Identification and proposed mechanism of action of thymidine kinase inhibition associated with cellular exposure to camptothecin analogs

[1]  Y. Pommier,et al.  Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. , 1998, Biochimica et biophysica acta.

[2]  S. Arbuck,et al.  Clinical applications of the camptothecins. , 1998, Biochimica et biophysica acta.

[3]  C. Erlichman,et al.  Effect of adding the topoisomerase I poison 7-ethyl-10-hydroxycamptothecin (SN-38) to 5-fluorouracil and folinic acid in HCT-8 cells: elevated dTTP pools and enhanced cytotoxicity , 1998, Cancer Chemotherapy and Pharmacology.

[4]  J. Grem,et al.  Modulation of fluorouracil cytotoxicity by interferon-alpha and -gamma. , 1998, Molecular pharmacology.

[5]  G. S. Johnson,et al.  An Information-Intensive Approach to the Molecular Pharmacology of Cancer , 1997, Science.

[6]  J. Grem,et al.  Cytotoxicity and DNA damage associated with pyrazoloacridine in MCF-7 breast cancer cells. , 1996, Biochemical pharmacology.

[7]  Y. Pommier Eukaryotic DNA topoisomerase I: genome gatekeeper and its intruders, camptothecins. , 1996, Seminars in oncology.

[8]  S. Steinberg,et al.  Determinants of sensitivity to 1-beta-D-arabinofuranosylcytosine in HCT 116 and NCI-H630 human colon carcinoma cells. , 1995, Molecular pharmacology.

[9]  D. Hedley,et al.  Effects of thymidylate synthase inhibition on thymidine kinase activity and nucleoside transporter expression. , 1995, Cancer research.

[10]  Y. Pommier,et al.  Mutation at the catalytic site of topoisomerase I in CEM/C2, a human leukemia cell line resistant to camptothecin. , 1995, Cancer research.

[11]  K W Kohn,et al.  Unscheduled activation of cyclin B1/Cdc2 kinase in human promyelocytic leukemia cell line HL60 cells undergoing apoptosis induced by DNA damage. , 1995, Cancer research.

[12]  W. Plunkett,et al.  Regulation of thymidine kinase and thymidylate synthase in intact human lymphoblast CCRF-CEM cells. , 1993, The Journal of biological chemistry.

[13]  G. Maley,et al.  Identification of an RNA binding site for human thymidylate synthase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[14]  D. Corbeil,et al.  Polarized distribution of neutral endopeptidase 24.11 at the cell surface of cultured human intestinal epithelial Caco-2 cells. , 1992, The Biochemical journal.

[15]  M. Black,et al.  A single amino acid substitution abolishes feedback inhibition of vaccinia virus thymidine kinase. , 1992, The Journal of biological chemistry.

[16]  R. Fager,et al.  Allosteric interaction of components of the replitase complex is responsible for enzyme cross-inhibition. , 1990, Molecular pharmacology.

[17]  Y. Pommier,et al.  Differential requirement of DNA replication for the cytotoxicity of DNA topoisomerase I and II inhibitors in Chinese hamster DC3F cells. , 1989, Cancer research.

[18]  K. Kohn,et al.  Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I. , 1989, Cancer research.

[19]  J. A. Fyfe,et al.  Enzymatic assay for deoxyribonucleoside triphosphates using synthetic oligonucleotides as template primers. , 1989, Analytical biochemistry.

[20]  D. Rodbard,et al.  Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. , 1985, The Journal of biological chemistry.

[21]  J. Yalowich,et al.  Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro. , 1985, Biochemical pharmacology.

[22]  A. Pardee,et al.  Multienzyme complex for metabolic channeling in mammalian DNA replication. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[23]  E. Bresnick,et al.  END-PRODUCT INHIBITION OF THYMIDINE KINASE ACTIVITY IN NORMAL AND LEUKEMIC HUMAN LEUKOCYTES. , 1964, Cancer research.

[24]  Y. Pommier,et al.  Silencing and selective methylation of the normal topoisomerase I gene in camptothecin-resistant CEM/C2 human leukemia cells. , 1996, Oncology research.

[25]  L. Liu,et al.  DNA topoisomerases: essential enzymes and lethal targets. , 1994, Annual review of pharmacology and toxicology.

[26]  R. Fager,et al.  Replitase: a complex integrating dNTP synthesis and DNA replication. , 1993, Critical reviews in eukaryotic gene expression.

[27]  Reddy Gp,et al.  Replitase: a complex integrating dNTP synthesis and DNA replication. , 1993 .

[28]  M. Friedkin Thymidylate synthetase. , 1973, Advances in enzymology and related areas of molecular biology.

[29]  D. Ives,et al.  Rapid determination of nucleoside kinase and nucleotidase activities with tritium-labeled substrates. , 1969, Analytical biochemistry.

[30]  T. Breitman,et al.  The feedback inhibition of thymidine kinase. , 1963, Biochimica et biophysica acta.