Safety and efficacy of cryopreserved autologous platelet concentrates in HLA‐alloimmunized patients with hematologic malignancies

Curative chemotherapy approaches in patients with malignancies and platelet (PLT) transfusion refractoriness due to alloimmunization may be hampered by the lack of suitable PLT donors. For these patients, transfusion of cryopreserved autologous PLTs is an option, but is time‐ and resource‐consuming. We aimed at further simplifying this process.

[1]  I. López-Vílchez,et al.  In vitro evaluation of the hemostatic effectiveness of cryopreserved platelets , 2016, Transfusion.

[2]  L. Alberio,et al.  Decreased generation of procoagulant platelets detected by flow cytometric analysis in patients with bleeding diathesis , 2014, Cytometry. Part B, Clinical cytometry.

[3]  A. Ho,et al.  Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study , 2012, The Lancet.

[4]  S. Assmann,et al.  Bleeding risks are higher in children versus adults given prophylactic platelet transfusions for treatment-induced hypoproliferative thrombocytopenia. , 2012, Blood.

[5]  A. Tobian,et al.  The impact of apheresis platelet manipulation on corrected count increment , 2012, Transfusion.

[6]  S. Khuri,et al.  Freezing human platelets with 6 percent dimethyl sulfoxide with removal of the supernatant solution before freezing and storage at −80°C without postthaw processing , 2005, Transfusion.

[7]  Edward J. Lee,et al.  Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patients. , 2005, Blood.

[8]  J. Aisner,et al.  Frozen Autologous Platelets in the Supportive Care of Patients with Leukemia , 2003, Transfusion.

[9]  P. Terasaki,et al.  Single human leukocyte antigen flow cytometry beads for accurate identification of human leukocyte antigen antibody specificities , 2003, Transplantation.

[10]  L. Broemeling,et al.  Safety and efficacy of transfusions of autologous cryopreserved platelets derived from recombinant human thrombopoietin to support chemotherapy-associated severe thrombocytopenia: a randomised cross-over study , 2002, The Lancet.

[11]  P. Noris,et al.  Transfusion of platelet concentrates cryopreserved with ThromboSol plus low‐dose dimethylsulphoxide in patients with severe thrombocytopenia: a pilot study , 2000, British journal of haematology.

[12]  L. Alberio,et al.  Surface expression and functional characterization of alpha-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin. , 2000, Blood.

[13]  P. Terasaki,et al.  Flow cytometric detection of HLA antibodies using a spectrum of microbeads. , 1999, Human immunology.

[14]  J. Arnold,et al.  A flow cytometric assay using mepacrine for study of uptake and release of platelet dense granule contents , 1995, British journal of haematology.

[15]  J. Fehr,et al.  Safety of stringent prophylactic platelet transfusion policy for patients with acute leukaemia , 1991, The Lancet.

[16]  T. Lister,et al.  Use of leucocyte‐poor blood components and HLA‐matched‐platelet donors to prevent HLA alloimmunization , 1986, British journal of haematology.

[17]  C. Schiffer,et al.  Successful transfusion of platelets cryopreserved for more than 3 years. , 1979, Blood.

[18]  C. Schiffer,et al.  Frozen autologous platelet transfusion for patients with leukemia. , 1978, The New England journal of medicine.

[19]  C. Schiffer,et al.  Clinical Experience with Transfusion of Cryopreserved Platelets , 1976, British journal of haematology.

[20]  C. Valeri.  Hemostatic effectiveness of liquid-preserved and previously frozen human platelets. , 1974, The New England journal of medicine.

[21]  A. Evans,et al.  Transfusions of fresh platelet concentrates to patients with secondary thrombocytopenia. , 1963, The New England journal of medicine.

[22]  N. Mantel,et al.  The quantitative relation between platelet count and hemorrhage in patients with acute leukemia. , 1962, The New England journal of medicine.

[23]  AL SNIECINSKIEl.  Prevention of Refractoriness and HLA-Alloimmunization Using Filtered Blood Products , 2005 .

[24]  Leukocyte reduction and ultraviolet B irradiation of platelets to prevent alloimmunization and refractoriness to platelet transfusions. , 1997, The New England journal of medicine.

[25]  A. Miller,et al.  Reporting results of cancer treatment , 1981, Cancer.