Testosterone supplementation for aging-associated sarcopenia.

Aging of humans is associated with a loss of muscle mass and function, and an increase in fat mass. Epidemiologic studies have demonstrated a correlation between bioavailable testosterone concentrations and fat-free mass and muscle strength. Testosterone replacement in older men with low testosterone levels increases fat-free mass and muscle strength, and decreases fat mass. However, we do not know whether testosterone replacement improves physical function and other health-related outcomes, or reduces the risk of disability, falls, or fractures in older men with low testosterone levels. The long-term risks and benefits of testosterone supplementation in older men are not known.

[1]  D. Grobbee,et al.  Endogenous sex hormones and cardiovascular disease in men. , 2003, The Journal of clinical endocrinology and metabolism.

[2]  S. Bhasin,et al.  Managing the risks of prostate disease during testosterone replacement therapy in older men: recommendations for a standardized monitoring plan. , 2003, Journal of andrology.

[3]  L. Woodhouse,et al.  Development of models to predict anabolic response to testosterone administration in healthy young men. , 2003, American journal of physiology. Endocrinology and metabolism.

[4]  R. Casaburi,et al.  Testosterone dose-dependently increases maximal voluntary strength and leg power, but does not affect fatigability or specific tension. , 2003, The Journal of clinical endocrinology and metabolism.

[5]  A. Kenny,et al.  Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[6]  S. Resnick,et al.  Longitudinal assessment of serum free testosterone concentration predicts memory performance and cognitive status in elderly men. , 2002, The Journal of clinical endocrinology and metabolism.

[7]  E. Metter,et al.  Interrelationships of serum testosterone and free testosterone index with FFM and strength in aging men. , 2002, American journal of physiology. Endocrinology and metabolism.

[8]  R. Casaburi,et al.  Testosterone-induced increase in muscle size in healthy young men is associated with muscle fiber hypertrophy. , 2002, American journal of physiology. Endocrinology and metabolism.

[9]  R. Wolfe,et al.  Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. , 2002, American journal of physiology. Endocrinology and metabolism.

[10]  A. Matsumoto.  Andropause: clinical implications of the decline in serum testosterone levels with aging in men. , 2002, The journals of gerontology. Series A, Biological sciences and medical sciences.

[11]  A. Araujo,et al.  Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study. , 2002, The Journal of clinical endocrinology and metabolism.

[12]  A. Vermeulen,et al.  Diagnosis of hypogonadism in the aging male , 2002, The aging male : the official journal of the International Society for the Study of the Aging Male.

[13]  R. Casaburi,et al.  Testosterone dose-response relationships in healthy young men. , 2001, American journal of physiology. Endocrinology and metabolism.

[14]  J. Buckwalter,et al.  Testosterone supplementation in older men: a rational idea whose time has not yet come. , 2001, Journal of andrology.

[15]  L. Woodhouse,et al.  Proof of the effect of testosterone on skeletal muscle. , 2001, The Journal of endocrinology.

[16]  A. Kenny,et al.  Effects of transdermal testosterone on bone and muscle in older men with low bioavailable testosterone levels. , 2001, The journals of gerontology. Series A, Biological sciences and medical sciences.

[17]  Ronenn Roubenoff,et al.  From the Chicago MeetingsSarcopenia , 2001 .

[18]  E. Metter,et al.  Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. , 2001, The Journal of clinical endocrinology and metabolism.

[19]  D. Schoenfeld,et al.  Effects of Testosterone and Progressive Resistance Training in Eugonadal Men with AIDS Wasting , 2000, Annals of Internal Medicine.

[20]  J. Berlin,et al.  Effects of testosterone replacement in hypogonadal men. , 2000, The Journal of clinical endocrinology and metabolism.

[21]  H. Perry,et al.  Testosterone and leptin in older African-American men: relationship to age, strength, function, and season. , 2000, Metabolism: clinical and experimental.

[22]  A. Iranmanesh,et al.  Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. , 2000, The Journal of clinical endocrinology and metabolism.

[23]  D. Spiegelman,et al.  Relation of lean body mass to health-related quality of life in persons with HIV. , 2000 .

[24]  W. O'Fallon,et al.  Epidemiology of Sarcopenia , 2000, Journal of the American Geriatrics Society.

[25]  M. Godschalk,et al.  Testosterone Improves Rehabilitation Outcomes in Ill Older Men , 2000, Journal of the American Geriatrics Society.

[26]  W. DeWolf,et al.  Is low serum free testosterone a marker for high grade prostate cancer? , 2000, The Journal of urology.

[27]  G. Beall,et al.  Testosterone replacement and resistance exercise in HIV-infected men with weight loss and low testosterone levels. , 2000, JAMA.

[28]  E. Barrett-Connor,et al.  Endogenous sex hormones and cognitive function in older men. , 1999, The Journal of clinical endocrinology and metabolism.

[29]  J. Berlin,et al.  Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. , 1999, The Journal of clinical endocrinology and metabolism.

[30]  M. Van Loan,et al.  Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: a randomized controlled trial. , 1999, JAMA.

[31]  R. Baumgartner,et al.  Predictors of skeletal muscle mass in elderly men and women , 1999, Mechanisms of Ageing and Development.

[32]  M. Van Loan,et al.  Effects of nandrolone decanoate therapy in borderline hypogonadal men with HIV-associated weight loss. , 1999, Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association.

[33]  R. Casaburi,et al.  Androgen effects on body composition and muscle function: implications for the use of androgens as anabolic agents in sarcopenic states. , 1998, Bailliere's clinical endocrinology and metabolism.

[34]  E. Nieschlag,et al.  Potential adverse effects of long-term testosterone therapy. , 1998, Bailliere's clinical endocrinology and metabolism.

[35]  A. Kilbourne,et al.  Effects of testosterone replacement with a nongenital, transdermal system, Androderm, in human immunodeficiency virus-infected men with low testosterone levels. , 1998, The Journal of clinical endocrinology and metabolism.

[36]  E. Velázquez M,et al.  Testosterone replacement therapy. , 1998, Archives of andrology.

[37]  A. Klibanski,et al.  Effects of Androgen Administration in Men with the AIDS Wasting Syndrome , 1998, Annals of Internal Medicine.

[38]  S. Heymsfield,et al.  Epidemiology of sarcopenia among the elderly in New Mexico. , 1998, American journal of epidemiology.

[39]  K. Nair,et al.  Age-related sarcopenia in humans is associated with reduced synthetic rates of specific muscle proteins. , 1998, The Journal of nutrition.

[40]  C. Cooper,et al.  Effect of exogenous testosterone on prostate volume, serum and semen prostate specific antigen levels in healthy young men. , 1998, The Journal of urology.

[41]  D. Schoenfeld,et al.  Using quantitative CT to assess adipose distribution in adult men with acquired hypogonadism. , 1998, AJR. American journal of roentgenology.

[42]  M. Saraste,et al.  Diagnosis of infective endocarditis. Sensitivity of the Duke vs von Reyn criteria. , 1998, Archives of internal medicine.

[43]  D. Fryburg,et al.  Short-term modulation of the androgen milieu alters pulsatile, but not exercise- or growth hormone (GH)-releasing hormone-stimulated GH secretion in healthy men: impact of gonadal steroid and GH secretory changes on metabolic outcomes. , 1997, The Journal of clinical endocrinology and metabolism.

[44]  I. Thompson,et al.  The effect of parenteral testosterone replacement on prostate specific antigen in hypogonadal men with erectile dysfunction. , 1997, The Journal of urology.

[45]  A. Kriska,et al.  Longitudinal relation between endogenous testosterone and cardiovascular disease risk factors in middle-aged men. A 13-year follow-up of former Multiple Risk Factor Intervention Trial participants. , 1997, American journal of epidemiology.

[46]  Martin Straume,et al.  Aging alters feed-forward and feedback linkages between LH and testosterone in healthy men. , 1997, American journal of physiology. Regulatory, integrative and comparative physiology.

[47]  R. Conwit,et al.  Age-associated loss of power and strength in the upper extremities in women and men. , 1997, The journals of gerontology. Series A, Biological sciences and medical sciences.

[48]  S. Winters,et al.  Serum LH concentrations in hypogonadal men during transdermal testosterone replacement through scrotal skin: further evidence that ageing enhances testosterone negative feedback , 1997, Clinical endocrinology.

[49]  H. Perry,et al.  Potentially predictive and manipulable blood serum correlates of aging in the healthy human male: progressive decreases in bioavailable testosterone, dehydroepiandrosterone sulfate, and the ratio of insulin-like growth factor 1 to growth hormone. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[50]  H. Perry,et al.  Testosterone replacement in older hypogonadal men: a 12-month randomized controlled trial. , 1997, The Journal of clinical endocrinology and metabolism.

[51]  T Harris,et al.  Muscle mass and strength: relation to function in population studies. , 1997, The Journal of nutrition.

[52]  P J Garry,et al.  Longitudinal changes in testosterone, luteinizing hormone, and follicle-stimulating hormone in healthy older men. , 1997, Metabolism: clinical and experimental.

[53]  P. Micevych,et al.  Anabolic-androgenic steroid induced alterations in choline acetyltransferase messenger RNA levels of spinal cord motoneurons in the male rat , 1997, Neuroscience.

[54]  R. Casaburi,et al.  Testosterone replacement increases fat-free mass and muscle size in hypogonadal men. , 1997, The Journal of clinical endocrinology and metabolism.

[55]  S. Arver,et al.  Prostate size in hypogonadal men treated with a nonscrotal permeation-enhanced testosterone transdermal system. , 1997, Urology.

[56]  W. DeWolf,et al.  Occult prostate cancer in men with low serum testosterone levels. , 1996, JAMA.

[57]  D. Schoenfeld,et al.  Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. , 1996, The Journal of clinical endocrinology and metabolism.

[58]  K. Nair,et al.  Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men--a clinical research center study. , 1996, The Journal of clinical endocrinology and metabolism.

[59]  A. Iranmanesh,et al.  Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center study. , 1996, The Journal of clinical endocrinology and metabolism.

[60]  C. Christiansen,et al.  The relationship of natural androgens to coronary heart disease in males: a review. , 1996, Atherosclerosis.

[61]  N. Ancy,et al.  The effects of supraphysiologic doses of testosterone on muscle size and strength in normal men. , 1996 .

[62]  Bardin Cw.  The Anabolic Action of Testosterone , 1996 .

[63]  W. Evans.  What is sarcopenia? , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[64]  E. Hadley,et al.  The significance of sarcopenia in old age. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[65]  R. Wolfe,et al.  Testosterone administration to elderly men increases skeletal muscle strength and protein synthesis. , 1995, The American journal of physiology.

[66]  J. Lexell,et al.  Human aging, muscle mass, and fiber type composition. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[67]  J. Judge,et al.  Strength is a major factor in balance, gait, and the occurrence of falls. , 1995, The journals of gerontology. Series A, Biological sciences and medical sciences.

[68]  J. M. Davies,et al.  Strength, power and related functional ability of healthy people aged 65-89 years. , 1994, Age and ageing.

[69]  E. Nieschlag,et al.  Prostate volume in testosterone‐treated and untreated hypogonadal men in comparison to age‐matched normal controls , 1994, Clinical endocrinology.

[70]  R. Swerdloff,et al.  Androgen deficiency and aging in men. , 1993, The Western journal of medicine.

[71]  E. Seeman,et al.  Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception. , 1993, The Journal of clinical endocrinology and metabolism.

[72]  H. Perry,et al.  Effects of Testosterone Replacement Therapy in Old Hypogonadal Males: A Preliminary Study , 1993, Journal of the American Geriatrics Society.

[73]  J. S. Tenover.  Effects of testosterone supplementation in the aging male. , 1992, The Journal of clinical endocrinology and metabolism.

[74]  P. Björntorp,et al.  Androgen treatment of middle-aged, obese men: effects on metabolism, muscle and adipose tissues. , 1992, The European journal of medicine.

[75]  G. Dalsky,et al.  Body composition of healthy sedentary and trained, young and older men and women. , 1992, Medicine and science in sports and exercise.

[76]  E. Barrett-Connor,et al.  The influence of aging on plasma sex hormones in men: the Telecom Study. , 1992, American journal of epidemiology.

[77]  L. Lipsitz,et al.  Leg extensor power and functional performance in very old men and women. , 1992, Clinical science.

[78]  J. Mckinlay,et al.  Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts Male Aging Study. , 1991, The Journal of clinical endocrinology and metabolism.

[79]  S. M. Breedlove,et al.  Sexual dimorphism and androgen effects on spinal motoneurons innervating the rat flexor digitorum brevis , 1991, Brain Research.

[80]  K. J. Lutz,et al.  A cross-sectional study of muscle strength and mass in 45- to 78-yr-old men and women. , 1991, Journal of applied physiology.

[81]  A. Vermeulen.  Clinical review 24: Androgens in the aging male. , 1991, The Journal of clinical endocrinology and metabolism.

[82]  L. Sjöström,et al.  Visceral fat accumulation in men is positively associated with insulin, glucose, and C-peptide levels, but negatively with testosterone levels. , 1990, Metabolism: clinical and experimental.

[83]  J. Miller,et al.  Randomized controlled trial of testosterone in myotonic dystrophy , 1989, Neurology.

[84]  J. Fleg,et al.  Role of muscle loss in the age-associated reduction in VO2 max. , 1988, Journal of applied physiology.

[85]  E. Barrett-Connor,et al.  Endogenous sex hormones and cardiovascular disease in men. A prospective population-based study. , 1988, Circulation.

[86]  J. Wilson,et al.  Androgen abuse by athletes. , 1988, Endocrine reviews.

[87]  A. Matsumoto,et al.  The effects of aging in normal men on bioavailable testosterone and luteinizing hormone secretion: response to clomiphene citrate. , 1987, The Journal of clinical endocrinology and metabolism.

[88]  Lester M. Wolfson,et al.  The Relationship of Knee and Ankle Weakness to Falls in Nursing Home Residents: An Isokinetic Study , 1987, Journal of the American Geriatrics Society.

[89]  H. Nankin,et al.  Decreased bioavailable testosterone in aging normal and impotent men. , 1986, The Journal of clinical endocrinology and metabolism.

[90]  M. Konagaya,et al.  A possible role for endogenous glucocorticoids in orchiectomy-induced atrophy of the rat levator ani muscle: studies with RU 38486, a potent and selective antiglucocorticoid. , 1986, Journal of steroid biochemistry.

[91]  J. Gustafsson,et al.  Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. , 1984, Endocrinology.

[92]  G. Borkan,et al.  Age changes in body composition revealed by computed tomography. , 1983, Journal of gerontology.

[93]  J Lexell,et al.  Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections , 1983, Muscle & nerve.

[94]  Walter J. Greenleaf,et al.  Hormonal changes and sexual function in aging men. , 1983, The Journal of clinical endocrinology and metabolism.

[95]  M. Vitiello,et al.  Loss of circadian rhythmicity in blood testosterone levels with aging in normal men. , 1983, The Journal of clinical endocrinology and metabolism.

[96]  K. Langer,et al.  Reproductive Function in Young Fathers and Grandfathers , 1983 .

[97]  K. Langer,et al.  Reproductive functions in young fathers and grandfathers. , 1982, The Journal of clinical endocrinology and metabolism.

[98]  E. Murono,et al.  The aging Leydig cell: VI. Response of testosterone precursors to gonadotrophin in men. , 1982, Acta endocrinologica.

[99]  P. Costa,et al.  Reproductive hormones in aging men. II. Basal pituitary gonadotropins and gonadotropin responses to luteinizing hormone-releasing hormone. , 1982, The Journal of clinical endocrinology and metabolism.

[100]  G. Strain,et al.  Age variation of the 24-hour mean plasma concentrations of androgens, estrogens, and gonadotropins in normal adult men. , 1982, The Journal of clinical endocrinology and metabolism.

[101]  J. Gustafsson,et al.  Regulation of the androgen and glucocorticoid receptors in rat and mouse skeletal muscle cytosol. , 1981, Endocrinology.

[102]  P. Tsitouras,et al.  Reproductive hormones in aging men. I. Measurement of sex steroids, basal luteinizing hormone, and Leydig cell response to human chorionic gonadotropin. , 1980, The Journal of clinical endocrinology and metabolism.

[103]  M. Krieg,et al.  Quantification of endogenous testosterone, 5α-dihydrotestosterone and 5α-androstane-3α, 17β-diol in subcellular fractions of the prostate, bulbocavernosus/levator ani muscle, skeletal muscle and heart muscle of the rat , 1980 .

[104]  G. Borkan,et al.  Fat redistribution and the changing body dimensions of the adult male. , 1977, Human biology.

[105]  K. Pirke,et al.  Age related changes and interrelationships between plasma testosterone, oestradiol and testosterone-binding globulin in normal adult males. , 1973, Acta endocrinologica.

[106]  L. P. Novâk,et al.  Aging, total body potassium, fat-free mass, and cell mass in males and females between ages 18 and 85 years. , 1972, Journal of gerontology.

[107]  Thomas R. Riley,et al.  A Randomized Double-blind Placebo-controlled Trial , 2004 .

[108]  S. Bhasin,et al.  Effects of an oral androgen on muscle and metabolism in older, community-dwelling men. , 2003, American journal of physiology. Endocrinology and metabolism.

[109]  T. Buchanan,et al.  The effects of varying doses of T on insulin sensitivity, plasma lipids, apolipoproteins, and C-reactive protein in healthy young men. , 2002, The Journal of clinical endocrinology and metabolism.

[110]  J. Tenover.  Experience with testosterone replacement in the elderly. , 2000, Mayo Clinic proceedings.

[111]  D. Schroeder,et al.  Possible guidelines for autologous red blood cell donations before total hip arthroplasty based on the surgical blood order equation. , 2000, Mayo Clinic proceedings.

[112]  P. Björntorp,et al.  Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens. , 1995, The Journal of clinical endocrinology and metabolism.

[113]  Kochakian Cd.  History, chemistry and pharmacodynamics of anabolic-androgenic steroids. , 1993 .

[114]  J. Mckinlay,et al.  An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis. , 1991, Journal of clinical epidemiology.

[115]  R. Griggs,et al.  Effect of testosterone on muscle mass and muscle protein synthesis. , 1989, Journal of applied physiology.

[116]  T. Nakada,et al.  Testosterone replacement therapy and prostate/seminal vesicle volume in Klinefelter's syndrome. , 1989, Archives of andrology.

[117]  N. Rance,et al.  Modulation of the cytosolic androgen receptor in striated muscle by sex steroids. , 1984, Endocrinology.

[118]  J. Aloia,et al.  Changes in body chemical composition with age measured by total-body neutron activation. , 1976, Metabolism: clinical and experimental.

[119]  N. Mauras,et al.  Journal of Clinical Endocrinology and Metabolism Printed in U.S.A. Copyright © 1998 by The Endocrine Society Testosterone Deficiency in Young Men: Marked Alterations in Whole Body Protein Kinetics, Strength, and Adiposity* , 2022 .

[120]  R. Wolfe,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Short-Term Oxandrolone Administration Stimulates Net Muscle Protein Synthesis in Young Men* , 2022 .