Studying human and animal skin optical properties by terahertz time-domain spectroscopy

Human and rat skin reflection spectra and the effect of glucose and glycerol on these spectra are studied in vivo by terahertz time-domain spectroscopy in the frequency range of 0.1–2.0 THz. Variations in skin optical properties proved to correlate with changes in the blood glucose level.

[1]  Olga G. Kosareva,et al.  Study of terahertz-radiation-induced DNA damage in human blood leukocytes , 2014 .

[2]  I. A. Ozheredov,et al.  Characteristic responses of biological and nanoscale systems in the terahertz frequency range , 2014 .

[3]  Valery V. Tuchin,et al.  Optical clearing of skin under action of glycerol: Ex vivo and in vivo investigations , 2010 .

[4]  Valery V. Tuchin,et al.  Terahertz time-domain spectroscopy of biological tissues , 2008 .

[5]  Valery V. Tuchin,et al.  In vitro terahertz monitoring of muscle tissue dehydration under the action of hyperosmotic agents , 2014 .

[6]  P. Okunieff,et al.  Evaluation of tumor energy metabolism and microvascular blood flow after glucose or mannitol administration using 31P nuclear magnetic resonance spectroscopy and laser Doppler flowmetry. , 1989, International journal of radiation oncology, biology, physics.

[7]  J. McGrath,et al.  Anatomy and Organization of Human Skin , 2008 .

[8]  G. Puppels,et al.  Combined in vivo confocal Raman spectroscopy and confocal microscopy of human skin. , 2003, Biophysical journal.

[9]  Valery V. Tuchin,et al.  OPTICAL PROPERTIES OF SKIN, SUBCUTANEOUS, AND MUSCLE TISSUES: A REVIEW , 2011 .

[10]  V. Tuchin.  Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis , 2000 .

[11]  Jeong-Woo Park,et al.  Photonic devices for tunable continuous-wave terahertz generation and detection , 2014, Photonics West - Optoelectronic Materials and Devices.

[12]  Massoud Motamedi,et al.  Specificity of noninvasive blood glucose sensing using optical coherence tomography technique: a pilot study. , 2003, Physics in medicine and biology.

[13]  Xiao Guo,et al.  Effects of optical clearing agents on noninvasive blood glucose monitoring with optical coherence tomography: a pilot study , 2012, Journal of biomedical optics.

[14]  Valery V. Tuchin,et al.  Terahertz Tissue Spectroscopy and Imaging , 2010 .

[15]  T. Redelmeier,et al.  Skin Barrier: Principles of Percutaneous Absorption , 1996 .

[16]  A. N. Bashkatov,et al.  Optical properties of human skin, subcutaneous and mucous tissues in the wavelength range from 400 to 2000 nm , 2005 .