Longitudinal Grey and White Matter Changes in Frontotemporal Dementia and Alzheimer’s Disease

Behavioural variant frontotemporal dementia (bvFTD) and Alzheimer’s disease (AD) dementia are characterised by progressive brain atrophy. Longitudinal MRI volumetry may help to characterise ongoing structural degeneration and support the differential diagnosis of dementia subtypes. Automated, observer-independent atlas-based MRI volumetry was applied to analyse 102 MRI data sets from 15 bvFTD, 14 AD, and 10 healthy elderly control participants with consecutive scans over at least 12 months. Anatomically defined targets were chosen a priori as brain structures of interest. Groups were compared regarding volumes at clinic presentation and annual change rates. Baseline volumes, especially of grey matter compartments, were significantly reduced in bvFTD and AD patients. Grey matter volumes of the caudate and the gyrus rectus were significantly smaller in bvFTD than AD. The bvFTD group could be separated from AD on the basis of caudate volume with high accuracy (79% cases correct). Annual volume decline was markedly larger in bvFTD and AD than controls, predominantly in white matter of temporal structures. Decline in grey matter volume of the lateral orbitofrontal gyrus separated bvFTD from AD and controls. Automated longitudinal MRI volumetry discriminates bvFTD from AD. In particular, greater reduction of orbitofrontal grey matter and temporal white matter structures after 12 months is indicative of bvFTD.

[1]  Marina Boccardi,et al.  The MRI pattern of frontal and temporal brain atrophy in fronto-temporal dementia , 2003, Neurobiology of Aging.

[2]  M. Weiner,et al.  Longitudinal Rates of Lobar Atrophy in Frontotemporal Dementia, Semantic Dementia, and Alzheimer's Disease , 2010, Alzheimer disease and associated disorders.

[3]  Guy B. Williams,et al.  Development of an MRI rating scale for multiple brain regions: comparison with volumetrics and with voxel-based morphometry , 2009, Neuroradiology.

[4]  Michael Hornberger,et al.  In vivo and post-mortem memory circuit integrity in frontotemporal dementia and Alzheimer's disease. , 2012, Brain : a journal of neurology.

[5]  J. Morris,et al.  The Cortical Signature of Alzheimer's Disease: Regionally Specific Cortical Thinning Relates to Symptom Severity in Very Mild to Mild AD Dementia and is Detectable in Asymptomatic Amyloid-Positive Individuals , 2008, Cerebral cortex.

[6]  Guy B. Williams,et al.  Patterns of Frontal Lobe Atrophy in Frontotemporal Dementia: A Volumetric MRI Study , 2006, Dementia and Geriatric Cognitive Disorders.

[7]  Nick C Fox,et al.  Rates of global and regional cerebral atrophy in AD and frontotemporal dementia , 2001, Neurology.

[8]  Sandra E. Black,et al.  Magnetic Resonance Imaging in Frontotemporal Dementia Shows Subcortical Atrophy , 2008, Dementia and Geriatric Cognitive Disorders.

[9]  Nathaniel Mercaldo,et al.  Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. , 2008, Brain : a journal of neurology.

[10]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[11]  Maria Luisa Gorno-Tempini,et al.  Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia. , 2008, Archives of neurology.

[12]  Karl J. Friston,et al.  Voxel-Based Morphometry—The Methods , 2000, NeuroImage.

[13]  Michael Hornberger,et al.  Fronto-striatal atrophy correlates of neuropsychiatric dysfunction in frontotemporal dementia (FTD) and Alzheimer's disease (AD) , 2013, Dementia & neuropsychologia.

[14]  J. Hodges,et al.  Sensitivity of current criteria for the diagnosis of behavioral variant frontotemporal dementia , 2009, Neurology.

[15]  R. Faber,et al.  Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. , 1999, Neurology.

[16]  M. Hornberger,et al.  Orbitofrontal Dysfunction Discriminates Behavioral Variant Frontotemporal Dementia from Alzheimer’s Disease , 2011, Dementia and Geriatric Cognitive Disorders.

[17]  Nick C Fox,et al.  Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. , 2011, Brain : a journal of neurology.

[18]  John R Hodges,et al.  The Addenbrooke's Cognitive Examination Revised (ACE‐R): a brief cognitive test battery for dementia screening , 2006, International journal of geriatric psychiatry.

[19]  L. Wahlund,et al.  Caudate Nucleus Volumes in Frontotemporal Lobar Degeneration: Differential Atrophy in Subtypes , 2008, American Journal of Neuroradiology.

[20]  J. Hodges,et al.  Grey and White Matter Changes across the Amyotrophic Lateral Sclerosis-Frontotemporal Dementia Continuum , 2012, PloS one.

[21]  X. Wu,et al.  Individual patient diagnosis of AD and FTD via high-dimensional pattern classification of MRI , 2008, NeuroImage.

[22]  S. Resnick,et al.  Longitudinal Magnetic Resonance Imaging Studies of Older Adults: A Shrinking Brain , 2003, The Journal of Neuroscience.

[23]  Clifford R Jack,et al.  Rates of cerebral atrophy differ in different degenerative pathologies. , 2006, Brain : a journal of neurology.

[24]  Sandra E. Black,et al.  Topographical Patterns of Lobar Atrophy in Frontotemporal Dementia and Alzheimer’s Disease , 2006, Dementia and Geriatric Cognitive Disorders.

[25]  Nick C Fox,et al.  Revising the definition of Alzheimer's disease: a new lexicon , 2010, The Lancet Neurology.

[26]  Stefan Klöppel,et al.  Intra- and interscanner variability of automated voxel-based volumetry based on a 3D probabilistic atlas of human cerebral structures , 2010, NeuroImage.

[27]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[28]  John Geng,et al.  Convergent grey and white matter evidence of orbitofrontal cortex changes related to disinhibition in behavioural variant frontotemporal dementia. , 2011, Brain : a journal of neurology.

[29]  R. Buckner,et al.  Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD , 2005, Neurology.

[30]  Michael Hornberger,et al.  Fronto-striatal atrophy correlates of inhibitory dysfunction in Parkinson's disease versus behavioural variant frontotemporal dementia , 2013, Cortex.

[31]  Philip Scheltens,et al.  Episodic memory and the medial temporal lobe: not all it seems. Evidence from the temporal variants of frontotemporal dementia , 2012, Journal of Neurology, Neurosurgery & Psychiatry.

[32]  N. Schuff,et al.  Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia. , 2006, Brain : a journal of neurology.

[33]  B L Miller,et al.  Patterns of brain atrophy in frontotemporal dementia and semantic dementia , 2002, Neurology.

[34]  M Filippi,et al.  Whole brain structural changes predict the mild cognitive impairment to Alzheimer's disease conversion: Evidence from the Alzheimer's Disease Neuroimaging Initiative , 2011, Alzheimer's & Dementia.

[35]  M. Hornberger,et al.  Clinical Staging and Disease Progression in Frontotemporal Dementia Supplemental Data at Www.neurology.org , 2022 .

[36]  Cornelius Weiller,et al.  Quantifying change in individual subjects affected by frontotemporal lobar degeneration using automated longitudinal MRI volumetry , 2012, Human brain mapping.

[37]  Charles DeCarli,et al.  Diagnostic Criteria for the Behavioral Variant of Frontotemporal Dementia (bvFTD): Current Limitations and Future Directions , 2007, Alzheimer disease and associated disorders.

[38]  J R Hodges,et al.  Retrosplenial cortex (BA 29/30) hypometabolism in mild cognitive impairment (prodromal Alzheimer's disease) , 2003, The European journal of neuroscience.

[39]  J. Hodges,et al.  Impaired acquisition rates of probabilistic associative learning in frontotemporal dementia is associated with fronto-striatal atrophy☆ , 2012, NeuroImage: Clinical.

[40]  J R Hodges,et al.  The prevalence of frontotemporal dementia , 2002, Neurology.

[41]  J. Hodges,et al.  Staging disease severity in pathologically confirmed cases of frontotemporal dementia , 2003, Neurology.

[42]  A. Burns.  Clinical diagnosis of Alzheimer's disease , 1991 .