Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model

[1]  E. Schwarz,et al.  Ex vivo Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels From TNF-Transgenic Mice With Inflammatory Arthritis , 2021, Frontiers in Physiology.

[2]  S. Raychaudhuri,et al.  IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation , 2021, Genome medicine.

[3]  C. Halin,et al.  Lymphatic endothelial-cell expressed ACKR3 is dispensable for postnatal lymphangiogenesis and lymphatic drainage function in mice , 2021, PloS one.

[4]  B. Kamińska,et al.  Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages , 2021, Nature Communications.

[5]  E. Schwarz,et al.  Lineage tracing reveals evidence of a popliteal lymphatic muscle progenitor cell that is distinct from skeletal and vascular muscle progenitors , 2020, Scientific Reports.

[6]  Raphael Gottardo,et al.  Integrated analysis of multimodal single-cell data , 2020, Cell.

[7]  J. Coselli,et al.  Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic Tissue , 2020, Circulation.

[8]  E. Schwarz,et al.  Ex vivo Demonstration of Functional Deficiencies in Popliteal Lymphatic Vessels from TNF-Tg Mice with Inflammatory Arthritis , 2020 .

[9]  E. Schwarz,et al.  Lymphatic muscle cells contribute to dysfunction of the synovial lymphatic system in inflammatory arthritis in mice , 2020, Arthritis Research & Therapy.

[10]  O. Troyanskaya,et al.  RNA Identification of PRIME Cells Predicting Rheumatoid Arthritis Flares. , 2020, The New England journal of medicine.

[11]  T. Otto,et al.  Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis , 2020, Nature Medicine.

[12]  Sarit Pal,et al.  Emerging Roles of Mast Cells in the Regulation of Lymphatic Immuno-Physiology , 2020, Frontiers in Immunology.

[13]  E. Schwarz,et al.  Altered Lymphatic Vessel Anatomy and Markedly Diminished Lymph Clearance in Affected Hands of Patients With Active Rheumatoid Arthritis , 2020, Arthritis & rheumatology.

[14]  N. Hacohen,et al.  Notch signaling drives synovial fibroblast identity and arthritis pathology , 2020, Nature.

[15]  Gary A. Churchill,et al.  Bayesian model selection reveals biological origins of zero inflation in single-cell transcriptomics , 2020, Genome Biology.

[16]  E. Schwarz,et al.  iNOS dependent and independent phases of lymph node expansion in mice with TNF-induced inflammatory-erosive arthritis , 2019, Arthritis Research & Therapy.

[17]  R. Irizarry.  ggplot2 , 2019, Introduction to Data Science.

[18]  E. Schwarz,et al.  Selective Sexual Dimorphisms in Musculoskeletal and Cardiopulmonary Pathologic Manifestations and Mortality Incidence in the Tumor Necrosis Factor–Transgenic Mouse Model of Rheumatoid Arthritis , 2019, Arthritis & rheumatology.

[19]  J. Schultze,et al.  Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases , 2019, Front. Immunol..

[20]  Ju Liu,et al.  Pathophysiology of aged lymphatic vessels , 2019, Aging.

[21]  C. Buckley.  Macrophages form a protective cellular barrier in joints , 2019, Nature.

[22]  Paul J. Hoffman,et al.  Comprehensive Integration of Single-Cell Data , 2018, Cell.

[23]  S. Raychaudhuri,et al.  Distinct fibroblast subsets drive inflammation and damage in arthritis , 2019, Nature.

[24]  Xianwen Ren,et al.  Direct Comparative Analyses of 10X Genomics Chromium and Smart-seq2 , 2019, bioRxiv.

[25]  Kamil Slowikowski,et al.  Tubular Cell and Keratinocyte Single-cell Transcriptomics Applied to Lupus Nephritis Reveal Type I IFN and Fibrosis Relevant Pathways , 2019, Nature Immunology.

[26]  Qing Nie,et al.  Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds , 2019, Nature Communications.

[27]  M. Bennett,et al.  Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels , 2018, Nature Communications.

[28]  Ying Sun,et al.  Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types , 2018, Scientific Data.

[29]  Jun Kit Wang,et al.  Hyaluronan Receptor LYVE‐1‐Expressing Macrophages Maintain Arterial Tone through Hyaluronan‐Mediated Regulation of Smooth Muscle Cell Collagen , 2018, Immunity.

[30]  N. Hacohen,et al.  Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry , 2018, bioRxiv.

[31]  Paul Hoffman,et al.  Integrating single-cell transcriptomic data across different conditions, technologies, and species , 2018, Nature Biotechnology.

[32]  Nir Hacohen,et al.  Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis , 2018, Nature Communications.

[33]  Koji Ando,et al.  A molecular atlas of cell types and zonation in the brain vasculature , 2018, Nature.

[34]  Leland McInnes,et al.  UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction , 2018, ArXiv.

[35]  R. N. Mitra,et al.  A Naturally Fluorescent Mgp Transgenic Mouse for Angiogenesis and Glaucoma Longitudinal Studies , 2018, Investigative ophthalmology & visual science.

[36]  Eelco F. J. Meijer,et al.  Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction , 2018, Science Translational Medicine.

[37]  E. Schwarz,et al.  Targeting lymphatic function as a novel therapeutic intervention for rheumatoid arthritis , 2018, Nature Reviews Rheumatology.

[38]  Publisher's Note , 2018, Anaesthesia.

[39]  C. Betsholtz,et al.  Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity , 2017, Development.

[40]  Chyuan-Sheng Lin,et al.  PDGFRβ-P2A-CreERT2 mice: a genetic tool to target pericytes in angiogenesis , 2017, Angiogenesis.

[41]  J. Thomson,et al.  Specification and Diversification of Pericytes and Smooth Muscle Cells from Mesenchymoangioblasts , 2017, Cell reports.

[42]  E. Schwarz,et al.  Brief Report: Treatment of Tumor Necrosis Factor–Transgenic Mice With Anti–Tumor Necrosis Factor Restores Lymphatic Contractions, Repairs Lymphatic Vessels, and May Increase Monocyte/Macrophage Egress , 2017, Arthritis & rheumatology.

[43]  Katherine A. Gallagher,et al.  Enhancement of macrophage inflammatory responses by CCL2 is correlated with increased miR-9 expression and downregulation of the ERK1/2 phosphatase Dusp6. , 2017, Cellular immunology.

[44]  T. Sasho,et al.  Increased DNA Methylation and Reduced Expression of Transcription Factors in Human Osteoarthritis Cartilage , 2016, Arthritis & rheumatology.

[45]  E. Schwarz,et al.  Lymphatic endothelial cells efferent to inflamed joints produce iNOS and inhibit lymphatic vessel contraction and drainage in TNF-induced arthritis in mice , 2016, Arthritis Research & Therapy.

[46]  M. Nussenzweig,et al.  Collecting Lymphatic Vessel Permeability Facilitates Adipose Tissue Inflammation and Distribution of Antigen to Lymph Node–Homing Adipose Tissue Dendritic Cells , 2015, The Journal of Immunology.

[47]  D. Cornfield,et al.  Pulmonary artery smooth muscle cell endothelin-1 expression modulates the pulmonary vascular response to chronic hypoxia. , 2015, American journal of physiology. Lung cellular and molecular physiology.

[48]  A. Regev,et al.  Spatial reconstruction of single-cell gene expression , 2015, Nature Biotechnology.

[49]  J. Li,et al.  The role of the lymphatic system in inflammatory-erosive arthritis. , 2015, Seminars in cell & developmental biology.

[50]  E. Neumann,et al.  Role of synovial fibroblasts in rheumatoid arthritis. , 2014, Current pharmaceutical design.

[51]  J. Scallan,et al.  Itching for Answers: How Histamine Relaxes Lymphatic Vessels , 2014, Microcirculation.

[52]  G. Firestein.  The disease formerly known as rheumatoid arthritis , 2014, Arthritis Research & Therapy.

[53]  E. Schwarz,et al.  Power Doppler Ultrasound Phenotyping of Expanding versus Collapsed Popliteal Lymph Nodes in Murine Inflammatory Arthritis , 2013, PloS one.

[54]  R. Kalluri,et al.  Origin and function of myofibroblasts in kidney fibrosis , 2013, Nature Medicine.

[55]  P. Tak,et al.  Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. , 2012, Journal of immunological methods.

[56]  Douglas J Adams,et al.  In Vivo Fate Mapping Identifies Mesenchymal Progenitor Cells , 2011, Stem cells.

[57]  Dai Fukumura,et al.  Impaired lymphatic contraction associated with immunosuppression , 2011, Proceedings of the National Academy of Sciences.

[58]  J. Li,et al.  CD23+/CD21hi B-cell translocation and ipsilateral lymph node collapse is associated with asymmetric arthritic flare in TNF-Tg mice , 2011, Arthritis research & therapy.

[59]  M. Volin,et al.  Characterization of CCL19 and CCL21 in rheumatoid arthritis. , 2011, Arthritis and rheumatism.

[60]  William Lehman,et al.  Tropomyosin variants describe distinct functional subcellular domains in differentiated vascular smooth muscle cells. , 2011, American journal of physiology. Cell physiology.

[61]  Pedro M. Valero-Mora,et al.  ggplot2: Elegant Graphics for Data Analysis , 2010 .

[62]  J. Li,et al.  Expanded CD23+/CD21hi B Cells in Inflamed Lymph Nodes Are Associated with the Onset of Inflammatory-Erosive Arthritis in TNF-Transgenic Mice and Are Targets of Anti-CD20 Therapy , 2010, The Journal of Immunology.

[63]  Allan R. Jones,et al.  A robust and high-throughput Cre reporting and characterization system for the whole mouse brain , 2009, Nature Neuroscience.

[64]  M. O. Papuga,et al.  Longitudinal assessment of synovial, lymph node, and bone volumes in inflammatory arthritis in mice by in vivo magnetic resonance imaging and microfocal computed tomography. , 2007, Arthritis and rheumatism.

[65]  A. Billiau,et al.  Pro-inflammatory properties of stromal cell-derived factor-1 (CXCL12) in collagen-induced arthritis , 2005, Arthritis research & therapy.

[66]  Véronique Lefebvre,et al.  The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. , 2005, The Journal of clinical investigation.

[67]  David C Zawieja,et al.  Lymphatic smooth muscle: the motor unit of lymph drainage. , 2004, The international journal of biochemistry & cell biology.

[68]  H. Sasamura,et al.  Extracellular Matrix Glycoprotein Biglycan Enhances Vascular Smooth Muscle Cell Proliferation and Migration , 2004, Circulation research.

[69]  E. Schwarz,et al.  The TNF-α transgenic mouse model of inflammatory arthritis , 2003, Springer Seminars in Immunopathology.

[70]  G. Owens,et al.  Combinatorial Control of Smooth Muscle–Specific Gene Expression , 2003, Arteriosclerosis, thrombosis, and vascular biology.

[71]  David Zawieja,et al.  Molecular and functional analyses of the contractile apparatus in lymphatic muscle , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[72]  M. Karkkainen,et al.  The Specificity of Receptor Binding by Vascular Endothelial Growth Factor-D Is Different in Mouse and Man* , 2001, The Journal of Biological Chemistry.

[73]  P. Libby,et al.  Cystatin C deficiency in human atherosclerosis and aortic aneurysms. , 1999, The Journal of clinical investigation.

[74]  C. Betsholtz,et al.  Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. , 1999, Development.

[75]  L. Matrisian,et al.  Measurement of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Blood and Tissues: Clinical and Experimental Applications , 1999, Annals of the New York Academy of Sciences.

[76]  I. Fraser,et al.  Structural interactions between actin, tropomyosin, caldesmon and calcium binding protein and the regulation of smooth muscle thin filaments. , 1998, Acta physiologica Scandinavica.

[77]  P L Weissberg,et al.  Smooth muscle cell heterogeneity: patterns of gene expression in vascular smooth muscle cells in vitro and in vivo. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[78]  K. Alitalo,et al.  Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[79]  R. Behringer,et al.  Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein , 1997, Nature.

[80]  G. Owens,et al.  Regulation of differentiation of vascular smooth muscle cells. , 1995, Physiological reviews.

[81]  M. Ferguson,et al.  Smooth muscle cell expression of extracellular matrix genes after arterial injury. , 1994, The American journal of pathology.

[82]  J. Li,et al.  Efficacy of B cell depletion therapy for murine joint arthritis flare is associated with increased lymphatic flow. , 2013, Arthritis and rheumatism.

[83]  E. Schwarz,et al.  The TNF-alpha transgenic mouse model of inflammatory arthritis. , 2003, Springer seminars in immunopathology.

[84]  G. Kollias,et al.  Transgenic and knockout analyses of the role of TNF in immune regulation and disease pathogenesis. , 1995, Journal of inflammation.

[85]  J. Winer,et al.  Aortic smooth muscle cells express and secrete vascular endothelial growth factor. , 1991, Growth factors.