Periorbital swelling: the important distinction between allergy and infection

Orbital cellulitis and abscess formation are rare complications of sinusitis, however acute orbital inflammation is secondary to sinusitis in about 70% of cases. Delay in diagnosis must not occur to avoid serious complications such as blindness and life threatening intracranial sepsis. A case is reported in which despite late referral, emergency surgical intervention was sight saving. The case is described of an occurrence of Ludwig’s angina with advanced stage of the disease with progressive and rapid airway compromise and fatal consequence. A review of the literature is undertaken to gain a better understanding of the disease, and gives the opportunity for presenting a summary of the key issues regarding this dreaded disease, particularly the immediate management of it in the emergency department. This paper reports a case of meningococcal septicaemia. This case shows that normal investigations may provide the unwary clinician with an unfounded reassurance when dealing with children with this serious infection. The use of gamma hydroxybutyrate (GHB) as a recreational drug has quickly spread among European young people during the past decade. Although it has been claimed that GHB can be potentially used to facilitate sexual assault, no case reports have been previously described. A case is described in which GHB was used with that criminal purpose and a review of previous literature is undertaken. Early identification of abdominal aortic aneurysms in some patients can be difficult and the diagnosis is missed in up to 30% of patients. Ultrasound cannot be used to identify a leak, but the presence of an aneurysm in an unstable patient is conclusive. With minimal training emergency physicians can easily identify the aorta and thus in the early phase of resuscitation an aneurysm can be confidently excluded. The purpose of the examination is not to delineate the extent of the aneurysm, but to identify those patients that will need emergency surgery. A series of patients presented to the department in an unstable condition with equivocal abdominal signs. An ultrasound scan in the resuscitation room by members of the emergency department revealed an aneurysm, which was enough to convince the vascular surgeons to take the patient straight to theatre with good results. In patients who are stable, computed tomography will continue to be used to evaluate the extent of the aneurysm and identify a leak. Suicidal ingestions of fireworks containing yellow phosphorus occur often during holidays. A case is reported of a 17 year old woman who intentionally ingested an estimated amount of 5.5 mg of yellow phosphorus, presenting with upper abdominal pain as the only complaint, a physical examination was normal. Blood tests showed a considerable decrease in the granulocyte count; the bone marrow biopsy revealed a decreased cellular mass with degenerative changes. Spontaneous remission was observed during the next 48 hours, with no further complaints. Delayed herniation of the abdominal contents through a congenital diaphragmatic hernia may occur beyond the neonatal period. The case is reported of a 9 month old child presenting with acute respiratory distress secondary to tension gastrothorax. The chest radiograph showed a tension gastrothorax. Nasogastric tube placement confirmed herniation of the stomach into the left chest and is the initial treatment of choice when a tension gastrothorax is identified. The late presenting congenital diaphragmatic hernia poses considerable diagnostic challenges often leading to misdiagnosis and risk of thoracocentesis. The possibility of late presenting congenital diaphragmatic hernia should be considered in unusual cases of pneumothorax, especially in the absence of trauma so that unnecessary procedures like chest tube drainage can be avoided. The case of an elderly man with priapism as his only symptom is presented. The importance of clinical signs and simple investigations to make a diagnosis of aortocaval fistula associated with abdominal aortic aneurysm are discussed.

[1]  A. Tonks Treating generalised anxiety disorder. , 2003, BMJ : British Medical Journal.

[2]  M. Harper,et al.  Utility of the peripheral blood white blood cell count for identifying sick young infants who need lumbar puncture. , 2003, Annals of emergency medicine.

[3]  R. Woods,et al.  Factors other than the Duke criteria associated with infective endocarditis among injection drug users. , 2002, Clinical and investigative medicine. Medecine clinique et experimentale.

[4]  Bruno Hoen,et al.  Changing profile of infective endocarditis: results of a 1-year survey in France. , 2002, JAMA.

[5]  R. Swanton,et al.  Mortality from infective endocarditis: clinical predictors of outcome , 2002, Heart.

[6]  Y. Ha,et al.  Diffusion-weighted MRI as a screening tool of stroke in the ED. , 2002, The American journal of emergency medicine.

[7]  I. Choi Parkinsonism after Carbon Monoxide Poisoning , 2002, European Neurology.

[8]  B. Hoen Special issues in the management of infective endocarditis caused by gram-positive cocci. , 2002, Infectious disease clinics of North America.

[9]  Vance G Fowler,et al.  Changing patient characteristics and the effect on mortality in endocarditis. , 2002, Archives of internal medicine.

[10]  Ò. Miró,et al.  Trends in Illicit Drug Emergencies: The Emerging Role of Gamma-Hydroxybutyrate , 2002, Journal of toxicology. Clinical toxicology.

[11]  A. Parhiscar,et al.  Deep Neck Abscess: A Retrospective Review of 210 Cases , 2001, The Annals of otology, rhinology, and laryngology.

[12]  W. Crumb,et al.  Effects of cocaine and its major metabolites on the HERG-encoded potassium channel. , 2001, The Journal of pharmacology and experimental therapeutics.

[13]  R. Steele,et al.  Medical management of orbital cellulitis , 2001, The Pediatric infectious disease journal.

[14]  M. A. Fernández,et al.  Infective Endocarditis—A Prospective Study at the End of the Twentieth Century: New Predisposing Conditions, New Etiologic Agents, and Still a High Mortality , 2001, Medicine.

[15]  I. Khan,et al.  Cocaine-induced torsades de pointes in idiopathic long Q-T syndrome. , 2001, American journal of therapeutics.

[16]  O. Miró,et al.  Intoxicación por éxtasis líquido: estudio de 22 casos , 2001 .

[17]  M. Caminiti,et al.  A rare complication of tooth abscess--Ludwig's angina and mediastinitis. , 2001, Journal.

[18]  H. Eufinger,et al.  Purulent pansinusitis, orbital cellulitis and rhinogenic intracranial complications. , 2001, Journal of maxillofacial surgery.

[19]  Stephen W. Smith,et al.  Adverse events, including death, associated with the use of 1,4-butanediol. , 2001, The New England journal of medicine.

[20]  L. Bielory Allergic and immunologic disorders of the eye. Part II: ocular allergy. , 2000, The Journal of allergy and clinical immunology.

[21]  Jun Chen,et al.  A structural basis for drug-induced long QT syndrome. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[22]  S. Langlois,et al.  Emergency department ultrasound scanning for abdominal aortic aneurysm: accessible, accurate, and advantageous. , 2000, Annals of emergency medicine.

[23]  J. Kim,et al.  The brain lesion responsible for parkinsonism after carbon monoxide poisoning. , 2000, Archives of neurology.

[24]  R. Schwartz,et al.  Drug-facilitated sexual assault ('date rape'). , 2000, Southern medical journal.

[25]  V. Biousse,et al.  Brief antiepileptic drug withdrawal prolongs interval to next seizure , 1999, Neurology.

[26]  L. Slaughter Involvement of drugs in sexual assault. , 2000, The Journal of reproductive medicine.

[27]  V. Fowler,et al.  Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. , 2000, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[28]  A. McNab,et al.  Current treatment and outcome in orbital cellulitis. , 1999, Australian and New Zealand journal of ophthalmology.

[29]  R. Leker,et al.  Features of dural sinus thrombosis simulating pseudotumor cerebri , 1999, European journal of neurology.

[30]  S J Salamone,et al.  Prevalence of drugs used in cases of alleged sexual assault. , 1999, Journal of analytical toxicology.

[31]  W. Shockley Ludwig angina: a review of current airway management. , 1999, Archives of otolaryngology--head & neck surgery.

[32]  N. Frimodt-Møller,et al.  Clinical features of Staphylococcus aureus endocarditis: a 10-year experience in Denmark. , 1999, Archives of internal medicine.

[33]  Lewis,et al.  Cerebral venous thrombosis: nothing, heparin, or local thrombolysis? , 1999, Stroke.

[34]  Jeffrey H. Miller,et al.  Small ruptured abdominal aneurysm diagnosed by emergency physician ultrasound. , 1999, The American journal of emergency medicine.

[35]  R. Purssell,et al.  Cardiovascular toxicity after ingestion of "herbal ecstacy". , 1999, The Journal of emergency medicine.

[36]  CA Olesch,et al.  Invasive meningococcal infection in Western Australia , 1999, Journal of paediatrics and child health.

[37]  P. Diwan,et al.  Analgesic, antiinflammatory and hypoglycaemic activities of Sida cordifolia , 1999, Phytotherapy research : PTR.

[38]  A. Bolger,et al.  Diagnosis and management of infective endocarditis and its complications. , 1998, Circulation.

[39]  J. Provenzale,et al.  Dural sinus thrombosis: findings on CT and MR imaging and diagnostic pitfalls. , 1998, AJR. American journal of roentgenology.

[40]  R. Alberico,et al.  Cerebral venography: comparison of CT and MR projection venography. , 1997, AJR. American journal of roentgenology.

[41]  R. Busch,et al.  Ludwig's Angina: Improved Treatment , 1997, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[42]  A. Sinusas,et al.  Long QTc and Torsades de Pointes in Human Immunodeficiency Virus Disease , 1997, Pacing and clinical electrophysiology : PACE.

[43]  R. Perera,et al.  Prolonged QT interval and cocaine use. , 1997, Journal of electrocardiology.

[44]  M. Rosenthal,et al.  Congenital diaphragmatic hernia misdiagnosed as tension pneumothorax , 1997, Pediatric pulmonology.

[45]  L. Seah,et al.  Acute orbital cellulitis--a review of 17 cases. , 1997, Annals of the Academy of Medicine, Singapore.

[46]  G. Simpson,et al.  Efficacy of lorazepam and haloperidol for rapid tranquilization in a psychiatric emergency room setting , 1997, International clinical psychopharmacology.

[47]  M. Devoto,et al.  Simplified technique for eyelid margin repair. , 1997, Archives of ophthalmology.

[48]  M. H. Williams,et al.  Effect of Eleutherococcus senticosus on submaximal and maximal exercise performance. , 1996, Medicine and science in sports and exercise.

[49]  L. Olaison,et al.  Epidemiologic Aspects of Infective Endocarditis in an Urban Population: A 5‐Year Prospective Study , 1995, Medicine.

[50]  P. Young,et al.  Airway management in Ludwig's angina. , 1995, British journal of hospital medicine.

[51]  C. Manstein,et al.  Changing trends in deep neck abscess , 1995 .

[52]  O. U. Fernandez,et al.  Acute hepatotoxicity from ingestion of yellow phosphorus-containing fireworks. , 1995, Journal of clinical gastroenterology.

[53]  S. Miller,et al.  Posttraumatic arterial priapism in children: management with embolization. , 1995, Radiology.

[54]  A. Demirci,et al.  Cerebral Dural Sinus Thrombosis , 1995, Angiology.

[55]  O. el-Silimy The place of endonasal endoscopy in the treatment of orbital cellulitis. , 1995, Rhinology.

[56]  J. Hayward,et al.  Orbital cellulitis demands early recognition, urgent admission and aggressive management. , 1995, Journal of accident & emergency medicine.

[57]  S. Thom,et al.  Delayed neuropsychologic sequelae after carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. , 1995, Annals of emergency medicine.

[58]  R. Écochard,et al.  Characteristics of infective endocarditis in France in 1991. A 1-year survey. , 1995, European heart journal.

[59]  R. Haug New criteria for diagnosis of infective endocarditis: Utilization of specific echocardiographic findings , 1994 .

[60]  C. Watanakunakorn Staphylococcus aureus endocarditis at a community teaching hospital, 1980 to 1991. An analysis of 106 cases. , 1994, Archives of internal medicine.

[61]  P. Fontaine,et al.  The safety of dorsal penile nerve block for neonatal circumcision. , 1994, The Journal of family practice.

[62]  M. Stearns,et al.  Orbital complications of sinusitis: avoid delays in diagnosis. , 1994, Postgraduate medical journal.

[63]  J. Fein,et al.  Diaphragmatic hernia masquerading as pneumothorax in two toddlers. , 1993, Annals of emergency medicine.

[64]  W. Colizza,et al.  Intravenous regional anesthesia in the treatment of forearm and wrist fractures and dislocations in children. , 1993, Canadian journal of surgery. Journal canadien de chirurgie.

[65]  M. S. Lee,et al.  Evaluation of outcome after acute carbon monoxide poisoning by brain CT. , 1993, Journal of Korean medical science.

[66]  W. Wolfram,et al.  Toxicity--seizures in an infant caused by (or related to) oral viscous lidocaine use. , 1992, The Journal of emergency medicine.

[67]  M. Karlan,et al.  Violence against women: Relevance for medical practitioners , 1992 .

[68]  C. Timon,et al.  Ludwig's angina: a place for steroid therapy in its management? , 1992, Oral health.

[69]  J. Templeton ABC of Major Trauma , 1992 .

[70]  A. Villringer,et al.  Heparin treatment in sinus venous thrombosis , 1991, The Lancet.

[71]  N. Schiller,et al.  Diagnostic value of transesophageal compared with transthoracic echocardiography in infective endocarditis. , 1991, Journal of the American College of Cardiology.

[72]  L. Spitz,et al.  Pitfalls in the diagnosis of congenital diaphragmatic hernia. , 1991, Archives of disease in childhood.

[73]  D. Schwartzman,et al.  Cocaine-induced torsades de pointes in a patient with the idiopathic long QT syndrome. , 1990, American heart journal.

[74]  C. Slovis,et al.  Endocarditis in intravenous drug abusers. , 1990, Emergency medicine clinics of North America.

[75]  Gl Ridgway,et al.  Principles and Practice of Infectious Diseases , 1990 .

[76]  P. Kelly,et al.  Congenital diaphragmatic hernia presenting as massive gastrothorax. , 1990, Annals of emergency medicine.

[77]  K. Tabbara,et al.  Orbital cellulitis: review of 23 cases from Saudi Arabia. , 1989, The British journal of ophthalmology.

[78]  D. Nyberg,et al.  Suspected leaking abdominal aortic aneurysm: use of sonography in the emergency room. , 1988, Radiology.

[79]  J. Mylotte,et al.  Prospective study of 114 consecutive episodes of Staphylococcus aureus bacteremia. , 1987, Reviews of infectious diseases.

[80]  Bruun Jn,et al.  Serum C-reactive protein in systemic infections due to Neisseria meningitidis. , 1986, NIPH annals.

[81]  J. Chiras,et al.  Cerebral venous thrombosis--a review of 38 cases. , 1985, Stroke.

[82]  M. Leicht,et al.  Lidocaine toxicity following subcutaneous administration. , 1984, Annals of emergency medicine.

[83]  W. Shawcross Recreational use of ergoline alkaloids from Argyreia nervosa. , 1983, Journal of psychoactive drugs.

[84]  I. Choi,et al.  Delayed neurologic sequelae in carbon monoxide intoxication. , 1983, Archives of neurology.

[85]  M. McCarron,et al.  Acute yellow phosphorus poisoning from pesticide pastes. , 1981, Clinical toxicology.

[86]  W. M. Smith,et al.  "Les torsades de pointes": an unusual ventricular arrhythmia. , 1980, Annals of internal medicine.

[87]  S. Sotheeswaran,et al.  Studies on Medicinal Plants of Sri Lanka , 1980, Planta medica.

[88]  R. G. Finch,et al.  Ludwig's angina. , 1980, JAMA.

[89]  J. Suzuki,et al.  A case of priapism with ruptured intracranial aneurysm , 1979, Journal of Neurology.

[90]  A. Benchimol,et al.  Accelerated ventricular rhythm and cocaine abuse. , 1978, Annals of internal medicine.

[91]  S. Mellick,et al.  Aortocaval fistula as a complication of leaking aortic aneurysm , 1977, The British journal of surgery.

[92]  E. Porta,et al.  Isotopic studies on the absorption and tissue distribution of white phosphorus in rats. , 1971, Experimental and molecular pathology.

[93]  J. Senior,et al.  Evaluation of corticosteroid and exchange-transfusion treatment of acute yellow-phosphorus intoxication. , 1971, The New England journal of medicine.

[94]  R. M. Kalbag Dural sinus thrombosis. , 1967, Journal of neurology, neurosurgery, and psychiatry.

[95]  Kenneth Wright,et al.  Letter to the editor , 1967, Commun. ACM.

[96]  E. Spaeth The closure of vertical lid lacerations and the repair of vertical lid cicatrices. , 1966, American journal of ophthalmology-glaucoma.

[97]  S KAYE,et al.  Carbon monoxide poisoning. , 1957, Virginia medical monthly.

[98]  H. Shwachman,et al.  Phosphorus poisoning with recovery accompanied by electrocardiographic changes. , 1948, The American journal of medicine.

[99]  I. Khan Long QT syndrome: diagnosis and management. , 2002, American heart journal.

[100]  Y. Shon,et al.  Serial diffusion-weighted MR Imaging in delayed postanoxic encephalopathy. A case study. , 2002, Journal of neuroradiology. Journal de neuroradiologie.

[101]  S. Shukla,et al.  An update on the epidemiology, pathogenesis and management of infective endocarditis with emphasis on Staphylococcus aureus. , 2002, WMJ : official publication of the State Medical Society of Wisconsin.

[102]  W. Kerns,et al.  Gamma hydroxybutyric acid (GHB) intoxication. , 2002, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

[103]  A. Taddio Pain Management for Neonatal Circumcision , 2001, Paediatric drugs.

[104]  E. Mylonakis,et al.  Infective endocarditis in adults. , 2001, The New England journal of medicine.

[105]  D. Caldicott,et al.  Gamma-hydroxybutyrate overdose and physostigmine: teaching new tricks to an old drug? , 2001, Annals of emergency medicine.

[106]  I. Julander,et al.  Endocarditis: Clinical Outcome and Benefit of Trans-oesophageal Echocardiography , 2000, Scandinavian journal of infectious diseases.

[107]  P. Chyka,et al.  Position statement: single-dose activated charcoal. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. , 1997, Journal of toxicology. Clinical toxicology.

[108]  E. Krenzelok,et al.  Position statements: gut decontamination. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. , 1997, Journal of toxicology. Clinical toxicology.

[109]  M. Tenenbein Position statement: whole bowel irrigation. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. , 1997, Journal of toxicology. Clinical toxicology.

[110]  K. Hartigan-Go,et al.  Position statement: cathartics. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. , 1997, Journal of toxicology. Clinical toxicology.

[111]  A. Wang,et al.  MRA of venous sinus thrombosis. , 1997, Clinical neuroscience.

[112]  E. Ruiz,et al.  Emergency Medicine: A Comprehensive Study Guide , 1996 .

[113]  R. Amedee,et al.  A review of odontogenic infections. , 1994, The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society.

[114]  Schuman Nj,et al.  Ludwig's angina: historical perspective. , 1993, The Journal of the Tennessee Dental Association.

[115]  H. Heinze,et al.  Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task. , 1993, Neuropsychobiology.

[116]  M. Terpenning Infective endocarditis. , 1992, Clinics in geriatric medicine.

[117]  G. S. L. Frcs Accident and Emergency Medicine , 1988, MCQ’s....Brainscan.

[118]  Moloney,et al.  The acute orbit. Preseptal (periorbital) cellulitis, subperiosteal abscess and orbital cellulitis due to sinusitis. , 1987, The Journal of laryngology and otology. Supplement.

[119]  C. Grant,et al.  Current management of congenital diaphragmatic hernia , 1986, Indian journal of pediatrics.

[120]  A. Nanji,et al.  Asystole and ventricular fibrillation associated with cocaine intoxication. , 1984, Chest.

[121]  G. I. Beloskurskaia,et al.  [Functional and morphologic characteristics of leukocytes in patients with chronic phosphorus poisoning]. , 1982, Gigiena truda i professional'nye zabolevaniia.

[122]  H. Mehta Primary repair of eyelid lacerations. , 1978, Transactions of the ophthalmological societies of the United Kingdom.

[123]  M. Li,et al.  Toxic effect of elemental phosphorus on L-cells cultivated in suspension. , 1970, Canadian journal of zoology.