KANAMYCIN IN THE TREATMENT OF PATIENTS WITH DIMINISHED KIDNEY FUNCTION

Kanamycin has become established as a useful and effective agent in the treatment of severe Gram-negative infections. The potential nephrotoxicity and ototoxicity have in the past limited its use in patients with decreased renal function. With increasing numbers of Gram-negative infections occurring as a complication of severe renal disease, it is appropriate to review the principles of kanamycin therapy in this clinical situation.

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