoMet) and [14COOH]S‐adenosyl‐L‐homocysteine (AdoHcy). MSO administration (3 hr) also decreased brain steady‐state levels of Met, AdoMet, and AdoHcy.

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