The Cbl family and other ubiquitin ligases: destructive forces in control of antigen receptor signaling.

[1]  M. Deckert,et al.  The immunological synapse and Rho GTPases. , 2005, Current topics in microbiology and immunology.

[2]  K. Katagiri,et al.  Rap1-mediated Lymphocyte Function-associated Antigen-1 Activation by the T Cell Antigen Receptor Is Dependent on Phospholipase C-γ1* , 2004, Journal of Biological Chemistry.

[3]  P. McPherson,et al.  The HECT Domain Ligase Itch Ubiquitinates Endophilin and Localizes to the trans-Golgi Network and Endosomal System* , 2004, Journal of Biological Chemistry.

[4]  Y. Ben-Neriah,et al.  Behind the scenes of anergy: a tale of three E3s , 2004, Nature Immunology.

[5]  K. Sada,et al.  Negative regulation of FcϵRI-mediated mast cell activation by a ubiquitin-protein ligase Cbl-b , 2004 .

[6]  Michael Loran Dustin,et al.  Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins , 2004, Nature Immunology.

[7]  Yun-Cai Liu,et al.  Ubiquitin ligases and the immune response. , 2003, Annual review of immunology.

[8]  Patricia A. Lovelace,et al.  Two isoforms of otubain 1 regulate T cell anergy via GRAIL , 2004, Nature Immunology.

[9]  M. Hermiston,et al.  CD45: a critical regulator of signaling thresholds in immune cells. , 2003, Annual review of immunology.

[10]  Arup K Chakraborty,et al.  The Immunological Synapse Balances T Cell Receptor Signaling and Degradation , 2003, Science.

[11]  R. Khokha,et al.  Cbl-3-Deficient Mice Exhibit Normal Epithelial Development , 2003, Molecular and Cellular Biology.

[12]  J. Benovic,et al.  The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4. , 2003, Developmental cell.

[13]  C. Goodnow,et al.  Scaffolding of antigen receptors for immunogenic versus tolerogenic signaling , 2003, Nature Immunology.

[14]  Lei Duan,et al.  Cbl-mediated Ubiquitinylation and Negative Regulation of Vav* , 2003, Journal of Biological Chemistry.

[15]  P. Soubeyran,et al.  Cbl signaling networks in the regulation of cell function , 2003, Cellular and Molecular Life Sciences CMLS.

[16]  H. Stenmark,et al.  Protein sorting into multivesicular endosomes. , 2003, Current opinion in cell biology.

[17]  Rick A. Rogers,et al.  Cbl-mediated Ubiquitinylation Is Required for Lysosomal Sorting of Epidermal Growth Factor Receptor but Is Dispensable for Endocytosis* , 2003, Journal of Biological Chemistry.

[18]  K. Katagiri,et al.  RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1 , 2003, Nature Immunology.

[19]  Yun-Cai Liu,et al.  Negative Regulation of T Cell Antigen Receptor-mediated Crk-L-C3G Signaling and Cell Adhesion by Cbl-b* , 2003, Journal of Biological Chemistry.

[20]  S. Pierce,et al.  Cbl-b Negatively Regulates B Cell Antigen Receptor Signaling in Mature B Cells through Ubiquitination of the Tyrosine Kinase Syk , 2003, The Journal of experimental medicine.

[21]  Morag Park,et al.  Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases. , 2003, Cancer cell.

[22]  I. Jang,et al.  Negative regulation of TCR signaling and T-cell activation by selective protein degradation. , 2003, Current opinion in immunology.

[23]  C. Elly,et al.  Negative regulation of Rap1 activation by the Cbl E3 ubiquitin ligase , 2003 .

[24]  L. Appleman,et al.  T cell anergy and costimulation , 2003, Immunological reviews.

[25]  C. Fathman,et al.  GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. , 2003, Immunity.

[26]  Andrew C Chan,et al.  Regulation of thymocyte development: only the meek survive. , 2003, Current opinion in immunology.

[27]  Tomas Mustelin,et al.  Positive and negative regulation of T-cell activation through kinases and phosphatases. , 2003, The Biochemical journal.

[28]  R. Schwartz T cell anergy. , 1993, Scientific American.

[29]  R. Abraham Rap1 redux , 2003, Nature Immunology.

[30]  M. Naramura,et al.  c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation , 2002, Nature Immunology.

[31]  I. Ho,et al.  Regulation of thymocyte homeostasis by Fliz1 , 2002, Immunology.

[32]  Yutaka Seino,et al.  Cblb is a major susceptibility gene for rat type 1 diabetes mellitus , 2002, Nature Genetics.

[33]  H. Band,et al.  Constitutive Endocytosis and Degradation of the Pre-T Cell Receptor , 2002, The Journal of experimental medicine.

[34]  Anjana Rao,et al.  Transcriptional Mechanisms Underlying Lymphocyte Tolerance , 2002, Cell.

[35]  H. Band,et al.  The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system , 2002, Journal of leukocyte biology.

[36]  H. Band,et al.  Negative regulation of Lck by Cbl ubiquitin ligase , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[37]  N. Hogg,et al.  Rap1A positively regulates T cells via integrin activation rather than inhibiting lymphocyte signaling , 2002, Nature Immunology.

[38]  R. Geahlen,et al.  The Lck SH3 Domain Negatively Regulates Localization to Lipid Rafts through an Interaction with c-Cbl* , 2002, The Journal of Biological Chemistry.

[39]  T. Hunter,et al.  Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation , 2002, Nature Immunology.

[40]  Y. Ben-Neriah Regulatory functions of ubiquitination in the immune system , 2002, Nature Immunology.

[41]  P. Stork,et al.  PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. , 2002, Molecular cell.

[42]  H. Band,et al.  The non‐receptor tyrosine kinase Syk is a target of Cbl‐mediated ubiquitylation upon B‐cell receptor stimulation , 2001, The EMBO journal.

[43]  A. Tsygankov,et al.  Beyond the RING: CBL proteins as multivalent adapters , 2001, Oncogene.

[44]  Yun-Cai Liu,et al.  Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells , 2001, Nature Immunology.

[45]  C. Arrieumerlou,et al.  T Cell Development and T Cell Responses in Mice with Mutations Affecting Tyrosines 292 or 315 of the Zap-70 Protein Tyrosine Kinase , 2001, The Journal of experimental medicine.

[46]  C. Elly,et al.  Cbl Promotes Ubiquitination of the T Cell Receptor ζ through an Adaptor Function of Zap-70* , 2001, The Journal of Biological Chemistry.

[47]  S. Latour,et al.  Proximal protein tyrosine kinases in immunoreceptor signaling. , 2001, Current opinion in immunology.

[48]  J. Penninger,et al.  Molecular controls of antigen receptor clustering and autoimmunity. , 2001, Trends in cell biology.

[49]  J. Bos,et al.  Rap1 signalling: adhering to new models , 2001, Nature Reviews Molecular Cell Biology.

[50]  W. Langdon,et al.  Cbl: many adaptations to regulate protein tyrosine kinases , 2001, Nature Reviews Molecular Cell Biology.

[51]  A. Weissman Ubiquitin and proteasomes: Themes and variations on ubiquitylation , 2001, Nature Reviews Molecular Cell Biology.

[52]  D. Bowtell,et al.  Cbl Associates with Pyk2 and Src to Regulate Src Kinase Activity, αvβ3 Integrin-Mediated Signaling, Cell Adhesion, and Osteoclast Motility , 2001, The Journal of cell biology.

[53]  S. Bromley,et al.  The immunological synapse. , 2001, Annual review of immunology.

[54]  L. Miosge,et al.  Autoimmunity, self-tolerance and immune homeostasis: from whole animal phenotypes to molecular pathways. , 2001, Advances in experimental medicine and biology.

[55]  F. Alt,et al.  Cbl-b is a negative regulator of receptor clustering and raft aggregation in T cells. , 2000, Immunity.

[56]  J. C. Pratt,et al.  Adapting to multiple personalities: Cbl is also a RING finger ubiquitin ligase. , 2000, Biochimica et biophysica acta.

[57]  A. Weiss,et al.  Signal transduction by the TCR for antigen. , 2000, Current opinion in immunology.

[58]  B. Druker,et al.  The Linker Phosphorylation Site Tyr292 Mediates the Negative Regulatory Effect of Cbl on ZAP-70 in T Cells1 , 2000, The Journal of Immunology.

[59]  Christopher E. Rudd,et al.  Lymphocyte signaling: Cbl sets the threshold for autoimmunity , 2000, Current Biology.

[60]  D. Bowtell,et al.  The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation , 2000, Molecular and Cellular Biology.

[61]  H. Nishina,et al.  Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b , 2000, Nature.

[62]  E. Shevach,et al.  Cbl-b regulates the CD28 dependence of T-cell activation , 2000, Nature.

[63]  B. Druker,et al.  The RING Finger Domain of Cbl Is Essential for Negative Regulation of the Syk Tyrosine Kinase* , 2000, The Journal of Biological Chemistry.

[64]  K. Sada,et al.  Point Mutation of a Tyrosine in the Linker Region of Syk Results in a Gain of Function , 2000, The Journal of Immunology.

[65]  B. Druker,et al.  Erratum: The RING finger domain of Cbl is essential for negative regulation of the Syk tyrosine kinase (Journal of Biological Chemistry (2000) 275 (414-422)) , 2000 .

[66]  B. Alarcón,et al.  Internalization and intracellular fate of TCR-CD3 complexes. , 2000, Critical reviews in immunology.

[67]  A Ciechanover,et al.  Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. , 1999, Molecular cell.

[68]  R. Baron,et al.  Leucine Zipper-mediated Homodimerization of the Adaptor Protein c-Cbl , 1999, The Journal of Biological Chemistry.

[69]  M. Eck,et al.  The Cbl protooncoprotein: a negative regulator of immune receptor signal transduction. , 1999, Immunology today.

[70]  S. Wenn,et al.  Beyond the Ring , 1999 .

[71]  L. Samelson,et al.  T cell antigen-receptor signal transduction. , 1999, Current opinion in immunology.

[72]  S. Harrison,et al.  Crystal structures of c-Src reveal features of its autoinhibitory mechanism. , 1999, Molecular cell.

[73]  Michael J. Eck,et al.  Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase , 1999, Nature.

[74]  C. Elly,et al.  A direct interaction between the adaptor protein Cbl-b and the kinase Zap-70 induces a positive signal in T cells , 1999, Current Biology.

[75]  R. Germain,et al.  Serial TCR engagement and down-modulation by peptide:MHC molecule ligands: relationship to the quality of individual TCR signaling events. , 1999, Journal of immunology.

[76]  H. Band,et al.  Cbl-mediated Negative Regulation of the Syk Tyrosine Kinase , 1998, The Journal of Biological Chemistry.

[77]  M. Naramura,et al.  Altered thymic positive selection and intracellular signals in Cbl-deficient mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[78]  D. Bowtell,et al.  Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice , 1998, Molecular and Cellular Biology.

[79]  M. Deckert,et al.  Coordinated Regulation of the Tyrosine Phosphorylation of Cbl by Fyn and Syk Tyrosine Kinases* , 1998, The Journal of Biological Chemistry.

[80]  L. Cantley,et al.  The Cbl Phosphotyrosine-binding Domain Selects a D(N/D)XpY Motif and Binds to the Tyr292Negative Regulatory Phosphorylation Site of ZAP-70* , 1997, The Journal of Biological Chemistry.

[81]  M. Barbacid,et al.  Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation , 1997, Oncogene.

[82]  G. Freeman,et al.  Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1. , 1997, Science.

[83]  R. Zinkernagel,et al.  Peptide‐induced T cell receptor down‐regulation on naive T cells predicts agonist/partial agonist properties and strictly correlates with T cell activation , 1997, European journal of immunology.

[84]  T. Mak,et al.  Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells. , 1997, Journal of immunology.

[85]  A. Lanzavecchia,et al.  Degradation of  T Cell Receptor (TCR)–CD3-ζ Complexes after Antigenic Stimulation , 1997, The Journal of experimental medicine.

[86]  L. Samelson,et al.  The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase. , 1997, Science.

[87]  A. Weiss,et al.  T cell antigen receptor signal transduction. , 1997, Current opinion in cell biology.

[88]  H. Band,et al.  The Cbl protooncogene product: from an enigmatic oncogene to center stage of signal transduction. , 1997, Critical reviews in oncogenesis.

[89]  C. Turck,et al.  B Cell Antigen Receptor Signaling Induces the Formation of Complexes Containing the Crk Adapter Proteins* , 1996, The Journal of Biological Chemistry.

[90]  A. Weiss,et al.  Enhancement of lymphocyte responsiveness by a gain-of-function mutation of ZAP-70 , 1996, Molecular and cellular biology.

[91]  H. Band,et al.  A Novel Phosphotyrosine-binding Domain in the N-terminal Transforming Region of Cbl Interacts Directly and Selectively with ZAP-70 in T Cells* , 1996, The Journal of Biological Chemistry.

[92]  T. Kurosaki,et al.  Distinct tyrosine phosphorylation sites in ZAP-70 mediate activation and negative regulation of antigen receptor function , 1996, Molecular and cellular biology.

[93]  J. Borst,et al.  Sos, Vav, and C3G Participate in B Cell Receptor-induced Signaling Pathways and Differentially Associate with Shc-Grb2, Crk, and Crk-L Adaptors (*) , 1996, The Journal of Biological Chemistry.

[94]  A. Weissman,et al.  T Cell Antigen Receptor Ubiquitination Is a Consequence of Receptor-mediated Tyrosine Kinase Activation (*) , 1996, The Journal of Biological Chemistry.

[95]  S. Shoelson,et al.  Stimulation through the T Cell Receptor Induces Cbl Association with Crk Proteins and the Guanine Nucleotide Exchange Protein C3G (*) , 1996, The Journal of Biological Chemistry.

[96]  S. Shoelson,et al.  p120 Is a Major Substrate of Tyrosine Phosphorylation upon B Cell Antigen Receptor Stimulation and Interacts in Vivo with Fyn and Syk Tyrosine Kinases, Grb2 and Shc Adaptors, and the p85 Subunit of Phosphatidylinositol 3-Kinase (*) , 1996, The Journal of Biological Chemistry.

[97]  S. Pillai,et al.  Association of Activated Phosphatidylinositol 3-Kinase with p120cbl in Antigen Receptor-ligated B Cells (*) , 1995, The Journal of Biological Chemistry.

[98]  S. Shoelson,et al.  The SH3 Domain-binding T Cell Tyrosyl Phosphoprotein p120 , 1995, The Journal of Biological Chemistry.

[99]  K. Robbins,et al.  Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene. , 1995, Oncogene.

[100]  A. Lanzavecchia,et al.  Serial triggering of many T-cell receptors by a few peptide–MHC complexes , 1995, Nature.