Plasma angiopoietin‐1, angiopoietin‐2 and Tie‐2 in breast and prostate cancer: a comparison with VEGF and Flt‐1

Background  Angiogenesis is essential for tumour growth and metastasis, and is coordinated by several classes of growth factors mediating their effect through receptors linked, in turn, to tyrosine kinase. These growth factors include angiopoietin‐1 (Ang‐1), angiopoietin‐2 (Ang‐2) and vascular endothelial growth factor (VEGF), which act through receptors Flt‐1 and Tie‐2.

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