Role of the GH-IGF1 system in progression of cancer
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[1] R. Berger,et al. Proteomic analysis of combined IGF1 receptor targeted therapy and chemotherapy identifies signatures associated with survival in breast cancer patients , 2020, Oncotarget.
[2] T. Key,et al. Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ∼430 000 women , 2020, Annals of oncology : official journal of the European Society for Medical Oncology.
[3] Chris Jones,et al. Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma , 2019, British Journal of Cancer.
[4] C. Boguszewski,et al. From dwarves to giants: South American's contribution to the history of growth hormone and related disorders. , 2019, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[5] H. Werner,et al. Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy , 2019, Expert opinion on investigational drugs.
[6] J. Kopchick,et al. The effects of growth hormone on therapy resistance in cancer , 2019, Cancer drug resistance.
[7] H. Werner,et al. Identification of ZYG11A as a candidate IGF1-dependent proto-oncogene in endometrial cancer , 2019, Oncotarget.
[8] S. Cianfarani. Risk of cancer in patients treated with recombinant human growth hormone in childhood , 2019, Annals of pediatric endocrinology & metabolism.
[9] C. Boguszewski,et al. Growth Hormone's Links to Cancer. , 2018, Endocrine reviews.
[10] M. Fleseriu,et al. Systemic Complications of Acromegaly and the Impact of the Current Treatment Landscape: An Update. , 2018, Endocrine reviews.
[11] O. Larsson,et al. Characterization of an activating R1353H insulin-like growth factor 1 receptor variant in a male with extreme tall height. , 2018, European journal of endocrinology.
[12] P. Chanson,et al. A Consensus Statement on acromegaly therapeutic outcomes , 2018, Nature Reviews Endocrinology.
[13] J. Coste,et al. Increased risk of bone tumors after growth hormone treatment in childhood: A population‐based cohort study in France , 2018, Cancer medicine.
[14] W. Kiess,et al. Long‐term safety of growth hormone—A combined registry analysis , 2018, Clinical endocrinology.
[15] H. Werner,et al. Oncogenic fusion proteins adopt the insulin-like growth factor signaling pathway , 2018, Molecular Cancer.
[16] J. Kopchick,et al. MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects? , 2018, European journal of endocrinology.
[17] A. Brooks,et al. The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects , 2018, Front. Endocrinol..
[18] D. Gurwitz,et al. Identification of thioredoxin-interacting protein (TXNIP) as a downstream target for IGF1 action , 2018, Proceedings of the National Academy of Sciences.
[19] H. Werner,et al. Differential expression of IGFBPs in Laron syndrome-derived lymphoblastoid cell lines: Potential correlation with reduced cancer incidence. , 2017, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[20] H. Werner,et al. Genome-wide profiling of congenital insulin-like growth factor-1 deficient patients: translational implications in cancer prevention and metabolism , 2017 .
[21] R. Berger,et al. Identification of BRCA1 As a Potential Biomarker for Insulin-Like Growth Factor-1 Receptor Targeted Therapy in Breast Cancer , 2017, Front. Endocrinol..
[22] T. Zhu,et al. Autocrine Human Growth Hormone Promotes Invasive and Cancer Stem Cell-Like Behavior of Hepatocellular Carcinoma Cells by STAT3 Dependent Inhibition of CLAUDIN-1 Expression , 2017, International journal of molecular sciences.
[23] R. Salvatori,et al. MECHANISMS IN ENDOCRINOLOGY: The multiple facets of GHRH/GH/IGF-I axis: lessons from lifetime, untreated, isolated GH deficiency due to a GHRH receptor gene mutation. , 2017, European journal of endocrinology.
[24] H. Werner,et al. IGF-I deficiency, longevity and cancer protection of patients with Laron syndrome. , 2017, Mutation research. Reviews in mutation research.
[25] S. Smaniotto,et al. Growth hormone modulates in vitro endothelial cell migration and formation of capillary‐like structures , 2017, Cell biology international.
[26] Shiyong Wu,et al. Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps , 2017, Hormones and Cancer.
[27] A. Tirosh,et al. Complications of acromegaly: thyroid and colon , 2017, Pituitary.
[28] C. Boguszewski,et al. MANAGEMENT OF ENDOCRINE DISEASE: Acromegaly and cancer: an old debate revisited. , 2016, European journal of endocrinology.
[29] H. Werner,et al. Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways , 2016, Front. Oncol..
[30] D. Gurwitz,et al. Identification of signaling pathways associated with cancer protection in Laron syndrome. , 2016, Endocrine-related cancer.
[31] C. Rudin,et al. Phase I Dose-Escalation Study of Linsitinib (OSI-906) and Erlotinib in Patients with Advanced Solid Tumors , 2016, Clinical Cancer Research.
[32] L. Bach. Insulin-Like Growth Factor Binding Proteins--an Update. , 2015, Pediatric endocrinology reviews : PER.
[33] D. Yee,et al. Minireview: Were the IGF Signaling Inhibitors All Bad? , 2015, Molecular endocrinology.
[34] T. Dawson,et al. Growth hormone and cancer: GH production and action in glioma? , 2015, General and comparative endocrinology.
[35] G. Johannsson,et al. Reviewing the safety of GH replacement therapy in adults. , 2015, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[36] L. Moilanen,et al. Mortality in acromegaly: a 20-year follow-up study. , 2015, Endocrine-related cancer.
[37] C. Sklar,et al. Risk of Neoplasia in Pediatric Patients Receiving Growth Hormone Therapy--A Report From the Pediatric Endocrine Society Drug and Therapeutics Committee. , 2015, The Journal of clinical endocrinology and metabolism.
[38] R. Subramani,et al. Growth hormone receptor inhibition decreases the growth and metastasis of pancreatic ductal adenocarcinoma , 2014, Experimental & Molecular Medicine.
[39] H. Werner,et al. Transcriptional and epigenetic control of IGF1R gene expression: implications in metabolism and cancer. , 2014, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[40] Xiao-yu Wu,et al. Growth hormone protects colorectal cancer cells from radiation by improving the ability of DNA damage repair. , 2014, Molecular medicine reports.
[41] H. Werner,et al. The IGF Hormonal Network in Endometrial Cancer: Functions, Regulation, and Targeting Approaches , 2014, Front. Endocrinol..
[42] L. Attardi,et al. Unravelling mechanisms of p53-mediated tumour suppression , 2014, Nature Reviews Cancer.
[43] G. Armstrong,et al. Growth hormone exposure as a risk factor for the development of subsequent neoplasms of the central nervous system: a report from the childhood cancer survivor study. , 2014, The Journal of clinical endocrinology and metabolism.
[44] Shin-ichiro Takahashi,et al. Something old, something new and something borrowed: emerging paradigm of insulin-like growth factor type 1 receptor (IGF-1R) signaling regulation , 2013, Cellular and Molecular Life Sciences.
[45] J. Kopchick,et al. Human metastatic melanoma cell lines express high levels of growth hormone receptor and respond to GH treatment. , 2013, Biochemical and biophysical research communications.
[46] S. Melmed,et al. Growth hormone is a cellular senescence target in pituitary and nonpituitary cells , 2013, Proceedings of the National Academy of Sciences.
[47] R. Baserga. The decline and fall of the IGF‐I receptor , 2013, Journal of cellular physiology.
[48] V. Rotter,et al. p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity , 2013, Cell Death and Differentiation.
[49] H. Werner,et al. IGF-1 and BRCA1 signalling pathways in familial cancer. , 2012, The Lancet. Oncology.
[50] T. Zhu,et al. Autocrine human GH promotes radioresistance in mammary and endometrial carcinoma cells. , 2012, Endocrine-related cancer.
[51] H. Werner. Tumor suppressors govern insulin-like growth factor signaling pathways: implications in metabolism and cancer , 2012, Oncogene.
[52] H. Schayek,et al. BRCA1 is Expressed in Uterine Serous Carcinoma (USC) and Controls Insulin-Like Growth Factor I Receptor (IGF-IR) Gene Expression in USC Cell Lines , 2012, International Journal of Gynecologic Cancer.
[53] M. Pollak. The insulin and insulin-like growth factor receptor family in neoplasia: an update , 2012, Nature Reviews Cancer.
[54] S. Malozowski. Reports of increased mortality and GH: will this affect current clinical practice? , 2012, The Journal of clinical endocrinology and metabolism.
[55] J. Coste,et al. Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study. , 2012, The Journal of clinical endocrinology and metabolism.
[56] J. Baselga,et al. A Phase I Pharmacokinetic and Pharmacodynamic Study of Dalotuzumab (MK-0646), an Anti-Insulin-like Growth Factor-1 Receptor Monoclonal Antibody, in Patients with Advanced Solid Tumors , 2011, Clinical Cancer Research.
[57] Z. Laron,et al. Growth hormone therapy: emerging dilemmas. , 2011, Pediatric endocrinology reviews : PER.
[58] Z. Laron,et al. Congenital IGF1 deficiency tends to confer protection against post-natal development of malignancies. , 2011, European journal of endocrinology.
[59] Federica Madia,et al. Growth Hormone Receptor Deficiency Is Associated with a Major Reduction in Pro-Aging Signaling, Cancer, and Diabetes in Humans , 2011, Science Translational Medicine.
[60] M. Oren,et al. New plays in the p53 theater. , 2011, Current opinion in genetics & development.
[61] M. Waters,et al. Role of the growth hormone–IGF-1 axis in cancer , 2011, Expert review of endocrinology & metabolism.
[62] H. Schayek,et al. Differential regulation of insulin-like growth factor-I receptor gene expression by wild type and mutant androgen receptor in prostate cancer cells , 2010, Molecular and Cellular Endocrinology.
[63] J. Spicer,et al. The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib dose-escalation, open-label study , 2010, British Journal of Cancer.
[64] R. Radinsky,et al. AMG 479, a fully human anti–insulin-like growth factor receptor type I monoclonal antibody, inhibits the growth and survival of pancreatic carcinoma cells , 2009, Molecular Cancer Therapeutics Molecular Cancer Therapeutics.
[65] C. Print,et al. Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma. , 2009, Endocrinology.
[66] M. Pollak,et al. The Type 1 Insulin-Like Growth Factor Receptor Pathway , 2008, Clinical Cancer Research.
[67] D. Johnston,et al. Paracrine overexpression of insulin-like growth factor-1 enhances mammary tumorigenesis in vivo. , 2008, The American journal of pathology.
[68] M. Mitchell,et al. Autocrine human growth hormone stimulates oncogenicity of endometrial carcinoma cells. , 2008, Endocrinology.
[69] P. Picci,et al. Targeting insulin-like growth factor 1 receptor in sarcomas , 2008, Current opinion in oncology.
[70] D. Leroith,et al. Reduced susceptibility to two-stage skin carcinogenesis in mice with low circulating insulin-like growth factor I levels. , 2008, Cancer research.
[71] J. Attems,et al. Intratumoral IGF-I protein expression is selectively upregulated in breast cancer patients with BRCA1/2 mutations. , 2007, Endocrine-related cancer.
[72] I. Holdaway. Excess Mortality in Acromegaly , 2007, Hormone Research in Paediatrics.
[73] Xiao-yu Wu,et al. Growth hormone receptor expression is up-regulated during tumorigenesis of human colorectal cancer. , 2007, The Journal of surgical research.
[74] R. Yarden,et al. Elevated insulin-like growth factor-I receptor (IGF-IR) levels in primary breast tumors associated with BRCA1 mutations. , 2007, Cancer letters.
[75] M. Waters,et al. Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis , 2007, Proceedings of the National Academy of Sciences.
[76] R. Yarden,et al. Insulin-like growth factor-I controls BRCA1 gene expression through activation of transcription factor Sp1. , 2007, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[77] C. Ingvar,et al. Absence of the common Insulin-like growth factor-1 19-repeat allele is associated with early age at breast cancer diagnosis in multiparous women , 2007, British Journal of Cancer.
[78] Z. Laron,et al. Patients with congenital deficiency of IGF-I seem protected from the development of malignancies: a preliminary report. , 2007, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[79] S. Melmed. Medical progress: Acromegaly. , 2006, The New England journal of medicine.
[80] Adrian V. Lee,et al. Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1. , 2006, The Journal of endocrinology.
[81] X. Coumoul,et al. Absence of the full-length breast cancer-associated gene-1 leads to increased expression of insulin-like growth factor signaling axis members. , 2006, Cancer research.
[82] H. Werner,et al. Transcriptional regulation of the insulin-like growth factor-I receptor gene in breast cancer , 2006, Molecular and Cellular Endocrinology.
[83] F Berrino,et al. IGF-I, IGFBP-3 and breast cancer risk in women: The European Prospective Investigation into Cancer and Nutrition (EPIC). , 2006, Endocrine-related cancer.
[84] V. Ray,et al. Disruption of growth hormone signaling retards early stages of prostate carcinogenesis in the C3(1)/T antigen mouse. , 2005, Endocrinology.
[85] H. Werner,et al. The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells. , 2005, Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society.
[86] M. Waters,et al. The oncogenic potential of autocrine human growth hormone in breast cancer. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[87] C. Sklar. Growth Hormone Treatment: Cancer Risk , 2004, Hormone Research in Paediatrics.
[88] R. Shi,et al. IGF‐I and breast cancer: A meta‐analysis , 2004, International journal of cancer.
[89] E. Weiss-Messer,et al. Growth hormone (GH) receptors in prostate cancer: gene expression in human tissues and cell lines and characterization, GH signaling and androgen receptor regulation in LNCaP cells , 2004, Molecular and Cellular Endocrinology.
[90] Matthias Egger,et al. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis , 2004, The Lancet.
[91] M. Armoni,et al. The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression , 2004, Cancer Research.
[92] Z. Laron,et al. Laron syndrome (primary growth hormone resistance or insensitivity): the personal experience 1958-2003. , 2004, The Journal of clinical endocrinology and metabolism.
[93] C. Lautier,et al. IGF-I receptor mutations resulting in intrauterine and postnatal growth retardation. , 2003, The New England journal of medicine.
[94] H. Werner,et al. Functional and Physical Interactions between BRCA1 and p53 in Transcriptional Regulation of the IGF-IR Gene , 2003, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[95] T. Ouchi,et al. BRCA1–Sp1 interactions in transcriptional regulation of the IGF‐IR gene , 2003, FEBS letters.
[96] H. Werner,et al. WT1-p53 Interactions in Insulin-like Growth Factor-I Receptor Gene Regulation* , 2003, The Journal of Biological Chemistry.
[97] J. Olsen,et al. Acromegaly and cancer risk: a cohort study in Sweden and Denmark , 2002, Cancer Causes & Control.
[98] R. Poulsom,et al. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. , 2002, Cancer research.
[99] R. Shi,et al. Insulin-like growth factor-I and prostate cancer: a meta-analysis , 2001, British Journal of Cancer.
[100] L. Kindblom,et al. Growth hormone receptor is expressed in human breast cancer. , 2001, The American journal of pathology.
[101] R. Fishel,et al. BRCA1 and cell signaling , 2000, Oncogene.
[102] A. Benner,et al. Down‐regulation of insulin‐like growth factor‐I receptor and insulin receptor substrate‐1 expression in advanced human breast cancer , 2000, International journal of cancer.
[103] G. Nilsson,et al. Increased expression of insulin-like growth factor I receptor in malignant cells expressing aberrant p53: functional impact. , 2000, Cancer research.
[104] W. Willett,et al. A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. , 2000, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
[105] A. Renehan,et al. Response: More About: Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF- Binding Protein-3 , 1999 .
[106] M. Lippman,et al. BRCA1 and BRCA2 in breast cancer , 1999, Breast Cancer Research and Treatment.
[107] C. Mantzoros,et al. Leptin in relation to carcinoma In situ of the breast: A study of pre‐menopausal cases and controls , 1999, International journal of cancer.
[108] David J Hunter,et al. Circulating concentrations of insulin-like growth factor I and risk of breast cancer , 1998, The Lancet.
[109] D. Germani,et al. In vitro effects of growth hormone (GH) and insulin‐like growth factor I and II (IGF‐I and ‐II) on chromosome fragility and p53 protein expression in human lymphocytes , 1998, European journal of clinical investigation.
[110] R. Baserga,et al. The IGF-I receptor and cancer , 1997, Endocrine.
[111] D. Graves,et al. Risk of leukemia in children treated with human growth hormone: review and reanalysis. , 1997, The Journal of pediatrics.
[112] I. Lerer,et al. The founder mutations 185delAG and 5382insC in BRCA1 and 6174delT in BRCA2 appear in 60% of ovarian cancer and 30% of early-onset breast cancer patients among Ashkenazi women. , 1997, American journal of human genetics.
[113] R. Baserga,et al. The insulin-like growth factor I receptor as a physiologically relevant target of p53 in apoptosis caused by interleukin-3 withdrawal , 1997, Molecular and cellular biology.
[114] H. Werner,et al. Wild-type and mutant p53 differentially regulate transcription of the insulin-like growth factor I receptor gene. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[115] K. Siddle,et al. c phosphorylation and activation of the IGF-I receptor in src-transformed cells. , 1994, The Journal of biological chemistry.
[116] Steven E. Bayer,et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. , 1994, Science.
[117] M. Skolnick,et al. BRCA1 mutations in primary breast and ovarian carcinomas. , 1994, Science.
[118] D. Coppola,et al. Effect of a null mutation of the insulin-like growth factor I receptor gene on growth and transformation of mouse embryo fibroblasts , 1994, Molecular and cellular biology.
[119] D. Easton,et al. Risks of cancer in BRCA1-mutation carriers , 1994, The Lancet.
[120] M. Rubini,et al. Simian virus 40 large tumor antigen is unable to transform mouse embryonic fibroblasts lacking type 1 insulin-like growth factor receptor. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[121] M. Hollstein,et al. Clinical implications of the p53 tumor-suppressor gene. , 1993, The New England journal of medicine.
[122] M. Oren. p53: the ultimate tumor suppressor gene? , 1992, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[123] N. Stahnke. Leukemia in growth-hormone-treated patients: an update, 1992. , 1992, Hormone research.
[124] A. Ferber,et al. The protooncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism. , 1991, Cancer research.
[125] K. Kinzler,et al. Identification of p53 as a sequence-specific DNA-binding protein , 1991, Science.
[126] H. Werner,et al. Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. , 1990, Molecular endocrinology.
[127] G. Novelli,et al. Laron dwarfism and mutations of the growth hormone-receptor gene. , 1989, The New England journal of medicine.
[128] L. Meacham,et al. Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism. , 1989, Proceedings of the National Academy of Sciences of the United States of America.
[129] A. Pertzelan,et al. Genetic pituitary dwarfism with high serum concentation of growth hormone--a new inborn error of metabolism? , 1966, Israel journal of medical sciences.
[130] H. Werner,et al. Fifty years on: New lessons from Laron syndrome. , 2017, The Israel Medical Association journal : IMAJ.
[131] H. Werner,et al. p53 Regulates insulin-like growth factor-I receptor gene expression in uterine serous carcinoma and predicts responsiveness to an insulin-like growth factor-I receptor-directed targeted therapy. , 2012, European journal of cancer.
[132] K. Parker,et al. Long-term safety of recombinant human growth hormone in children. , 2010, The Journal of clinical endocrinology and metabolism.
[133] H. Werner. The Pathophysiological Significance of IGF-I Receptor Overexpression: New Insights , 2009 .
[134] J. Vandenbroucke,et al. Mortality in acromegaly: a metaanalysis. , 2008, The Journal of clinical endocrinology and metabolism.
[135] B. Ray,et al. Results of hypophysectomy in the treatment of metastatic mammary carcinoma , 1959, Cancer.